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PSPH (phosphoserine phosphatase)

Identity

Alias_namesPSP
Other aliasPSPHD
HGNC (Hugo) PSPH
LocusID (NCBI) 5723
Atlas_Id 52528
Location 7p11.2  [Link to chromosome band 7p11]
Location_base_pair Starts at 56011051 and ends at 56051575 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCDC22 (Xp11.23) / PSPH (7p11.2)CYB561 (17q23.3) / PSPH (7p11.2)EGFR (7p11.2) / PSPH (7p11.2)
HERC3 (4q22.1) / PSPH (7p11.2)HYOU1 (11q23.3) / PSPH (7p11.2)LANCL2 (7p11.2) / PSPH (7p11.2)
MALAT1 (11q13.1) / PSPH (7p11.2)PSPH (7p11.2) / EFNB2 (13q33.3)PSPH (7p11.2) / GPATCH1 (19q13.11)
PSPH (7p11.2) / ITCH (20q11.22)PSPH (7p11.2) / PHKG1 (7p11.2)PSPH (7p11.2) / PSPH (7p11.2)
PSPH (7p11.2) / SNRNP35 (12q24.31)PSPH (7p11.2) / TBC1D1 (4p14)SEPT7P2 (7p12.3) / PSPH (7p11.2)
SFXN3 (10q24.31) / PSPH (7p11.2)SLC12A1 (15q21.1) / PSPH (7p11.2)PSPH 7p11.2 / PHKG1 7p11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PSPH   9577
Cards
Entrez_Gene (NCBI)PSPH  5723  phosphoserine phosphatase
AliasesPSP; PSPHD
GeneCards (Weizmann)PSPH
Ensembl hg19 (Hinxton)ENSG00000146733 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146733 [Gene_View]  chr7:56011051-56051575 [Contig_View]  PSPH [Vega]
ICGC DataPortalENSG00000146733
TCGA cBioPortalPSPH
AceView (NCBI)PSPH
Genatlas (Paris)PSPH
WikiGenes5723
SOURCE (Princeton)PSPH
Genetics Home Reference (NIH)PSPH
Genomic and cartography
GoldenPath hg38 (UCSC)PSPH  -     chr7:56011051-56051575 -  7p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PSPH  -     7p11.2   [Description]    (hg19-Feb_2009)
EnsemblPSPH - 7p11.2 [CytoView hg19]  PSPH - 7p11.2 [CytoView hg38]
Mapping of homologs : NCBIPSPH [Mapview hg19]  PSPH [Mapview hg38]
OMIM172480   614023   
Gene and transcription
Genbank (Entrez)AK054677 AK126156 AK223508 AK315235 AW574794
RefSeq transcript (Entrez)NM_004577
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PSPH
Cluster EST : UnigeneHs.512656 [ NCBI ]
CGAP (NCI)Hs.512656
Alternative Splicing GalleryENSG00000146733
Gene ExpressionPSPH [ NCBI-GEO ]   PSPH [ EBI - ARRAY_EXPRESS ]   PSPH [ SEEK ]   PSPH [ MEM ]
Gene Expression Viewer (FireBrowse)PSPH [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5723
GTEX Portal (Tissue expression)PSPH
Human Protein AtlasENSG00000146733-PSPH [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78330   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP78330  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP78330
Splice isoforms : SwissVarP78330
Catalytic activity : Enzyme3.1.3.3 [ Enzyme-Expasy ]   3.1.3.33.1.3.3 [ IntEnz-EBI ]   3.1.3.3 [ BRENDA ]   3.1.3.3 [ KEGG ]   
PhosPhoSitePlusP78330
Domains : Interpro (EBI)HAD-like_dom    Pser_Pase_dom_2   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)PSPH
DMDM Disease mutations5723
Blocks (Seattle)PSPH
PDB (SRS)1L8L    1L8O    1NNL   
PDB (PDBSum)1L8L    1L8O    1NNL   
PDB (IMB)1L8L    1L8O    1NNL   
PDB (RSDB)1L8L    1L8O    1NNL   
Structural Biology KnowledgeBase1L8L    1L8O    1NNL   
SCOP (Structural Classification of Proteins)1L8L    1L8O    1NNL   
CATH (Classification of proteins structures)1L8L    1L8O    1NNL   
SuperfamilyP78330
Human Protein Atlas [tissue]ENSG00000146733-PSPH [tissue]
Peptide AtlasP78330
HPRD01406
