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PTGER3 (prostaglandin E receptor 3)

Identity

Alias_namesprostaglandin E receptor 3 (subtype EP3)
Alias_symbol (synonym)EP3
Other aliasEP3-I
EP3-II
EP3-III
EP3-IV
EP3-VI
EP3e
PGE2-R
HGNC (Hugo) PTGER3
LocusID (NCBI) 5733
Atlas_Id 51416
Location 1p31.1  [Link to chromosome band 1p31]
Location_base_pair Starts at 71418115 and ends at 71513491 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
RERE (1p36.23) / PTGER3 (1p31.1)ZNF644 (1p22.2) / PTGER3 (1p31.1)ZNF644 1p22.2 / PTGER3 1p31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PTGER3   9595
Cards
Entrez_Gene (NCBI)PTGER3  5733  prostaglandin E receptor 3
AliasesEP3; EP3-I; EP3-II; EP3-III; 
EP3-IV; EP3-VI; EP3e; PGE2-R
GeneCards (Weizmann)PTGER3
Ensembl hg19 (Hinxton)ENSG00000050628 [Gene_View]  chr1:71418115-71513491 [Contig_View]  PTGER3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000050628 [Gene_View]  chr1:71418115-71513491 [Contig_View]  PTGER3 [Vega]
ICGC DataPortalENSG00000050628
TCGA cBioPortalPTGER3
AceView (NCBI)PTGER3
Genatlas (Paris)PTGER3
WikiGenes5733
SOURCE (Princeton)PTGER3
Genetics Home Reference (NIH)PTGER3
Genomic and cartography
GoldenPath hg19 (UCSC)PTGER3  -     chr1:71418115-71513491 -  1p31.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PTGER3  -     1p31.1   [Description]    (hg38-Dec_2013)
EnsemblPTGER3 - 1p31.1 [CytoView hg19]  PTGER3 - 1p31.1 [CytoView hg38]
Mapping of homologs : NCBIPTGER3 [Mapview hg19]  PTGER3 [Mapview hg38]
OMIM176806   
Gene and transcription
Genbank (Entrez)AB451481 AI273491 AK290634 AK315825 AL050227
RefSeq transcript (Entrez)NM_000957 NM_001126044 NM_198712 NM_198713 NM_198714 NM_198715 NM_198716 NM_198717 NM_198718 NM_198719 NM_198720
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_029509 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)PTGER3
Cluster EST : UnigeneHs.445000 [ NCBI ]
CGAP (NCI)Hs.445000
Alternative Splicing GalleryENSG00000050628
Gene ExpressionPTGER3 [ NCBI-GEO ]   PTGER3 [ EBI - ARRAY_EXPRESS ]   PTGER3 [ SEEK ]   PTGER3 [ MEM ]
Gene Expression Viewer (FireBrowse)PTGER3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5733
GTEX Portal (Tissue expression)PTGER3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP43115   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP43115  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP43115
Splice isoforms : SwissVarP43115
PhosPhoSitePlusP43115
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)EP3_rcpt_2    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    Prostanoid_rcpt    Prostglndn_DP_rcpt    Prostglndn_EP3_rcpt   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)PTGER3
DMDM Disease mutations5733
Blocks (Seattle)PTGER3
SuperfamilyP43115
Human Protein AtlasENSG00000050628
Peptide AtlasP43115
HPRD08906
IPIIPI00411362   IPI01010513   IPI00395012   IPI00478116   IPI00889746   IPI00221021   IPI00394835   IPI00554479   IPI00783234   IPI00941973   IPI00554795   IPI00554511   IPI00479636   IPI00375543   
Protein Interaction databases
DIP (DOE-UCLA)P43115
IntAct (EBI)P43115
FunCoupENSG00000050628
BioGRIDPTGER3
STRING (EMBL)PTGER3
ZODIACPTGER3
Ontologies - Pathways
QuickGOP43115
Ontology : AmiGORNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding  prostaglandin E receptor activity  nuclear envelope  plasma membrane  integral component of plasma membrane  transcription, DNA-templated  G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  female pregnancy  cell death  cell surface  positive regulation of gene expression  negative regulation of norepinephrine secretion  intestine smooth muscle contraction  urinary bladder smooth muscle contraction  integral component of membrane  intracellular receptor signaling pathway  negative regulation of cAMP biosynthetic process  positive regulation of cAMP biosynthetic process  brush border membrane  positive regulation of fever generation  nuclear membrane  response to estradiol  response to progesterone  response to drug  neuronal cell body  positive regulation of vasoconstriction  positive regulation of circadian sleep/wake cycle, non-REM sleep  negative regulation of insulin secretion  maternal process involved in parturition  cellular response to lipopolysaccharide  cellular response to interleukin-1  negative regulation of platelet aggregation  negative regulation of potassium ion transmembrane transport  response to salt  negative regulation of calcium ion transmembrane transport  negative regulation of gastrin-induced gastric acid secretion  positive regulation of smooth muscle contraction involved in micturition  cellular response to forskolin  positive regulation of inhibitory G-protein coupled receptor phosphorylation  negative regulation of circadian sleep/wake cycle, wakefulness  positive regulation of myofibroblast contraction  positive regulation of colon smooth muscle contraction  positive regulation of gastric mucosal blood circulation  prostaglandin receptor internalization  proximal neuron projection  positive regulation of neutrophil extravasation  negative regulation of forebrain neuron differentiation  
