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PSME1 (proteasome activator subunit 1)

Identity

Alias_namesproteasome (prosome
Alias_symbol (synonym)IFI5111
PA28alpha
Other aliasHEL-S-129m
PA28A
REGalpha
HGNC (Hugo) PSME1
LocusID (NCBI) 5720
Atlas_Id 43788
Location 14q12  [Link to chromosome band 14q12]
Location_base_pair Starts at 24136158 and ends at 24138967 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
KCNE3 (11q13.4) / PSME1 (14q12)MYH9 (22q12.3) / PSME1 (14q12)PSME1 (14q12) / IQCE (7p22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PSME1   9568
Cards
Entrez_Gene (NCBI)PSME1  5720  proteasome activator subunit 1
AliasesHEL-S-129m; IFI5111; PA28A; PA28alpha; 
REGalpha
GeneCards (Weizmann)PSME1
Ensembl hg19 (Hinxton)ENSG00000092010 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000092010 [Gene_View]  chr14:24136158-24138967 [Contig_View]  PSME1 [Vega]
ICGC DataPortalENSG00000092010
TCGA cBioPortalPSME1
AceView (NCBI)PSME1
Genatlas (Paris)PSME1
WikiGenes5720
SOURCE (Princeton)PSME1
Genetics Home Reference (NIH)PSME1
Genomic and cartography
GoldenPath hg38 (UCSC)PSME1  -     chr14:24136158-24138967 +  14q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PSME1  -     14q12   [Description]    (hg19-Feb_2009)
EnsemblPSME1 - 14q12 [CytoView hg19]  PSME1 - 14q12 [CytoView hg38]
Mapping of homologs : NCBIPSME1 [Mapview hg19]  PSME1 [Mapview hg38]
OMIM600654   
Gene and transcription
Genbank (Entrez)AI445328 AK307150 AK308572 AK311490 AK312211
RefSeq transcript (Entrez)NM_001281528 NM_001281529 NM_006263 NM_176783
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PSME1
Cluster EST : UnigeneHs.75348 [ NCBI ]
CGAP (NCI)Hs.75348
Alternative Splicing GalleryENSG00000092010
Gene ExpressionPSME1 [ NCBI-GEO ]   PSME1 [ EBI - ARRAY_EXPRESS ]   PSME1 [ SEEK ]   PSME1 [ MEM ]
Gene Expression Viewer (FireBrowse)PSME1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5720
GTEX Portal (Tissue expression)PSME1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ06323   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ06323  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ06323
Splice isoforms : SwissVarQ06323
PhosPhoSitePlusQ06323
Domains : Interpro (EBI)Proteasome_activ_pa28    Proteasome_activ_pa28_C    Proteasome_activ_pa28_N   
Domain families : Pfam (Sanger)PA28_alpha (PF02251)    PA28_beta (PF02252)   
Domain families : Pfam (NCBI)pfam02251    pfam02252   
Conserved Domain (NCBI)PSME1
DMDM Disease mutations5720
Blocks (Seattle)PSME1
PDB (SRS)1AVO   
PDB (PDBSum)1AVO   
PDB (IMB)1AVO   
PDB (RSDB)1AVO   
Structural Biology KnowledgeBase1AVO   
SCOP (Structural Classification of Proteins)1AVO   
CATH (Classification of proteins structures)1AVO   
SuperfamilyQ06323
Human Protein AtlasENSG00000092010
Peptide AtlasQ06323
HPRD02803
IPIIPI00479722   IPI00748256   
Protein Interaction databases
DIP (DOE-UCLA)Q06323
IntAct (EBI)Q06323
FunCoupENSG00000092010
BioGRIDPSME1
STRING (EMBL)PSME1
ZODIACPSME1
Ontologies - Pathways
QuickGOQ06323
Ontology : AmiGOMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  nucleoplasm  cytoplasm  cytosol  regulation of cellular amino acid metabolic process  proteasome activator complex  positive regulation of endopeptidase activity  negative regulation of G2/M transition of mitotic cell cycle  protein deubiquitination  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  endopeptidase activator activity  regulation of proteasomal protein catabolic process  regulation of transcription from RNA polymerase II promoter in response to hypoxia  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  regulation of G1/S transition of mitotic cell cycle  
Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  nucleoplasm  cytoplasm  cytosol  regulation of cellular amino acid metabolic process  proteasome activator complex  positive regulation of endopeptidase activity  negative regulation of G2/M transition of mitotic cell cycle  protein deubiquitination  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  endopeptidase activator activity  regulation of proteasomal protein catabolic process  regulation of transcription from RNA polymerase II promoter in response to hypoxia  extracellular exosome  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  regulation of G1/S transition of mitotic cell cycle  
Pathways : KEGGProteasome    Antigen processing and presentation   
NDEx NetworkPSME1
Atlas of Cancer Signalling NetworkPSME1
Wikipedia pathwaysPSME1
Orthology - Evolution
OrthoDB5720
GeneTree (enSembl)ENSG00000092010
Phylogenetic Trees/Animal Genes : TreeFamPSME1
HOVERGENQ06323
HOGENOMQ06323
Homologs : HomoloGenePSME1
Homology/Alignments : Family Browser (UCSC)PSME1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSME1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSME1
dbVarPSME1
ClinVarPSME1
1000_GenomesPSME1 
Exome Variant ServerPSME1
ExAC (Exome Aggregation Consortium)PSME1 (select the gene name)
Genetic variants : HAPMAP5720
Genomic Variants (DGV)PSME1 [DGVbeta]
DECIPHERPSME1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPSME1 
Mutations
ICGC Data PortalPSME1 
TCGA Data PortalPSME1 
Broad Tumor PortalPSME1
OASIS PortalPSME1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSME1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSME1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSME1
DgiDB (Drug Gene Interaction Database)PSME1
DoCM (Curated mutations)PSME1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSME1 (select a term)
intoGenPSME1
Cancer3DPSME1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600654   
Orphanet
MedgenPSME1
Genetic Testing Registry PSME1
NextProtQ06323 [Medical]
TSGene5720
GENETestsPSME1
Target ValidationPSME1
Huge Navigator PSME1 [HugePedia]
snp3D : Map Gene to Disease5720
BioCentury BCIQPSME1
ClinGenPSME1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5720
Chemical/Pharm GKB GenePA33914
Clinical trialPSME1
Miscellaneous
canSAR (ICR)PSME1 (select the gene name)
Probes
Litterature
PubMed93 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSME1
EVEXPSME1
GoPubMedPSME1
iHOPPSME1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:11:58 CEST 2017

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