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PSMF1 (proteasome inhibitor subunit 1)

Identity

Alias_namesproteasome (prosome
Alias_symbol (synonym)PI31
Other alias
HGNC (Hugo) PSMF1
LocusID (NCBI) 9491
Atlas_Id 55437
Location 20p13  [Link to chromosome band 20p13]
Location_base_pair Starts at 1113229 and ends at 1172246 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CLTB (5q35.2) / PSMF1 (20p13)CRLS1 (20p12.3) / PSMF1 (20p13)FCMR (1q32.1) / PSMF1 (20p13)
PDIA3 (15q15.3) / PSMF1 (20p13)RGL1 (1q25.3) / PSMF1 (20p13)SGTA (19p13.3) / PSMF1 (20p13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PSMF1   9571
Cards
Entrez_Gene (NCBI)PSMF1  9491  proteasome inhibitor subunit 1
AliasesPI31
GeneCards (Weizmann)PSMF1
Ensembl hg19 (Hinxton)ENSG00000125818 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125818 [Gene_View]  chr20:1113229-1172246 [Contig_View]  PSMF1 [Vega]
ICGC DataPortalENSG00000125818
TCGA cBioPortalPSMF1
AceView (NCBI)PSMF1
Genatlas (Paris)PSMF1
WikiGenes9491
SOURCE (Princeton)PSMF1
Genetics Home Reference (NIH)PSMF1
Genomic and cartography
GoldenPath hg38 (UCSC)PSMF1  -     chr20:1113229-1172246 +  20p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PSMF1  -     20p13   [Description]    (hg19-Feb_2009)
EnsemblPSMF1 - 20p13 [CytoView hg19]  PSMF1 - 20p13 [CytoView hg38]
Mapping of homologs : NCBIPSMF1 [Mapview hg19]  PSMF1 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AA699495 AA885338 AF055032 AK098612 AK294134
RefSeq transcript (Entrez)NM_001323407 NM_001323408 NM_001323409 NM_001323410 NM_006814 NM_178578 NM_178579
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PSMF1
Cluster EST : UnigeneHs.656042 [ NCBI ]
CGAP (NCI)Hs.656042
Alternative Splicing GalleryENSG00000125818
Gene ExpressionPSMF1 [ NCBI-GEO ]   PSMF1 [ EBI - ARRAY_EXPRESS ]   PSMF1 [ SEEK ]   PSMF1 [ MEM ]
Gene Expression Viewer (FireBrowse)PSMF1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9491
GTEX Portal (Tissue expression)PSMF1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92530   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92530  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92530
Splice isoforms : SwissVarQ92530
PhosPhoSitePlusQ92530
Domains : Interpro (EBI)PI31_Prot_C    PI31_Prot_N   
Domain families : Pfam (Sanger)PI31_Prot_C (PF08577)    PI31_Prot_N (PF11566)   
Domain families : Pfam (NCBI)pfam08577    pfam11566   
Conserved Domain (NCBI)PSMF1
DMDM Disease mutations9491
Blocks (Seattle)PSMF1
PDB (SRS)2VT8    4OUH   
PDB (PDBSum)2VT8    4OUH   
PDB (IMB)2VT8    4OUH   
PDB (RSDB)2VT8    4OUH   
Structural Biology KnowledgeBase2VT8    4OUH   
SCOP (Structural Classification of Proteins)2VT8    4OUH   
CATH (Classification of proteins structures)2VT8    4OUH   
SuperfamilyQ92530
Human Protein AtlasENSG00000125818
Peptide AtlasQ92530
HPRD17919
IPIIPI00009949   IPI00910492   IPI00827831   IPI00643536   IPI00643918   
Protein Interaction databases
DIP (DOE-UCLA)Q92530
IntAct (EBI)Q92530
FunCoupENSG00000125818
BioGRIDPSMF1
STRING (EMBL)PSMF1
ZODIACPSMF1
Ontologies - Pathways
QuickGOQ92530
Ontology : AmiGOMAPK cascade  protein polyubiquitination  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  endopeptidase inhibitor activity  protein binding  nucleoplasm  endoplasmic reticulum  cytosol  cytosol  proteasome core complex  ubiquitin-dependent protein catabolic process  regulation of cellular amino acid metabolic process  negative regulation of endopeptidase activity  negative regulation of G2/M transition of mitotic cell cycle  membrane  protein deubiquitination  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  protein homodimerization activity  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  protein heterodimerization activity  perinuclear region of cytoplasm  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  proteasome binding  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  negative regulation of proteasomal protein catabolic process  
Ontology : EGO-EBIMAPK cascade  protein polyubiquitination  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  endopeptidase inhibitor activity  protein binding  nucleoplasm  endoplasmic reticulum  cytosol  cytosol  proteasome core complex  ubiquitin-dependent protein catabolic process  regulation of cellular amino acid metabolic process  negative regulation of endopeptidase activity  negative regulation of G2/M transition of mitotic cell cycle  membrane  protein deubiquitination  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  protein homodimerization activity  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  protein heterodimerization activity  perinuclear region of cytoplasm  T cell receptor signaling pathway  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of transcription from RNA polymerase II promoter in response to hypoxia  proteasome binding  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  negative regulation of proteasomal protein catabolic process  
Pathways : KEGGProteasome   
NDEx NetworkPSMF1
Atlas of Cancer Signalling NetworkPSMF1
Wikipedia pathwaysPSMF1
Orthology - Evolution
OrthoDB9491
GeneTree (enSembl)ENSG00000125818
Phylogenetic Trees/Animal Genes : TreeFamPSMF1
HOVERGENQ92530
HOGENOMQ92530
Homologs : HomoloGenePSMF1
Homology/Alignments : Family Browser (UCSC)PSMF1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSMF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSMF1
dbVarPSMF1
ClinVarPSMF1
1000_GenomesPSMF1 
Exome Variant ServerPSMF1
ExAC (Exome Aggregation Consortium)PSMF1 (select the gene name)
Genetic variants : HAPMAP9491
Genomic Variants (DGV)PSMF1 [DGVbeta]
DECIPHERPSMF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPSMF1 
Mutations
ICGC Data PortalPSMF1 
TCGA Data PortalPSMF1 
Broad Tumor PortalPSMF1
OASIS PortalPSMF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSMF1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSMF1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSMF1
DgiDB (Drug Gene Interaction Database)PSMF1
DoCM (Curated mutations)PSMF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSMF1 (select a term)
intoGenPSMF1
Cancer3DPSMF1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenPSMF1
Genetic Testing Registry PSMF1
NextProtQ92530 [Medical]
TSGene9491
GENETestsPSMF1
Target ValidationPSMF1
Huge Navigator PSMF1 [HugePedia]
snp3D : Map Gene to Disease9491
BioCentury BCIQPSMF1
ClinGenPSMF1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9491
Chemical/Pharm GKB GenePA33917
Clinical trialPSMF1
Miscellaneous
canSAR (ICR)PSMF1 (select the gene name)
Probes
Litterature
PubMed61 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSMF1
EVEXPSMF1
GoPubMedPSMF1
iHOPPSMF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:27:01 CEST 2017

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