Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PTGES (prostaglandin E synthase)

Identity

Alias_namesMGST1L1
Alias_symbol (synonym)MGST-IV
PIG12
MGST1-L1
TP53I12
Other aliasMPGES
PGES
PP102
PP1294
mPGES-1
HGNC (Hugo) PTGES
LocusID (NCBI) 9536
Atlas_Id 41895
Location 9q34.11  [Link to chromosome band 9q34]
Location_base_pair Starts at 129738336 and ends at 129753065 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
IVD (15q15.1) / PTGES (9q34.11)PTGES (9q34.11) / SOX2-OT (3q26.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PTGES   9599
Cards
Entrez_Gene (NCBI)PTGES  9536  prostaglandin E synthase
AliasesMGST-IV; MGST1-L1; MGST1L1; MPGES; 
PGES; PIG12; PP102; PP1294; TP53I12; mPGES-1
GeneCards (Weizmann)PTGES
Ensembl hg19 (Hinxton)ENSG00000148344 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000148344 [Gene_View]  chr9:129738336-129753065 [Contig_View]  PTGES [Vega]
ICGC DataPortalENSG00000148344
TCGA cBioPortalPTGES
AceView (NCBI)PTGES
Genatlas (Paris)PTGES
WikiGenes9536
SOURCE (Princeton)PTGES
Genetics Home Reference (NIH)PTGES
Genomic and cartography
GoldenPath hg38 (UCSC)PTGES  -     chr9:129738336-129753065 -  9q34.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTGES  -     9q34.11   [Description]    (hg19-Feb_2009)
EnsemblPTGES - 9q34.11 [CytoView hg19]  PTGES - 9q34.11 [CytoView hg38]
Mapping of homologs : NCBIPTGES [Mapview hg19]  PTGES [Mapview hg38]
OMIM605172   
Gene and transcription
Genbank (Entrez)AF010316 AF027740 AF217965 AF217972 AK127663
RefSeq transcript (Entrez)NM_004878 NM_198797
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PTGES
Cluster EST : UnigeneHs.146688 [ NCBI ]
CGAP (NCI)Hs.146688
Alternative Splicing GalleryENSG00000148344
Gene ExpressionPTGES [ NCBI-GEO ]   PTGES [ EBI - ARRAY_EXPRESS ]   PTGES [ SEEK ]   PTGES [ MEM ]
Gene Expression Viewer (FireBrowse)PTGES [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9536
GTEX Portal (Tissue expression)PTGES
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14684   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14684  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14684
Splice isoforms : SwissVarO14684
Catalytic activity : Enzyme5.3.99.3 [ Enzyme-Expasy ]   5.3.99.35.3.99.3 [ IntEnz-EBI ]   5.3.99.3 [ BRENDA ]   5.3.99.3 [ KEGG ]   
PhosPhoSitePlusO14684
Domains : Interpro (EBI)MAPEG-like_dom    Membr-assoc_MAPEG   
Domain families : Pfam (Sanger)MAPEG (PF01124)   
Domain families : Pfam (NCBI)pfam01124   
Conserved Domain (NCBI)PTGES
DMDM Disease mutations9536
Blocks (Seattle)PTGES
PDB (SRS)3DWW    4AL0    4AL1    4BPM    4WAB    4YK5    4YL0    4YL1    4YL3    5BQG    5BQH    5BQI    5K0I   
PDB (PDBSum)3DWW    4AL0    4AL1    4BPM    4WAB    4YK5    4YL0    4YL1    4YL3    5BQG    5BQH    5BQI    5K0I   
PDB (IMB)3DWW    4AL0    4AL1    4BPM    4WAB    4YK5    4YL0    4YL1    4YL3    5BQG    5BQH    5BQI    5K0I   
PDB (RSDB)3DWW    4AL0    4AL1    4BPM    4WAB    4YK5    4YL0    4YL1    4YL3    5BQG    5BQH    5BQI    5K0I   
Structural Biology KnowledgeBase3DWW    4AL0    4AL1    4BPM    4WAB    4YK5    4YL0    4YL1    4YL3    5BQG    5BQH    5BQI    5K0I   
SCOP (Structural Classification of Proteins)3DWW    4AL0    4AL1    4BPM    4WAB    4YK5    4YL0    4YL1    4YL3    5BQG    5BQH    5BQI    5K0I   
CATH (Classification of proteins structures)3DWW    4AL0    4AL1    4BPM    4WAB    4YK5    4YL0    4YL1    4YL3    5BQG    5BQH    5BQI    5K0I   
