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PSMC5 (proteasome 26S subunit, ATPase 5)

Identity

Alias_namesproteasome (prosome
Alias_symbol (synonym)SUG1
p45/SUG
TBP10
p45
S8
TRIP1
SUG-1
Other alias
HGNC (Hugo) PSMC5
LocusID (NCBI) 5705
Atlas_Id 55443
Location 17q23.3  [Link to chromosome band 17q23]
Location_base_pair Starts at 63827684 and ends at 63832027 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MCMBP (10q26.11) / PSMC5 (17q23.3)MICAL2 (11p15.3) / PSMC5 (17q23.3)PSMC5 (17q23.3) / ALDH4A1 (1p36.13)
PSMC5 (17q23.3) / ATP5A1 (18q21.1)PSMC5 (17q23.3) / PER1 (17p13.1)PSMC5 (17q23.3) / PNPO (17q21.32)
PSMC5 (17q23.3) / PSD3 (8p22)PSMC5 (17q23.3) / PSMC5 (17q23.3)PSMC5 (17q23.3) / SLC4A5 (2p13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PSMC5   9552
Cards
Entrez_Gene (NCBI)PSMC5  5705  proteasome 26S subunit, ATPase 5
AliasesS8; SUG-1; SUG1; TBP10; 
TRIP1; p45; p45/SUG
GeneCards (Weizmann)PSMC5
Ensembl hg19 (Hinxton)ENSG00000087191 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000087191 [Gene_View]  chr17:63827684-63832027 [Contig_View]  PSMC5 [Vega]
ICGC DataPortalENSG00000087191
TCGA cBioPortalPSMC5
AceView (NCBI)PSMC5
Genatlas (Paris)PSMC5
WikiGenes5705
SOURCE (Princeton)PSMC5
Genetics Home Reference (NIH)PSMC5
Genomic and cartography
GoldenPath hg38 (UCSC)PSMC5  -     chr17:63827684-63832027 +  17q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PSMC5  -     17q23.3   [Description]    (hg19-Feb_2009)
EnsemblPSMC5 - 17q23.3 [CytoView hg19]  PSMC5 - 17q23.3 [CytoView hg38]
Mapping of homologs : NCBIPSMC5 [Mapview hg19]  PSMC5 [Mapview hg38]
OMIM601681   
Gene and transcription
Genbank (Entrez)AF035309 AI193169 AK095836 AK098484 AK290758
RefSeq transcript (Entrez)NM_001199163 NM_002805
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PSMC5
Cluster EST : UnigeneHs.79387 [ NCBI ]
CGAP (NCI)Hs.79387
Alternative Splicing GalleryENSG00000087191
Gene ExpressionPSMC5 [ NCBI-GEO ]   PSMC5 [ EBI - ARRAY_EXPRESS ]   PSMC5 [ SEEK ]   PSMC5 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMC5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5705
GTEX Portal (Tissue expression)PSMC5
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62195   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62195  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62195
Splice isoforms : SwissVarP62195
PhosPhoSitePlusP62195
Domaine pattern : Prosite (Expaxy)AAA (PS00674)   
Domains : Interpro (EBI)26S_Psome_P45    AAA+_ATPase    ATPase_AAA_core    ATPase_AAA_CS    P-loop_NTPase   
Domain families : Pfam (Sanger)AAA (PF00004)   
Domain families : Pfam (NCBI)pfam00004   
Domain families : Smart (EMBL)AAA (SM00382)  
Conserved Domain (NCBI)PSMC5
DMDM Disease mutations5705
Blocks (Seattle)PSMC5
PDB (SRS)2KRK    3KW6    5GJQ    5GJR    5L4G    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (PDBSum)2KRK    3KW6    5GJQ    5GJR    5L4G    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (IMB)2KRK    3KW6    5GJQ    5GJR    5L4G    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (RSDB)2KRK    3KW6    5GJQ    5GJR    5L4G    5T0C    5T0G    5T0H    5T0I    5T0J   
Structural Biology KnowledgeBase2KRK    3KW6    5GJQ    5GJR    5L4G    5T0C    5T0G    5T0H    5T0I    5T0J   
SCOP (Structural Classification of Proteins)2KRK    3KW6    5GJQ    5GJR    5L4G    5T0C    5T0G    5T0H    5T0I    5T0J   
CATH (Classification of proteins structures)2KRK    3KW6    5GJQ    5GJR    5L4G    5T0C    5T0G    5T0H    5T0I    5T0J   
SuperfamilyP62195
Human Protein AtlasENSG00000087191
Peptide AtlasP62195
HPRD03400
IPIIPI00023919   IPI00555749   IPI00745502   
Protein Interaction databases
DIP (DOE-UCLA)P62195
IntAct (EBI)P62195
FunCoupENSG00000087191
BioGRIDPSMC5
STRING (EMBL)PSMC5
ZODIACPSMC5
Ontologies - Pathways
QuickGOP62195
