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PSME3 (proteasome activator subunit 3)

Identity

Alias_namesproteasome (prosome
Alias_symbol (synonym)Ki
PA28-gamma
REG-GAMMA
PA28G
Other aliasHEL-S-283
PA28gamma
HGNC (Hugo) PSME3
LocusID (NCBI) 10197
Atlas_Id 51215
Location 17q21.31  [Link to chromosome band 17q21]
Location_base_pair Starts at 40985159 and ends at 40995777 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CALM1 (14q32.11) / PSME3 (17q21.31)PSME3 (17q21.31) / LMNB2 (19p13.3)PSME3 (17q21.31) / PSME3 (17q21.31)
PSME3 (17q21.31) / TRIM44 (11p13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PSME3   9570
Cards
Entrez_Gene (NCBI)PSME3  10197  proteasome activator subunit 3
AliasesHEL-S-283; Ki; PA28-gamma; PA28G; 
PA28gamma; REG-GAMMA
GeneCards (Weizmann)PSME3
Ensembl hg19 (Hinxton)ENSG00000131467 [Gene_View]  chr17:40985159-40995777 [Contig_View]  PSME3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000131467 [Gene_View]  chr17:40985159-40995777 [Contig_View]  PSME3 [Vega]
ICGC DataPortalENSG00000131467
TCGA cBioPortalPSME3
AceView (NCBI)PSME3
Genatlas (Paris)PSME3
WikiGenes10197
SOURCE (Princeton)PSME3
Genetics Home Reference (NIH)PSME3
Genomic and cartography
GoldenPath hg19 (UCSC)PSME3  -     chr17:40985159-40995777 +  17q21.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PSME3  -     17q21.31   [Description]    (hg38-Dec_2013)
EnsemblPSME3 - 17q21.31 [CytoView hg19]  PSME3 - 17q21.31 [CytoView hg38]
Mapping of homologs : NCBIPSME3 [Mapview hg19]  PSME3 [Mapview hg38]
OMIM605129   
Gene and transcription
Genbank (Entrez)AI304773 AK057221 AK074999 AK292618 AK303211
RefSeq transcript (Entrez)NM_001267045 NM_005789 NM_176863
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)PSME3
Cluster EST : UnigeneHs.152978 [ NCBI ]
CGAP (NCI)Hs.152978
Alternative Splicing GalleryENSG00000131467
Gene ExpressionPSME3 [ NCBI-GEO ]   PSME3 [ EBI - ARRAY_EXPRESS ]   PSME3 [ SEEK ]   PSME3 [ MEM ]
Gene Expression Viewer (FireBrowse)PSME3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10197
GTEX Portal (Tissue expression)PSME3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61289   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61289  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61289
Splice isoforms : SwissVarP61289
PhosPhoSitePlusP61289
Domains : Interpro (EBI)Proteasome_activ_pa28    Proteasome_activ_pa28_C    Proteasome_activ_pa28_N   
Domain families : Pfam (Sanger)PA28_alpha (PF02251)    PA28_beta (PF02252)   
Domain families : Pfam (NCBI)pfam02251    pfam02252   
Conserved Domain (NCBI)PSME3
DMDM Disease mutations10197
Blocks (Seattle)PSME3
SuperfamilyP61289
Human Protein AtlasENSG00000131467
Peptide AtlasP61289
HPRD05500
IPIIPI00030243   IPI00219445   IPI01010908   IPI00922362   IPI01011561   
Protein Interaction databases
DIP (DOE-UCLA)P61289
IntAct (EBI)P61289
FunCoupENSG00000131467
BioGRIDPSME3
STRING (EMBL)PSME3
ZODIACPSME3
Ontologies - Pathways
QuickGOP61289
Ontology : AmiGOMAPK cascade  protein polyubiquitination  proteasome complex  p53 binding  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytoplasm  cytosol  regulation of cellular amino acid metabolic process  apoptotic process  proteasome activator complex  positive regulation of endopeptidase activity  membrane  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  identical protein binding  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  Wnt signaling pathway, planar cell polarity pathway  endopeptidase activator activity  regulation of proteasomal protein catabolic process  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  MDM2/MDM4 family protein binding  regulation of G1/S transition of mitotic cell cycle  negative regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  proteasome complex  p53 binding  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytoplasm  cytosol  regulation of cellular amino acid metabolic process  apoptotic process  proteasome activator complex  positive regulation of endopeptidase activity  membrane  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  identical protein binding  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  Wnt signaling pathway, planar cell polarity pathway  endopeptidase activator activity  regulation of proteasomal protein catabolic process  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  MDM2/MDM4 family protein binding  regulation of G1/S transition of mitotic cell cycle  negative regulation of extrinsic apoptotic signaling pathway  
Pathways : KEGGProteasome    Antigen processing and presentation    Hepatitis C   
NDEx NetworkPSME3
Atlas of Cancer Signalling NetworkPSME3
Wikipedia pathwaysPSME3
Orthology - Evolution
OrthoDB10197
GeneTree (enSembl)ENSG00000131467
Phylogenetic Trees/Animal Genes : TreeFamPSME3
HOVERGENP61289
HOGENOMP61289
Homologs : HomoloGenePSME3
Homology/Alignments : Family Browser (UCSC)PSME3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSME3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSME3
dbVarPSME3
ClinVarPSME3
1000_GenomesPSME3 
Exome Variant ServerPSME3
ExAC (Exome Aggregation Consortium)PSME3 (select the gene name)
Genetic variants : HAPMAP10197
Genomic Variants (DGV)PSME3 [DGVbeta]
DECIPHER (Syndromes)17:40985159-40995777  ENSG00000131467
CONAN: Copy Number AnalysisPSME3 
Mutations
ICGC Data PortalPSME3 
TCGA Data PortalPSME3 
Broad Tumor PortalPSME3
OASIS PortalPSME3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSME3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSME3
intOGen PortalPSME3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSME3
DgiDB (Drug Gene Interaction Database)PSME3
DoCM (Curated mutations)PSME3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSME3 (select a term)
intoGenPSME3
Cancer3DPSME3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605129   
Orphanet
MedgenPSME3
Genetic Testing Registry PSME3
NextProtP61289 [Medical]
TSGene10197
GENETestsPSME3
Huge Navigator PSME3 [HugePedia]
snp3D : Map Gene to Disease10197
BioCentury BCIQPSME3
ClinGenPSME3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10197
Chemical/Pharm GKB GenePA33916
Clinical trialPSME3
Miscellaneous
canSAR (ICR)PSME3 (select the gene name)
Probes
Litterature
PubMed138 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSME3
EVEXPSME3
GoPubMedPSME3
iHOPPSME3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:23:26 CET 2017

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