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PTEN (Phosphatase and Tensin homolog deleted on chromosome Ten)

Written1999-07Michel Longy
Unite de Genetique Oncologique, Institut Bergonie, 180, rue de Saint-Genes, 33076 Bordeaux, France

(Note : for Links provided by Atlas : click)

Identity

Alias_namesBZS
MHAM
Alias_symbol (synonym)MMAC1
TEP1
PTEN1
Other aliasMMAC1 (Mutated in Multiple Advanced Cancer 1)
TEP 1 (TGFb regulated and Epithelial cell enriched Phosphatase 1)
HGNC (Hugo) PTEN
LocusID (NCBI) 5728
Atlas_Id 158
Location 10q23.31  [Link to chromosome band 10q23]
Location_base_pair Starts at 87863438 and ends at 87971930 bp from pter ( according to hg19-Feb_2009)  [Mapping PTEN.png]
Local_order between D10S1765 and D10S541
Fusion genes
(updated 2016)		EXOC4 (7q33) / PTEN (10q23.31)PTEN (10q23.31) / C1orf226 (1q23.3)PTEN (10q23.31) / CTNNA3 (10q21.3)
PTEN (10q23.31) / PACS1 (11q13.1)PTEN (10q23.31) / PEBP1 (12q24.23)PTEN (10q23.31) / PRDX3 (10q26.11)
SEC31A (4q21.22) / PTEN (10q23.31)

DNA/RNA

Description 9 exons, all coding; exon 1 has an unusually long 5' untranslated GC-rich region; exon 5 codes for the phosphatase core motif
Transcription 2 major detected transcripts; respectively 2 and 5 kb; open reading frame : 1209 bp

Protein

Description 403 aminoacids, 47 kDa; N-terminal phosphatase domain (from a.a. 1 to 185) with the catalytic core motif between; a.a. 123-131 encoded by exon 5; C-terminal PDZ binding domain
Localisation cytoplasmic localization (immunohistochemistry)
Function phosphatase activity; substrate : phosphatidylinositol 3,4,5-tri phosphate (PIP3); PTEN appears as a negative regulator of the PI3K/AKT signaling pathway; It is unclear if PTEN is able to dephosphorylate a protein substrate in vivo; tumor suppressive function: biallelic inactivation is observed in several tumor-types and inactivating germline mutations are responsible for a cancer prone syndrome, the Cowden disease; anti-invasive and anti-proliferative effects were documented in several cell lines

Mutations

Germinal germline mutations have been documented in Cowden disease and in Bannayan, Riley, Ruvalcaba phenotype (see below); they are observed along the various exons of the gene except the 9th (never described) and the 1st (very few reports); a mutational hot spot is observed in exon 5 in relation with the catalytic core motif; in the great majority of the cases, inactivating mutations are observed, either by protein truncation, or by misense mutation within the phosphatase domain
Somatic mutations are observed in several tumor type; they lead to a biallelic inactivation of the gene either by homozygous deletion, or by a combination of point mutation and a large deletion of the second allele

Implicated in

Note
  
Entity Cowden disease and Bannayan, Riley, Ruvalcaba phenotype
Disease Cowden disease is also known as multiple hamartoma syndrome, a cancer prone condition with autosomal dominant pattern of inheritance and high susceptibility to breast carcinoma and in a less extent to thyroid carcinoma; Bannayan, Ryley, Ruvalcaba syndrome correspond to the pediatric contrepart of Cowden disease with phenotypic overlap between the 2 syndromes (macrocephaly, intestinal polyps, lipomas, genital pigmented macules)
  
  
Entity sporadic malignant tumors
Disease somatic mutations were observed mainly in glioblastoma and in endometrial carcinoma, about 30% of these two kinds of tumors showing point mutations; only a few mutations were reported in prostate carcinoma, malignant melanoma, non Hodgkin lymphomas, breast carcinoma
  

Bibliography

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer.
Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, Wigler MH, Parsons R
Science (New York, N.Y.). 1997 ; 275 (5308) : 1943-1947.
PMID 9072974
 
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate.
Maehama T, Dixon JE
The Journal of biological chemistry. 1998 ; 273 (22) : 13375-13378.
PMID 9593664
 
Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation.
Marsh DJ, Coulon V, Lunetta KL, Rocca-Serra P, Dahia PL, Zheng Z, Liaw D, Caron S, Duboué B, Lin AY, Richardson AL, Bonnetblanc JM, Bressieux JM, Cabarrot-Moreau A, Chompret A, Demange L, Eeles RA, Yahanda AM, Fearon ER, Fricker JP, Gorlin RJ, Hodgson SV, Huson S, Lacombe D, Eng C
Human molecular genetics. 1998 ; 7 (3) : 507-515.
PMID 9467011
 
PTEN: sometimes taking it off can be better than putting it on.
Myers MP, Tonks NK
American journal of human genetics. 1997 ; 61 (6) : 1234-1238.
PMID 9399917
 
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers.
Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T, Davis T, Frye C, Hu R, Swedlund B, Teng DH, Tavtigian SV
Nature genetics. 1997 ; 15 (4) : 356-362.
PMID 9090379
 

Citation

This paper should be referenced as such :
Longy, M
PTEN (phosphatase, tensin homolog deleted on chromosome ten)
Atlas Genet Cytogenet Oncol Haematol. 1999;3(3):128-129.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/PTENID158.html

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Aggressive natural killer leukemia (ANKL)

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 22 ]
  Head and Neck: Odontogenic tumor: Ameloblastoma
Nervous system: Astrocytic tumors
Bladder: Urothelial carcinomas
Breast tumors : an overview
Kidney: Chromophobe renal cell carcinoma
Colon: Colorectal adenocarcinoma
Breast: Ductal carcinoma
Fallopian tube tumors: an overview
Nervous System: Glioma: an overview
Head and Neck: Squamous cell carcinoma: an overview
Lung: small cell cancer
Male breast cancer
Thyroid: Medullary carcinoma
Nervous system: Meningioma
Ovary: Epithelial tumors
Pancreatic tumors: an overview
Prostate tumors: an overview
Kidney: Renal cell carcinoma: an overview
Skin: Melanoma
Soft tissue tumors: an overview
Lung: Translocations in Small Cell Carcinoma
Uterus Tumours: an Overview

Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 7 ]
  Bannayan-Riley-Ruvalcaba syndrome Cowden disease Familial nervous system tumour syndromes Hereditary breast cancer Lhermitte-Duclos disease Li-Fraumeni syndrome Proteus syndrome

