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PSMD2 (proteasome 26S subunit, non-ATPase 2)

Identity

Alias_namesproteasome (prosome
Alias_symbol (synonym)S2
P97
TRAP2
MGC14274
Rpn1
Other aliasRPN1
HGNC (Hugo) PSMD2
LocusID (NCBI) 5708
Atlas_Id 41889
Location 3q27.1  [Link to chromosome band 3q27]
Location_base_pair Starts at 184299098 and ends at 184309054 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DHFR (5q14.1) / PSMD2 (3q27.1)DST (6p12.1) / PSMD2 (3q27.1)MECOM (3q26.2) / PSMD2 (3q27.1)
PSMD2 (3q27.1) / ECE2 (3q27.1)PSMD2 (3q27.1) / HDAC10 (22q13.33)PSMD2 (3q27.1) / INPP1 (2q32.2)
PSMD2 (3q27.1) / MECOM (3q26.2)PSMD2 (3q27.1) / PRDM16 (1p36.32)PSMD2 (3q27.1) / PSMD2 (3q27.1)
PSMD2 (3q27.1) / TTC39C (18q11.2)PSMD2 (3q27.1) / YBX2 (17p13.1)SERPINA1 (14q32.13) / PSMD2 (3q27.1)
SYS1 (20q13.12) / PSMD2 (3q27.1)PSMD2 3q27.1 / ECE2 3q27.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  ECE2/PSMD2 (3q27)
PSMD2/ECE2 (3q27)


