Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PSMC4 (proteasome 26S subunit, ATPase 4)

Identity

Alias_namesMIP224
proteasome (prosome
Alias_symbol (synonym)TBP7
S6
MGC8570
MGC13687
MGC23214
TBP-7
Other aliasRPT3
HGNC (Hugo) PSMC4
LocusID (NCBI) 5704
Atlas_Id 52776
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 39971005 and ends at 39981764 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ELL3 (15q15.3) / PSMC4 (19q13.2)MXD4 (4p16.3) / PSMC4 (19q13.2)PSMC4 (19q13.2) / PSMC4 (19q13.2)
PSMC4 (19q13.2) / WNT7B (22q13.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PSMC4   9551
Cards
Entrez_Gene (NCBI)PSMC4  5704  proteasome 26S subunit, ATPase 4
AliasesMIP224; RPT3; S6; TBP-7; 
TBP7
GeneCards (Weizmann)PSMC4
Ensembl hg19 (Hinxton)ENSG00000013275 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000013275 [Gene_View]  chr19:39971005-39981764 [Contig_View]  PSMC4 [Vega]
ICGC DataPortalENSG00000013275
TCGA cBioPortalPSMC4
AceView (NCBI)PSMC4
Genatlas (Paris)PSMC4
WikiGenes5704
SOURCE (Princeton)PSMC4
Genetics Home Reference (NIH)PSMC4
Genomic and cartography
GoldenPath hg38 (UCSC)PSMC4  -     chr19:39971005-39981764 +  19q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PSMC4  -     19q13.2   [Description]    (hg19-Feb_2009)
EnsemblPSMC4 - 19q13.2 [CytoView hg19]  PSMC4 - 19q13.2 [CytoView hg38]
Mapping of homologs : NCBIPSMC4 [Mapview hg19]  PSMC4 [Mapview hg38]
OMIM602707   
Gene and transcription
Genbank (Entrez)AF020736 AF038965 AK290285 AK310135 AK313183
RefSeq transcript (Entrez)NM_006503 NM_153001
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PSMC4
Cluster EST : UnigeneHs.211594 [ NCBI ]
CGAP (NCI)Hs.211594
Alternative Splicing GalleryENSG00000013275
Gene ExpressionPSMC4 [ NCBI-GEO ]   PSMC4 [ EBI - ARRAY_EXPRESS ]   PSMC4 [ SEEK ]   PSMC4 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMC4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5704
GTEX Portal (Tissue expression)PSMC4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP43686   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP43686  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP43686
Splice isoforms : SwissVarP43686
PhosPhoSitePlusP43686
Domaine pattern : Prosite (Expaxy)AAA (PS00674)   
Domains : Interpro (EBI)26S_Psome_P45    AAA+_ATPase    ATPase_AAA_core    ATPase_AAA_CS    P-loop_NTPase   
Domain families : Pfam (Sanger)AAA (PF00004)   
Domain families : Pfam (NCBI)pfam00004   
Domain families : Smart (EMBL)AAA (SM00382)  
Conserved Domain (NCBI)PSMC4
DMDM Disease mutations5704
Blocks (Seattle)PSMC4
PDB (SRS)2DVW    5GJQ    5GJR    5L4G    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (PDBSum)2DVW    5GJQ    5GJR    5L4G    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (IMB)2DVW    5GJQ    5GJR    5L4G    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (RSDB)2DVW    5GJQ    5GJR    5L4G    5T0C    5T0G    5T0H    5T0I    5T0J   
Structural Biology KnowledgeBase2DVW    5GJQ    5GJR    5L4G    5T0C    5T0G    5T0H    5T0I    5T0J   
SCOP (Structural Classification of Proteins)2DVW    5GJQ    5GJR    5L4G    5T0C    5T0G    5T0H    5T0I    5T0J   
CATH (Classification of proteins structures)2DVW    5GJQ    5GJR    5L4G    5T0C    5T0G    5T0H    5T0I    5T0J   
SuperfamilyP43686
Human Protein AtlasENSG00000013275
Peptide AtlasP43686
HPRD04085
IPIIPI00020042   IPI00216770   
Protein Interaction databases
DIP (DOE-UCLA)P43686
IntAct (EBI)P43686
FunCoupENSG00000013275
BioGRIDPSMC4
STRING (EMBL)PSMC4
ZODIACPSMC4
Ontologies - Pathways
QuickGOP43686
