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PSMC5 (proteasome 26S subunit, ATPase 5)

Identity

Alias_namesproteasome (prosome
Alias_symbol (synonym)SUG1
p45/SUG
TBP10
p45
S8
TRIP1
SUG-1
Other alias
HGNC (Hugo) PSMC5
LocusID (NCBI) 5705
Atlas_Id 55443
Location 17q23.3  [Link to chromosome band 17q23]
Location_base_pair Starts at 63827410 and ends at 63832027 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MCMBP (10q26.11) / PSMC5 (17q23.3)MICAL2 (11p15.3) / PSMC5 (17q23.3)PSMC5 (17q23.3) / ALDH4A1 (1p36.13)
PSMC5 (17q23.3) / ATP5A1 (18q21.1)PSMC5 (17q23.3) / PER1 (17p13.1)PSMC5 (17q23.3) / PNPO (17q21.32)
PSMC5 (17q23.3) / PSD3 (8p22)PSMC5 (17q23.3) / PSMC5 (17q23.3)PSMC5 (17q23.3) / SLC4A5 (2p13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PSMC5   9552
Cards
Entrez_Gene (NCBI)PSMC5  5705  proteasome 26S subunit, ATPase 5
AliasesS8; SUG-1; SUG1; TBP10; 
TRIP1; p45; p45/SUG
GeneCards (Weizmann)PSMC5
Ensembl hg19 (Hinxton)ENSG00000087191 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000087191 [Gene_View]  ENSG00000087191 [Sequence]  chr17:63827410-63832027 [Contig_View]  PSMC5 [Vega]
ICGC DataPortalENSG00000087191
TCGA cBioPortalPSMC5
AceView (NCBI)PSMC5
Genatlas (Paris)PSMC5
WikiGenes5705
SOURCE (Princeton)PSMC5
Genetics Home Reference (NIH)PSMC5
Genomic and cartography
GoldenPath hg38 (UCSC)PSMC5  -     chr17:63827410-63832027 +  17q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PSMC5  -     17q23.3   [Description]    (hg19-Feb_2009)
EnsemblPSMC5 - 17q23.3 [CytoView hg19]  PSMC5 - 17q23.3 [CytoView hg38]
Mapping of homologs : NCBIPSMC5 [Mapview hg19]  PSMC5 [Mapview hg38]
OMIM601681   
Gene and transcription
Genbank (Entrez)AF035309 AI193169 AK095836 AK098484 AK290758
RefSeq transcript (Entrez)NM_001199163 NM_002805
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PSMC5
Cluster EST : UnigeneHs.79387 [ NCBI ]
CGAP (NCI)Hs.79387
Alternative Splicing GalleryENSG00000087191
Gene ExpressionPSMC5 [ NCBI-GEO ]   PSMC5 [ EBI - ARRAY_EXPRESS ]   PSMC5 [ SEEK ]   PSMC5 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMC5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5705
GTEX Portal (Tissue expression)PSMC5
Human Protein AtlasENSG00000087191-PSMC5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62195   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62195  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62195
Splice isoforms : SwissVarP62195
PhosPhoSitePlusP62195
Domaine pattern : Prosite (Expaxy)AAA (PS00674)   
Domains : Interpro (EBI)26S_Psome_P45-like    AAA+_ATPase    ATPase_AAA_core    ATPase_AAA_CS    P-loop_NTPase    PSMC5   
Domain families : Pfam (Sanger)AAA (PF00004)   
Domain families : Pfam (NCBI)pfam00004   
Domain families : Smart (EMBL)AAA (SM00382)  
Conserved Domain (NCBI)PSMC5
DMDM Disease mutations5705
Blocks (Seattle)PSMC5
PDB (SRS)2KRK    3KW6    5GJQ    5GJR    5L4G    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VGZ    5VHF    5VHH    5VHI    5VHJ    5VHM    5VHN    5VHO    5VHP    5VHQ    5VHR    5VHS   
PDB (PDBSum)2KRK    3KW6    5GJQ    5GJR    5L4G    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VGZ    5VHF    5VHH    5VHI    5VHJ    5VHM    5VHN    5VHO    5VHP    5VHQ    5VHR    5VHS   
PDB (IMB)2KRK    3KW6    5GJQ    5GJR    5L4G    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VGZ    5VHF    5VHH    5VHI    5VHJ    5VHM    5VHN    5VHO    5VHP    5VHQ    5VHR    5VHS   
PDB (RSDB)2KRK    3KW6    5GJQ    5GJR    5L4G    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VGZ    5VHF    5VHH    5VHI    5VHJ    5VHM    5VHN    5VHO    5VHP    5VHQ    5VHR    5VHS   
Structural Biology KnowledgeBase2KRK    3KW6    5GJQ    5GJR    5L4G    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VGZ    5VHF    5VHH    5VHI    5VHJ    5VHM    5VHN    5VHO    5VHP    5VHQ    5VHR    5VHS   
SCOP (Structural Classification of Proteins)2KRK    3KW6    5GJQ    5GJR    5L4G    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VGZ    5VHF    5VHH    5VHI    5VHJ    5VHM    5VHN    5VHO    5VHP    5VHQ    5VHR    5VHS   
CATH (Classification of proteins structures)2KRK    3KW6    5GJQ    5GJR    5L4G    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VGZ    5VHF    5VHH    5VHI    5VHJ    5VHM    5VHN    5VHO    5VHP    5VHQ    5VHR    5VHS   
SuperfamilyP62195
Human Protein Atlas [tissue]ENSG00000087191-PSMC5 [tissue]
