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PSMD3 (proteasome 26S subunit, non-ATPase 3)

Identity

Alias_namesTSTA2
tissue specific transplantation antigen 2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
Alias_symbol (synonym)S3
P58
Rpn3
Other aliasRPN3
HGNC (Hugo) PSMD3
LocusID (NCBI) 5709
Atlas_Id 41890
Location 17q21.1  [Link to chromosome band 17q21]
Location_base_pair Starts at 39980768 and ends at 39997960 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ASAP1 (8q24.21) / PSMD3 (17q21.1)CANT1 (17q25.3) / PSMD3 (17q21.1)CHURC1 (14q23.3) / PSMD3 (17q21.1)
MIB2 (1p36.33) / PSMD3 (17q21.1)PSMD3 (17q21.1) / CDK12 (17q12)PSMD3 (17q21.1) / PRELID1 (5q35.3)
PSMD3 (17q21.1) / UNC45B (17q12)RARA (17q21.2) / PSMD3 (17q21.1)THRA (17q21.1) / PSMD3 (17q21.1)
CANT1 17q25.3 / PSMD3 17q21.1PSMD3 17q21.1 / UNC45B 17q12RARA 17q21.2 / PSMD3 17q21.1
THRA 17q21.1 / PSMD3 17q21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  dup(17)(q12q21) PSMD3/CDK12
t(17;17)(q12;q21) PSMD3/UNC45B
RARA/PSMD3 (17q21)
THRA/PSMD3 (17q21)
t(17;17)(q21;q25) CANT1/PSMD3


