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PTGES (prostaglandin E synthase)

Identity

Alias (NCBI)MGST-IV
MGST1-L1
MGST1L1
MPGES
PGES
PIG12
PP102
PP1294
TP53I12
mPGES-1
HGNC (Hugo) PTGES
HGNC Alias symbMGST-IV
PIG12
MGST1-L1
TP53I12
HGNC Alias namemicrosomal glutathione S-transferase 1-like 1
 tumor protein p53 inducible protein 12
 p53-induced gene 12
 microsomal prostaglandin E synthase-1
 glutathione S-transferase 1-like 1
 MGST1-like 1
HGNC Previous nameMGST1L1
LocusID (NCBI) 9536
Atlas_Id 41895
Location 9q34.11  [Link to chromosome band 9q34]
Location_base_pair Starts at 129738349 and ends at 129753042 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IVD (15q15.1) / PTGES (9q34.11)PTGES (9q34.11) / SOX2-OT (3q26.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)PTGES   9599
Cards
Entrez_Gene (NCBI)PTGES    prostaglandin E synthase
AliasesMGST-IV; MGST1-L1; MGST1L1; MPGES; 
PGES; PIG12; PP102; PP1294; TP53I12; mPGES-1
GeneCards (Weizmann)PTGES
Ensembl hg19 (Hinxton)ENSG00000148344 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000148344 [Gene_View]  ENSG00000148344 [Sequence]  chr9:129738349-129753042 [Contig_View]  PTGES [Vega]
ICGC DataPortalENSG00000148344
TCGA cBioPortalPTGES
AceView (NCBI)PTGES
Genatlas (Paris)PTGES
SOURCE (Princeton)PTGES
Genetics Home Reference (NIH)PTGES
Genomic and cartography
GoldenPath hg38 (UCSC)PTGES  -     chr9:129738349-129753042 -  9q34.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTGES  -     9q34.11   [Description]    (hg19-Feb_2009)
GoldenPathPTGES - 9q34.11 [CytoView hg19]  PTGES - 9q34.11 [CytoView hg38]
ImmunoBaseENSG00000148344
genome Data Viewer NCBIPTGES [Mapview hg19]  
OMIM605172   
Gene and transcription
Genbank (Entrez)AF010316 AF027740 AF217965 AF217972 AK127663
RefSeq transcript (Entrez)NM_004878 NM_198797
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PTGES
Alternative Splicing GalleryENSG00000148344
Gene ExpressionPTGES [ NCBI-GEO ]   PTGES [ EBI - ARRAY_EXPRESS ]   PTGES [ SEEK ]   PTGES [ MEM ]
Gene Expression Viewer (FireBrowse)PTGES [ Firebrowse - Broad ]
GenevisibleExpression of PTGES in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9536
GTEX Portal (Tissue expression)PTGES
Human Protein AtlasENSG00000148344-PTGES [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14684   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14684  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14684
Splice isoforms : SwissVarO14684
PhosPhoSitePlusO14684
Domains : Interpro (EBI)MAPEG-like_dom_sf    Membr-assoc_MAPEG    MGST1-like   
Domain families : Pfam (Sanger)MAPEG (PF01124)   
Domain families : Pfam (NCBI)pfam01124   
Conserved Domain (NCBI)PTGES
Blocks (Seattle)PTGES
PDB (RSDB)3DWW    4AL0    4AL1    4BPM    4WAB    4YK5    4YL0    4YL1    4YL3    5BQG    5BQH    5BQI    5K0I    5T36    5T37    5TL9   
PDB Europe3DWW    4AL0    4AL1    4BPM    4WAB    4YK5    4YL0    4YL1    4YL3    5BQG    5BQH    5BQI    5K0I    5T36    5T37    5TL9   
PDB (PDBSum)3DWW    4AL0    4AL1    4BPM    4WAB    4YK5    4YL0    4YL1    4YL3    5BQG    5BQH    5BQI    5K0I    5T36    5T37    5TL9   
PDB (IMB)3DWW    4AL0    4AL1    4BPM    4WAB    4YK5    4YL0    4YL1    4YL3    5BQG    5BQH    5BQI    5K0I    5T36    5T37    5TL9   
Structural Biology KnowledgeBase3DWW    4AL0    4AL1    4BPM    4WAB    4YK5    4YL0    4YL1    4YL3    5BQG    5BQH    5BQI    5K0I    5T36    5T37    5TL9   
SCOP (Structural Classification of Proteins)3DWW    4AL0    4AL1    4BPM    4WAB    4YK5    4YL0    4YL1    4YL3    5BQG    5BQH    5BQI    5K0I    5T36    5T37    5TL9   
CATH (Classification of proteins structures)3DWW    4AL0    4AL1    4BPM    4WAB    4YK5    4YL0    4YL1    4YL3    5BQG    5BQH    5BQI    5K0I    5T36    5T37    5TL9   
SuperfamilyO14684
Human Protein Atlas [tissue]ENSG00000148344-PTGES [tissue]
Peptide AtlasO14684
HPRD05528
IPIIPI00297858   IPI00386510   
Protein Interaction databases
DIP (DOE-UCLA)O14684
IntAct (EBI)O14684