External links

Nomenclature
HGNC (Hugo)PTEN   9588
LRG (Locus Reference Genomic)LRG_311
Cards
AtlasPTENID158
Entrez_Gene (NCBI)PTEN  5728  phosphatase and tensin homolog
Aliases10q23del; BZS; CWS1; DEC; 
GLM2; MHAM; MMAC1; PTEN1; PTENbeta; TEP1
GeneCards (Weizmann)PTEN
Ensembl hg19 (Hinxton)ENSG00000171862 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171862 [Gene_View]  chr10:87863438-87971930 [Contig_View]  PTEN [Vega]
ICGC DataPortalENSG00000171862
TCGA cBioPortalPTEN
AceView (NCBI)PTEN
Genatlas (Paris)PTEN
WikiGenes5728
SOURCE (Princeton)PTEN
Genetics Home Reference (NIH)PTEN
Genomic and cartography
GoldenPath hg38 (UCSC)PTEN  -     chr10:87863438-87971930 +  10q23.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTEN  -     10q23.31   [Description]    (hg19-Feb_2009)
EnsemblPTEN - 10q23.31 [CytoView hg19]  PTEN - 10q23.31 [CytoView hg38]
Mapping of homologs : NCBIPTEN [Mapview hg19]  PTEN [Mapview hg38]
OMIM153480   155600   158350   176807   188470   275355   276950   601728   601728   605309   607174   608089   613028   
Gene and transcription
Genbank (Entrez)AA017584 AA836562 AI825848 AK021619 AK024986
RefSeq transcript (Entrez)NM_000314 NM_001304717 NM_001304718
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PTEN
Cluster EST : UnigeneHs.729457 [ NCBI ]
CGAP (NCI)Hs.729457
Alternative Splicing GalleryENSG00000171862
Gene ExpressionPTEN [ NCBI-GEO ]   PTEN [ EBI - ARRAY_EXPRESS ]   PTEN [ SEEK ]   PTEN [ MEM ]
Gene Expression Viewer (FireBrowse)PTEN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5728
GTEX Portal (Tissue expression)PTEN
Protein : pattern, domain, 3D structure
UniProt/SwissProtP60484   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP60484  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP60484
Splice isoforms : SwissVarP60484
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   
PhosPhoSitePlusP60484
Domaine pattern : Prosite (Expaxy)C2_TENSIN (PS51182)    PPASE_TENSIN (PS51181)   
Domains : Interpro (EBI)Bifunc_PIno_P3_Pase/Pase_PTEN    C2_dom    Dual-sp_phosphatase_cat-dom    Prot-tyrosine_phosphatase-like    Tensin_C2-dom    Tensin_lipid_phosphatase_dom    Tyr_Pase_AS    Tyr_Pase_cat   
Domain families : Pfam (Sanger)DSPc (PF00782)    PTEN_C2 (PF10409)   
Domain families : Pfam (NCBI)pfam00782    pfam10409   
Domain families : Smart (EMBL)PTEN_C2 (SM01326)  PTPc_motif (SM00404)  
Conserved Domain (NCBI)PTEN
DMDM Disease mutations5728
Blocks (Seattle)PTEN
PDB (SRS)1D5R    2KYL    4O1V    5BUG    5BZX    5BZZ   
PDB (PDBSum)1D5R    2KYL    4O1V    5BUG    5BZX    5BZZ   
PDB (IMB)1D5R    2KYL    4O1V    5BUG    5BZX    5BZZ   
PDB (RSDB)1D5R    2KYL    4O1V    5BUG    5BZX    5BZZ   
Structural Biology KnowledgeBase1D5R    2KYL    4O1V    5BUG    5BZX    5BZZ   
SCOP (Structural Classification of Proteins)1D5R    2KYL    4O1V    5BUG    5BZX    5BZZ   
CATH (Classification of proteins structures)1D5R    2KYL    4O1V    5BUG    5BZX    5BZZ   
SuperfamilyP60484
Human Protein AtlasENSG00000171862
Peptide AtlasP60484
HPRD03431
Protein Interaction databases
DIP (DOE-UCLA)P60484
IntAct (EBI)P60484
FunCoupENSG00000171862
BioGRIDPTEN
STRING (EMBL)PTEN
ZODIACPTEN
Ontologies - Pathways
QuickGOP60484
Ontology : AmiGOregulation of cyclin-dependent protein serine/threonine kinase activity  magnesium ion binding  angiogenesis  negative regulation of protein phosphorylation  negative regulation of protein phosphorylation  regulation of B cell apoptotic process  phosphatidylinositol-3-phosphatase activity  phosphoprotein phosphatase activity  protein serine/threonine phosphatase activity  protein tyrosine phosphatase activity  platelet-derived growth factor receptor binding  protein binding  extracellular region  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytoplasm  mitochondrion  cytosol  cytosol  plasma membrane  protein dephosphorylation  protein dephosphorylation  phosphatidylinositol biosynthetic process  apoptotic process  neuron-neuron synaptic transmission  synapse assembly  central nervous system development  heart development  aging  response to nutrient  learning or memory  memory  locomotory behavior  protein tyrosine/serine/threonine phosphatase activity  cell proliferation  positive regulation of cell proliferation  negative regulation of cell proliferation  negative regulation of cell proliferation  lipid binding  response to glucose  cytoplasmic side of plasma membrane  response to zinc ion  negative regulation of epithelial to mesenchymal transition  regulation of neuron projection development  anaphase-promoting complex binding  negative regulation of phosphatidylinositol 3-kinase signaling  negative regulation of phosphatidylinositol 3-kinase signaling  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity  apical plasma membrane  cell migration  protein deubiquitination  PML body  enzyme binding  protein kinase binding  dentate gyrus development  central nervous system neuron axonogenesis  PDZ domain binding  negative regulation of cell migration  adult behavior  negative regulation of myelination  regulation of protein stability  negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle  regulation of synaptic transmission, GABAergic  central nervous system myelin