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PTGDS (prostaglandin D2 synthase)

Identity

Alias_namesprostaglandin D2 synthase (21kD, brain)
prostaglandin D2 synthase 21kDa (brain)
Alias_symbol (synonym)PGDS
L-PGDS
Other aliasLPGDS
PDS
PGD2
PGDS2
HGNC (Hugo) PTGDS
LocusID (NCBI) 5730
Atlas_Id 49884
Location 9q34.3  [Link to chromosome band 9q34]
Location_base_pair Starts at 136977504 and ends at 136981742 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MYBPC2 (19q13.33) / PTGDS (9q34.3)PTGDS (9q34.3) / DIP2C (10p15.3)PTGDS (9q34.3) / EEA1 (12q22)
PTGDS (9q34.3) / FAM63A (1q21.3)PTGDS (9q34.3) / HIP1R (12q24.31)PTGDS (9q34.3) / HKR1 (19q13.12)
PTGDS (9q34.3) / MYL7 (7p13)PTGDS (9q34.3) / PTGDS (9q34.3)PTGDS (9q34.3) / SIDT2 (11q23.3)
SRRM2 (16p13.3) / PTGDS (9q34.3)PTGDS 9q34.3 / EEA1 12q22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PTGDS   9592
Cards
Entrez_Gene (NCBI)PTGDS  5730  prostaglandin D2 synthase
AliasesL-PGDS; LPGDS; PDS; PGD2; 
PGDS; PGDS2
GeneCards (Weizmann)PTGDS
Ensembl hg19 (Hinxton)ENSG00000107317 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107317 [Gene_View]  chr9:136977504-136981742 [Contig_View]  PTGDS [Vega]
ICGC DataPortalENSG00000107317
TCGA cBioPortalPTGDS
AceView (NCBI)PTGDS
Genatlas (Paris)PTGDS
WikiGenes5730
SOURCE (Princeton)PTGDS
Genetics Home Reference (NIH)PTGDS
Genomic and cartography
GoldenPath hg38 (UCSC)PTGDS  -     chr9:136977504-136981742 +  9q34.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTGDS  -     9q34.3   [Description]    (hg19-Feb_2009)
EnsemblPTGDS - 9q34.3 [CytoView hg19]  PTGDS - 9q34.3 [CytoView hg38]
Mapping of homologs : NCBIPTGDS [Mapview hg19]  PTGDS [Mapview hg38]
OMIM176803   
Gene and transcription
Genbank (Entrez)AA621632 AI659247 AK075333 AK312817 AY026356
RefSeq transcript (Entrez)NM_000954
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PTGDS
Cluster EST : UnigeneHs.446429 [ NCBI ]
CGAP (NCI)Hs.446429
Alternative Splicing GalleryENSG00000107317
Gene ExpressionPTGDS [ NCBI-GEO ]   PTGDS [ EBI - ARRAY_EXPRESS ]   PTGDS [ SEEK ]   PTGDS [ MEM ]
Gene Expression Viewer (FireBrowse)PTGDS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5730
GTEX Portal (Tissue expression)PTGDS
Protein : pattern, domain, 3D structure
UniProt/SwissProtP41222   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP41222  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP41222
Splice isoforms : SwissVarP41222
Catalytic activity : Enzyme5.3.99.2 [ Enzyme-Expasy ]   5.3.99.25.3.99.2 [ IntEnz-EBI ]   5.3.99.2 [ BRENDA ]   5.3.99.2 [ KEGG ]   
PhosPhoSitePlusP41222
Domaine pattern : Prosite (Expaxy)LIPOCALIN (PS00213)   
Domains : Interpro (EBI)Calycin    Calycin-like    Lipocalin    Lipocalin_CS    Lipocln_cytosolic_FA-bd_dom    PstgldnD_synth   
Domain families : Pfam (Sanger)Lipocalin (PF00061)   
Domain families : Pfam (NCBI)pfam00061   
Conserved Domain (NCBI)PTGDS
DMDM Disease mutations5730
Blocks (Seattle)PTGDS
PDB (SRS)2WWP    3O19    3O22    3O2Y    4IMN    4IMO    4ORR    4ORS    4ORU    4ORW    4ORX    4ORY    4OS0    4OS3    4OS8    5WY9   
PDB (PDBSum)2WWP    3O19    3O22    3O2Y    4IMN    4IMO    4ORR    4ORS    4ORU    4ORW    4ORX    4ORY    4OS0    4OS3    4OS8    5WY9   
PDB (IMB)2WWP    3O19    3O22    3O2Y    4IMN    4IMO    4ORR    4ORS    4ORU    4ORW    4ORX    4ORY    4OS0    4OS3    4OS8    5WY9   
PDB (RSDB)2WWP    3O19    3O22    3O2Y    4IMN    4IMO    4ORR    4ORS    4ORU    4ORW    4ORX    4ORY    4OS0    4OS3    4OS8    5WY9   
Structural Biology KnowledgeBase2WWP    3O19    3O22    3O2Y    4IMN    4IMO    4ORR    4ORS    4ORU    4ORW    4ORX    4ORY    4OS0    4OS3    4OS8    5WY9   