Peptide AtlasP62195
HPRD03400
IPIIPI00023919   IPI00555749   IPI00745502   
Protein Interaction databases
DIP (DOE-UCLA)P62195
IntAct (EBI)P62195
FunCoupENSG00000087191
BioGRIDPSMC5
STRING (EMBL)PSMC5
ZODIACPSMC5
Ontologies - Pathways
QuickGOP62195
Ontology : AmiGOproteasome complex  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  cytoplasm  cytosol  regulation of transcription by RNA polymerase II  transcription factor binding  transcription factor binding  proteasome regulatory particle, base subcomplex  membrane  inclusion body  protein deubiquitination  ATPase activity  ATPase activity  TBP-class protein binding  proteasome accessory complex  cytoplasmic vesicle  thyrotropin-releasing hormone receptor binding  nuclear proteasome complex  cytosolic proteasome complex  proteasome-activating ATPase activity  negative regulation of programmed cell death  proteasome-mediated ubiquitin-dependent protein catabolic process  post-translational protein modification  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of RNA polymerase II transcriptional preinitiation complex assembly  modulation of chemical synaptic transmission  extracellular exosome  blood microparticle  positive regulation of inclusion body assembly  postsynapse  positive regulation of proteasomal protein catabolic process  
Ontology : EGO-EBIproteasome complex  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  cytoplasm  cytosol  regulation of transcription by RNA polymerase II  transcription factor binding  transcription factor binding  proteasome regulatory particle, base subcomplex  membrane  inclusion body  protein deubiquitination  ATPase activity  ATPase activity  TBP-class protein binding  proteasome accessory complex  cytoplasmic vesicle  thyrotropin-releasing hormone receptor binding  nuclear proteasome complex  cytosolic proteasome complex  proteasome-activating ATPase activity  negative regulation of programmed cell death  proteasome-mediated ubiquitin-dependent protein catabolic process  post-translational protein modification  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of RNA polymerase II transcriptional preinitiation complex assembly  modulation of chemical synaptic transmission  extracellular exosome  blood microparticle  positive regulation of inclusion body assembly  postsynapse  positive regulation of proteasomal protein catabolic process  
Pathways : KEGGProteasome    Epstein-Barr virus infection   
NDEx NetworkPSMC5
Atlas of Cancer Signalling NetworkPSMC5
Wikipedia pathwaysPSMC5
Orthology - Evolution
OrthoDB5705
GeneTree (enSembl)ENSG00000087191
Phylogenetic Trees/Animal Genes : TreeFamPSMC5
HOVERGENP62195
HOGENOMP62195
Homologs : HomoloGenePSMC5
Homology/Alignments : Family Browser (UCSC)PSMC5
Gene fusions - Rearrangements
Fusion : QuiverPSMC5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSMC5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMC5
dbVarPSMC5
ClinVarPSMC5
1000_GenomesPSMC5 
Exome Variant ServerPSMC5
ExAC (Exome Aggregation Consortium)ENSG00000087191
GNOMAD BrowserENSG00000087191
Varsome BrowserPSMC5
Genetic variants : HAPMAP5705
Genomic Variants (DGV)PSMC5 [DGVbeta]
DECIPHERPSMC5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPSMC5 
Mutations
ICGC Data PortalPSMC5 
TCGA Data PortalPSMC5 
Broad Tumor PortalPSMC5
OASIS PortalPSMC5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMC5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSMC5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSMC5
DgiDB (Drug Gene Interaction Database)PSMC5
DoCM (Curated mutations)PSMC5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSMC5 (select a term)
intoGenPSMC5
Cancer3DPSMC5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601681   
Orphanet
DisGeNETPSMC5
MedgenPSMC5
Genetic Testing Registry PSMC5
NextProtP62195 [Medical]
TSGene5705
GENETestsPSMC5
Target ValidationPSMC5
Huge Navigator PSMC5 [HugePedia]
snp3D : Map Gene to Disease5705
BioCentury BCIQPSMC5
ClinGenPSMC5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5705
Chemical/Pharm GKB GenePA33897
Clinical trialPSMC5
Miscellaneous
canSAR (ICR)PSMC5 (select the gene name)
Probes
Litterature
PubMed210 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSMC5
EVEXPSMC5
GoPubMedPSMC5
iHOPPSMC5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:32:56 CET 2018

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