maintenance  response to estradiol  regulation of cellular component size  regulation of myeloid cell apoptotic process  response to ATP  multicellular organismal response to stress  social behavior  peptidyl-tyrosine dephosphorylation  myelin sheath adaxonal region  response to drug  maternal behavior  identical protein binding  cell projection  neuron projection  negative regulation of apoptotic process  dendritic spine  Schmidt-Lanterman incisure  protein kinase B signaling  endothelial cell migration  inositol phosphate metabolic process  postsynaptic membrane  response to ethanol  locomotor rhythm  negative regulation of cell size  negative regulation of organ growth  response to arsenic-containing substance  inositol phosphate dephosphorylation  phosphatidylinositol dephosphorylation  phosphatidylinositol dephosphorylation  platelet-derived growth factor receptor signaling pathway  phosphatidylinositol-mediated signaling  negative regulation of axon regeneration  cardiac muscle tissue development  forebrain morphogenesis  brain morphogenesis  negative regulation of epithelial cell proliferation  negative regulation of phagocytosis  negative regulation of axonogenesis  protein stabilization  T cell receptor signaling pathway  positive regulation of sequence-specific DNA binding transcription factor activity  negative regulation of keratinocyte migration  inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity  inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity  phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity  phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity  negative regulation of focal adhesion assembly  negative regulation of protein kinase B signaling  rhythmic synaptic transmission  negative regulation of cardiac muscle cell proliferation  canonical Wnt signaling pathway  synapse maturation  prepulse inhibition  male mating behavior  long-term synaptic potentiation  long term synaptic depression  prostate gland growth  dendritic spine morphogenesis  negative regulation of dendritic spine morphogenesis  negative regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  cellular response to electrical stimulus  cellular response to hypoxia  negative regulation of ribosome biogenesis  negative regulation of cell aging  negative regulation of excitatory postsynaptic potential  presynaptic membrane assembly  postsynaptic density assembly  negative regulation of wound healing, spreading of epidermal cells  positive regulation of TRAIL-activated apoptotic signaling pathway  positive regulation of ubiquitin protein ligase activity  ubiquitin-specific protease binding  positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process  negative regulation of G1/S transition of mitotic cell cycle  positive regulation of excitatory postsynaptic potential  negative regulation of synaptic vesicle clustering  
Ontology : EGO-EBIregulation of cyclin-dependent protein serine/threonine kinase activity  magnesium ion binding  angiogenesis  negative regulation of protein phosphorylation  negative regulation of protein phosphorylation  regulation of B cell apoptotic process  phosphatidylinositol-3-phosphatase activity  phosphoprotein phosphatase activity  protein serine/threonine phosphatase activity  protein tyrosine phosphatase activity  platelet-derived growth factor receptor binding  protein binding  extracellular region  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytoplasm  mitochondrion  cytosol  cytosol  plasma membrane  protein dephosphorylation  protein dephosphorylation  phosphatidylinositol biosynthetic process  apoptotic process  neuron-neuron synaptic transmission  synapse assembly  central nervous system development  heart development  aging  response to nutrient  learning or memory  memory  locomotory behavior  protein tyrosine/serine/threonine phosphatase activity  cell proliferation  positive regulation of cell proliferation  negative regulation of cell proliferation  negative regulation of cell proliferation  lipid binding  response to glucose  cytoplasmic side of plasma membrane  response to zinc ion  negative regulation of epithelial to mesenchymal transition  regulation of neuron projection development  anaphase-promoting complex binding  negative regulation of phosphatidylinositol 3-kinase signaling  negative regulation of phosphatidylinositol 3-kinase signaling  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity  apical plasma membrane  cell migration  protein deubiquitination  PML body  enzyme binding  protein kinase binding  dentate gyrus development  central nervous system neuron axonogenesis  PDZ domain binding  negative regulation of cell migration  adult behavior  negative regulation of myelination  regulation of protein stability  negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle  regulation of synaptic transmission, GABAergic  central nervous system myelin maintenance  response to estradiol  regulation of cellular component size  regulation of myeloid cell apoptotic process  response to ATP  multicellular organismal response to stress  social behavior  peptidyl-tyrosine dephosphorylation  myelin sheath adaxonal region  response to drug  maternal behavior  identical protein