SCOP (Structural Classification of Proteins)2WWP    3O19    3O22    3O2Y    4IMN    4IMO    4ORR    4ORS    4ORU    4ORW    4ORX    4ORY    4OS0    4OS3    4OS8    5WY9   
CATH (Classification of proteins structures)2WWP    3O19    3O22    3O2Y    4IMN    4IMO    4ORR    4ORS    4ORU    4ORW    4ORX    4ORY    4OS0    4OS3    4OS8    5WY9   
SuperfamilyP41222
Human Protein AtlasENSG00000107317
Peptide AtlasP41222
HPRD08904
IPIIPI00013179   IPI00514285   IPI00514208   IPI00513767   IPI00644952   
Protein Interaction databases
DIP (DOE-UCLA)P41222
IntAct (EBI)P41222
FunCoupENSG00000107317
BioGRIDPTGDS
STRING (EMBL)PTGDS
ZODIACPTGDS
Ontologies - Pathways
QuickGOP41222
Ontology : AmiGOprostaglandin biosynthetic process  prostaglandin biosynthetic process  prostaglandin-D synthase activity  prostaglandin-D synthase activity  prostaglandin-D synthase activity  transporter activity  retinoid binding  fatty acid binding  protein binding  extracellular region  extracellular space  endoplasmic reticulum membrane  rough endoplasmic reticulum  Golgi apparatus  transport  cyclooxygenase pathway  nuclear membrane  regulation of circadian sleep/wake cycle, sleep  perinuclear region of cytoplasm  extracellular exosome  
Ontology : EGO-EBIprostaglandin biosynthetic process  prostaglandin biosynthetic process  prostaglandin-D synthase activity  prostaglandin-D synthase activity  prostaglandin-D synthase activity  transporter activity  retinoid binding  fatty acid binding  protein binding  extracellular region  extracellular space  endoplasmic reticulum membrane  rough endoplasmic reticulum  Golgi apparatus  transport  cyclooxygenase pathway  nuclear membrane  regulation of circadian sleep/wake cycle, sleep  perinuclear region of cytoplasm  extracellular exosome  
Pathways : KEGGArachidonic acid metabolism   
NDEx NetworkPTGDS
Atlas of Cancer Signalling NetworkPTGDS
Wikipedia pathwaysPTGDS
Orthology - Evolution
OrthoDB5730
GeneTree (enSembl)ENSG00000107317
Phylogenetic Trees/Animal Genes : TreeFamPTGDS
HOVERGENP41222
HOGENOMP41222
Homologs : HomoloGenePTGDS
Homology/Alignments : Family Browser (UCSC)PTGDS
Gene fusions - Rearrangements
Fusion : MitelmanPTGDS/EEA1 [9q34.3/12q22]  
Fusion: TCGAPTGDS 9q34.3 EEA1 12q22 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTGDS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTGDS
dbVarPTGDS
ClinVarPTGDS
1000_GenomesPTGDS 
Exome Variant ServerPTGDS
ExAC (Exome Aggregation Consortium)PTGDS (select the gene name)
Genetic variants : HAPMAP5730
Genomic Variants (DGV)PTGDS [DGVbeta]
DECIPHERPTGDS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTGDS 
Mutations
ICGC Data PortalPTGDS 
TCGA Data PortalPTGDS 
Broad Tumor PortalPTGDS
OASIS PortalPTGDS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTGDS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTGDS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTGDS
DgiDB (Drug Gene Interaction Database)PTGDS
DoCM (Curated mutations)PTGDS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTGDS (select a term)
intoGenPTGDS
Cancer3DPTGDS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176803   
Orphanet
MedgenPTGDS
Genetic Testing Registry PTGDS
NextProtP41222 [Medical]
TSGene5730
GENETestsPTGDS
Huge Navigator PTGDS [HugePedia]
snp3D : Map Gene to Disease5730
BioCentury BCIQPTGDS
ClinGenPTGDS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5730
Chemical/Pharm GKB GenePA33945
Clinical trialPTGDS
Miscellaneous
canSAR (ICR)PTGDS (select the gene name)
Probes
Litterature
PubMed124 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTGDS
EVEXPTGDS
GoPubMedPTGDS
iHOPPTGDS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:33:23 CEST 2017

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