Ontology : AmiGOMAPK cascade  protein polyubiquitination  proteasome complex  blastocyst development  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  ATP binding  nucleus  nucleoplasm  cytosol  cytosol  proteolysis  regulation of cellular amino acid metabolic process  proteasome regulatory particle, base subcomplex  negative regulation of G2/M transition of mitotic cell cycle  membrane  inclusion body  protein deubiquitination  ATPase activity  TBP-class protein binding  proteasome accessory complex  ubiquitin-dependent ERAD pathway  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  nuclear proteasome complex  cytosolic proteasome complex  tumor necrosis factor-mediated signaling pathway  proteasome-activating ATPase activity  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  synapse  positive regulation of RNA polymerase II transcriptional preinitiation complex assembly  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  positive regulation of proteasomal protein catabolic process  
Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  proteasome complex  blastocyst development  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  ATP binding  nucleus  nucleoplasm  cytosol  cytosol  proteolysis  regulation of cellular amino acid metabolic process  proteasome regulatory particle, base subcomplex  negative regulation of G2/M transition of mitotic cell cycle  membrane  inclusion body  protein deubiquitination  ATPase activity  TBP-class protein binding  proteasome accessory complex  ubiquitin-dependent ERAD pathway  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  nuclear proteasome complex  cytosolic proteasome complex  tumor necrosis factor-mediated signaling pathway  proteasome-activating ATPase activity  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  synapse  positive regulation of RNA polymerase II transcriptional preinitiation complex assembly  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  positive regulation of proteasomal protein catabolic process  
Pathways : KEGGProteasome    Epstein-Barr virus infection   
NDEx NetworkPSMC4
Atlas of Cancer Signalling NetworkPSMC4
Wikipedia pathwaysPSMC4
Orthology - Evolution
OrthoDB5704
GeneTree (enSembl)ENSG00000013275
Phylogenetic Trees/Animal Genes : TreeFamPSMC4
HOVERGENP43686
HOGENOMP43686
Homologs : HomoloGenePSMC4
Homology/Alignments : Family Browser (UCSC)PSMC4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSMC4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMC4
dbVarPSMC4
ClinVarPSMC4
1000_GenomesPSMC4 
Exome Variant ServerPSMC4
ExAC (Exome Aggregation Consortium)PSMC4 (select the gene name)
Genetic variants : HAPMAP5704
Genomic Variants (DGV)PSMC4 [DGVbeta]
DECIPHERPSMC4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPSMC4 
Mutations
ICGC Data PortalPSMC4 
TCGA Data PortalPSMC4 
Broad Tumor PortalPSMC4
OASIS PortalPSMC4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMC4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSMC4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSMC4
DgiDB (Drug Gene Interaction Database)PSMC4
DoCM (Curated mutations)PSMC4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSMC4 (select a term)
intoGenPSMC4
Cancer3DPSMC4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602707   
Orphanet
MedgenPSMC4
Genetic Testing Registry PSMC4
NextProtP43686 [Medical]
TSGene5704
GENETestsPSMC4
Target ValidationPSMC4
Huge Navigator PSMC4 [HugePedia]
snp3D : Map Gene to Disease5704
BioCentury BCIQPSMC4
ClinGenPSMC4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5704
Chemical/Pharm GKB GenePA33896
Clinical trialPSMC4
Miscellaneous
canSAR (ICR)PSMC4 (select the gene name)
Probes
Litterature
PubMed114 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSMC4
EVEXPSMC4
GoPubMedPSMC4
iHOPPSMC4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 14:04:39 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.