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PSMD11 (proteasome 26S subunit, non-ATPase 11)

Identity

Alias (NCBI)Rpn6
S9
p44.5
HGNC (Hugo) PSMD11
HGNC Alias symbS9
p44.5
MGC3844
Rpn6
HGNC Previous nameproteasome (prosome, macropain) 26S subunit, non-ATPase, 11
LocusID (NCBI) 5717
Atlas_Id 41888
Location 17q11.2  [Link to chromosome band 17q11]
Location_base_pair Starts at 32444510 and ends at 32483319 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AKAP10 (17p11.2) / PSMD11 (17q11.2)CASC15 (6p22.3) / PSMD11 (17q11.2)NF1 (17q11.2) / PSMD11 (17q11.2)
PSMD11 (17q11.2) / CEP112 (17q24.1)PSMD11 (17q11.2) / CTNND1 (11q12.1)PSMD11 (17q11.2) / PSMD11 (17q11.2)
TMED10 (14q24.3) / PSMD11 (17q11.2)WIPF2 (17q21.1) / PSMD11 (17q11.2)NF1 17q11.2 / PSMD11 17q11.2
PSMD11 17q11.2 / CEP112 17q24.1TMED10 14q24.3 / PSMD11 17q11.2WIPF2 17q21.1 / PSMD11 17q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(17;17)(q11;q11) NF1/PSMD11


External links

 

