PTGDS (prostaglandin D2 synthase)

2007-12-01  

Identity

HGNC
LOCATION
9q34.3
LOCUSID
ALIAS
L-PGDS,LPGDS,PDS,PGD2,PGDS,PGDS2
FUSION GENES

Other Information

Locus ID:

NCBI: 5730
MIM: 176803
HGNC: 9592
Ensembl: ENSG00000107317

Variants:

dbSNP: 5730
ClinVar: 5730
TCGA: ENSG00000107317
COSMIC: PTGDS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107317ENST00000371625P41222
ENSG00000107317ENST00000371625A0A024R8G3
ENSG00000107317ENST00000444903H0Y4L4
ENSG00000107317ENST00000446677H0Y5A1
ENSG00000107317ENST00000457950Q5SQ11
ENSG00000107317ENST00000640716A0A1W2PPU3

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
3500
4000

Pathways

PathwaySourceExternal ID
Arachidonic acid metabolismKEGGko00590
Arachidonic acid metabolismKEGGhsa00590
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)REACTOMER-HSA-2162123

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
117519912002Pronounced eosinophilic lung inflammation and Th2 cytokine release in human lipocalin-type prostaglandin D synthase transgenic mice.54
170930432006Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep.42
174042102007Lipocalin-type prostaglandin D synthase/beta-trace is a major amyloid beta-chaperone in human cerebrospinal fluid.35
264315802016Hematopoietic prostaglandin D synthase defines a proeosinophilic pathogenic effector human T(H)2 cell subpopulation with enhanced function.33
192762902009Common polymorphisms in the prostaglandin pathway genes and their association with breast cancer susceptibility and survival.23
191245062009Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.22
233350432013Comparison of serum concentrations of β-trace protein, β2-microglobulin, cystatin C, and creatinine in the US population.22
235181942013Novel filtration markers as predictors of all-cause and cardiovascular mortality in US adults.22
200081502010Dendritic cells express hematopoietic prostaglandin D synthase and function as a source of prostaglandin D2 in the skin.19

Citation

Dessen P

PTGDS (prostaglandin D2 synthase)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49884/ptgds