Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PSMC3 (proteasome 26S subunit, ATPase 3)

Identity

Alias_namesproteasome (prosome
Alias_symbol (synonym)TBP1
TBP-1
Other alias
HGNC (Hugo) PSMC3
LocusID (NCBI) 5702
Atlas_Id 41886
Location 11p11.2  [Link to chromosome band 11p11]
Location_base_pair Starts at 47418769 and ends at 47426473 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MYO7A (11q13.5) / PSMC3 (11p11.2)PSMC3 (11p11.2) / AKIRIN1 (1p34.3)PSMC3 (11p11.2) / DAP (5p15.2)
PSMC3 (11p11.2) / POLR2D (2q14.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PSMC3   9549
Cards
Entrez_Gene (NCBI)PSMC3  5702  proteasome 26S subunit, ATPase 3
AliasesTBP1
GeneCards (Weizmann)PSMC3
Ensembl hg19 (Hinxton)ENSG00000165916 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165916 [Gene_View]  chr11:47418769-47426473 [Contig_View]  PSMC3 [Vega]
ICGC DataPortalENSG00000165916
TCGA cBioPortalPSMC3
AceView (NCBI)PSMC3
Genatlas (Paris)PSMC3
WikiGenes5702
SOURCE (Princeton)PSMC3
Genetics Home Reference (NIH)PSMC3
Genomic and cartography
GoldenPath hg38 (UCSC)PSMC3  -     chr11:47418769-47426473 -  11p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PSMC3  -     11p11.2   [Description]    (hg19-Feb_2009)
EnsemblPSMC3 - 11p11.2 [CytoView hg19]  PSMC3 - 11p11.2 [CytoView hg38]
Mapping of homologs : NCBIPSMC3 [Mapview hg19]  PSMC3 [Mapview hg38]
OMIM186852   
Gene and transcription
Genbank (Entrez)AK222485 AK291896 AK313518 BC008713 BC073165
RefSeq transcript (Entrez)NM_002804
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PSMC3
Cluster EST : UnigeneHs.250758 [ NCBI ]
CGAP (NCI)Hs.250758
Alternative Splicing GalleryENSG00000165916
Gene ExpressionPSMC3 [ NCBI-GEO ]   PSMC3 [ EBI - ARRAY_EXPRESS ]   PSMC3 [ SEEK ]   PSMC3 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMC3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5702
GTEX Portal (Tissue expression)PSMC3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17980   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP17980  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP17980
Splice isoforms : SwissVarP17980
PhosPhoSitePlusP17980
Domaine pattern : Prosite (Expaxy)AAA (PS00674)   
Domains : Interpro (EBI)26S_Psome_P45    AAA+_ATPase    ATPase_AAA_core    ATPase_AAA_CS    P-loop_NTPase   
Domain families : Pfam (Sanger)AAA (PF00004)   
Domain families : Pfam (NCBI)pfam00004   
Domain families : Smart (EMBL)AAA (SM00382)  
Conserved Domain (NCBI)PSMC3
DMDM Disease mutations5702
Blocks (Seattle)PSMC3
PDB (SRS)5GJQ    5GJR    5L4G    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (PDBSum)5GJQ    5GJR    5L4G    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (IMB)5GJQ    5GJR    5L4G    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (RSDB)5GJQ    5GJR    5L4G    5T0C    5T0G    5T0H    5T0I    5T0J   
Structural Biology KnowledgeBase5GJQ    5GJR    5L4G    5T0C    5T0G    5T0H    5T0I    5T0J   
SCOP (Structural Classification of Proteins)5GJQ    5GJR    5L4G    5T0C    5T0G    5T0H    5T0I    5T0J   
CATH (Classification of proteins structures)5GJQ    5GJR    5L4G    5T0C    5T0G    5T0H    5T0I    5T0J   
SuperfamilyP17980
Human Protein AtlasENSG00000165916
Peptide AtlasP17980
HPRD01733
IPIIPI00018398   IPI00979423   IPI00978735   IPI00979951   IPI00978171   IPI00980661   IPI00978915   IPI00982304   IPI00979529   
Protein Interaction databases
DIP (DOE-UCLA)P17980
IntAct (EBI)P17980
FunCoupENSG00000165916
BioGRIDPSMC3
STRING (EMBL)PSMC3
ZODIACPSMC3
Ontologies - Pathways
QuickGOP17980