BioGRIDPTGES
STRING (EMBL)PTGES
ZODIACPTGES
Ontologies - Pathways
QuickGOO14684
Ontology : AmiGOprostaglandin biosynthetic process  prostaglandin biosynthetic process  acute inflammatory response  chronic inflammatory response  glutathione transferase activity  glutathione peroxidase activity  prostaglandin-D synthase activity  protein binding  nuclear envelope lumen  endoplasmic reticulum membrane  prostaglandin metabolic process  signal transduction  negative regulation of cell population proliferation  response to organic cyclic compound  membrane  integral component of membrane  integral component of membrane  sensory perception of pain  cyclooxygenase pathway  regulation of fever generation  positive regulation of prostaglandin secretion  response to lipopolysaccharide  response to retinoic acid  response to cytokine  glutathione binding  perinuclear region of cytoplasm  prostaglandin-E synthase activity  prostaglandin-E synthase activity  regulation of inflammatory response  response to calcium ion  cellular oxidant detoxification  
Ontology : EGO-EBIprostaglandin biosynthetic process  prostaglandin biosynthetic process  acute inflammatory response  chronic inflammatory response  glutathione transferase activity  glutathione peroxidase activity  prostaglandin-D synthase activity  protein binding  nuclear envelope lumen  endoplasmic reticulum membrane  prostaglandin metabolic process  signal transduction  negative regulation of cell population proliferation  response to organic cyclic compound  membrane  integral component of membrane  integral component of membrane  sensory perception of pain  cyclooxygenase pathway  regulation of fever generation  positive regulation of prostaglandin secretion  response to lipopolysaccharide  response to retinoic acid  response to cytokine  glutathione binding  perinuclear region of cytoplasm  prostaglandin-E synthase activity  prostaglandin-E synthase activity  regulation of inflammatory response  response to calcium ion  cellular oxidant detoxification  
Pathways : BIOCARTAEicosanoid Metabolism [Genes]   
Pathways : KEGGArachidonic acid metabolism   
NDEx NetworkPTGES
Atlas of Cancer Signalling NetworkPTGES
Wikipedia pathwaysPTGES
Orthology - Evolution
OrthoDB9536
GeneTree (enSembl)ENSG00000148344
Phylogenetic Trees/Animal Genes : TreeFamPTGES
HOGENOMO14684
Homologs : HomoloGenePTGES
Homology/Alignments : Family Browser (UCSC)PTGES
Gene fusions - Rearrangements
Fusion : QuiverPTGES
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTGES [hg38]
dbVarPTGES
ClinVarPTGES
MonarchPTGES
1000_GenomesPTGES 
Exome Variant ServerPTGES
GNOMAD BrowserENSG00000148344
Varsome BrowserPTGES
Genomic Variants (DGV)PTGES [DGVbeta]
DECIPHERPTGES [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTGES 
Mutations
ICGC Data PortalPTGES 
TCGA Data PortalPTGES 
Broad Tumor PortalPTGES
OASIS PortalPTGES [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTGES  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPTGES
Mutations and Diseases : HGMDPTGES
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTGES
DgiDB (Drug Gene Interaction Database)PTGES
DoCM (Curated mutations)PTGES (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTGES (select a term)
intoGenPTGES
Cancer3DPTGES(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605172   
Orphanet
DisGeNETPTGES
MedgenPTGES
Genetic Testing Registry PTGES
NextProtO14684 [Medical]
GENETestsPTGES
Target ValidationPTGES
Huge Navigator PTGES [HugePedia]
ClinGenPTGES
Clinical trials, drugs, therapy
MyCancerGenomePTGES
Protein Interactions : CTD
Pharm GKB GenePA33948
Pharm GKB PathwaysPA152241951   PA166121942   
PharosO14684
Clinical trialPTGES
Miscellaneous
canSAR (ICR)PTGES (select the gene name)
HarmonizomePTGES
DataMed IndexPTGES
Probes
Litterature
PubMed152 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPTGES
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 25 19:41:40 CET 2021

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