Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PSMD11 (proteasome 26S subunit, non-ATPase 11)

Identity

Alias_namesproteasome (prosome, macropain) 26S subunit, non-ATPase, 11
Alias_symbol (synonym)S9
p44.5
MGC3844
Rpn6
Other alias
HGNC (Hugo) PSMD11
LocusID (NCBI) 5717
Atlas_Id 41888
Location 17q11.2  [Link to chromosome band 17q11]
Location_base_pair Starts at 32444463 and ends at 32483319 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AKAP10 (17p11.2) / PSMD11 (17q11.2)CASC15 (6p22.3) / PSMD11 (17q11.2)NF1 (17q11.2) / PSMD11 (17q11.2)
PSMD11 (17q11.2) / CEP112 (17q24.1)PSMD11 (17q11.2) / CTNND1 (11q12.1)PSMD11 (17q11.2) / PSMD11 (17q11.2)
TMED10 (14q24.3) / PSMD11 (17q11.2)WIPF2 (17q21.1) / PSMD11 (17q11.2)NF1 17q11.2 / PSMD11 17q11.2
PSMD11 17q11.2 / CEP112 17q24.1TMED10 14q24.3 / PSMD11 17q11.2WIPF2 17q21.1 / PSMD11 17q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias TL_t1717q11q11ID3005


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 6 ]

Solid Tumors TranslocLungSquamCellCarcID6819 TT_t1417q24q11ID101870 TT_t1717p11q11ID6963 TT_t1717q11q11ID102398 TT_t1717q11q21ID102460
TT_t1717q11q24ID102485


