| Nomenclature |
|---|
| HGNC (Hugo) | PSMC4 9551 |
| Cards |
|---|
| Entrez_Gene (NCBI) | PSMC4 5704 proteasome 26S subunit, ATPase 4 |
| Aliases | MIP224; RPT3; S6; TBP-7; |
| TBP7 |
| GeneCards (Weizmann) | PSMC4 |
| Ensembl hg19 (Hinxton) | ENSG00000013275 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000013275 [Gene_View] chr19:39971005-39981764 [Contig_View] PSMC4 [Vega] |
| ICGC DataPortal | ENSG00000013275 |
| TCGA cBioPortal | PSMC4 |
| AceView (NCBI) | PSMC4 |
| Genatlas (Paris) | PSMC4 |
| WikiGenes | 5704 |
| SOURCE (Princeton) | PSMC4 |
| Genetics Home Reference (NIH) | PSMC4 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | PSMC4 - chr19:39971005-39981764 + 19q13.2 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | PSMC4 - 19q13.2 [Description] (hg19-Feb_2009) |
| Ensembl | PSMC4 - 19q13.2 [CytoView hg19] PSMC4 - 19q13.2 [CytoView hg38] |
| Mapping of homologs : NCBI | PSMC4 [Mapview hg19] PSMC4 [Mapview hg38] |
| OMIM | 602707 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF020736 AF038965 AK290285 AK310135 AK313183 |
| RefSeq transcript (Entrez) | NM_006503 NM_153001 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | PSMC4 |
| Cluster EST : Unigene | Hs.211594 [ NCBI ] |
| CGAP (NCI) | Hs.211594 |
| Alternative Splicing Gallery | ENSG00000013275 |
| Gene Expression | PSMC4 [ NCBI-GEO ] PSMC4 [ EBI - ARRAY_EXPRESS ]
PSMC4 [ SEEK ] PSMC4 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | PSMC4 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 5704 |
| GTEX Portal (Tissue expression) | PSMC4 |
| Human Protein Atlas | ENSG00000013275-PSMC4 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P43686 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P43686 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P43686 |
| Splice isoforms : SwissVar | P43686 |
| PhosPhoSitePlus | P43686 |
| Domaine pattern : Prosite (Expaxy) | AAA (PS00674) |
| Domains : Interpro (EBI) | 26S_Psome_P45 AAA+_ATPase ATPase_AAA_core ATPase_AAA_CS P-loop_NTPase |
| Domain families : Pfam (Sanger) | AAA (PF00004) |
| Domain families : Pfam (NCBI) | pfam00004 |
| Domain families : Smart (EMBL) | AAA (SM00382) |
| Conserved Domain (NCBI) | PSMC4 |
| DMDM Disease mutations | 5704 |
| Blocks (Seattle) | PSMC4 |
| PDB (SRS) | 2DVW 5GJQ 5GJR 5L4G 5T0C 5T0G 5T0H 5T0I 5T0J |
| PDB (PDBSum) | 2DVW 5GJQ 5GJR 5L4G 5T0C 5T0G 5T0H 5T0I 5T0J |
| PDB (IMB) | 2DVW 5GJQ 5GJR 5L4G 5T0C 5T0G 5T0H 5T0I 5T0J |
| PDB (RSDB) | 2DVW 5GJQ 5GJR 5L4G 5T0C 5T0G 5T0H 5T0I 5T0J |
| Structural Biology KnowledgeBase | 2DVW 5GJQ 5GJR 5L4G 5T0C 5T0G 5T0H 5T0I 5T0J |
| SCOP (Structural Classification of Proteins) | 2DVW 5GJQ 5GJR 5L4G 5T0C 5T0G 5T0H 5T0I 5T0J |
| CATH (Classification of proteins structures) | 2DVW 5GJQ 5GJR 5L4G 5T0C 5T0G 5T0H 5T0I 5T0J |
| Superfamily | P43686 |
| Human Protein Atlas [tissue] | ENSG00000013275-PSMC4 [tissue] |
| Peptide Atlas | P43686 |
| HPRD | 04085 |
| IPI | IPI00020042 IPI00216770 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P43686 |
| IntAct (EBI) | P43686 |
| FunCoup | ENSG00000013275 |
| BioGRID | PSMC4 |
| STRING (EMBL) | PSMC4 |
| ZODIAC | PSMC4 |
| Ontologies - Pathways |
|---|
| QuickGO | P43686 |
| Ontology : AmiGO | MAPK cascade protein polyubiquitination proteasome complex blastocyst development stimulatory C-type lectin receptor signaling pathway antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent protein binding ATP binding nucleus nucleus nucleoplasm cytosol cytosol proteolysis regulation of cellular amino acid metabolic process proteasome regulatory particle, base subcomplex negative regulation of G2/M transition of mitotic cell cycle membrane inclusion body protein deubiquitination ATPase activity TBP-class protein binding proteasome accessory complex ubiquitin-dependent ERAD pathway anaphase-promoting complex-dependent catabolic process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process nuclear proteasome complex cytosolic proteasome complex tumor necrosis factor-mediated signaling pathway proteasome-activating ATPase activity NIK/NF-kappaB signaling Fc-epsilon receptor signaling pathway proteasome-mediated ubiquitin-dependent protein catabolic process regulation of mRNA stability post-translational protein modification synapse positive regulation of RNA polymerase II transcriptional preinitiation complex assembly T cell receptor signaling pathway negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition transmembrane transport Wnt signaling pathway, planar cell polarity pathway regulation of transcription from RNA polymerase II promoter in response to hypoxia interleukin-1-mediated signaling pathway negative regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway positive regulation of proteasomal protein catabolic process regulation of hematopoietic stem cell differentiation |