Nomenclature
HGNC (Hugo)PSMD11   9556
Cards
Entrez_Gene (NCBI)PSMD11    proteasome 26S subunit, non-ATPase 11
AliasesRpn6; S9; p44.5
GeneCards (Weizmann)PSMD11
Ensembl hg19 (Hinxton)ENSG00000108671 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108671 [Gene_View]  ENSG00000108671 [Sequence]  chr17:32444510-32483319 [Contig_View]  PSMD11 [Vega]
ICGC DataPortalENSG00000108671
TCGA cBioPortalPSMD11
AceView (NCBI)PSMD11
Genatlas (Paris)PSMD11
SOURCE (Princeton)PSMD11
Genetics Home Reference (NIH)PSMD11
Genomic and cartography
GoldenPath hg38 (UCSC)PSMD11  -     chr17:32444510-32483319 +  17q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PSMD11  -     17q11.2   [Description]    (hg19-Feb_2009)
GoldenPathPSMD11 - 17q11.2 [CytoView hg19]  PSMD11 - 17q11.2 [CytoView hg38]
ImmunoBaseENSG00000108671
Genome Data Viewer NCBIPSMD11 [Mapview hg19]  
OMIM604449   
Gene and transcription
Genbank (Entrez)AB003102 AF001212 AK093602 AK223196 AK290602
RefSeq transcript (Entrez)NM_001270482 NM_002815
Consensus coding sequences : CCDS (NCBI)PSMD11
Gene ExpressionPSMD11 [ NCBI-GEO ]   PSMD11 [ EBI - ARRAY_EXPRESS ]   PSMD11 [ SEEK ]   PSMD11 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMD11 [ Firebrowse - Broad ]
GenevisibleExpression of PSMD11 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5717
GTEX Portal (Tissue expression)PSMD11
Human Protein AtlasENSG00000108671-PSMD11 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00231   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00231  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00231
PhosPhoSitePlusO00231
Domaine pattern : Prosite (Expaxy)PCI (PS50250)   
Domains : Interpro (EBI)PCI_dom    PSMD11    Rpn6_C_helix    Rpn6_N    TPR-like_helical_dom_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)PCI (PF01399)    RPN6_C_helix (PF18503)    RPN6_N (PF18055)   
Domain families : Pfam (NCBI)pfam01399    pfam18503    pfam18055   
Domain families : Smart (EMBL)PINT (SM00088)  
Conserved Domain (NCBI)PSMD11
PDB (RSDB)5GJQ    5GJR    5L4K    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VFP    5VFQ    5VFR    5VFS    5VFT    5VFU    5VGZ    5VHF    5VHH    5VHI    5VHS    6MSB    6MSD    6MSE    6MSG    6MSH    6MSJ    6MSK    6WJD    6WJN   
PDB Europe5GJQ    5GJR    5L4K    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VFP    5VFQ    5VFR    5VFS    5VFT    5VFU    5VGZ    5VHF    5VHH    5VHI    5VHS    6MSB    6MSD    6MSE    6MSG    6MSH    6MSJ    6MSK    6WJD    6WJN   
PDB (PDBSum)5GJQ    5GJR    5L4K    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VFP    5VFQ    5VFR    5VFS    5VFT    5VFU    5VGZ    5VHF    5VHH    5VHI    5VHS    6MSB    6MSD    6MSE    6MSG    6MSH    6MSJ    6MSK    6WJD    6WJN   
PDB (IMB)5GJQ    5GJR    5L4K    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VFP    5VFQ    5VFR    5VFS    5VFT    5VFU    5VGZ    5VHF    5VHH    5VHI    5VHS    6MSB    6MSD    6MSE    6MSG    6MSH    6MSJ    6MSK    6WJD    6WJN   
Structural Biology KnowledgeBase5GJQ    5GJR    5L4K    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VFP    5VFQ    5VFR    5VFS    5VFT    5VFU    5VGZ    5VHF    5VHH    5VHI    5VHS    6MSB    6MSD    6MSE    6MSG    6MSH    6MSJ    6MSK    6WJD    6WJN   
SCOP (Structural Classification of Proteins)5GJQ    5GJR    5L4K    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VFP    5VFQ    5VFR    5VFS    5VFT    5VFU    5VGZ    5VHF    5VHH    5VHI    5VHS    6MSB    6MSD    6MSE    6MSG    6MSH    6MSJ    6MSK    6WJD    6WJN   
CATH (Classification of proteins structures)5GJQ    5GJR    5L4K    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VFP    5VFQ    5VFR    5VFS    5VFT    5VFU    5VGZ    5VHF    5VHH    5VHI    5VHS    6MSB    6MSD    6MSE    6MSG    6MSH    6MSJ    6MSK    6WJD    6WJN   
SuperfamilyO00231
AlphaFold pdb e-kbO00231   
Human Protein Atlas [tissue]ENSG00000108671-PSMD11 [tissue]
HPRD05119
Protein Interaction databases
DIP (DOE-UCLA)O00231
IntAct (EBI)O00231
BioGRIDPSMD11
STRING (EMBL)PSMD11
ZODIACPSMD11
Ontologies - Pathways
QuickGOO00231
Ontology : AmiGOMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  structural molecule activity  protein binding  extracellular region  nucleus  nucleoplasm  cytosol  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  regulation of cellular amino acid metabolic process  proteasome regulatory particle, lid subcomplex  negative regulation of G2/M transition of mitotic cell cycle  membrane  protein deubiquitination  proteasome accessory complex  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  secretory granule lumen  pre-replicative complex assembly  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  proteasome assembly  proteasome assembly  neutrophil degranulation  regulation of mRNA stability  post-translational protein modification  stem cell differentiation  T cell receptor signaling pathway  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  interleukin-1-mediated signaling pathway  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  regulation of mitotic cell cycle phase transition  regulation of hematopoietic stem cell differentiation  ficolin-1-rich granule lumen  
Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  structural molecule activity  protein binding  extracellular region  nucleus  nucleoplasm  cytosol  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  regulation of cellular amino acid metabolic process  proteasome regulatory particle, lid subcomplex  negative regulation of G2/M transition of mitotic cell cycle  membrane  protein deubiquitination  proteasome accessory complex  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  secretory granule lumen  pre-replicative complex assembly  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  proteasome assembly  proteasome assembly  neutrophil degranulation  regulation of mRNA stability  post-translational protein modification  stem cell differentiation  T cell receptor signaling pathway  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  interleukin-1-mediated signaling pathway  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  regulation of mitotic cell cycle phase transition  regulation of hematopoietic stem cell differentiation  ficolin-1-rich granule lumen  
Pathways : KEGGProteasome    Epstein-Barr virus infection   
NDEx NetworkPSMD11
Atlas of Cancer Signalling NetworkPSMD11
Wikipedia pathwaysPSMD11
Orthology - Evolution
OrthoDB5717
GeneTree (enSembl)ENSG00000108671
Phylogenetic Trees/Animal Genes : TreeFamPSMD11
Homologs : HomoloGenePSMD11
Homology/Alignments : Family Browser (UCSC)PSMD11
Gene fusions - Rearrangements
Fusion : MitelmanAKAP10/PSMD11 [17p11.2/17q11.2]  
Fusion : MitelmanNF1/PSMD11 [17q11.2/17q11.2]  
Fusion : MitelmanPSMD11/CEP112 [17q11.2/17q24.1]  
Fusion : MitelmanTMED10/PSMD11 [14q24.3/17q11.2]  
Fusion : MitelmanWIPF2/PSMD11 [17q21.1/17q11.2]  
Fusion : QuiverPSMD11
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSMD11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMD11
dbVarPSMD11
ClinVarPSMD11
MonarchPSMD11
1000_GenomesPSMD11 
Exome Variant ServerPSMD11
GNOMAD BrowserENSG00000108671
Varsome BrowserPSMD11
ACMGPSMD11 variants
VarityO00231
Genomic Variants (DGV)PSMD11 [DGVbeta]
DECIPHERPSMD11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPSMD11 
Mutations
ICGC Data PortalPSMD11 
TCGA Data PortalPSMD11 
Broad Tumor PortalPSMD11
OASIS PortalPSMD11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMD11  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPSMD11
Mutations and Diseases : HGMDPSMD11
intOGen PortalPSMD11
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPSMD11
DgiDB (Drug Gene Interaction Database)PSMD11
DoCM (Curated mutations)PSMD11
CIViC (Clinical Interpretations of Variants in Cancer)PSMD11
Cancer3DPSMD11
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604449   
Orphanet
DisGeNETPSMD11
MedgenPSMD11
Genetic Testing Registry PSMD11
NextProtO00231 [Medical]
GENETestsPSMD11
Target ValidationPSMD11
Huge Navigator PSMD11 [HugePedia]
ClinGenPSMD11
Clinical trials, drugs, therapy
MyCancerGenomePSMD11
Protein Interactions : CTDPSMD11
Pharm GKB GenePA33902
PharosO00231
Clinical trialPSMD11
Miscellaneous
canSAR (ICR)PSMD11
HarmonizomePSMD11
DataMed IndexPSMD11
Probes
Litterature
PubMed165 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPSMD11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:27:16 CEST 2021

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