Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PSME4 (proteasome activator subunit 4)

Identity

Alias_namesproteasome (prosome
Alias_symbol (synonym)PA200
KIAA0077
Other alias
HGNC (Hugo) PSME4
LocusID (NCBI) 23198
Atlas_Id 43438
Location 2p16.2  [Link to chromosome band 2p16]
Location_base_pair Starts at 53864067 and ends at 53970840 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PPP4R3B (2p16.1) / PSME4 (2p16.2)PSME4 (2p16.2) / PPP1CB (2p23.2)PSME4 (2p16.2) / STON1-GTF2A1L (2p16.3)
PSME4 2p16.2 / STON1-GTF2A1L 2p16.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)PSME4   20635
Cards
Entrez_Gene (NCBI)PSME4  23198  proteasome activator subunit 4
AliasesPA200
GeneCards (Weizmann)PSME4
Ensembl hg19 (Hinxton)ENSG00000068878 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000068878 [Gene_View]  chr2:53864067-53970840 [Contig_View]  PSME4 [Vega]
ICGC DataPortalENSG00000068878
TCGA cBioPortalPSME4
AceView (NCBI)PSME4
Genatlas (Paris)PSME4
WikiGenes23198
SOURCE (Princeton)PSME4
Genetics Home Reference (NIH)PSME4
Genomic and cartography
GoldenPath hg38 (UCSC)PSME4  -     chr2:53864067-53970840 -  2p16.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PSME4  -     2p16.2   [Description]    (hg19-Feb_2009)
EnsemblPSME4 - 2p16.2 [CytoView hg19]  PSME4 - 2p16.2 [CytoView hg38]
Mapping of homologs : NCBIPSME4 [Mapview hg19]  PSME4 [Mapview hg38]
OMIM607705   
Gene and transcription
Genbank (Entrez)AA884260 AB621805 AK025517 AK026085 AK124923
RefSeq transcript (Entrez)NM_014614
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PSME4
Cluster EST : UnigeneHs.413801 [ NCBI ]
CGAP (NCI)Hs.413801
Alternative Splicing GalleryENSG00000068878
Gene ExpressionPSME4 [ NCBI-GEO ]   PSME4 [ EBI - ARRAY_EXPRESS ]   PSME4 [ SEEK ]   PSME4 [ MEM ]
Gene Expression Viewer (FireBrowse)PSME4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23198
GTEX Portal (Tissue expression)PSME4
Human Protein AtlasENSG00000068878-PSME4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14997   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14997  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14997
Splice isoforms : SwissVarQ14997
PhosPhoSitePlusQ14997
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Blm10_mid    DUF3437   
Domain families : Pfam (Sanger)BLM10_mid (PF16507)    DUF3437 (PF11919)   
Domain families : Pfam (NCBI)pfam16507    pfam11919   
Conserved Domain (NCBI)PSME4
DMDM Disease mutations23198
Blocks (Seattle)PSME4
SuperfamilyQ14997
Human Protein Atlas [tissue]ENSG00000068878-PSME4 [tissue]
Peptide AtlasQ14997
HPRD09652
IPIIPI00005260   IPI00783948   IPI00829629   IPI00829635   IPI00894486   
Protein Interaction databases
DIP (DOE-UCLA)Q14997
IntAct (EBI)Q14997
FunCoupENSG00000068878
BioGRIDPSME4
STRING (EMBL)PSME4
ZODIACPSME4
Ontologies - Pathways
QuickGOQ14997
Ontology : AmiGOMAPK cascade  protein polyubiquitination  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  nucleus  nucleus  nucleoplasm  cytosol  cytosol  cytosol  proteasome core complex  DNA repair  regulation of cellular amino acid metabolic process  cellular response to DNA damage stimulus  multicellular organism development  proteasomal ubiquitin-independent protein catabolic process  proteasomal ubiquitin-independent protein catabolic process  positive regulation of peptidase activity  negative regulation of G2/M transition of mitotic cell cycle  peptidase activator activity  peptidase activator activity  protein deubiquitination  nuclear speck  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  spermatogenesis, exchange of chromosomal proteins  spermatogenesis, exchange of chromosomal proteins  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  T cell receptor signaling pathway  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  lysine-acetylated histone binding  lysine-acetylated histone binding  proteasome binding  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  spermatoproteasome complex  spermatoproteasome complex  
Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  nucleus  nucleus  nucleoplasm  cytosol  cytosol  cytosol  proteasome core complex  DNA repair  regulation of cellular amino acid metabolic process  cellular response to DNA damage stimulus  multicellular organism development  proteasomal ubiquitin-independent protein catabolic process  proteasomal ubiquitin-independent protein catabolic process  positive regulation of peptidase activity  negative regulation of G2/M transition of mitotic cell cycle  peptidase activator activity  peptidase activator activity  protein deubiquitination  nuclear speck  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  spermatogenesis, exchange of chromosomal proteins  spermatogenesis, exchange of chromosomal proteins  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  T cell receptor signaling pathway  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  lysine-acetylated histone binding  lysine-acetylated histone binding  proteasome binding  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  spermatoproteasome complex  spermatoproteasome complex  
Pathways : KEGGProteasome   
NDEx NetworkPSME4
Atlas of Cancer Signalling NetworkPSME4
Wikipedia pathwaysPSME4
Orthology - Evolution
OrthoDB23198
GeneTree (enSembl)ENSG00000068878
Phylogenetic Trees/Animal Genes : TreeFamPSME4
HOVERGENQ14997
HOGENOMQ14997
Homologs : HomoloGenePSME4
Homology/Alignments : Family Browser (UCSC)PSME4
Gene fusions - Rearrangements
Fusion : MitelmanPSME4/PPP1CB [2p16.2/2p23.2]  
Fusion : MitelmanPSME4/STON1-GTF2A1L [2p16.2/2p16.3]  [t(2;2)(p16;p16)]  
Fusion: TCGA_MDACCPSME4 2p16.2 STON1-GTF2A1L 2p16.3 LUAD
Tumor Fusion PortalPSME4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSME4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSME4
dbVarPSME4
ClinVarPSME4
1000_GenomesPSME4 
Exome Variant ServerPSME4
ExAC (Exome Aggregation Consortium)ENSG00000068878
GNOMAD BrowserENSG00000068878
Genetic variants : HAPMAP23198
Genomic Variants (DGV)PSME4 [DGVbeta]
DECIPHERPSME4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPSME4 
Mutations
ICGC Data PortalPSME4 
TCGA Data PortalPSME4 
Broad Tumor PortalPSME4
OASIS PortalPSME4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSME4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSME4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSME4
DgiDB (Drug Gene Interaction Database)PSME4
DoCM (Curated mutations)PSME4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSME4 (select a term)
intoGenPSME4
Cancer3DPSME4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607705   
Orphanet
DisGeNETPSME4
MedgenPSME4
Genetic Testing Registry PSME4
NextProtQ14997 [Medical]
TSGene23198
GENETestsPSME4
Target ValidationPSME4
Huge Navigator PSME4 [HugePedia]
snp3D : Map Gene to Disease23198
BioCentury BCIQPSME4
ClinGenPSME4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23198
Chemical/Pharm GKB GenePA134872587
Clinical trialPSME4
Miscellaneous
canSAR (ICR)PSME4 (select the gene name)
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSME4
EVEXPSME4
GoPubMedPSME4
iHOPPSME4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:30:48 CET 2017

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