PTAFR (platelet activating factor receptor)

2007-02-01  

Identity

HGNC
LOCATION
1p35.3
LOCUSID
ALIAS
PAFR
FUSION GENES

Other Information

Locus ID:

NCBI: 5724
MIM: 173393
HGNC: 9582
Ensembl: ENSG00000169403

Variants:

dbSNP: 5724
ClinVar: 5724
TCGA: ENSG00000169403
COSMIC: PTAFR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169403ENST00000305392P25105
ENSG00000169403ENST00000373857P25105
ENSG00000169403ENST00000539896P25105

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Staphylococcus aureus infectionKEGGko05150
Staphylococcus aureus infectionKEGGhsa05150
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300
Signaling by InterleukinsREACTOMER-HSA-449147
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Neutrophil degranulationREACTOMER-HSA-6798695
Interleukin-10 signalingREACTOMER-HSA-6783783

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
163060502006Platelet-activating factor mediates MMP-2 expression and activation via phosphorylation of cAMP-response element-binding protein and contributes to melanoma metastasis.42
161158942005Ultraviolet B radiation generates platelet-activating factor-like phospholipids underlying cutaneous damage.41
197039032009Crosstalk between protease-activated receptor 1 and platelet-activating factor receptor regulates melanoma cell adhesion molecule (MCAM/MUC18) expression and melanoma metastasis.37
203924872010Activation of human mast cells through the platelet-activating factor receptor.37
216156742011Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia.34
186326382008Activation of platelet-activating factor receptor and pleiotropic effects on tyrosine phospho-EGFR/Src/FAK/paxillin in ovarian cancer.33
145007262003Trafficking, ubiquitination, and down-regulation of the human platelet-activating factor receptor.29
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
200323012010Hypoxia-inducible factor-dependent regulation of platelet-activating factor receptor as a route for gram-positive bacterial translocation across epithelia.23

Citation

Dessen P

PTAFR (platelet activating factor receptor)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43861/ptafr