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PSMD12 (proteasome 26S subunit, non-ATPase 12)

Identity

Alias (NCBI)Rpn5
STISS
p55
HGNC (Hugo) PSMD12
HGNC Alias symbp55
Rpn5
HGNC Previous nameproteasome (prosome, macropain) 26S subunit, non-ATPase, 12
LocusID (NCBI) 5718
Atlas_Id 55415
Location 17q24.2  [Link to chromosome band 17q24]
Location_base_pair Starts at 67337916 and ends at 67366577 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ABAT (16p13.2) / PSMD12 (17q24.2)BAIAP2 (17q25.3) / PSMD12 (17q24.2)PSMD12 (17q24.2) / KIAA2022 (Xq13.3)
PSMD12 (17q24.2) / PITPNC1 (17q24.2)SUPT4H1 (17q22) / PSMD12 (17q24.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PSMD12   9557
Cards
Entrez_Gene (NCBI)PSMD12    proteasome 26S subunit, non-ATPase 12
AliasesRpn5; STISS; p55
GeneCards (Weizmann)PSMD12
Ensembl hg19 (Hinxton)ENSG00000197170 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197170 [Gene_View]  ENSG00000197170 [Sequence]  chr17:67337916-67366577 [Contig_View]  PSMD12 [Vega]
ICGC DataPortalENSG00000197170
TCGA cBioPortalPSMD12
AceView (NCBI)PSMD12
Genatlas (Paris)PSMD12
SOURCE (Princeton)PSMD12
Genetics Home Reference (NIH)PSMD12
Genomic and cartography
GoldenPath hg38 (UCSC)PSMD12  -     chr17:67337916-67366577 -  17q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PSMD12  -     17q24.2   [Description]    (hg19-Feb_2009)
GoldenPathPSMD12 - 17q24.2 [CytoView hg19]  PSMD12 - 17q24.2 [CytoView hg38]
ImmunoBaseENSG00000197170
Genome Data Viewer NCBIPSMD12 [Mapview hg19]  
OMIM604450   617516   
Gene and transcription
Genbank (Entrez)AB003103 AK091198 AK222679 AK307821 AK308883
RefSeq transcript (Entrez)NM_001316341 NM_002816 NM_174871
Consensus coding sequences : CCDS (NCBI)PSMD12
Gene ExpressionPSMD12 [ NCBI-GEO ]   PSMD12 [ EBI - ARRAY_EXPRESS ]   PSMD12 [ SEEK ]   PSMD12 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMD12 [ Firebrowse - Broad ]
GenevisibleExpression of PSMD12 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5718
GTEX Portal (Tissue expression)PSMD12
Human Protein AtlasENSG00000197170-PSMD12 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00232   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00232  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00232
PhosPhoSitePlusO00232
Domaine pattern : Prosite (Expaxy)PCI (PS50250)   
Domains : Interpro (EBI)PCI_dom    PSMD12    PSMD12/CSN4    RPN5_C    WH-like_DNA-bd_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)PCI (PF01399)    RPN5_C (PF18098)   
Domain families : Pfam (NCBI)pfam01399    pfam18098   
Domain families : Smart (EMBL)PINT (SM00088)  
Conserved Domain (NCBI)PSMD12
PDB (RSDB)5GJQ    5GJR    5L4K    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VFP    5VFQ    5VFR    5VFS    5VFT    5VFU    5VGZ    5VHF    5VHH    5VHI    5VHS    6MSB    6MSD    6MSE    6MSG    6MSH    6MSJ    6MSK    6WJD    6WJN   
PDB Europe5GJQ    5GJR    5L4K    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VFP    5VFQ    5VFR    5VFS    5VFT    5VFU    5VGZ    5VHF    5VHH    5VHI    5VHS    6MSB    6MSD    6MSE    6MSG    6MSH    6MSJ    6MSK    6WJD    6WJN   
PDB (PDBSum)5GJQ    5GJR    5L4K    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VFP    5VFQ    5VFR    5VFS    5VFT    5VFU    5VGZ    5VHF    5VHH    5VHI    5VHS    6MSB    6MSD    6MSE    6MSG    6MSH    6MSJ    6MSK    6WJD    6WJN   
PDB (IMB)5GJQ    5GJR    5L4K    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VFP    5VFQ    5VFR    5VFS    5VFT    5VFU    5VGZ    5VHF    5VHH    5VHI    5VHS    6MSB    6MSD    6MSE    6MSG    6MSH    6MSJ    6MSK    6WJD    6WJN   
Structural Biology KnowledgeBase5GJQ    5GJR    5L4K    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VFP    5VFQ    5VFR    5VFS    5VFT    5VFU    5VGZ    5VHF    5VHH    5VHI    5VHS    6MSB    6MSD    6MSE    6MSG    6MSH    6MSJ    6MSK    6WJD    6WJN   
SCOP (Structural Classification of Proteins)5GJQ    5GJR    5L4K    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VFP    5VFQ    5VFR    5VFS    5VFT    5VFU    5VGZ    5VHF    5VHH    5VHI    5VHS    6MSB    6MSD    6MSE    6MSG    6MSH    6MSJ    6MSK    6WJD    6WJN   
CATH (Classification of proteins structures)5GJQ    5GJR    5L4K    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VFP    5VFQ    5VFR    5VFS    5VFT    5VFU    5VGZ    5VHF    5VHH    5VHI    5VHS    6MSB    6MSD    6MSE    6MSG    6MSH    6MSJ    6MSK    6WJD    6WJN   