Ontology : AmiGOMAPK cascade  protein polyubiquitination  proteasome complex  P-body  blastocyst development  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  ATP binding  extracellular region  nucleus  nucleoplasm  cytosol  regulation of cellular amino acid metabolic process  proteasome regulatory particle, base subcomplex  negative regulation of G2/M transition of mitotic cell cycle  membrane  viral process  protein deubiquitination  ATPase activity  TBP-class protein binding  proteasome accessory complex  ubiquitin-dependent ERAD pathway  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  nuclear proteasome complex  cytosolic proteasome complex  tumor necrosis factor-mediated signaling pathway  secretory granule lumen  proteasome-activating ATPase activity  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  identical protein binding  proteasome-mediated ubiquitin-dependent protein catabolic process  neutrophil degranulation  regulation of mRNA stability  modulation by host of viral transcription  positive regulation of RNA polymerase II transcriptional preinitiation complex assembly  positive regulation of transcription from RNA polymerase II promoter  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  positive regulation of proteasomal protein catabolic process  ficolin-1-rich granule lumen  
Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  proteasome complex  P-body  blastocyst development  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  ATP binding  extracellular region  nucleus  nucleoplasm  cytosol  regulation of cellular amino acid metabolic process  proteasome regulatory particle, base subcomplex  negative regulation of G2/M transition of mitotic cell cycle  membrane  viral process  protein deubiquitination  ATPase activity  TBP-class protein binding  proteasome accessory complex  ubiquitin-dependent ERAD pathway  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  nuclear proteasome complex  cytosolic proteasome complex  tumor necrosis factor-mediated signaling pathway  secretory granule lumen  proteasome-activating ATPase activity  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  identical protein binding  proteasome-mediated ubiquitin-dependent protein catabolic process  neutrophil degranulation  regulation of mRNA stability  modulation by host of viral transcription  positive regulation of RNA polymerase II transcriptional preinitiation complex assembly  positive regulation of transcription from RNA polymerase II promoter  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  positive regulation of proteasomal protein catabolic process  ficolin-1-rich granule lumen  
Pathways : KEGGProteasome    Epstein-Barr virus infection   
NDEx NetworkPSMC3
Atlas of Cancer Signalling NetworkPSMC3
Wikipedia pathwaysPSMC3
Orthology - Evolution
OrthoDB5702
GeneTree (enSembl)ENSG00000165916
Phylogenetic Trees/Animal Genes : TreeFamPSMC3
HOVERGENP17980
HOGENOMP17980
Homologs : HomoloGenePSMC3
Homology/Alignments : Family Browser (UCSC)PSMC3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSMC3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMC3
dbVarPSMC3
ClinVarPSMC3
1000_GenomesPSMC3 
Exome Variant ServerPSMC3
ExAC (Exome Aggregation Consortium)PSMC3 (select the gene name)
Genetic variants : HAPMAP5702
Genomic Variants (DGV)PSMC3 [DGVbeta]
DECIPHERPSMC3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPSMC3 
Mutations
ICGC Data PortalPSMC3 
TCGA Data PortalPSMC3 
Broad Tumor PortalPSMC3
OASIS PortalPSMC3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMC3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSMC3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSMC3
DgiDB (Drug Gene Interaction Database)PSMC3
DoCM (Curated mutations)PSMC3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSMC3 (select a term)
intoGenPSMC3
Cancer3DPSMC3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM186852   
Orphanet
MedgenPSMC3
Genetic Testing Registry PSMC3
NextProtP17980 [Medical]
TSGene5702
GENETestsPSMC3
Target ValidationPSMC3
Huge Navigator PSMC3 [HugePedia]
snp3D : Map Gene to Disease5702
BioCentury BCIQPSMC3
ClinGenPSMC3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5702
Chemical/Pharm GKB GenePA33894
Clinical trialPSMC3
Miscellaneous
canSAR (ICR)PSMC3 (select the gene name)
Probes
Litterature
PubMed133 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSMC3
EVEXPSMC3
GoPubMedPSMC3
iHOPPSMC3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:51:30 CEST 2017

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