PTGER2 (prostaglandin E receptor 2)

2007-02-01  

Identity

HGNC
PTGER2
LOCATION
14q22.1
LOCUSID
5732
ALIAS
EP2

Other Information

Locus ID:

NCBI: 5732
MIM: 176804
HGNC: 9594
Ensembl: ENSG00000125384

Variants:

dbSNP: 5732
ClinVar: 5732
TCGA: ENSG00000125384
COSMIC: PTGER2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125384ENST00000245457P43116
ENSG00000125384ENST00000557436G3V2Y6

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Pathways in cancerKEGGhsa05200
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Renin secretionKEGGhsa04924
Renin secretionKEGGko04924
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Eicosanoid ligand-binding receptorsREACTOMER-HSA-391903
Prostanoid ligand receptorsREACTOMER-HSA-391908
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA175GNASGenePathwayassociated20938371
PA443450AsthmaDiseaseClinicalAnnotationassociatedPD17496729
PA448497aspirinChemicalClinicalAnnotationassociatedPD17496729

References

Pubmed IDYearTitleCitations
192736252009Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.157
121492182002Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells.135
162672252005Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease.97
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
170282622007Prostaglandin E(2) inhibits collagen expression and proliferation in patient-derived normal lung fibroblasts via E prostanoid 2 receptor and cAMP signaling.67
210814692011NF-κB targets miR-16 and miR-21 in gastric cancer: involvement of prostaglandin E receptors.64
155394592005Prostaglandin E(2) inhibits fibroblast migration by E-prostanoid 2 receptor-mediated increase in PTEN activity.62
247284102014Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2.55
188295292008Prostaglandin E2 regulates tumor angiogenesis in prostate cancer.53
208895712010Hypermethylation of PTGER2 confers prostaglandin E2 resistance in fibrotic fibroblasts from humans and mice.52

Citation

Dessen P

PTGER2 (prostaglandin E receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46566/ptger2