External links

Nomenclature
HGNC (Hugo)PSMD2   9559
Cards
Entrez_Gene (NCBI)PSMD2  5708  proteasome 26S subunit, non-ATPase 2
AliasesP97; RPN1; S2; TRAP2
GeneCards (Weizmann)PSMD2
Ensembl hg19 (Hinxton)ENSG00000175166 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175166 [Gene_View]  ENSG00000175166 [Sequence]  chr3:184299098-184309054 [Contig_View]  PSMD2 [Vega]
ICGC DataPortalENSG00000175166
TCGA cBioPortalPSMD2
AceView (NCBI)PSMD2
Genatlas (Paris)PSMD2
WikiGenes5708
SOURCE (Princeton)PSMD2
Genetics Home Reference (NIH)PSMD2
Genomic and cartography
GoldenPath hg38 (UCSC)PSMD2  -     chr3:184299098-184309054 +  3q27.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PSMD2  -     3q27.1   [Description]    (hg19-Feb_2009)
EnsemblPSMD2 - 3q27.1 [CytoView hg19]  PSMD2 - 3q27.1 [CytoView hg38]
Mapping of homologs : NCBIPSMD2 [Mapview hg19]  PSMD2 [Mapview hg38]
OMIM606223   
Gene and transcription
Genbank (Entrez)AB209843 AI026024 AK095245 AK297256 AK301759
RefSeq transcript (Entrez)NM_001278708 NM_001278709 NM_002808
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PSMD2
Cluster EST : UnigeneHs.518464 [ NCBI ]
CGAP (NCI)Hs.518464
Alternative Splicing GalleryENSG00000175166
Gene ExpressionPSMD2 [ NCBI-GEO ]   PSMD2 [ EBI - ARRAY_EXPRESS ]   PSMD2 [ SEEK ]   PSMD2 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMD2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5708
GTEX Portal (Tissue expression)PSMD2
Human Protein AtlasENSG00000175166-PSMD2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13200   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13200  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13200
Splice isoforms : SwissVarQ13200
PhosPhoSitePlusQ13200
Domains : Interpro (EBI)26S_Psome_Rpn1    ARM-like    ARM-type_fold    Proteasome/cyclosome_rpt   
Domain families : Pfam (Sanger)PC_rep (PF01851)   
Domain families : Pfam (NCBI)pfam01851   
Conserved Domain (NCBI)PSMD2
DMDM Disease mutations5708
Blocks (Seattle)PSMD2
PDB (SRS)5GJQ    5GJR    5L4K    5LN3    5T0C    5T0G    5T0H    5T0I    5T0J    5VHF    5VHH    5VHI    5VHJ    5VHM    5VHN    5VHO    5VHP    5VHQ    5VHR    5VHS   
PDB (PDBSum)5GJQ    5GJR    5L4K    5LN3    5T0C    5T0G    5T0H    5T0I    5T0J    5VHF    5VHH    5VHI    5VHJ    5VHM    5VHN    5VHO    5VHP    5VHQ    5VHR    5VHS   
PDB (IMB)5GJQ    5GJR    5L4K    5LN3    5T0C    5T0G    5T0H    5T0I    5T0J    5VHF    5VHH    5VHI    5VHJ    5VHM    5VHN    5VHO    5VHP    5VHQ    5VHR    5VHS   
PDB (RSDB)5GJQ    5GJR    5L4K    5LN3    5T0C    5T0G    5T0H    5T0I    5T0J    5VHF    5VHH    5VHI    5VHJ    5VHM    5VHN    5VHO    5VHP    5VHQ    5VHR    5VHS   
Structural Biology KnowledgeBase5GJQ    5GJR    5L4K    5LN3    5T0C    5T0G    5T0H    5T0I    5T0J    5VHF    5VHH    5VHI    5VHJ    5VHM    5VHN    5VHO    5VHP    5VHQ    5VHR    5VHS   
SCOP (Structural Classification of Proteins)5GJQ    5GJR    5L4K    5LN3    5T0C    5T0G    5T0H    5T0I    5T0J    5VHF    5VHH    5VHI    5VHJ    5VHM    5VHN    5VHO    5VHP    5VHQ    5VHR    5VHS   
CATH (Classification of proteins structures)5GJQ    5GJR    5L4K    5LN3    5T0C    5T0G    5T0H    5T0I    5T0J    5VHF    5VHH    5VHI    5VHJ    5VHM    5VHN    5VHO    5VHP    5VHQ    5VHR    5VHS   
SuperfamilyQ13200
Human Protein Atlas [tissue]ENSG00000175166-PSMD2 [tissue]
Peptide AtlasQ13200
HPRD05870
IPIIPI00012268   IPI01014808   IPI00384420   IPI00926410   IPI00926258   IPI00795529   IPI00925813   IPI00925595   IPI00925437   
Protein Interaction databases
DIP (DOE-UCLA)Q13200
IntAct (EBI)Q13200
FunCoupENSG00000175166
BioGRIDPSMD2
STRING (EMBL)PSMD2
ZODIACPSMD2
Ontologies - Pathways
QuickGOQ13200
Ontology : AmiGOproteasome complex  endopeptidase activity  protein binding  extracellular region  nucleus  nucleoplasm  cytosol  proteasome regulatory particle  proteasome regulatory particle, base subcomplex  membrane  protein deubiquitination  proteasome accessory complex  enzyme regulator activity  proteasome storage granule  secretory granule lumen  regulation of protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  neutrophil degranulation  post-translational protein modification  regulation of catalytic activity  extracellular exosome  ficolin-1-rich granule lumen  
Ontology : EGO-EBIproteasome complex  endopeptidase activity  protein binding  extracellular region  nucleus  nucleoplasm  cytosol  proteasome regulatory particle  proteasome regulatory particle, base subcomplex  membrane  protein deubiquitination  proteasome accessory complex  enzyme regulator activity  proteasome storage granule  secretory granule lumen  regulation of protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  neutrophil degranulation  post-translational protein modification  regulation of catalytic activity  extracellular exosome  ficolin-1-rich granule lumen  
Pathways : KEGGProteasome    Epstein-Barr virus infection   
NDEx NetworkPSMD2
Atlas of Cancer Signalling NetworkPSMD2
Wikipedia pathwaysPSMD2
Orthology - Evolution
OrthoDB5708
GeneTree (enSembl)ENSG00000175166
Phylogenetic Trees/Animal Genes : TreeFamPSMD2
HOVERGENQ13200
HOGENOMQ13200
Homologs : HomoloGenePSMD2
Homology/Alignments : Family Browser (UCSC)PSMD2
Gene fusions - Rearrangements
Fusion : MitelmanPSMD2/ECE2 [3q27.1/3q27.1]  
Fusion PortalPSMD2 3q27.1 ECE2 3q27.1 BRCA
Fusion : QuiverPSMD2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSMD2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMD2
dbVarPSMD2
ClinVarPSMD2
1000_GenomesPSMD2 
Exome Variant ServerPSMD2
ExAC (Exome Aggregation Consortium)ENSG00000175166
GNOMAD BrowserENSG00000175166
Varsome BrowserPSMD2
Genetic variants : HAPMAP5708
Genomic Variants (DGV)PSMD2 [DGVbeta]
DECIPHERPSMD2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPSMD2 
Mutations
ICGC Data PortalPSMD2 
TCGA Data PortalPSMD2 
Broad Tumor PortalPSMD2
OASIS PortalPSMD2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMD2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSMD2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSMD2
DgiDB (Drug Gene Interaction Database)PSMD2
DoCM (Curated mutations)PSMD2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSMD2 (select a term)
intoGenPSMD2
Cancer3DPSMD2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606223   
Orphanet
DisGeNETPSMD2
MedgenPSMD2
Genetic Testing Registry PSMD2
NextProtQ13200 [Medical]
TSGene5708
GENETestsPSMD2
Target ValidationPSMD2
Huge Navigator PSMD2 [HugePedia]
snp3D : Map Gene to Disease5708
BioCentury BCIQPSMD2
ClinGenPSMD2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5708
Chemical/Pharm GKB GenePA33905
Clinical trialPSMD2
Miscellaneous
canSAR (ICR)PSMD2 (select the gene name)
Probes
Litterature
PubMed173 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSMD2
EVEXPSMD2
GoPubMedPSMD2
iHOPPSMD2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:32:59 CET 2018

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