Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PTGER4 (prostaglandin E receptor 4)

Identity

Alias (NCBI)EP4
EP4R
HGNC (Hugo) PTGER4
HGNC Alias symbEP4
HGNC Previous nameprostaglandin E receptor 4 (subtype EP4)
LocusID (NCBI) 5734
Atlas_Id 43737
Location 5p13.1  [Link to chromosome band 5p13]
Location_base_pair Starts at 40679915 and ends at 40693735 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)PTGER4   9596
Cards
Entrez_Gene (NCBI)PTGER4  5734  prostaglandin E receptor 4
AliasesEP4; EP4R
GeneCards (Weizmann)PTGER4
Ensembl hg19 (Hinxton)ENSG00000171522 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171522 [Gene_View]  ENSG00000171522 [Sequence]  chr5:40679915-40693735 [Contig_View]  PTGER4 [Vega]
ICGC DataPortalENSG00000171522
TCGA cBioPortalPTGER4
AceView (NCBI)PTGER4
Genatlas (Paris)PTGER4
WikiGenes5734
SOURCE (Princeton)PTGER4
Genetics Home Reference (NIH)PTGER4
Genomic and cartography
GoldenPath hg38 (UCSC)PTGER4  -     chr5:40679915-40693735 +  5p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTGER4  -     5p13.1   [Description]    (hg19-Feb_2009)
GoldenPathPTGER4 - 5p13.1 [CytoView hg19]  PTGER4 - 5p13.1 [CytoView hg38]
ImmunoBaseENSG00000171522
genome Data Viewer NCBIPTGER4 [Mapview hg19]  
OMIM601586   
Gene and transcription
Genbank (Entrez)AY429109 BC027934 BC101534 BC113523 BM312677
RefSeq transcript (Entrez)NM_000958
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PTGER4
Alternative Splicing GalleryENSG00000171522
Gene ExpressionPTGER4 [ NCBI-GEO ]   PTGER4 [ EBI - ARRAY_EXPRESS ]   PTGER4 [ SEEK ]   PTGER4 [ MEM ]
Gene Expression Viewer (FireBrowse)PTGER4 [ Firebrowse - Broad ]
GenevisibleExpression of PTGER4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5734
GTEX Portal (Tissue expression)PTGER4
Human Protein AtlasENSG00000171522-PTGER4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35408   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35408  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35408
Splice isoforms : SwissVarP35408
PhosPhoSitePlusP35408
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    Prost_EP4_rcpt    Prostanoid_rcpt    Prostglndn_DP_rcpt   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)PTGER4
DMDM Disease mutations5734
Blocks (Seattle)PTGER4
PDB (RSDB)5YHL    5YWY   
PDB Europe5YHL    5YWY   
PDB (PDBSum)5YHL    5YWY   
PDB (IMB)5YHL    5YWY   
Structural Biology KnowledgeBase5YHL    5YWY   
SCOP (Structural Classification of Proteins)5YHL    5YWY   
CATH (Classification of proteins structures)5YHL    5YWY   
SuperfamilyP35408
Human Protein Atlas [tissue]ENSG00000171522-PTGER4 [tissue]
Peptide AtlasP35408
HPRD03350
IPIIPI00018648   IPI00980993   
Protein Interaction databases
DIP (DOE-UCLA)P35408
IntAct (EBI)P35408
FunCoupENSG00000171522
BioGRIDPTGER4
STRING (EMBL)PTGER4
ZODIACPTGER4
Ontologies - Pathways
QuickGOP35408
Ontology : AmiGOprostaglandin E receptor activity  prostaglandin E receptor activity  protein binding  plasma membrane  plasma membrane  inflammatory response  immune response  G protein-coupled receptor signaling pathway  adenylate cyclase-modulating G protein-coupled receptor signaling pathway  adenylate cyclase-activating G protein-coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  JNK cascade  response to mechanical stimulus  integral component of membrane  regulation of ossification  response to lipopolysaccharide  negative regulation of integrin activation  T-helper cell differentiation  negative regulation of cytokine secretion  positive regulation of cytokine secretion  negative regulation of inflammatory response  negative regulation of inflammatory response  positive regulation of inflammatory response  regulation of stress fiber assembly  bone development  ERK1 and ERK2 cascade  cellular response to mechanical stimulus  cellular response to prostaglandin E stimulus  negative regulation of eosinophil extravasation  
Ontology : EGO-EBIprostaglandin E receptor activity  prostaglandin E receptor activity  protein binding  plasma membrane  plasma membrane  inflammatory response  immune response  G protein-coupled receptor signaling pathway  adenylate cyclase-modulating G protein-coupled receptor signaling pathway  adenylate cyclase-activating G protein-coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  JNK cascade  response to mechanical stimulus  integral component of membrane  regulation of ossification  response to lipopolysaccharide  negative regulation of integrin activation  T-helper cell differentiation  negative regulation of cytokine secretion  positive regulation of cytokine secretion  negative regulation of inflammatory response  negative regulation of inflammatory response  positive regulation of inflammatory response  regulation of stress fiber assembly  bone development  ERK1 and ERK2 cascade  cellular response to mechanical stimulus  cellular response to prostaglandin E stimulus  negative regulation of eosinophil extravasation  
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkPTGER4
Atlas of Cancer Signalling NetworkPTGER4
Wikipedia pathwaysPTGER4
Orthology - Evolution
OrthoDB5734
GeneTree (enSembl)ENSG00000171522
Phylogenetic Trees/Animal Genes : TreeFamPTGER4
HOGENOMP35408
Homologs : HomoloGenePTGER4
Homology/Alignments : Family Browser (UCSC)PTGER4
Gene fusions - Rearrangements
Fusion : QuiverPTGER4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTGER4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTGER4
dbVarPTGER4
ClinVarPTGER4
MonarchPTGER4
1000_GenomesPTGER4 
Exome Variant ServerPTGER4
GNOMAD BrowserENSG00000171522
Varsome BrowserPTGER4
Genetic variants : HAPMAP5734
Genomic Variants (DGV)PTGER4 [DGVbeta]
DECIPHERPTGER4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTGER4 
Mutations
ICGC Data PortalPTGER4 
TCGA Data PortalPTGER4 
Broad Tumor PortalPTGER4
OASIS PortalPTGER4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTGER4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPTGER4
Mutations and Diseases : HGMDPTGER4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTGER4
DgiDB (Drug Gene Interaction Database)PTGER4
DoCM (Curated mutations)PTGER4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTGER4 (select a term)
intoGenPTGER4
Cancer3DPTGER4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601586   
Orphanet
DisGeNETPTGER4
MedgenPTGER4
Genetic Testing Registry PTGER4
NextProtP35408 [Medical]
TSGene5734
GENETestsPTGER4
Target ValidationPTGER4
Huge Navigator PTGER4 [HugePedia]
snp3D : Map Gene to Disease5734
BioCentury BCIQPTGER4
ClinGenPTGER4
Clinical trials, drugs, therapy
Protein Interactions : CTD5734
Pharm GKB GenePA289
Pharm GKB PathwaysPA152241951   PA166121942   
Clinical trialPTGER4
Miscellaneous
canSAR (ICR)PTGER4 (select the gene name)
HarmonizomePTGER4
DataMed IndexPTGER4
Probes
Litterature
PubMed174 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTGER4
EVEXPTGER4
GoPubMedPTGER4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:28:49 CEST 2020

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