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PTGER3 (prostaglandin E receptor 3)

Identity

Alias_namesprostaglandin E receptor 3 (subtype EP3)
Alias_symbol (synonym)EP3
Other aliasEP3-I
EP3-II
EP3-III
EP3-IV
EP3-VI
EP3e
PGE2-R
lnc003875
HGNC (Hugo) PTGER3
LocusID (NCBI) 5733
Atlas_Id 51416
Location 1p31.1  [Link to chromosome band 1p31]
Location_base_pair Starts at 70970781 and ends at 71047808 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RERE (1p36.23) / PTGER3 (1p31.1)ZNF644 (1p22.2) / PTGER3 (1p31.1)ZNF644 1p22.2 / PTGER3 1p31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]

Solid Tumors TT_t0101p22p31ID103585

External links

Nomenclature
HGNC (Hugo)PTGER3   9595
Cards
Entrez_Gene (NCBI)PTGER3  5733  prostaglandin E receptor 3
AliasesEP3; EP3-I; EP3-II; EP3-III; 
EP3-IV; EP3-VI; EP3e; PGE2-R; lnc003875
GeneCards (Weizmann)PTGER3
Ensembl hg19 (Hinxton)ENSG00000050628 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000050628 [Gene_View]  ENSG00000050628 [Sequence]  chr1:70970781-71047808 [Contig_View]  PTGER3 [Vega]
ICGC DataPortalENSG00000050628
TCGA cBioPortalPTGER3
AceView (NCBI)PTGER3
Genatlas (Paris)PTGER3
WikiGenes5733
SOURCE (Princeton)PTGER3
Genetics Home Reference (NIH)PTGER3
Genomic and cartography
GoldenPath hg38 (UCSC)PTGER3  -     chr1:70970781-71047808 -  1p31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTGER3  -     1p31.1   [Description]    (hg19-Feb_2009)
GoldenPathPTGER3 - 1p31.1 [CytoView hg19]  PTGER3 - 1p31.1 [CytoView hg38]
ImmunoBaseENSG00000050628
Mapping of homologs : NCBIPTGER3 [Mapview hg19]  PTGER3 [Mapview hg38]
OMIM176806   
Gene and transcription
Genbank (Entrez)AB451481 AI273491 AK290634 AK315825 AL050227
RefSeq transcript (Entrez)NM_000957 NM_001126044 NM_198712 NM_198713 NM_198714 NM_198715 NM_198716 NM_198717 NM_198718 NM_198719 NM_198720
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PTGER3
Alternative Splicing GalleryENSG00000050628
Gene ExpressionPTGER3 [ NCBI-GEO ]   PTGER3 [ EBI - ARRAY_EXPRESS ]   PTGER3 [ SEEK ]   PTGER3 [ MEM ]
Gene Expression Viewer (FireBrowse)PTGER3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5733
GTEX Portal (Tissue expression)PTGER3
Human Protein AtlasENSG00000050628-PTGER3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP43115   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP43115  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP43115
Splice isoforms : SwissVarP43115
PhosPhoSitePlusP43115
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)EP3_rcpt_2    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    Prostanoid_rcpt    Prostglndn_DP_rcpt    Prostglndn_EP3_rcpt   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)PTGER3
DMDM Disease mutations5733
Blocks (Seattle)PTGER3
PDB (RSDB)6AK3    6M9T   
PDB Europe6AK3    6M9T   
PDB (PDBSum)6AK3    6M9T   
PDB (IMB)6AK3    6M9T   
Structural Biology KnowledgeBase6AK3    6M9T   
SCOP (Structural Classification of Proteins)6AK3    6M9T   
CATH (Classification of proteins structures)6AK3    6M9T   
SuperfamilyP43115
Human Protein Atlas [tissue]ENSG00000050628-PTGER3 [tissue]
Peptide AtlasP43115
HPRD08906
IPIIPI00411362   IPI01010513   IPI00395012   IPI00478116   IPI00889746   IPI00221021   IPI00394835   IPI00554479   IPI00783234   IPI00941973   IPI00554795   IPI00554511   IPI00479636   IPI00375543   
Protein Interaction databases
DIP (DOE-UCLA)P43115
IntAct (EBI)P43115
FunCoupENSG00000050628
BioGRIDPTGER3
STRING (EMBL)PTGER3
