Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PSME2 (proteasome activator subunit 2)

Identity

Alias_namesproteasome (prosome
Alias_symbol (synonym)PA28beta
Other aliasPA28B
REGbeta
HGNC (Hugo) PSME2
LocusID (NCBI) 5721
Atlas_Id 46565
Location 14q12  [Link to chromosome band 14q12]
Location_base_pair Starts at 24143365 and ends at 24146646 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CTTN (11q13.3) / PSME2 (14q12)PSME2 (14q12) / ANKRD46 (8q22.2)PSME2 (14q12) / RAB10 (2p23.3)
PSME2 (14q12) / RPS20 (8q12.1)PSME2 (14q12) / SNAP91 (6q14.2)TGOLN2 (2p11.2) / PSME2 (14q12)
CTTN 11q13.3 / PSME2 14q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;14)(q13;q12) CTTN/PSME2

External links

Nomenclature
HGNC (Hugo)PSME2   9569
Cards
Entrez_Gene (NCBI)PSME2  5721  proteasome activator subunit 2
AliasesPA28B; PA28beta; REGbeta
GeneCards (Weizmann)PSME2
Ensembl hg19 (Hinxton)ENSG00000100911 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100911 [Gene_View]  chr14:24143365-24146646 [Contig_View]  PSME2 [Vega]
ICGC DataPortalENSG00000100911
TCGA cBioPortalPSME2
AceView (NCBI)PSME2
Genatlas (Paris)PSME2
WikiGenes5721
SOURCE (Princeton)PSME2
Genetics Home Reference (NIH)PSME2
Genomic and cartography
GoldenPath hg38 (UCSC)PSME2  -     chr14:24143365-24146646 -  14q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PSME2  -     14q12   [Description]    (hg19-Feb_2009)
EnsemblPSME2 - 14q12 [CytoView hg19]  PSME2 - 14q12 [CytoView hg38]
Mapping of homologs : NCBIPSME2 [Mapview hg19]  PSME2 [Mapview hg38]
OMIM602161   
Gene and transcription
Genbank (Entrez)AK026580 AK225876 AK311569 AY771595 BC004368
RefSeq transcript (Entrez)NM_002818
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PSME2
Cluster EST : UnigeneHs.512410 [ NCBI ]
CGAP (NCI)Hs.512410
Alternative Splicing GalleryENSG00000100911
Gene ExpressionPSME2 [ NCBI-GEO ]   PSME2 [ EBI - ARRAY_EXPRESS ]   PSME2 [ SEEK ]   PSME2 [ MEM ]
Gene Expression Viewer (FireBrowse)PSME2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5721
GTEX Portal (Tissue expression)PSME2
Human Protein AtlasENSG00000100911-PSME2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UL46   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UL46  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UL46
Splice isoforms : SwissVarQ9UL46
PhosPhoSitePlusQ9UL46
Domains : Interpro (EBI)Proteasome_activ_pa28    Proteasome_activ_pa28_C    Proteasome_activ_pa28_N   
Domain families : Pfam (Sanger)PA28_alpha (PF02251)    PA28_beta (PF02252)   
Domain families : Pfam (NCBI)pfam02251    pfam02252   
Conserved Domain (NCBI)PSME2
DMDM Disease mutations5721
Blocks (Seattle)PSME2
SuperfamilyQ9UL46
Human Protein Atlas [tissue]ENSG00000100911-PSME2 [tissue]
Peptide AtlasQ9UL46
HPRD03697
IPIIPI00943181   
Protein Interaction databases
DIP (DOE-UCLA)Q9UL46
IntAct (EBI)Q9UL46
FunCoupENSG00000100911
BioGRIDPSME2
STRING (EMBL)PSME2
ZODIACPSME2
Ontologies - Pathways
QuickGOQ9UL46
Ontology : AmiGOMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  nucleoplasm  cytoplasm  cytosol  regulation of cellular amino acid metabolic process  proteasome activator complex  positive regulation of endopeptidase activity  negative regulation of G2/M transition of mitotic cell cycle  membrane  protein deubiquitination  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  interleukin-12-mediated signaling pathway  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  identical protein binding  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  post-translational protein modification  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  endopeptidase activator activity  regulation of proteasomal protein catabolic process  regulation of transcription from RNA polymerase II promoter in response to hypoxia  extracellular exosome  interleukin-1-mediated signaling pathway  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  regulation of hematopoietic stem cell differentiation  regulation of G1/S transition of mitotic cell cycle  
Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  proteasome complex  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  nucleoplasm  cytoplasm  cytosol  regulation of cellular amino acid metabolic process  proteasome activator complex  positive regulation of endopeptidase activity  negative regulation of G2/M transition of mitotic cell cycle  membrane  protein deubiquitination  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  interleukin-12-mediated signaling pathway  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  identical protein binding  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  post-translational protein modification  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  endopeptidase activator activity  regulation of proteasomal protein catabolic process  regulation of transcription from RNA polymerase II promoter in response to hypoxia  extracellular exosome  interleukin-1-mediated signaling pathway  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  regulation of hematopoietic stem cell differentiation  regulation of G1/S transition of mitotic cell cycle  
Pathways : KEGGAntigen processing and presentation   
NDEx NetworkPSME2
Atlas of Cancer Signalling NetworkPSME2
Wikipedia pathwaysPSME2
Orthology - Evolution
OrthoDB5721
GeneTree (enSembl)ENSG00000100911
Phylogenetic Trees/Animal Genes : TreeFamPSME2
HOVERGENQ9UL46
HOGENOMQ9UL46
Homologs : HomoloGenePSME2
Homology/Alignments : Family Browser (UCSC)PSME2
Gene fusions - Rearrangements
Fusion : MitelmanCTTN/PSME2 [11q13.3/14q12]  [t(11;14)(q13;q12)]  
Fusion: TCGA_MDACCCTTN 11q13.3 PSME2 14q12 BRCA
Fusion PortalCTTN 11q13.3 PSME2 14q12 BRCA
Fusion : QuiverPSME2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSME2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSME2
dbVarPSME2
ClinVarPSME2
1000_GenomesPSME2 
Exome Variant ServerPSME2
ExAC (Exome Aggregation Consortium)ENSG00000100911
GNOMAD BrowserENSG00000100911
Genetic variants : HAPMAP5721
Genomic Variants (DGV)PSME2 [DGVbeta]
DECIPHERPSME2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPSME2 
Mutations
ICGC Data PortalPSME2 
TCGA Data PortalPSME2 
Broad Tumor PortalPSME2
OASIS PortalPSME2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSME2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSME2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSME2
DgiDB (Drug Gene Interaction Database)PSME2
DoCM (Curated mutations)PSME2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSME2 (select a term)
intoGenPSME2
Cancer3DPSME2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602161   
Orphanet
DisGeNETPSME2
MedgenPSME2
Genetic Testing Registry PSME2
NextProtQ9UL46 [Medical]
TSGene5721
GENETestsPSME2
Target ValidationPSME2
Huge Navigator PSME2 [HugePedia]
snp3D : Map Gene to Disease5721
BioCentury BCIQPSME2
ClinGenPSME2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5721
Chemical/Pharm GKB GenePA33915
Clinical trialPSME2
Miscellaneous
canSAR (ICR)PSME2 (select the gene name)
Probes
Litterature
PubMed77 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSME2
EVEXPSME2
GoPubMedPSME2
iHOPPSME2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Feb 28 13:32:59 CET 2018
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