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PSMD3 (proteasome 26S subunit, non-ATPase 3)

Identity

Alias_namesTSTA2
tissue specific transplantation antigen 2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
Alias_symbol (synonym)S3
P58
Rpn3
Other aliasRPN3
HGNC (Hugo) PSMD3
LocusID (NCBI) 5709
Atlas_Id 41890
Location 17q21.1  [Link to chromosome band 17q21]
Location_base_pair Starts at 39980768 and ends at 39997960 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ASAP1 (8q24.21) / PSMD3 (17q21.1)CANT1 (17q25.3) / PSMD3 (17q21.1)CHURC1 (14q23.3) / PSMD3 (17q21.1)
MIB2 (1p36.33) / PSMD3 (17q21.1)PSMD3 (17q21.1) / CDK12 (17q12)PSMD3 (17q21.1) / PRELID1 (5q35.3)
PSMD3 (17q21.1) / UNC45B (17q12)RARA (17q21.2) / PSMD3 (17q21.1)THRA (17q21.1) / PSMD3 (17q21.1)
CANT1 17q25.3 / PSMD3 17q21.1PSMD3 17q21.1 / UNC45B 17q12RARA 17q21.2 / PSMD3 17q21.1
THRA 17q21.1 / PSMD3 17q21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PSMD3   9560
Cards
Entrez_Gene (NCBI)PSMD3  5709  proteasome 26S subunit, non-ATPase 3
AliasesP58; RPN3; S3; TSTA2
GeneCards (Weizmann)PSMD3
Ensembl hg19 (Hinxton)ENSG00000108344 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108344 [Gene_View]  chr17:39980768-39997960 [Contig_View]  PSMD3 [Vega]
ICGC DataPortalENSG00000108344
TCGA cBioPortalPSMD3
AceView (NCBI)PSMD3
Genatlas (Paris)PSMD3
WikiGenes5709
SOURCE (Princeton)PSMD3
Genetics Home Reference (NIH)PSMD3
Genomic and cartography
GoldenPath hg38 (UCSC)PSMD3  -     chr17:39980768-39997960 +  17q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PSMD3  -     17q21.1   [Description]    (hg19-Feb_2009)
EnsemblPSMD3 - 17q21.1 [CytoView hg19]  PSMD3 - 17q21.1 [CytoView hg38]
Mapping of homologs : NCBIPSMD3 [Mapview hg19]  PSMD3 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AA143716 AF091075 AK022896 AK054611 AK055358
RefSeq transcript (Entrez)NM_002809
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PSMD3
Cluster EST : UnigeneHs.12970 [ NCBI ]
CGAP (NCI)Hs.12970
Alternative Splicing GalleryENSG00000108344
Gene ExpressionPSMD3 [ NCBI-GEO ]   PSMD3 [ EBI - ARRAY_EXPRESS ]   PSMD3 [ SEEK ]   PSMD3 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMD3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5709
GTEX Portal (Tissue expression)PSMD3
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43242   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43242  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43242
Splice isoforms : SwissVarO43242
PhosPhoSitePlusO43242
Domains : Interpro (EBI)26S_Psome_reg_C    PCI_dom    TPR-like_helical_dom    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)PCI (PF01399)    Rpn3_C (PF08375)   
Domain families : Pfam (NCBI)pfam01399    pfam08375   
Domain families : Smart (EMBL)PINT (SM00088)  
Conserved Domain (NCBI)PSMD3
DMDM Disease mutations5709
Blocks (Seattle)PSMD3
PDB (SRS)5GJQ    5GJR    5L4K    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (PDBSum)5GJQ    5GJR    5L4K    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (IMB)5GJQ    5GJR    5L4K    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (RSDB)5GJQ    5GJR    5L4K    5T0C    5T0G    5T0H    5T0I    5T0J   
Structural Biology KnowledgeBase5GJQ    5GJR    5L4K    5T0C    5T0G    5T0H    5T0I    5T0J   
SCOP (Structural Classification of Proteins)5GJQ    5GJR    5L4K    5T0C    5T0G    5T0H    5T0I    5T0J   
CATH (Classification of proteins structures)5GJQ    5GJR    5L4K    5T0C    5T0G    5T0H    5T0I    5T0J   
SuperfamilyO43242
Human Protein AtlasENSG00000108344
Peptide AtlasO43242
HPRD10170
IPIIPI00011603   IPI01014869   IPI01015295   IPI00383659   
Protein Interaction databases
DIP (DOE-UCLA)O43242
IntAct (EBI)O43242
FunCoupENSG00000108344
BioGRIDPSMD3
STRING (EMBL)PSMD3
ZODIACPSMD3
Ontologies - Pathways