SuperfamilyO14684
Human Protein AtlasENSG00000148344
Peptide AtlasO14684
HPRD05528
IPIIPI00297858   IPI00386510   
Protein Interaction databases
DIP (DOE-UCLA)O14684
IntAct (EBI)O14684
FunCoupENSG00000148344
BioGRIDPTGES
STRING (EMBL)PTGES
ZODIACPTGES
Ontologies - Pathways
QuickGOO14684
Ontology : AmiGOprostaglandin biosynthetic process  acute inflammatory response  chronic inflammatory response  nuclear envelope lumen  endoplasmic reticulum membrane  prostaglandin metabolic process  signal transduction  negative regulation of cell proliferation  response to organic cyclic compound  membrane  integral component of membrane  cyclooxygenase pathway  response to lipopolysaccharide  response to retinoic acid  response to cytokine  glutathione binding  perinuclear region of cytoplasm  prostaglandin-E synthase activity  prostaglandin-E synthase activity  response to calcium ion  
Ontology : EGO-EBIprostaglandin biosynthetic process  acute inflammatory response  chronic inflammatory response  nuclear envelope lumen  endoplasmic reticulum membrane  prostaglandin metabolic process  signal transduction  negative regulation of cell proliferation  response to organic cyclic compound  membrane  integral component of membrane  cyclooxygenase pathway  response to lipopolysaccharide  response to retinoic acid  response to cytokine  glutathione binding  perinuclear region of cytoplasm  prostaglandin-E synthase activity  prostaglandin-E synthase activity  response to calcium ion  
Pathways : BIOCARTAEicosanoid Metabolism [Genes]   
Pathways : KEGGArachidonic acid metabolism   
NDEx NetworkPTGES
Atlas of Cancer Signalling NetworkPTGES
Wikipedia pathwaysPTGES
Orthology - Evolution
OrthoDB9536
GeneTree (enSembl)ENSG00000148344
Phylogenetic Trees/Animal Genes : TreeFamPTGES
HOVERGENO14684
HOGENOMO14684
Homologs : HomoloGenePTGES
Homology/Alignments : Family Browser (UCSC)PTGES
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTGES [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTGES
dbVarPTGES
ClinVarPTGES
1000_GenomesPTGES 
Exome Variant ServerPTGES
ExAC (Exome Aggregation Consortium)PTGES (select the gene name)
Genetic variants : HAPMAP9536
Genomic Variants (DGV)PTGES [DGVbeta]
DECIPHERPTGES [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTGES 
Mutations
ICGC Data PortalPTGES 
TCGA Data PortalPTGES 
Broad Tumor PortalPTGES
OASIS PortalPTGES [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTGES  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTGES
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTGES
DgiDB (Drug Gene Interaction Database)PTGES
DoCM (Curated mutations)PTGES (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTGES (select a term)
intoGenPTGES
Cancer3DPTGES(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605172   
Orphanet
MedgenPTGES
Genetic Testing Registry PTGES
NextProtO14684 [Medical]
TSGene9536
GENETestsPTGES
Target ValidationPTGES
Huge Navigator PTGES [HugePedia]
snp3D : Map Gene to Disease9536
BioCentury BCIQPTGES
ClinGenPTGES
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9536
Chemical/Pharm GKB GenePA33948
Clinical trialPTGES
Miscellaneous
canSAR (ICR)PTGES (select the gene name)
Probes
Litterature
PubMed132 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTGES
EVEXPTGES
GoPubMedPTGES
iHOPPTGES
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:51:42 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.