SuperfamilyO00232
AlphaFold pdb e-kbO00232   
Human Protein Atlas [tissue]ENSG00000197170-PSMD12 [tissue]
HPRD05120
Protein Interaction databases
DIP (DOE-UCLA)O00232
IntAct (EBI)O00232
BioGRIDPSMD12
STRING (EMBL)PSMD12
ZODIACPSMD12
Ontologies - Pathways
QuickGOO00232
Ontology : AmiGOMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  extracellular region  nucleoplasm  cytoplasm  cytosol  proteasome regulatory particle  regulation of cellular amino acid metabolic process  proteasome regulatory particle, lid subcomplex  negative regulation of G2/M transition of mitotic cell cycle  membrane  protein deubiquitination  proteasome accessory complex  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  nuclear proteasome complex  tumor necrosis factor-mediated signaling pathway  secretory granule lumen  pre-replicative complex assembly  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  neutrophil degranulation  regulation of mRNA stability  post-translational protein modification  T cell receptor signaling pathway  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  extracellular exosome  interleukin-1-mediated signaling pathway  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  regulation of mitotic cell cycle phase transition  regulation of hematopoietic stem cell differentiation  ficolin-1-rich granule lumen  
Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  extracellular region  nucleoplasm  cytoplasm  cytosol  proteasome regulatory particle  regulation of cellular amino acid metabolic process  proteasome regulatory particle, lid subcomplex  negative regulation of G2/M transition of mitotic cell cycle  membrane  protein deubiquitination  proteasome accessory complex  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  nuclear proteasome complex  tumor necrosis factor-mediated signaling pathway  secretory granule lumen  pre-replicative complex assembly  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  neutrophil degranulation  regulation of mRNA stability  post-translational protein modification  T cell receptor signaling pathway  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  extracellular exosome  interleukin-1-mediated signaling pathway  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  regulation of mitotic cell cycle phase transition  regulation of hematopoietic stem cell differentiation  ficolin-1-rich granule lumen  
Pathways : KEGGProteasome    Epstein-Barr virus infection   
NDEx NetworkPSMD12
Atlas of Cancer Signalling NetworkPSMD12
Wikipedia pathwaysPSMD12
Orthology - Evolution
OrthoDB5718
GeneTree (enSembl)ENSG00000197170
Phylogenetic Trees/Animal Genes : TreeFamPSMD12
Homologs : HomoloGenePSMD12
Homology/Alignments : Family Browser (UCSC)PSMD12
Gene fusions - Rearrangements
Fusion : QuiverPSMD12
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSMD12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMD12
dbVarPSMD12
ClinVarPSMD12
MonarchPSMD12
1000_GenomesPSMD12 
Exome Variant ServerPSMD12
GNOMAD BrowserENSG00000197170
Varsome BrowserPSMD12
ACMGPSMD12 variants
VarityO00232
Genomic Variants (DGV)PSMD12 [DGVbeta]
DECIPHERPSMD12 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPSMD12 
Mutations
ICGC Data PortalPSMD12 
TCGA Data PortalPSMD12 
Broad Tumor PortalPSMD12
OASIS PortalPSMD12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMD12  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPSMD12
Mutations and Diseases : HGMDPSMD12
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPSMD12
DgiDB (Drug Gene Interaction Database)PSMD12
DoCM (Curated mutations)PSMD12
CIViC (Clinical Interpretations of Variants in Cancer)PSMD12
Cancer3DPSMD12
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604450    617516   
Orphanet
DisGeNETPSMD12
MedgenPSMD12
Genetic Testing Registry PSMD12
NextProtO00232 [Medical]
GENETestsPSMD12
Target ValidationPSMD12
Huge Navigator PSMD12 [HugePedia]
ClinGenPSMD12
Clinical trials, drugs, therapy
MyCancerGenomePSMD12
Protein Interactions : CTDPSMD12
Pharm GKB GenePA33903
PharosO00232
Clinical trialPSMD12
Miscellaneous
canSAR (ICR)PSMD12
HarmonizomePSMD12
DataMed IndexPSMD12
Probes
Litterature
PubMed140 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPSMD12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:27:16 CEST 2021

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