PTGDR2 (prostaglandin D2 receptor 2)

2014-09-01  

Identity

HGNC
LOCATION
11q12.2
LOCUSID
ALIAS
CD294,CRTH2,DL1R,DP2,GPR44

Other Information

Locus ID:

NCBI: 11251
MIM: 604837
HGNC: 4502
Ensembl: ENSG00000183134

Variants:

dbSNP: 11251
ClinVar: 11251
TCGA: ENSG00000183134
COSMIC: PTGDR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183134ENST00000332539Q9Y5Y4

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Eicosanoid ligand-binding receptorsREACTOMER-HSA-391903
Prostanoid ligand receptorsREACTOMER-HSA-391908
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
219090912011Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161.372
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
258506542015The prostaglandin D₂ receptor CRTH2 regulates accumulation of group 2 innate lymphoid cells in the inflamed lung.73
217622242012A randomized, double-blind, placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma.47
192476922009Analyses of associations with asthma in four asthma population samples from Canada and Australia.39
118016282002Cutting edge: agonistic effect of indomethacin on a prostaglandin D2 receptor, CRTH2.24
178783782007The role of the prostaglandin D2 receptor, DP, in eosinophil trafficking.23
153457052004Sequence variants of the gene encoding chemoattractant receptor expressed on Th2 cells (CRTH2) are associated with asthma and differentially influence mRNA stability.22
153457052004Sequence variants of the gene encoding chemoattractant receptor expressed on Th2 cells (CRTH2) are associated with asthma and differentially influence mRNA stability.22
14668348200411-Dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils.21

Citation

Dessen P

PTGDR2 (prostaglandin D2 receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-09-01

Online version: http://atlasgeneticsoncology.org/gene/54870/ptgdr2