ZODIACPTGER3
Ontologies - Pathways
QuickGOP43115
Ontology : AmiGOprostaglandin E receptor activity  prostaglandin E receptor activity  cell  nuclear envelope  plasma membrane  plasma membrane  integral component of plasma membrane  inflammatory response  G protein-coupled receptor signaling pathway  adenylate cyclase-activating G protein-coupled receptor signaling pathway  phospholipase C-activating G protein-coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  cell death  intestine smooth muscle contraction  integral component of membrane  positive regulation of fever generation  negative regulation of gastric acid secretion  
Ontology : EGO-EBIprostaglandin E receptor activity  prostaglandin E receptor activity  cell  nuclear envelope  plasma membrane  plasma membrane  integral component of plasma membrane  inflammatory response  G protein-coupled receptor signaling pathway  adenylate cyclase-activating G protein-coupled receptor signaling pathway  phospholipase C-activating G protein-coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  cell death  intestine smooth muscle contraction  integral component of membrane  positive regulation of fever generation  negative regulation of gastric acid secretion  
Pathways : KEGGCalcium signaling pathway    Neuroactive ligand-receptor interaction   
NDEx NetworkPTGER3
Atlas of Cancer Signalling NetworkPTGER3
Wikipedia pathwaysPTGER3
Orthology - Evolution
OrthoDB5733
GeneTree (enSembl)ENSG00000050628
Phylogenetic Trees/Animal Genes : TreeFamPTGER3
HOGENOMP43115
Homologs : HomoloGenePTGER3
Homology/Alignments : Family Browser (UCSC)PTGER3
Gene fusions - Rearrangements
Fusion : MitelmanZNF644/PTGER3 [1p22.2/1p31.1]  [t(1;1)(p22;p31)]  
Fusion PortalZNF644 1p22.2 PTGER3 1p31.1 LUAD
Fusion : QuiverPTGER3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTGER3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTGER3
dbVarPTGER3
ClinVarPTGER3
1000_GenomesPTGER3 
Exome Variant ServerPTGER3
ExAC (Exome Aggregation Consortium)ENSG00000050628
GNOMAD BrowserENSG00000050628
Varsome BrowserPTGER3
Genetic variants : HAPMAP5733
Genomic Variants (DGV)PTGER3 [DGVbeta]
DECIPHERPTGER3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTGER3 
Mutations
ICGC Data PortalPTGER3 
TCGA Data PortalPTGER3 
Broad Tumor PortalPTGER3
OASIS PortalPTGER3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTGER3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPTGER3
Mutations and Diseases : HGMDPTGER3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTGER3
DgiDB (Drug Gene Interaction Database)PTGER3
DoCM (Curated mutations)PTGER3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTGER3 (select a term)
intoGenPTGER3
Cancer3DPTGER3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176806   
Orphanet
DisGeNETPTGER3
MedgenPTGER3
Genetic Testing Registry PTGER3
NextProtP43115 [Medical]
TSGene5733
GENETestsPTGER3
Target ValidationPTGER3
Huge Navigator PTGER3 [HugePedia]
snp3D : Map Gene to Disease5733
BioCentury BCIQPTGER3
ClinGenPTGER3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5733
Chemical/Pharm GKB GenePA288
Clinical trialPTGER3
Miscellaneous
canSAR (ICR)PTGER3 (select the gene name)
HarmonizomePTGER3
DataMed IndexPTGER3
Probes
Litterature
PubMed106 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTGER3
EVEXPTGER3
GoPubMedPTGER3
iHOPPTGER3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Mar 11 19:26:50 CET 2020
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