Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PSMC2 (proteasome 26S subunit, ATPase 2)

Identity

Alias_namesproteasome (prosome
Alias_symbol (synonym)MSS1
S7
Nbla10058
Other alias
HGNC (Hugo) PSMC2
LocusID (NCBI) 5701
Atlas_Id 55448
Location 7q22.1  [Link to chromosome band 7q22]
Location_base_pair Starts at 102987971 and ends at 103002914 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CGA (6q14.3) / PSMC2 (7q22.1)GTF3C4 (9q34.13) / PSMC2 (7q22.1)PSMC2 (7q22.1) / APC (5q22.2)
PSMC2 (7q22.1) / PSMC2 (7q22.1)PSMC2 (7q22.1) / PTPRF (1p34.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PSMC2   9548
Cards
Entrez_Gene (NCBI)PSMC2  5701  proteasome 26S subunit, ATPase 2
AliasesMSS1; Nbla10058; S7
GeneCards (Weizmann)PSMC2
Ensembl hg19 (Hinxton)ENSG00000161057 [Gene_View]  chr7:102987971-103002914 [Contig_View]  PSMC2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000161057 [Gene_View]  chr7:102987971-103002914 [Contig_View]  PSMC2 [Vega]
ICGC DataPortalENSG00000161057
TCGA cBioPortalPSMC2
AceView (NCBI)PSMC2
Genatlas (Paris)PSMC2
WikiGenes5701
SOURCE (Princeton)PSMC2
Genetics Home Reference (NIH)PSMC2
Genomic and cartography
GoldenPath hg19 (UCSC)PSMC2  -     chr7:102987971-103002914 +  7q22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PSMC2  -     7q22.1   [Description]    (hg38-Dec_2013)
EnsemblPSMC2 - 7q22.1 [CytoView hg19]  PSMC2 - 7q22.1 [CytoView hg38]
Mapping of homologs : NCBIPSMC2 [Mapview hg19]  PSMC2 [Mapview hg38]
OMIM154365   
Gene and transcription
Genbank (Entrez)AB075520 AK298529 AK298821 AK312648 BC002589
RefSeq transcript (Entrez)NM_001204453 NM_002803
RefSeq genomic (Entrez)NC_000007 NC_018918 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)PSMC2
Cluster EST : UnigeneHs.437366 [ NCBI ]
CGAP (NCI)Hs.437366
Alternative Splicing GalleryENSG00000161057
Gene ExpressionPSMC2 [ NCBI-GEO ]   PSMC2 [ EBI - ARRAY_EXPRESS ]   PSMC2 [ SEEK ]   PSMC2 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5701
GTEX Portal (Tissue expression)PSMC2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35998   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35998  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35998
Splice isoforms : SwissVarP35998
PhosPhoSitePlusP35998
Domaine pattern : Prosite (Expaxy)AAA (PS00674)   
Domains : Interpro (EBI)26S_Psome_P45    AAA+_ATPase    ATPase_AAA_core    ATPase_AAA_CS    P-loop_NTPase   
Domain families : Pfam (Sanger)AAA (PF00004)   
Domain families : Pfam (NCBI)pfam00004   
Domain families : Smart (EMBL)AAA (SM00382)  
Conserved Domain (NCBI)PSMC2
DMDM Disease mutations5701
Blocks (Seattle)PSMC2
SuperfamilyP35998
Human Protein AtlasENSG00000161057
Peptide AtlasP35998
HPRD01105
IPIIPI00021435   IPI01015219   IPI00927053   
Protein Interaction databases
DIP (DOE-UCLA)P35998
IntAct (EBI)P35998
FunCoupENSG00000161057
BioGRIDPSMC2
STRING (EMBL)PSMC2
ZODIACPSMC2
Ontologies - Pathways
QuickGOP35998
Ontology : AmiGOMAPK cascade  protein polyubiquitination  proteasome complex  cytoplasmic mRNA processing body  osteoblast differentiation  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytosol  ubiquitin-dependent protein catabolic process  regulation of cellular amino acid metabolic process  proteasome regulatory particle, base subcomplex  membrane  viral process  ATPase activity  TBP-class protein binding  proteasome accessory complex  ER-associated ubiquitin-dependent protein catabolic process  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process  nuclear proteasome complex  cytosolic proteasome complex  tumor necrosis factor-mediated signaling pathway  proteasome-activating ATPase activity  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  intracellular membrane-bounded organelle  regulation of mRNA stability  positive regulation of RNA polymerase II transcriptional preinitiation complex assembly  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  Wnt signaling pathway, planar cell polarity pathway  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  positive regulation of proteasomal protein catabolic process  
Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  proteasome complex  cytoplasmic mRNA processing body  osteoblast differentiation  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytosol  ubiquitin-dependent protein catabolic process  regulation of cellular amino acid metabolic process  proteasome regulatory particle, base subcomplex  membrane  viral process  ATPase activity  TBP-class protein binding  proteasome accessory complex  ER-associated ubiquitin-dependent protein catabolic process  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process  nuclear proteasome complex  cytosolic proteasome complex  tumor necrosis factor-mediated signaling pathway  proteasome-activating ATPase activity  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  intracellular membrane-bounded organelle  regulation of mRNA stability  positive regulation of RNA polymerase II transcriptional preinitiation complex assembly  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  Wnt signaling pathway, planar cell polarity pathway  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  positive regulation of proteasomal protein catabolic process  
Pathways : KEGGProteasome    Epstein-Barr virus infection   
NDEx NetworkPSMC2
Atlas of Cancer Signalling NetworkPSMC2
Wikipedia pathwaysPSMC2
Orthology - Evolution
OrthoDB5701
GeneTree (enSembl)ENSG00000161057
Phylogenetic Trees/Animal Genes : TreeFamPSMC2
HOVERGENP35998
HOGENOMP35998
Homologs : HomoloGenePSMC2
Homology/Alignments : Family Browser (UCSC)PSMC2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSMC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMC2
dbVarPSMC2
ClinVarPSMC2
1000_GenomesPSMC2 
Exome Variant ServerPSMC2
ExAC (Exome Aggregation Consortium)PSMC2 (select the gene name)
Genetic variants : HAPMAP5701
Genomic Variants (DGV)PSMC2 [DGVbeta]
DECIPHER (Syndromes)7:102987971-103002914  ENSG00000161057
CONAN: Copy Number AnalysisPSMC2 
Mutations
ICGC Data PortalPSMC2 
TCGA Data PortalPSMC2 
Broad Tumor PortalPSMC2
OASIS PortalPSMC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSMC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSMC2
DgiDB (Drug Gene Interaction Database)PSMC2
DoCM (Curated mutations)PSMC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSMC2 (select a term)
intoGenPSMC2
Cancer3DPSMC2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM154365   
Orphanet
MedgenPSMC2
Genetic Testing Registry PSMC2
NextProtP35998 [Medical]
TSGene5701
GENETestsPSMC2
Huge Navigator PSMC2 [HugePedia]
snp3D : Map Gene to Disease5701
BioCentury BCIQPSMC2
ClinGenPSMC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5701
Chemical/Pharm GKB GenePA33893
Clinical trialPSMC2
Miscellaneous
canSAR (ICR)PSMC2 (select the gene name)
Probes
Litterature
PubMed130 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSMC2
EVEXPSMC2
GoPubMedPSMC2
iHOPPSMC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:16:00 CEST 2017

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