| Ontology : EGO-EBI | MAPK cascade protein polyubiquitination proteasome complex blastocyst development stimulatory C-type lectin receptor signaling pathway antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent protein binding ATP binding nucleus nucleus nucleoplasm cytosol cytosol proteolysis regulation of cellular amino acid metabolic process proteasome regulatory particle, base subcomplex negative regulation of G2/M transition of mitotic cell cycle membrane inclusion body protein deubiquitination ATPase activity TBP-class protein binding proteasome accessory complex ubiquitin-dependent ERAD pathway anaphase-promoting complex-dependent catabolic process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process nuclear proteasome complex cytosolic proteasome complex tumor necrosis factor-mediated signaling pathway proteasome-activating ATPase activity NIK/NF-kappaB signaling Fc-epsilon receptor signaling pathway proteasome-mediated ubiquitin-dependent protein catabolic process regulation of mRNA stability post-translational protein modification synapse positive regulation of RNA polymerase II transcriptional preinitiation complex assembly T cell receptor signaling pathway negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition transmembrane transport Wnt signaling pathway, planar cell polarity pathway regulation of transcription from RNA polymerase II promoter in response to hypoxia interleukin-1-mediated signaling pathway negative regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway positive regulation of proteasomal protein catabolic process regulation of hematopoietic stem cell differentiation |
| Pathways : KEGG | Proteasome |
| NDEx Network | PSMC4 |
| Atlas of Cancer Signalling Network | PSMC4 |
| Wikipedia pathways | PSMC4 |
| Orthology - Evolution |
|---|
| OrthoDB | 5704 |
| GeneTree (enSembl) | ENSG00000013275 |
| Phylogenetic Trees/Animal Genes : TreeFam | PSMC4 |
| HOVERGEN | P43686 |
| HOGENOM | P43686 |
| Homologs : HomoloGene | PSMC4 |
| Homology/Alignments : Family Browser (UCSC) | PSMC4 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | PSMC4 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | PSMC4 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | PSMC4 |
| dbVar | PSMC4 |
| ClinVar | PSMC4 |
| 1000_Genomes | PSMC4 |
| Exome Variant Server | PSMC4 |
| ExAC (Exome Aggregation Consortium) | ENSG00000013275 |
| GNOMAD Browser | ENSG00000013275 |
| Genetic variants : HAPMAP | 5704 |
| Genomic Variants (DGV) | PSMC4 [DGVbeta] |
| DECIPHER | PSMC4 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | PSMC4 |
| Mutations |
|---|
| ICGC Data Portal | PSMC4 |
| TCGA Data Portal | PSMC4 |
| Broad Tumor Portal | PSMC4 |
| OASIS Portal | PSMC4 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | PSMC4 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | PSMC4 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search PSMC4 |
| DgiDB (Drug Gene Interaction Database) | PSMC4 |
| DoCM (Curated mutations) | PSMC4 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | PSMC4 (select a term) |
| intoGen | PSMC4 |
| Cancer3D | PSMC4(select the gene name) |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 602707 |
| Orphanet | |
| DisGeNET | PSMC4 |
| Medgen | PSMC4 |
| Genetic Testing Registry | PSMC4
|
| NextProt | P43686 [Medical] |
| TSGene | 5704 |
| GENETests | PSMC4 |
| Target Validation | PSMC4 |
| Huge Navigator |
PSMC4 [HugePedia] |
| snp3D : Map Gene to Disease | 5704 |
| BioCentury BCIQ | PSMC4 |
| ClinGen | PSMC4 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 5704 |
| Chemical/Pharm GKB Gene | PA33896 |
| Clinical trial | PSMC4 |
| Miscellaneous |
|---|
| canSAR (ICR) | PSMC4 (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 121 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | PSMC4 |
| EVEX | PSMC4 |
| GoPubMed | PSMC4 |
| iHOP | PSMC4 |
