Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PSMD14 (proteasome 26S subunit, non-ATPase 14)

Identity

Alias_namesproteasome (prosome
Alias_symbol (synonym)POH1
pad1
Rpn11
Other aliasPAD1
RPN11
HGNC (Hugo) PSMD14
LocusID (NCBI) 10213
Atlas_Id 52919
Location 2q24.2  [Link to chromosome band 2q24]
Location_base_pair Starts at 161308275 and ends at 161411717 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EEF1A1 (6q13) / PSMD14 (2q24.2)GCA (2q24.2) / PSMD14 (2q24.2)ROBO2 (3p12.3) / PSMD14 (2q24.2)
SOX4 (6p22.3) / PSMD14 (2q24.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PSMD14   16889
Cards
Entrez_Gene (NCBI)PSMD14  10213  proteasome 26S subunit, non-ATPase 14
AliasesPAD1; POH1; RPN11
GeneCards (Weizmann)PSMD14
Ensembl hg19 (Hinxton)ENSG00000115233 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115233 [Gene_View]  chr2:161308275-161411717 [Contig_View]  PSMD14 [Vega]
ICGC DataPortalENSG00000115233
TCGA cBioPortalPSMD14
AceView (NCBI)PSMD14
Genatlas (Paris)PSMD14
WikiGenes10213
SOURCE (Princeton)PSMD14
Genetics Home Reference (NIH)PSMD14
Genomic and cartography
GoldenPath hg38 (UCSC)PSMD14  -     chr2:161308275-161411717 +  2q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PSMD14  -     2q24.2   [Description]    (hg19-Feb_2009)
EnsemblPSMD14 - 2q24.2 [CytoView hg19]  PSMD14 - 2q24.2 [CytoView hg38]
Mapping of homologs : NCBIPSMD14 [Mapview hg19]  PSMD14 [Mapview hg38]
OMIM607173   
Gene and transcription
Genbank (Entrez)AB209220 AK055128 AK091095 BC009524 BC066336
RefSeq transcript (Entrez)NM_005805
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PSMD14
Cluster EST : UnigeneHs.740477 [ NCBI ]
CGAP (NCI)Hs.740477
Alternative Splicing GalleryENSG00000115233
Gene ExpressionPSMD14 [ NCBI-GEO ]   PSMD14 [ EBI - ARRAY_EXPRESS ]   PSMD14 [ SEEK ]   PSMD14 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMD14 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10213
GTEX Portal (Tissue expression)PSMD14
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00487   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00487  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00487
Splice isoforms : SwissVarO00487
Catalytic activity : Enzyme3.4.19.- [ Enzyme-Expasy ]   3.4.19.-3.4.19.- [ IntEnz-EBI ]   3.4.19.- [ BRENDA ]   3.4.19.- [ KEGG ]   
PhosPhoSitePlusO00487
Domains : Interpro (EBI)JAMM/MPN+_dom    Rpn11/EIF3F_C   
Domain families : Pfam (Sanger)JAB (PF01398)    MitMem_reg (PF13012)   
Domain families : Pfam (NCBI)pfam01398    pfam13012   
Domain families : Smart (EMBL)JAB_MPN (SM00232)  
Conserved Domain (NCBI)PSMD14
DMDM Disease mutations10213
Blocks (Seattle)PSMD14
PDB (SRS)5GJQ    5GJR    5L4K    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (PDBSum)5GJQ    5GJR    5L4K    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (IMB)5GJQ    5GJR    5L4K    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (RSDB)5GJQ    5GJR    5L4K    5T0C    5T0G    5T0H    5T0I    5T0J   
Structural Biology KnowledgeBase5GJQ    5GJR    5L4K    5T0C    5T0G    5T0H    5T0I    5T0J   
SCOP (Structural Classification of Proteins)5GJQ    5GJR    5L4K    5T0C    5T0G    5T0H    5T0I    5T0J   
CATH (Classification of proteins structures)5GJQ    5GJR    5L4K    5T0C    5T0G    5T0H    5T0I    5T0J   
SuperfamilyO00487
Human Protein AtlasENSG00000115233
Peptide AtlasO00487
HPRD06208
IPIIPI00024821   IPI00915790   
Protein Interaction databases
DIP (DOE-UCLA)O00487
IntAct (EBI)O00487
FunCoupENSG00000115233
BioGRIDPSMD14
STRING (EMBL)PSMD14
ZODIACPSMD14
Ontologies - Pathways
QuickGOO00487