Ontology : AmiGOMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytosol  regulation of transcription from RNA polymerase II promoter  regulation of cellular amino acid metabolic process  transcription factor binding  transcription factor binding  proteasome regulatory particle, base subcomplex  negative regulation of G2/M transition of mitotic cell cycle  membrane  inclusion body  protein deubiquitination  ATPase activity  ATPase activity  TBP-class protein binding  proteasome accessory complex  ubiquitin-dependent ERAD pathway  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  cytoplasmic vesicle  thyrotropin-releasing hormone receptor binding  nuclear proteasome complex  cytosolic proteasome complex  tumor necrosis factor-mediated signaling pathway  proteasome-activating ATPase activity  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  negative regulation of programmed cell death  proteasome-mediated ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of RNA polymerase II transcriptional preinitiation complex assembly  modulation of synaptic transmission  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  extracellular exosome  blood microparticle  negative regulation of canonical Wnt signaling pathway  positive regulation of inclusion body assembly  positive regulation of canonical Wnt signaling pathway  postsynapse  positive regulation of proteasomal protein catabolic process  
Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytosol  regulation of transcription from RNA polymerase II promoter  regulation of cellular amino acid metabolic process  transcription factor binding  transcription factor binding  proteasome regulatory particle, base subcomplex  negative regulation of G2/M transition of mitotic cell cycle  membrane  inclusion body  protein deubiquitination  ATPase activity  ATPase activity  TBP-class protein binding  proteasome accessory complex  ubiquitin-dependent ERAD pathway  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  cytoplasmic vesicle  thyrotropin-releasing hormone receptor binding  nuclear proteasome complex  cytosolic proteasome complex  tumor necrosis factor-mediated signaling pathway  proteasome-activating ATPase activity  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  negative regulation of programmed cell death  proteasome-mediated ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of RNA polymerase II transcriptional preinitiation complex assembly  modulation of synaptic transmission  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  extracellular exosome  blood microparticle  negative regulation of canonical Wnt signaling pathway  positive regulation of inclusion body assembly  positive regulation of canonical Wnt signaling pathway  postsynapse  positive regulation of proteasomal protein catabolic process  
Pathways : KEGGProteasome    Epstein-Barr virus infection   
NDEx NetworkPSMC5
Atlas of Cancer Signalling NetworkPSMC5
Wikipedia pathwaysPSMC5
Orthology - Evolution
OrthoDB5705
GeneTree (enSembl)ENSG00000087191
Phylogenetic Trees/Animal Genes : TreeFamPSMC5
HOVERGENP62195
HOGENOMP62195
Homologs : HomoloGenePSMC5
Homology/Alignments : Family Browser (UCSC)PSMC5
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSMC5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMC5
dbVarPSMC5
ClinVarPSMC5
1000_GenomesPSMC5 
Exome Variant ServerPSMC5
ExAC (Exome Aggregation Consortium)PSMC5 (select the gene name)
Genetic variants : HAPMAP5705
Genomic Variants (DGV)PSMC5 [DGVbeta]
DECIPHERPSMC5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPSMC5 
Mutations
ICGC Data PortalPSMC5 
TCGA Data PortalPSMC5 
Broad Tumor PortalPSMC5
OASIS PortalPSMC5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMC5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSMC5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSMC5
DgiDB (Drug Gene Interaction Database)PSMC5
DoCM (Curated mutations)PSMC5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSMC5 (select a term)
intoGenPSMC5
Cancer3DPSMC5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601681   
Orphanet
MedgenPSMC5
Genetic Testing Registry PSMC5
NextProtP62195 [Medical]
TSGene5705
GENETestsPSMC5
Target ValidationPSMC5
Huge Navigator PSMC5 [HugePedia]
snp3D : Map Gene to Disease5705
BioCentury BCIQPSMC5
ClinGenPSMC5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5705
Chemical/Pharm GKB GenePA33897
Clinical trialPSMC5
Miscellaneous
canSAR (ICR)PSMC5 (select the gene name)
Probes
Litterature
PubMed185 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSMC5
EVEXPSMC5
GoPubMedPSMC5
iHOPPSMC5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:51:31 CEST 2017

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