binding  cell projection  neuron projection  negative regulation of apoptotic process  dendritic spine  Schmidt-Lanterman incisure  protein kinase B signaling  endothelial cell migration  inositol phosphate metabolic process  postsynaptic membrane  response to ethanol  locomotor rhythm  negative regulation of cell size  negative regulation of organ growth  response to arsenic-containing substance  inositol phosphate dephosphorylation  phosphatidylinositol dephosphorylation  phosphatidylinositol dephosphorylation  platelet-derived growth factor receptor signaling pathway  phosphatidylinositol-mediated signaling  negative regulation of axon regeneration  cardiac muscle tissue development  forebrain morphogenesis  brain morphogenesis  negative regulation of epithelial cell proliferation  negative regulation of phagocytosis  negative regulation of axonogenesis  protein stabilization  T cell receptor signaling pathway  positive regulation of sequence-specific DNA binding transcription factor activity  negative regulation of keratinocyte migration  inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity  inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity  phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity  phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity  negative regulation of focal adhesion assembly  negative regulation of protein kinase B signaling  rhythmic synaptic transmission  negative regulation of cardiac muscle cell proliferation  canonical Wnt signaling pathway  synapse maturation  prepulse inhibition  male mating behavior  long-term synaptic potentiation  long term synaptic depression  prostate gland growth  dendritic spine morphogenesis  negative regulation of dendritic spine morphogenesis  negative regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  cellular response to electrical stimulus  cellular response to hypoxia  negative regulation of ribosome biogenesis  negative regulation of cell aging  negative regulation of excitatory postsynaptic potential  presynaptic membrane assembly  postsynaptic density assembly  negative regulation of wound healing, spreading of epidermal cells  positive regulation of TRAIL-activated apoptotic signaling pathway  positive regulation of ubiquitin protein ligase activity  ubiquitin-specific protease binding  positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process  negative regulation of G1/S transition of mitotic cell cycle  positive regulation of excitatory postsynaptic potential  negative regulation of synaptic vesicle clustering  
Pathways : BIOCARTA [Genes]   
Pathways : KEGG   
REACTOMEP60484 [protein]
REACTOME PathwaysR-HSA-5689896 [pathway]   
NDEx NetworkPTEN
Atlas of Cancer Signalling NetworkPTEN
Wikipedia pathwaysPTEN
Orthology - Evolution
OrthoDB5728
GeneTree (enSembl)ENSG00000171862
Phylogenetic Trees/Animal Genes : TreeFamPTEN
HOVERGENP60484
HOGENOMP60484
Homologs : HomoloGenePTEN
Homology/Alignments : Family Browser (UCSC)PTEN
Gene fusions - Rearrangements
Fusion : MitelmanPTEN/C1orf226 [10q23.31/1q23.3]  
Fusion : MitelmanPTEN/CTNNA3 [10q23.31/10q21.3]  [t(10;10)(q21;q23)]  
Fusion: TCGAPTEN 10q23.31 C1orf226 1q23.3 PRAD
Fusion: TCGAPTEN 10q23.31 CTNNA3 10q21.3 PRAD
Fusion Cancer (Beijing)PTEN [10q23.31]  -  PACS1 [11q13.1]  [FUSC004337]  [FUSC004337]  [FUSC004337]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTEN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTEN
dbVarPTEN
ClinVarPTEN
1000_GenomesPTEN 
Exome Variant ServerPTEN
ExAC (Exome Aggregation Consortium)PTEN (select the gene name)
Genetic variants : HAPMAP5728
Genomic Variants (DGV)PTEN [DGVbeta]
DECIPHERPTEN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTEN 
Mutations
ICGC Data PortalPTEN 
TCGA Data PortalPTEN 
Broad Tumor PortalPTEN
OASIS PortalPTEN [ Somatic mutations - Copy number]
Cancer Gene: CensusPTEN 
Somatic Mutations in Cancer : COSMICPTEN  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTEN
intOGen PortalPTEN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Zhejiang University Center for Genetic and Genomic Medicine (ZJU-CGGM)
BioMutasearch PTEN
DgiDB (Drug Gene Interaction Database)PTEN
DoCM (Curated mutations)PTEN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTEN (select a term)
intoGenPTEN
NCG5 (London)PTEN
Cancer3DPTEN(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM153480    155600    158350    176807    188470    275355    276950    601728    601728    605309    607174    608089    613028   
Orphanet243    565    1473    16690    2675    18693    3384    10898    10867    11125   
MedgenPTEN
Genetic Testing Registry PTEN
NextProtP60484 [Medical]
TSGene5728
GENETestsPTEN
Target ValidationPTEN
Huge Navigator PTEN [HugePedia]
snp3D : Map Gene to Disease5728
BioCentury BCIQPTEN
ClinGenPTEN (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5728
Chemical/Pharm GKB GenePA33942
Drug Sensitivity PTEN
Clinical trialPTEN
Miscellaneous
canSAR (ICR)PTEN (select the gene name)
Other databasehttp://cancergenome.broadinstitute.org/index.php?tgene=PTEN
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTEN
EVEXPTEN
GoPubMedPTEN
iHOPPTEN
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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