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PSMC6 (proteasome 26S subunit, ATPase 6)

Identity

Alias_namesproteasome (prosome
Alias_symbol (synonym)p42
Other aliasCADP44
HEL-S-73
P44
SUG2
HGNC (Hugo) PSMC6
LocusID (NCBI) 5706
Atlas_Id 55421
Location 14q22.1  [Link to chromosome band 14q22]
Location_base_pair Starts at 53173896 and ends at 53194716 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PSMC6   9553
Cards
Entrez_Gene (NCBI)PSMC6  5706  proteasome 26S subunit, ATPase 6
AliasesCADP44; HEL-S-73; P44; SUG2; 
p42
GeneCards (Weizmann)PSMC6
Ensembl hg19 (Hinxton)ENSG00000100519 [Gene_View]  chr14:53173896-53194716 [Contig_View]  PSMC6 [Vega]
Ensembl hg38 (Hinxton)ENSG00000100519 [Gene_View]  chr14:53173896-53194716 [Contig_View]  PSMC6 [Vega]
ICGC DataPortalENSG00000100519
TCGA cBioPortalPSMC6
AceView (NCBI)PSMC6
Genatlas (Paris)PSMC6
WikiGenes5706
SOURCE (Princeton)PSMC6
Genetics Home Reference (NIH)PSMC6
Genomic and cartography
GoldenPath hg19 (UCSC)PSMC6  -     chr14:53173896-53194716 +  14q22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PSMC6  -     14q22.1   [Description]    (hg38-Dec_2013)
EnsemblPSMC6 - 14q22.1 [CytoView hg19]  PSMC6 - 14q22.1 [CytoView hg38]
Mapping of homologs : NCBIPSMC6 [Mapview hg19]  PSMC6 [Mapview hg38]
OMIM602708   
Gene and transcription
Genbank (Entrez)AA846884 AF006305 AK127456 AK299155 AK307087
RefSeq transcript (Entrez)NM_002806
RefSeq genomic (Entrez)NC_000014 NC_018925 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)PSMC6
Cluster EST : UnigeneHs.156171 [ NCBI ]
CGAP (NCI)Hs.156171
Alternative Splicing GalleryENSG00000100519
Gene ExpressionPSMC6 [ NCBI-GEO ]   PSMC6 [ EBI - ARRAY_EXPRESS ]   PSMC6 [ SEEK ]   PSMC6 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMC6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5706
GTEX Portal (Tissue expression)PSMC6
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62333   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62333  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62333
Splice isoforms : SwissVarP62333
PhosPhoSitePlusP62333
Domaine pattern : Prosite (Expaxy)AAA (PS00674)   
Domains : Interpro (EBI)26S_Psome_P45    AAA+_ATPase    ATPase_AAA_core    ATPase_AAA_CS    P-loop_NTPase   
Domain families : Pfam (Sanger)AAA (PF00004)   
Domain families : Pfam (NCBI)pfam00004   
Domain families : Smart (EMBL)AAA (SM00382)  
Conserved Domain (NCBI)PSMC6
DMDM Disease mutations5706
Blocks (Seattle)PSMC6
SuperfamilyP62333
Human Protein AtlasENSG00000100519
Peptide AtlasP62333
HPRD04086
IPIIPI00910829   IPI01025330   IPI01025315   IPI01025065   IPI01025179   IPI01024811   IPI01024931   IPI01026432   IPI01026558   IPI00926977   
Protein Interaction databases
DIP (DOE-UCLA)P62333
IntAct (EBI)P62333
FunCoupENSG00000100519
BioGRIDPSMC6
STRING (EMBL)PSMC6
ZODIACPSMC6
Ontologies - Pathways
QuickGOP62333
Ontology : AmiGOMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  ATP binding  nucleus  nucleoplasm  cytosol  ubiquitin-dependent protein catabolic process  regulation of cellular amino acid metabolic process  proteasome regulatory particle, base subcomplex  membrane  ATPase activity  TBP-class protein binding  proteasome accessory complex  ER-associated ubiquitin-dependent protein catabolic process  protein binding, bridging  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process  nuclear proteasome complex  cytosolic proteasome complex  tumor necrosis factor-mediated signaling pathway  proteasome-activating ATPase activity  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  positive regulation of RNA polymerase II transcriptional preinitiation complex assembly  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  Wnt signaling pathway, planar cell polarity pathway  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  positive regulation of proteasomal protein catabolic process  
Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  ATP binding  nucleus  nucleoplasm  cytosol  ubiquitin-dependent protein catabolic process  regulation of cellular amino acid metabolic process  proteasome regulatory particle, base subcomplex  membrane  ATPase activity  TBP-class protein binding  proteasome accessory complex  ER-associated ubiquitin-dependent protein catabolic process  protein binding, bridging  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process  nuclear proteasome complex  cytosolic proteasome complex  tumor necrosis factor-mediated signaling pathway  proteasome-activating ATPase activity  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  positive regulation of RNA polymerase II transcriptional preinitiation complex assembly  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  Wnt signaling pathway, planar cell polarity pathway  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  positive regulation of proteasomal protein catabolic process  
Pathways : KEGGProteasome    Epstein-Barr virus infection   
NDEx NetworkPSMC6
Atlas of Cancer Signalling NetworkPSMC6
Wikipedia pathwaysPSMC6
Orthology - Evolution
OrthoDB5706
GeneTree (enSembl)ENSG00000100519
Phylogenetic Trees/Animal Genes : TreeFamPSMC6
HOVERGENP62333
HOGENOMP62333
Homologs : HomoloGenePSMC6
Homology/Alignments : Family Browser (UCSC)PSMC6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSMC6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMC6
dbVarPSMC6
ClinVarPSMC6
1000_GenomesPSMC6 
Exome Variant ServerPSMC6
ExAC (Exome Aggregation Consortium)PSMC6 (select the gene name)
Genetic variants : HAPMAP5706
Genomic Variants (DGV)PSMC6 [DGVbeta]
DECIPHER (Syndromes)14:53173896-53194716  ENSG00000100519
CONAN: Copy Number AnalysisPSMC6 
Mutations
ICGC Data PortalPSMC6 
TCGA Data PortalPSMC6 
Broad Tumor PortalPSMC6
OASIS PortalPSMC6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMC6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSMC6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSMC6
DgiDB (Drug Gene Interaction Database)PSMC6
DoCM (Curated mutations)PSMC6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSMC6 (select a term)
intoGenPSMC6
Cancer3DPSMC6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602708   
Orphanet
MedgenPSMC6
Genetic Testing Registry PSMC6
NextProtP62333 [Medical]
TSGene5706
GENETestsPSMC6
Huge Navigator PSMC6 [HugePedia]
snp3D : Map Gene to Disease5706
BioCentury BCIQPSMC6
ClinGenPSMC6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5706
Chemical/Pharm GKB GenePA33898
Clinical trialPSMC6
Miscellaneous
canSAR (ICR)PSMC6 (select the gene name)
Probes
Litterature
PubMed102 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSMC6
EVEXPSMC6
GoPubMedPSMC6
iHOPPSMC6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:16:01 CEST 2017

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