Ontology : AmiGOMAPK cascade  protein polyubiquitination  proteasome complex  proteasome complex  double-strand break repair via homologous recombination  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  extracellular region  nucleus  nucleoplasm  cytosol  double-strand break repair via nonhomologous end joining  ubiquitin-dependent protein catabolic process  regulation of cellular amino acid metabolic process  metallopeptidase activity  proteasome regulatory particle, lid subcomplex  positive regulation of endopeptidase activity  negative regulation of G2/M transition of mitotic cell cycle  protein deubiquitination  proteasome accessory complex  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  cytosolic proteasome complex  tumor necrosis factor-mediated signaling pathway  secretory granule lumen  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  neutrophil degranulation  regulation of mRNA stability  response to ethanol  metal ion binding  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  endopeptidase activator activity  regulation of proteasomal protein catabolic process  regulation of transcription from RNA polymerase II promoter in response to hypoxia  Lys63-specific deubiquitinase activity  extracellular exosome  protein K63-linked deubiquitination  protein K63-linked deubiquitination  proteasome binding  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  ficolin-1-rich granule lumen  
Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  proteasome complex  proteasome complex  double-strand break repair via homologous recombination  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  extracellular region  nucleus  nucleoplasm  cytosol  double-strand break repair via nonhomologous end joining  ubiquitin-dependent protein catabolic process  regulation of cellular amino acid metabolic process  metallopeptidase activity  proteasome regulatory particle, lid subcomplex  positive regulation of endopeptidase activity  negative regulation of G2/M transition of mitotic cell cycle  protein deubiquitination  proteasome accessory complex  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  cytosolic proteasome complex  tumor necrosis factor-mediated signaling pathway  secretory granule lumen  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  neutrophil degranulation  regulation of mRNA stability  response to ethanol  metal ion binding  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  endopeptidase activator activity  regulation of proteasomal protein catabolic process  regulation of transcription from RNA polymerase II promoter in response to hypoxia  Lys63-specific deubiquitinase activity  extracellular exosome  protein K63-linked deubiquitination  protein K63-linked deubiquitination  proteasome binding  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  ficolin-1-rich granule lumen  
Pathways : KEGGProteasome    Epstein-Barr virus infection   
NDEx NetworkPSMD14
Atlas of Cancer Signalling NetworkPSMD14
Wikipedia pathwaysPSMD14
Orthology - Evolution
OrthoDB10213
GeneTree (enSembl)ENSG00000115233
Phylogenetic Trees/Animal Genes : TreeFamPSMD14
HOVERGENO00487
HOGENOMO00487
Homologs : HomoloGenePSMD14
Homology/Alignments : Family Browser (UCSC)PSMD14
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSMD14 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMD14
dbVarPSMD14
ClinVarPSMD14
1000_GenomesPSMD14 
Exome Variant ServerPSMD14
ExAC (Exome Aggregation Consortium)PSMD14 (select the gene name)
Genetic variants : HAPMAP10213
Genomic Variants (DGV)PSMD14 [DGVbeta]
DECIPHERPSMD14 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPSMD14 
Mutations
ICGC Data PortalPSMD14 
TCGA Data PortalPSMD14 
Broad Tumor PortalPSMD14
OASIS PortalPSMD14 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMD14  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSMD14
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSMD14
DgiDB (Drug Gene Interaction Database)PSMD14
DoCM (Curated mutations)PSMD14 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSMD14 (select a term)
intoGenPSMD14
Cancer3DPSMD14(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607173   
Orphanet
MedgenPSMD14
Genetic Testing Registry PSMD14
NextProtO00487 [Medical]
TSGene10213
GENETestsPSMD14
Target ValidationPSMD14
Huge Navigator PSMD14 [HugePedia]
snp3D : Map Gene to Disease10213
BioCentury BCIQPSMD14
ClinGenPSMD14
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10213
Chemical/Pharm GKB GenePA134957776
Clinical trialPSMD14
Miscellaneous
canSAR (ICR)PSMD14 (select the gene name)
Probes
Litterature
PubMed72 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSMD14
EVEXPSMD14
GoPubMedPSMD14
iHOPPSMD14
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:11:57 CEST 2017

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