Ontology : EGO-EBIRNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding  prostaglandin E receptor activity  nuclear envelope  plasma membrane  integral component of plasma membrane  transcription, DNA-templated  G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  female pregnancy  cell death  cell surface  positive regulation of gene expression  negative regulation of norepinephrine secretion  intestine smooth muscle contraction  urinary bladder smooth muscle contraction  integral component of membrane  intracellular receptor signaling pathway  negative regulation of cAMP biosynthetic process  positive regulation of cAMP biosynthetic process  brush border membrane  positive regulation of fever generation  nuclear membrane  response to estradiol  response to progesterone  response to drug  neuronal cell body  positive regulation of vasoconstriction  positive regulation of circadian sleep/wake cycle, non-REM sleep  negative regulation of insulin secretion  maternal process involved in parturition  cellular response to lipopolysaccharide  cellular response to interleukin-1  negative regulation of platelet aggregation  negative regulation of potassium ion transmembrane transport  response to salt  negative regulation of calcium ion transmembrane transport  negative regulation of gastrin-induced gastric acid secretion  positive regulation of smooth muscle contraction involved in micturition  cellular response to forskolin  positive regulation of inhibitory G-protein coupled receptor phosphorylation  negative regulation of circadian sleep/wake cycle, wakefulness  positive regulation of myofibroblast contraction  positive regulation of colon smooth muscle contraction  positive regulation of gastric mucosal blood circulation  prostaglandin receptor internalization  proximal neuron projection  positive regulation of neutrophil extravasation  negative regulation of forebrain neuron differentiation  
Pathways : BIOCARTAEicosanoid Metabolism [Genes]   
Pathways : KEGGCalcium signaling pathway    Neuroactive ligand-receptor interaction   
NDEx NetworkPTGER3
Atlas of Cancer Signalling NetworkPTGER3
Wikipedia pathwaysPTGER3
Orthology - Evolution
OrthoDB5733
GeneTree (enSembl)ENSG00000050628
Phylogenetic Trees/Animal Genes : TreeFamPTGER3
HOVERGENP43115
HOGENOMP43115
Homologs : HomoloGenePTGER3
Homology/Alignments : Family Browser (UCSC)PTGER3
Gene fusions - Rearrangements
Fusion : MitelmanZNF644/PTGER3 [1p22.2/1p31.1]  [t(1;1)(p22;p31)]  
Fusion: TCGAZNF644 1p22.2 PTGER3 1p31.1 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTGER3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTGER3
dbVarPTGER3
ClinVarPTGER3
1000_GenomesPTGER3 
Exome Variant ServerPTGER3
ExAC (Exome Aggregation Consortium)PTGER3 (select the gene name)
Genetic variants : HAPMAP5733
Genomic Variants (DGV)PTGER3 [DGVbeta]
DECIPHER (Syndromes)1:71418115-71513491  ENSG00000050628
CONAN: Copy Number AnalysisPTGER3 
Mutations
ICGC Data PortalPTGER3 
TCGA Data PortalPTGER3 
Broad Tumor PortalPTGER3
OASIS PortalPTGER3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTGER3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTGER3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTGER3
DgiDB (Drug Gene Interaction Database)PTGER3
DoCM (Curated mutations)PTGER3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTGER3 (select a term)
intoGenPTGER3
Cancer3DPTGER3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176806   
Orphanet
MedgenPTGER3
Genetic Testing Registry PTGER3
NextProtP43115 [Medical]
TSGene5733
GENETestsPTGER3
Huge Navigator PTGER3 [HugePedia]
snp3D : Map Gene to Disease5733
BioCentury BCIQPTGER3
ClinGenPTGER3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5733
Chemical/Pharm GKB GenePA288
Clinical trialPTGER3
Miscellaneous
canSAR (ICR)PTGER3 (select the gene name)
Probes
Litterature
PubMed88 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTGER3
EVEXPTGER3
GoPubMedPTGER3
iHOPPTGER3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:23:32 CET 2017

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