PTGER3 (prostaglandin E receptor 3)

2010-04-01  

Identity

HGNC
LOCATION
1p31.1
LOCUSID
ALIAS
EP3,EP3-I,EP3-II,EP3-III,EP3-IV,EP3-VI,EP3e,PGE2-R,lnc003875
FUSION GENES

Other Information

Locus ID:

NCBI: 5733
MIM: 176806
HGNC: 9595
Ensembl: ENSG00000050628

Variants:

dbSNP: 5733
ClinVar: 5733
TCGA: ENSG00000050628
COSMIC: PTGER3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000050628ENST00000306666P43115
ENSG00000050628ENST00000351052P43115
ENSG00000050628ENST00000354608F8WAJ7
ENSG00000050628ENST00000356595P43115
ENSG00000050628ENST00000361210O00325
ENSG00000050628ENST00000370924P43115
ENSG00000050628ENST00000370931P43115
ENSG00000050628ENST00000370932A0A0A0MRP3
ENSG00000050628ENST00000460330P43115
ENSG00000050628ENST00000479353P43115
ENSG00000050628ENST00000497146A0A0B4J204
ENSG00000050628ENST00000628037P43115

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Pathways in cancerKEGGhsa05200
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Regulation of lipolysis in adipocytesKEGGhsa04923
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Eicosanoid ligand-binding receptorsREACTOMER-HSA-391903
Prostanoid ligand receptorsREACTOMER-HSA-391908
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164712308Ace Inhibitors, PlainChemicalClinicalAnnotationassociatedPD21052031
PA443450AsthmaDiseaseClinicalAnnotationassociatedPD17496729
PA443803CoughDiseaseClinicalAnnotationassociatedPD21052031
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD21052031
PA448497aspirinChemicalClinicalAnnotationassociatedPD17496729

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
201104112010COX-2 and prostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems.41
229152432012Inflammatory prostaglandin E2 signaling in a mouse model of Alzheimer disease.38
206738682010A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).36
205160732010Shear-induced interleukin-6 synthesis in chondrocytes: roles of E prostanoid (EP) 2 and EP3 in cAMP/protein kinase A- and PI3-K/Akt-dependent NF-kappaB activation.33
233494872013Prostaglandin E2 receptor, EP3, is induced in diabetic islets and negatively regulates glucose- and hormone-stimulated insulin secretion.32
266611652016Inhibition of prostaglandin E2 receptor EP3 mitigates thrombin-induced brain injury.32
188187482008Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.31
195275142009Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.31

Citation

Dessen P

PTGER3 (prostaglandin E receptor 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-04-01

Online version: http://atlasgeneticsoncology.org/gene/51416/ptger3