External links

Nomenclature
HGNC (Hugo)PSMD3   9560
Cards
Entrez_Gene (NCBI)PSMD3  5709  proteasome 26S subunit, non-ATPase 3
AliasesP58; RPN3; S3; TSTA2
GeneCards (Weizmann)PSMD3
Ensembl hg19 (Hinxton)ENSG00000108344 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108344 [Gene_View]  ENSG00000108344 [Sequence]  chr17:39980768-39997960 [Contig_View]  PSMD3 [Vega]
ICGC DataPortalENSG00000108344
TCGA cBioPortalPSMD3
AceView (NCBI)PSMD3
Genatlas (Paris)PSMD3
WikiGenes5709
SOURCE (Princeton)PSMD3
Genetics Home Reference (NIH)PSMD3
Genomic and cartography
GoldenPath hg38 (UCSC)PSMD3  -     chr17:39980768-39997960 +  17q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PSMD3  -     17q21.1   [Description]    (hg19-Feb_2009)
EnsemblPSMD3 - 17q21.1 [CytoView hg19]  PSMD3 - 17q21.1 [CytoView hg38]
Mapping of homologs : NCBIPSMD3 [Mapview hg19]  PSMD3 [Mapview hg38]
OMIM617676   
Gene and transcription
Genbank (Entrez)AA143716 AF091075 AK022896 AK054611 AK055358
RefSeq transcript (Entrez)NM_002809
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PSMD3
Cluster EST : UnigeneHs.12970 [ NCBI ]
CGAP (NCI)Hs.12970
Alternative Splicing GalleryENSG00000108344
Gene ExpressionPSMD3 [ NCBI-GEO ]   PSMD3 [ EBI - ARRAY_EXPRESS ]   PSMD3 [ SEEK ]   PSMD3 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMD3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5709
GTEX Portal (Tissue expression)PSMD3
Human Protein AtlasENSG00000108344-PSMD3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43242   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43242  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43242
Splice isoforms : SwissVarO43242
PhosPhoSitePlusO43242
Domaine pattern : Prosite (Expaxy)PCI (PS50250)   
Domains : Interpro (EBI)26S_Psome_reg_C    PCI_dom    PSMD3    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)PCI (PF01399)    Rpn3_C (PF08375)   
Domain families : Pfam (NCBI)pfam01399    pfam08375   
Domain families : Smart (EMBL)PINT (SM00088)  
Conserved Domain (NCBI)PSMD3
DMDM Disease mutations5709
Blocks (Seattle)PSMD3
PDB (SRS)5GJQ    5GJR    5L4K    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VGZ    5VHF    5VHH    5VHI    5VHS   
PDB (PDBSum)5GJQ    5GJR    5L4K    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VGZ    5VHF    5VHH    5VHI    5VHS   
PDB (IMB)5GJQ    5GJR    5L4K    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VGZ    5VHF    5VHH    5VHI    5VHS   
PDB (RSDB)5GJQ    5GJR    5L4K    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VGZ    5VHF    5VHH    5VHI    5VHS   
Structural Biology KnowledgeBase5GJQ    5GJR    5L4K    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VGZ    5VHF    5VHH    5VHI    5VHS   
SCOP (Structural Classification of Proteins)5GJQ    5GJR    5L4K    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VGZ    5VHF    5VHH    5VHI    5VHS   
CATH (Classification of proteins structures)5GJQ    5GJR    5L4K    5LN3    5M32    5T0C    5T0G    5T0H    5T0I    5T0J    5VGZ    5VHF    5VHH    5VHI    5VHS   
SuperfamilyO43242
Human Protein Atlas [tissue]ENSG00000108344-PSMD3 [tissue]
Peptide AtlasO43242
HPRD10170
IPIIPI00011603   IPI01014869   IPI01015295   IPI00383659   
Protein Interaction databases
DIP (DOE-UCLA)O43242
IntAct (EBI)O43242
FunCoupENSG00000108344
BioGRIDPSMD3
STRING (EMBL)PSMD3
ZODIACPSMD3
Ontologies - Pathways
QuickGOO43242
Ontology : AmiGOproteasome complex  protein binding  extracellular region  nucleus  nucleoplasm  cytosol  ubiquitin-dependent protein catabolic process  proteasome regulatory particle, lid subcomplex  membrane  protein deubiquitination  proteasome accessory complex  enzyme regulator activity  secretory granule lumen  regulation of protein catabolic process  neutrophil degranulation  post-translational protein modification  regulation of catalytic activity  extracellular exosome  ficolin-1-rich granule lumen  
Ontology : EGO-EBIproteasome complex  protein binding  extracellular region  nucleus  nucleoplasm  cytosol  ubiquitin-dependent protein catabolic process  proteasome regulatory particle, lid subcomplex  membrane  protein deubiquitination  proteasome accessory complex  enzyme regulator activity  secretory granule lumen  regulation of protein catabolic process  neutrophil degranulation  post-translational protein modification  regulation of catalytic activity  extracellular exosome  ficolin-1-rich granule lumen  
Pathways : KEGGProteasome    Epstein-Barr virus infection   
NDEx NetworkPSMD3
Atlas of Cancer Signalling NetworkPSMD3
Wikipedia pathwaysPSMD3
Orthology - Evolution
OrthoDB5709
GeneTree (enSembl)ENSG00000108344
Phylogenetic Trees/Animal Genes : TreeFamPSMD3
HOVERGENO43242
HOGENOMO43242
Homologs : HomoloGenePSMD3
Homology/Alignments : Family Browser (UCSC)PSMD3
Gene fusions - Rearrangements
Fusion : MitelmanCANT1/PSMD3 [17q25.3/17q21.1]  [t(17;17)(q21;q25)]  
Fusion : MitelmanPSMD3/CDK12 [17q21.1/17q12]  [dup(17)(q12q21)]  
Fusion : MitelmanPSMD3/UNC45B [17q21.1/17q12]  [t(17;17)(q12;q21)]  
Fusion : MitelmanRARA/PSMD3 [17q21.2/17q21.1]  [t(17;17)(q21;q21)]  
Fusion : MitelmanTHRA/PSMD3 [17q21.1/17q21.1]  [t(17;17)(q21;q21)]  
Fusion PortalCANT1 17q25.3 PSMD3 17q21.1 BRCA
Fusion PortalPSMD3 17q21.1 UNC45B 17q12 LGG
Fusion PortalRARA 17q21.2 PSMD3 17q21.1 BRCA
Fusion PortalTHRA 17q21.1 PSMD3 17q21.1 LUAD
Fusion : QuiverPSMD3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSMD3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMD3
dbVarPSMD3
ClinVarPSMD3
1000_GenomesPSMD3 
Exome Variant ServerPSMD3
ExAC (Exome Aggregation Consortium)ENSG00000108344
GNOMAD BrowserENSG00000108344
Varsome BrowserPSMD3
Genetic variants : HAPMAP5709
Genomic Variants (DGV)PSMD3 [DGVbeta]
DECIPHERPSMD3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPSMD3 
Mutations
ICGC Data PortalPSMD3 
TCGA Data PortalPSMD3 
Broad Tumor PortalPSMD3
OASIS PortalPSMD3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMD3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSMD3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSMD3
DgiDB (Drug Gene Interaction Database)PSMD3
DoCM (Curated mutations)PSMD3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSMD3 (select a term)
intoGenPSMD3
Cancer3DPSMD3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617676   
Orphanet
DisGeNETPSMD3
MedgenPSMD3
Genetic Testing Registry PSMD3
NextProtO43242 [Medical]
TSGene5709
GENETestsPSMD3
Target ValidationPSMD3
Huge Navigator PSMD3 [HugePedia]
snp3D : Map Gene to Disease5709
BioCentury BCIQPSMD3
ClinGenPSMD3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5709
Chemical/Pharm GKB GenePA38123
Clinical trialPSMD3
Miscellaneous
canSAR (ICR)PSMD3 (select the gene name)
Probes
Litterature
PubMed122 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSMD3
EVEXPSMD3
GoPubMedPSMD3
iHOPPSMD3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:32:59 CET 2018

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