IPIIPI00019178   IPI00927730   IPI00925737   IPI00925485   IPI00925131   
Protein Interaction databases
DIP (DOE-UCLA)P78330
IntAct (EBI)P78330
FunCoupENSG00000146733
BioGRIDPSPH
STRING (EMBL)PSPH
ZODIACPSPH
Ontologies - Pathways
QuickGOP78330
Ontology : AmiGOmagnesium ion binding  phosphoserine phosphatase activity  phosphoserine phosphatase activity  calcium ion binding  cytosol  L-serine metabolic process  L-serine biosynthetic process  response to mechanical stimulus  dephosphorylation  response to nutrient levels  response to testosterone  protein homodimerization activity  neuron projection  
Ontology : EGO-EBImagnesium ion binding  phosphoserine phosphatase activity  phosphoserine phosphatase activity  calcium ion binding  cytosol  L-serine metabolic process  L-serine biosynthetic process  response to mechanical stimulus  dephosphorylation  response to nutrient levels  response to testosterone  protein homodimerization activity  neuron projection  
Pathways : KEGGGlycine, serine and threonine metabolism   
NDEx NetworkPSPH
Atlas of Cancer Signalling NetworkPSPH
Wikipedia pathwaysPSPH
Orthology - Evolution
OrthoDB5723
GeneTree (enSembl)ENSG00000146733
Phylogenetic Trees/Animal Genes : TreeFamPSPH
HOVERGENP78330
HOGENOMP78330
Homologs : HomoloGenePSPH
Homology/Alignments : Family Browser (UCSC)PSPH
Gene fusions - Rearrangements
Fusion : MitelmanEGFR/PSPH [7p11.2/7p11.2]  [t(7;7)(p11;p11)]  
Fusion : MitelmanLANCL2/PSPH [7p11.2/7p11.2]  [t(7;7)(p11;p11)]  
Fusion : MitelmanPSPH/PHKG1 [7p11.2/7p11.2]  [t(7;7)(p11;p11)]  
Fusion: TCGA_MDACCPSPH 7p11.2 PHKG1 7p11.2 BRCA
Tumor Fusion PortalPSPH
Fusion Cancer (Beijing)SEPT7P2 [7p12.3]  -  PSPH [7p11.2]  [FUSC000332]  [FUSC000332]  [FUSC000332]  [FUSC000332]  [FUSC000332]  [FUSC000332]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPSPH [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PSPH
dbVarPSPH
ClinVarPSPH
1000_GenomesPSPH 
Exome Variant ServerPSPH
ExAC (Exome Aggregation Consortium)ENSG00000146733
GNOMAD BrowserENSG00000146733
Genetic variants : HAPMAP5723
Genomic Variants (DGV)PSPH [DGVbeta]
DECIPHERPSPH [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPSPH 
Mutations
ICGC Data PortalPSPH 
TCGA Data PortalPSPH 
Broad Tumor PortalPSPH
OASIS PortalPSPH [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPSPH  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPSPH
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PSPH
DgiDB (Drug Gene Interaction Database)PSPH
DoCM (Curated mutations)PSPH (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PSPH (select a term)
intoGenPSPH
Cancer3DPSPH(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM172480    614023   
Orphanet11376   
DisGeNETPSPH
MedgenPSPH
Genetic Testing Registry PSPH
NextProtP78330 [Medical]
TSGene5723
GENETestsPSPH
Target ValidationPSPH
Huge Navigator PSPH [HugePedia]
snp3D : Map Gene to Disease5723
BioCentury BCIQPSPH
ClinGenPSPH
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5723
Chemical/Pharm GKB GenePA33928
Clinical trialPSPH
Miscellaneous
canSAR (ICR)PSPH (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePSPH
EVEXPSPH
GoPubMedPSPH
iHOPPSPH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:30:49 CET 2017

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