QuickGOO43242
Ontology : AmiGOMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  extracellular region  nucleus  nucleoplasm  cytosol  ubiquitin-dependent protein catabolic process  regulation of cellular amino acid metabolic process  proteasome regulatory particle, lid subcomplex  negative regulation of G2/M transition of mitotic cell cycle  membrane  protein deubiquitination  proteasome accessory complex  enzyme regulator activity  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  secretory granule lumen  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  neutrophil degranulation  regulation of mRNA stability  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  ficolin-1-rich granule lumen  
Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  extracellular region  nucleus  nucleoplasm  cytosol  ubiquitin-dependent protein catabolic process  regulation of cellular amino acid metabolic process  proteasome regulatory particle, lid subcomplex  negative regulation of G2/M transition of mitotic cell cycle  membrane  protein deubiquitination  proteasome accessory complex  enzyme regulator activity  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  secretory granule lumen  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  neutrophil degranulation  regulation of mRNA stability  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  ficolin-1-rich granule lumen  
Pathways : KEGGProteasome    Epstein-Barr virus infection   
NDEx NetworkPSMD3
Atlas of Cancer Signalling NetworkPSMD3
Wikipedia pathwaysPSMD3
Orthology - Evolution
OrthoDB5709
GeneTree (enSembl)ENSG00000108344
Phylogenetic Trees/Animal Genes : TreeFamPSMD3
HOVERGENO43242
HOGENOMO43242
Homologs : HomoloGenePSMD3
Homology/Alignments : Family Browser (UCSC)PSMD3
Gene fusions - Rearrangements
Fusion : MitelmanCANT1/PSMD3 [17q25.3/17q21.1]  [t(17;17)(q21;q25)]  
Fusion : MitelmanPSMD3/CDK12 [17q21.1/17q12]  [dup(17)(q12q21)]  
Fusion : MitelmanPSMD3/UNC45B [17q21.1/17q12]  [t(17;17)(q12;q21)]  
Fusion : MitelmanRARA/PSMD3 [17q21.2/17q21.1]  [t(17;17)(q21;q21)]  
Fusion : MitelmanTHRA/PSMD3 [17q21.1/17q21.1]  [t(17;17)(q21;q21)]  
Fusion: TCGACANT1 17q25.3 PSMD3 17q21.1 BRCA
Fusion: TCGAPSMD3 17q21.1 UNC45B 17q12 LGG
Fusion: TCGARARA 17q21.2 PSMD3 17q21.1 BRCA
Fusion: TCGATHRA 17q21.1 PSMD3 17q21.1 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSMD3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMD3
dbVarPSMD3
ClinVarPSMD3
1000_GenomesPSMD3 
Exome Variant ServerPSMD3
ExAC (Exome Aggregation Consortium)PSMD3 (select the gene name)
Genetic variants : HAPMAP5709
Genomic Variants (DGV)PSMD3 [DGVbeta]
DECIPHERPSMD3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPSMD3 
Mutations
ICGC Data PortalPSMD3 
TCGA Data PortalPSMD3 
Broad Tumor PortalPSMD3
OASIS PortalPSMD3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMD3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSMD3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSMD3
DgiDB (Drug Gene Interaction Database)PSMD3
DoCM (Curated mutations)PSMD3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSMD3 (select a term)
intoGenPSMD3
Cancer3DPSMD3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenPSMD3
Genetic Testing Registry PSMD3
NextProtO43242 [Medical]
TSGene5709
GENETestsPSMD3
Huge Navigator PSMD3 [HugePedia]
snp3D : Map Gene to Disease5709
BioCentury BCIQPSMD3
ClinGenPSMD3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5709
Chemical/Pharm GKB GenePA38123
Clinical trialPSMD3
Miscellaneous
canSAR (ICR)PSMD3 (select the gene name)
Probes
Litterature
PubMed99 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSMD3
EVEXPSMD3
GoPubMedPSMD3
iHOPPSMD3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:33:16 CEST 2017

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