Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PSMD8 (proteasome 26S subunit, non-ATPase 8)

Identity

Alias_namesproteasome (prosome
Alias_symbol (synonym)S14
Nin1p
p31
HIP6
HYPF
Rpn12
Other aliasHEL-S-91n
HGNC (Hugo) PSMD8
LocusID (NCBI) 5714
Atlas_Id 55427
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 38374550 and ends at 38383824 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ELF2 (4q31.1) / PSMD8 (19q13.2)ITGAL (16p11.2) / PSMD8 (19q13.2)PSMD8 (19q13.2) / HDLBP (2q37.3)
PSMD8 (19q13.2) / SLC35B2 (6p21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PSMD8   9566
Cards
Entrez_Gene (NCBI)PSMD8  5714  proteasome 26S subunit, non-ATPase 8
AliasesHEL-S-91n; HIP6; HYPF; Nin1p; 
Rpn12; S14; p31
GeneCards (Weizmann)PSMD8
Ensembl hg19 (Hinxton)ENSG00000099341 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000099341 [Gene_View]  chr19:38374550-38383824 [Contig_View]  PSMD8 [Vega]
ICGC DataPortalENSG00000099341
TCGA cBioPortalPSMD8
AceView (NCBI)PSMD8
Genatlas (Paris)PSMD8
WikiGenes5714
SOURCE (Princeton)PSMD8
Genetics Home Reference (NIH)PSMD8
Genomic and cartography
GoldenPath hg38 (UCSC)PSMD8  -     chr19:38374550-38383824 +  19q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PSMD8  -     19q13.2   [Description]    (hg19-Feb_2009)
EnsemblPSMD8 - 19q13.2 [CytoView hg19]  PSMD8 - 19q13.2 [CytoView hg38]
Mapping of homologs : NCBIPSMD8 [Mapview hg19]  PSMD8 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK301771 AK304486 AK308809 BC001164 BC065006
RefSeq transcript (Entrez)NM_002812
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PSMD8
Cluster EST : UnigeneHs.78466 [ NCBI ]
CGAP (NCI)Hs.78466
Alternative Splicing GalleryENSG00000099341
Gene ExpressionPSMD8 [ NCBI-GEO ]   PSMD8 [ EBI - ARRAY_EXPRESS ]   PSMD8 [ SEEK ]   PSMD8 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMD8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5714
GTEX Portal (Tissue expression)PSMD8
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48556   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP48556  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP48556
Splice isoforms : SwissVarP48556
PhosPhoSitePlusP48556
Domains : Interpro (EBI)26S_Psome_Rpn12    CSN8_PSD8_EIF3K   
Domain families : Pfam (Sanger)CSN8_PSD8_EIF3K (PF10075)   
Domain families : Pfam (NCBI)pfam10075   
Conserved Domain (NCBI)PSMD8
DMDM Disease mutations5714
Blocks (Seattle)PSMD8
PDB (SRS)5GJQ    5GJR    5L4K    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (PDBSum)5GJQ    5GJR    5L4K    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (IMB)5GJQ    5GJR    5L4K    5T0C    5T0G    5T0H    5T0I    5T0J   
PDB (RSDB)5GJQ    5GJR    5L4K    5T0C    5T0G    5T0H    5T0I    5T0J   
Structural Biology KnowledgeBase5GJQ    5GJR    5L4K    5T0C    5T0G    5T0H    5T0I    5T0J   
SCOP (Structural Classification of Proteins)5GJQ    5GJR    5L4K    5T0C    5T0G    5T0H    5T0I    5T0J   
CATH (Classification of proteins structures)5GJQ    5GJR    5L4K    5T0C    5T0G    5T0H    5T0I    5T0J   
SuperfamilyP48556
Human Protein AtlasENSG00000099341
Peptide AtlasP48556
HPRD10171
IPIIPI00937278   
Protein Interaction databases
DIP (DOE-UCLA)P48556
IntAct (EBI)P48556
FunCoupENSG00000099341
BioGRIDPSMD8
STRING (EMBL)PSMD8
ZODIACPSMD8
Ontologies - Pathways
QuickGOP48556
Ontology : AmiGOMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  nucleus  nucleoplasm  cytosol  cytosol  proteasome regulatory particle  regulation of cellular amino acid metabolic process  proteasome regulatory particle, lid subcomplex  negative regulation of G2/M transition of mitotic cell cycle  protein deubiquitination  proteasome accessory complex  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  regulation of protein stability  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  proteasome assembly  regulation of mRNA stability  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  positive regulation of protein targeting to mitochondrion  
Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  nucleus  nucleoplasm  cytosol  cytosol  proteasome regulatory particle  regulation of cellular amino acid metabolic process  proteasome regulatory particle, lid subcomplex  negative regulation of G2/M transition of mitotic cell cycle  protein deubiquitination  proteasome accessory complex  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  regulation of protein stability  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  proteasome assembly  regulation of mRNA stability  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  positive regulation of protein targeting to mitochondrion  
Pathways : KEGGProteasome    Epstein-Barr virus infection   
NDEx NetworkPSMD8
Atlas of Cancer Signalling NetworkPSMD8
Wikipedia pathwaysPSMD8
Orthology - Evolution
OrthoDB5714
GeneTree (enSembl)ENSG00000099341
Phylogenetic Trees/Animal Genes : TreeFamPSMD8
HOVERGENP48556
HOGENOMP48556
Homologs : HomoloGenePSMD8
Homology/Alignments : Family Browser (UCSC)PSMD8
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSMD8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMD8
dbVarPSMD8
ClinVarPSMD8
1000_GenomesPSMD8 
Exome Variant ServerPSMD8
ExAC (Exome Aggregation Consortium)PSMD8 (select the gene name)
Genetic variants : HAPMAP5714
Genomic Variants (DGV)PSMD8 [DGVbeta]
DECIPHERPSMD8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPSMD8 
Mutations
ICGC Data PortalPSMD8 
TCGA Data PortalPSMD8 
Broad Tumor PortalPSMD8
OASIS PortalPSMD8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMD8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSMD8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSMD8
DgiDB (Drug Gene Interaction Database)PSMD8
DoCM (Curated mutations)PSMD8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSMD8 (select a term)
intoGenPSMD8
Cancer3DPSMD8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenPSMD8
Genetic Testing Registry PSMD8
NextProtP48556 [Medical]
TSGene5714
GENETestsPSMD8
Target ValidationPSMD8
Huge Navigator PSMD8 [HugePedia]
snp3D : Map Gene to Disease5714
BioCentury BCIQPSMD8
ClinGenPSMD8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5714
Chemical/Pharm GKB GenePA33912
Clinical trialPSMD8
Miscellaneous
canSAR (ICR)PSMD8 (select the gene name)
Probes
Litterature
PubMed85 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSMD8
EVEXPSMD8
GoPubMedPSMD8
iHOPPSMD8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:11:58 CEST 2017

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