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PSMD3 (proteasome 26S subunit, non-ATPase 3)

Identity

Alias_namesTSTA2
tissue specific transplantation antigen 2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
Alias_symbol (synonym)S3
P58
Rpn3
Other aliasRPN3
HGNC (Hugo) PSMD3
LocusID (NCBI) 5709
Atlas_Id 41890
Location 17q21.1  [Link to chromosome band 17q21]
Location_base_pair Starts at 39980768 and ends at 39997960 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ASAP1 (8q24.21) / PSMD3 (17q21.1)CANT1 (17q25.3) / PSMD3 (17q21.1)CHURC1 (14q23.3) / PSMD3 (17q21.1)
MIB2 (1p36.33) / PSMD3 (17q21.1)PSMD3 (17q21.1) / CDK12 (17q12)PSMD3 (17q21.1) / PRELID1 (5q35.3)
PSMD3 (17q21.1) / UNC45B (17q12)RARA (17q21.2) / PSMD3 (17q21.1)THRA (17q21.1) / PSMD3 (17q21.1)
CANT1 17q25.3 / PSMD3 17q21.1PSMD3 17q21.1 / UNC45B 17q12RARA 17q21.2 / PSMD3 17q21.1
THRA 17q21.1 / PSMD3 17q21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

<\ABLE$WiDTH=100%>Nomenclature HGNC (Hugo)PSMD3   9560 Cards Entrez_Gene (NCBI)PSMD3  5709  proteasome 26S subunit, non-ATPase 3 AliasesP58; RPN3; S3; TSTA2 GeneCards (Weizmann)PSMD3 Ensembl hg19 (Hinxton)ENSG00000108344 [Gene_View] Ensembl hg38 (Hinxton)ENSG00000108344 [Gene_View]  chr17:39980768-39997960 [Contig_View]  PSMD3 [Vega] ICGC DataPortalENSG00000108344 TCGA cBioPortalPSMD3 AceView (NCBI)PSMD3 Genatlas (Paris)PSMD3 WikiGenes5709 SOURCE (Princeton)PSMD3 Genetics Home Reference (NIH)PSMD3 Genomic and cartography GoldenPath hg38 (UCSC)PSMD3  -     chr17:39980768-39997960 +  17q21.1   [Description]    (hg38-Dec_2013) GoldenPath hg19 (UCSC)PSMD3  -     17q21.1   [Description]    (hg19-Feb_2009) EnsemblPSMD3 - 17q21.1 [CytoView hg19]  PSMD3 - 17q21.1 [CytoView hg38] Mapping of homologs : NCBIPSMD3 [Mapview hg19]  PSMD3 [Mapview hg38] Gene and transcription Genbank (Entrez)AA143716 AF091075 AK022896 AK054611 AK055358 RefSeq transcript (Entrez)NM_002809 RefSeq genomic (Entrez) Consensus coding sequences : CCDS (NCBI)PSMD3 Cluster EST : UnigeneHs.12970 [ NCBI ] CGAP (NCI)Hs.12970 Alternative Splicing GalleryENSG00000108344 Gene ExpressionPSMD3 [ NCBI-GEO ]   PSMD3 [ EBI - ARRAY_EXPRESS ]   PSMD3 [ SEEK ]   PSMD3 [ MEM ] Gene Expression Viewer (FireBrowse)PSMD3 [ Firebrowse - Broad ] SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60] GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]   BioGPS (Tissue expression)5709 GTEX Portal (Tissue expression)PSMD3 Protein : pattern, domain, 3D structure UniProt/SwissProtO43242   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction] NextProtO43242  [Sequence]  [Exons]  [Medical]  [Publications] With graphics : InterProO43242 Splice isoforms : SwissVarO43242 PhosPhoSitePlusO43242 Domains : Interpro (EBI)26S_Psome_reg_C    PCI_dom    TPR-like_helical_dom    WHTH_DNA-bd_dom    Domain families : Pfam (Sanger)PCI (PF01399)    Rpn3_C (PF08375)    Domain families : Pfam (NCBI)pfam01399    pfam08375    Domain families : Smart (EMBL)PINT (SM00088)   Conserved Domain (NCBI)PSMD3 DMDM Disease mutations5709 Blocks (Seattle)PSMD3 PDB (SRS)5GJQ    5GJR    5L4K    5T0C    5T0G    5T0H    5T0I    5T0J    PDB (PDBSum)5GJQ    5GJR    5L4K    5T0C    5T0G    5T0H    5T0I    5T0J    PDB (IMB)5GJQ    5GJR    5L4K    5T0C    5T0G    5T0H    5T0I    5T0J    PDB (RSDB)5GJQ    5GJR    5L4K    5T0C    5T0G    5T0H    5T0I    5T0J    Structural Biology KnowledgeBase5GJQ    5GJR    5L4K    5T0C    5T0G    5T0H    5T0I    5T0J    SCOP (Structural Classification of Proteins)5GJQ    5GJR    5L4K    5T0C    5T0G    5T0H    5T0I    5T0J    CATH (Classification of proteins structures)5GJQ    5GJR    5L4K    5T0C    5T0G    5T0H    5T0I    5T0J    SuperfamilyO43242 Human Protein AtlasENSG00000108344 Peptide AtlasO43242 HPRD10170 IPIIPI00011603   IPI01014869   IPI01015295   IPI00383659    Protein Interaction databases DIP (DOE-UCLA)O43242 IntAct (EBI)O43242 FunCoupENSG00000108344 BioGRIDPSMD3 STRING (EMBL)PSMD3 ZODIACPSMD3 Ontologies - Pathways QuickGOO43242 Ontology : AmiGOMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  extracellular region  nucleus  nucleoplasm  cytosol  ubiquitin-dependent protein catabolic process  regulation of cellular amino acid metabolic process  proteasome regulatory particle, lid subcomplex  negative regulation of G2/M transition of mitotic cell cycle  membrane  protein deubiquitination  proteasome accessory complex  enzyme regulator activity  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  secretory granule lumen  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  neutrophil degranulation  regulation of mRNA stability  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  ficolin-1-rich granule lumen   Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  extracellular region  nucleus  nucleoplasm  cytosol  ubiquitin-dependent protein catabolic process  regulation of cellular amino acid metabolic process  proteasome regulatory particle, lid subcomplex  negative regulation of G2/M transition of mitotic cell cycle  membrane  protein deubiquitination  proteasome accessory complex  enzyme regulator activity  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  secretory granule lumen  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  neutrophil degranulation  regulation of mRNA stability  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  ficolin-1-rich granule lumen   Pathways : KEGGProteasome    Epstein-Barr virus infection    NDEx NetworkPSMD3 Atlas of Cancer Signalling NetworkPSMD3 Wikipedia pathwaysPSMD3 Orthology - Evolution OrthoDB5709 GeneTree (enSembl)ENSG00000108344 Phylogenetic Trees/Animal Genes : TreeFamPSMD3 HOVERGENO43242 HOGENOMO43242 Homologs : HomoloGenePSMD3 Homology/Alignments : Family Browser (UCSC)PSMD3 Gene fusions - Rearrangements Fusion : MitelmanCANT1/PSMD3 [17q25.3/17q21.1]  [t(17;17)(q21;q25)]   Fusion : MitelmanPSMD3/CDK12 [17q21.1/17q12]  [dup(17)(q12q21)]   Fusion : MitelmanPSMD3/UNC45B [17q21.1/17q12]  [t(17;17)(q12;q21)]   Fusion : MitelmanRARA/PSMD3 [17q21.2/17q21.1]  [t(17;17)(q21;q21)]   Fusion : MitelmanTHRA/PSMD3 [17q21.1/17q21.1]  [t(17;17)(q21;q21)]   Fusion: TCGACANT1 17q25.3 PSMD3 17q21.1 BRCA Fusion: TCGAPSMD3 17q21.1 UNC45B 17q12 LGG Fusion: TCGARARA 17q21.2 PSMD3 17q21.1 BRCA Fusion: TCGATHRA 17q21.1 PSMD3 17q21.1 LUAD Polymorphisms : SNP and Copy number variants NCBI Variation ViewerPSMD3 [hg38] dbSNP Single Nucleotide Polymorphism (NCBI)PSMD3 dbVarPSMD3 ClinVarPSMD3 1000_GenomesPSMD3  Exome Variant ServerPSMD3 ExAC (Exome Aggregation Consortium)PSMD3 (select the gene name) Genetic variants : HAPMAP5709 Genomic Variants (DGV)PSMD3 [DGVbeta] DECIPHERPSMD3 [patients]   [syndromes]   [variants]   [genes]   CONAN: Copy Number AnalysisPSMD3  Mutations ICGC Data PortalPSMD3  TCGA Data PortalPSMD3  Broad Tumor PortalPSMD3 OASIS PortalPSMD3 [ Somatic mutations - Copy number] Somatic Mutations in Cancer : COSMICPSMD3  [overview]  [genome browser]  [tissue]  [distribution]   Mutations and Diseases : HGMDPSMD3 LOVD (Leiden Open Variation Database)Whole genome datasets LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation BioMutasearch PSMD3 DgiDB (Drug Gene Interaction Database)PSMD3 DoCM (Curated mutations)PSMD3 (select the gene name) CIViC (Clinical Interpretations of Variants in Cancer)PSMD3 (select a term) intoGenPSMD3 Cancer3DPSMD3(select the gene name) Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] DiseasesOMIM Orphanet MedgenPSMD3 Genetic Testing Registry PSMD3 NextProtO43242 [Medical] TSGene5709 GENETestsPSMD3 Target ValidationPSMD3 Huge Navigator PSMD3 [HugePedia] snp3D : Map Gene to Disease5709 BioCentury BCIQPSMD3 ClinGenPSMD3 Clinical trials, drugs, therapyChemical/Protein Interactions : CTD5709 Chemical/Pharm GKB GenePA38123 Clinical trialPSMD3 MiscellaneouscanSAR (ICR)PSMD3 (select the gene name) ProbesLitteraturePubMed99 Pubmed reference(s) in Entrez GeneRIFsGene References Into Functions (Entrez) CoreMinePSMD3 EVEXPSMD3 GoPubMedPSMD3 iHOPPSMD3

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