External links

Nomenclature
HGNC (Hugo)PSMD11   9556
Cards
Entrez_Gene (NCBI)PSMD11  5717  proteasome 26S subunit, non-ATPase 11
AliasesRpn6; S9; p44.5
GeneCards (Weizmann)PSMD11
Ensembl hg19 (Hinxton)ENSG00000108671 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108671 [Gene_View]  ENSG00000108671 [Sequence]  chr17:32444463-32483319 [Contig_View]  PSMD11 [Vega]
ICGC DataPortalENSG00000108671
TCGA cBioPortalPSMD11
AceView (NCBI)PSMD11
Genatlas (Paris)PSMD11
WikiGenes5717
SOURCE (Princeton)PSMD11
Genetics Home Reference (NIH)PSMD11
Genomic and cartography
GoldenPath hg38 (UCSC)PSMD11  -     chr17:32444463-32483319 +  17q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PSMD11  -     17q11.2   [Description]    (hg19-Feb_2009)
GoldenPathPSMD11 - 17q11.2 [CytoView hg19]  PSMD11 - 17q11.2 [CytoView hg38]
ImmunoBaseENSG00000108671
Mapping of homologs : NCBIPSMD11 [Mapview hg19]  PSMD11 [Mapview hg38]
OMIM604449   
Gene and transcription
Genbank (Entrez)AB003102 AF001212 AK093602 AK223196 AK290602
RefSeq transcript (Entrez)NM_001270482 NM_002815
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PSMD11
Cluster EST : UnigeneHs.443379 [ NCBI ]
CGAP (NCI)Hs.443379
Alternative Splicing GalleryENSG00000108671
Gene ExpressionPSMD11 [ NCBI-GEO ]   PSMD11 [ EBI - ARRAY_EXPRESS ]   PSMD11 [ SEEK ]   PSMD11 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMD11 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5717
GTEX Portal (Tissue expression)PSMD11
Human Protein AtlasENSG00000108671-PSMD11 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00231   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00231  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00231
Splice isoforms : SwissVarO00231
PhosPhoSitePlusO00231
Domaine pattern : Prosite (Expaxy)PCI (PS50250)   
Domains : Interpro (EBI)PCI_dom    PSMD11    TPR-like_helical_dom_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)PCI (PF01399)   
Domain families : Pfam (NCBI)pfam01399   
Domain families : Smart (EMBL)PINT (SM00088)  
Conserved Domain (NCBI)PSMD11
DMDM Disease mutations5717
Blocks (Seattle)PSMD11
PDB (RSDB)5GJQ    5GJR    5L4K    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VGZ    5VHF    5VHH    5VHI    5VHS   
PDB Europe5GJQ    5GJR    5L4K    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VGZ    5VHF    5VHH    5VHI    5VHS   
PDB (PDBSum)5GJQ    5GJR    5L4K    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VGZ    5VHF    5VHH    5VHI    5VHS   
PDB (IMB)5GJQ    5GJR    5L4K    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VGZ    5VHF    5VHH    5VHI    5VHS   
Structural Biology KnowledgeBase5GJQ    5GJR    5L4K    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VGZ    5VHF    5VHH    5VHI    5VHS   
SCOP (Structural Classification of Proteins)5GJQ    5GJR    5L4K    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VGZ    5VHF    5VHH    5VHI    5VHS   
CATH (Classification of proteins structures)5GJQ    5GJR    5L4K    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VGZ    5VHF    5VHH    5VHI    5VHS   
SuperfamilyO00231
Human Protein Atlas [tissue]ENSG00000108671-PSMD11 [tissue]
Peptide AtlasO00231
HPRD05119
IPIIPI00105598   IPI00790498   
Protein Interaction databases
DIP (DOE-UCLA)O00231
IntAct (EBI)O00231
FunCoupENSG00000108671
BioGRIDPSMD11
STRING (EMBL)PSMD11
ZODIACPSMD11
Ontologies - Pathways
QuickGOO00231
Ontology : AmiGOMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  structural molecule activity  protein binding  extracellular region  nucleus  nucleoplasm  cytosol  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  regulation of cellular amino acid metabolic process  proteasome regulatory particle, lid subcomplex  negative regulation of G2/M transition of mitotic cell cycle  membrane  protein deubiquitination  proteasome accessory complex  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  secretory granule lumen  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  proteasome assembly  proteasome assembly  neutrophil degranulation  regulation of mRNA stability  post-translational protein modification  stem cell differentiation  T cell receptor signaling pathway  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  interleukin-1-mediated signaling pathway  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  regulation of mitotic cell cycle phase transition  regulation of hematopoietic stem cell differentiation  ficolin-1-rich granule lumen  
Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  structural molecule activity  protein binding  extracellular region  nucleus  nucleoplasm  cytosol  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  regulation of cellular amino acid metabolic process  proteasome regulatory particle, lid subcomplex  negative regulation of G2/M transition of mitotic cell cycle  membrane  protein deubiquitination  proteasome accessory complex  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  secretory granule lumen  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  proteasome assembly  proteasome assembly  neutrophil degranulation  regulation of mRNA stability  post-translational protein modification  stem cell differentiation  T cell receptor signaling pathway  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  interleukin-1-mediated signaling pathway  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  regulation of mitotic cell cycle phase transition  regulation of hematopoietic stem cell differentiation  ficolin-1-rich granule lumen  
Pathways : KEGGProteasome    Epstein-Barr virus infection   
NDEx NetworkPSMD11
Atlas of Cancer Signalling NetworkPSMD11
Wikipedia pathwaysPSMD11
Orthology - Evolution
OrthoDB5717
GeneTree (enSembl)ENSG00000108671
Phylogenetic Trees/Animal Genes : TreeFamPSMD11
HOGENOMO00231
Homologs : HomoloGenePSMD11
Homology/Alignments : Family Browser (UCSC)PSMD11
Gene fusions - Rearrangements
Fusion : MitelmanAKAP10/PSMD11 [17p11.2/17q11.2]  [t(17;17)(p11;q11)]  
Fusion : MitelmanNF1/PSMD11 [17q11.2/17q11.2]  [t(17;17)(q11;q11)]  
Fusion : MitelmanPSMD11/CEP112 [17q11.2/17q24.1]  [t(17;17)(q11;q24)]  
Fusion : MitelmanTMED10/PSMD11 [14q24.3/17q11.2]  [t(14;17)(q24;q11)]  
Fusion : MitelmanWIPF2/PSMD11 [17q21.1/17q11.2]  [t(17;17)(q11;q21)]  
Fusion PortalNF1 17q11.2 PSMD11 17q11.2 LUAD
Fusion PortalPSMD11 17q11.2 CEP112 17q24.1 BRCA
Fusion PortalTMED10 14q24.3 PSMD11 17q11.2 PRAD
Fusion PortalWIPF2 17q21.1 PSMD11 17q11.2 BRCA
Fusion : QuiverPSMD11
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSMD11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMD11
dbVarPSMD11
ClinVarPSMD11
1000_GenomesPSMD11 
Exome Variant ServerPSMD11
ExAC (Exome Aggregation Consortium)ENSG00000108671
GNOMAD BrowserENSG00000108671
Varsome BrowserPSMD11
Genetic variants : HAPMAP5717
Genomic Variants (DGV)PSMD11 [DGVbeta]
DECIPHERPSMD11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPSMD11 
Mutations
ICGC Data PortalPSMD11 
TCGA Data PortalPSMD11 
Broad Tumor PortalPSMD11
OASIS PortalPSMD11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMD11  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPSMD11
Mutations and Diseases : HGMDPSMD11
intOGen PortalPSMD11
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSMD11
DgiDB (Drug Gene Interaction Database)PSMD11
DoCM (Curated mutations)PSMD11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSMD11 (select a term)
intoGenPSMD11
Cancer3DPSMD11(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604449   
Orphanet
DisGeNETPSMD11
MedgenPSMD11
Genetic Testing Registry PSMD11
NextProtO00231 [Medical]
TSGene5717
GENETestsPSMD11
Target ValidationPSMD11
Huge Navigator PSMD11 [HugePedia]
snp3D : Map Gene to Disease5717
BioCentury BCIQPSMD11
ClinGenPSMD11
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5717
Chemical/Pharm GKB GenePA33902
Clinical trialPSMD11
Miscellaneous
canSAR (ICR)PSMD11 (select the gene name)
DataMed IndexPSMD11
Probes
Litterature
PubMed131 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSMD11
EVEXPSMD11
GoPubMedPSMD11
iHOPPSMD11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 26 18:25:01 CEST 2019

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