Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PTGES2 (prostaglandin E synthase 2)

Identity

Alias_namesC9orf15
chromosome 9 open reading frame 15
Alias_symbol (synonym)FLJ14038
Other aliasGBF-1
GBF1
PGES2
mPGES-2
HGNC (Hugo) PTGES2
LocusID (NCBI) 80142
Atlas_Id 51067
Location 9q34.11  [Link to chromosome band 9q34]
Location_base_pair Starts at 130882972 and ends at 130890467 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
COL5A1 (9q34.3) / PTGES2 (9q34.11)FAM102A (9q34.11) / PTGES2 (9q34.11)PTGES2 (9q34.11) / DENND1A (9q33.3)
PTGES2 (9q34.11) / MLXIP (12q24.31)PTGES2 (9q34.11) / PTGES2 (9q34.11)COL5A1 9q34.3 / PTGES2 9q34.11
FAM102A 9q34.11 / PTGES2 9q34.11PTGES2 9q34.11 / DENND1A 9q33.3PTGES2 9q34.11 / MLXIP 12q24.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PTGES2   17822
Cards
Entrez_Gene (NCBI)PTGES2  80142  prostaglandin E synthase 2
AliasesC9orf15; GBF-1; GBF1; PGES2; 
mPGES-2
GeneCards (Weizmann)PTGES2
Ensembl hg19 (Hinxton)ENSG00000148334 [Gene_View]  chr9:130882972-130890467 [Contig_View]  PTGES2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000148334 [Gene_View]  chr9:130882972-130890467 [Contig_View]  PTGES2 [Vega]
ICGC DataPortalENSG00000148334
TCGA cBioPortalPTGES2
AceView (NCBI)PTGES2
Genatlas (Paris)PTGES2
WikiGenes80142
SOURCE (Princeton)PTGES2
Genetics Home Reference (NIH)PTGES2
Genomic and cartography
GoldenPath hg19 (UCSC)PTGES2  -     chr9:130882972-130890467 -  9q34.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PTGES2  -     9q34.11   [Description]    (hg38-Dec_2013)
EnsemblPTGES2 - 9q34.11 [CytoView hg19]  PTGES2 - 9q34.11 [CytoView hg38]
Mapping of homologs : NCBIPTGES2 [Mapview hg19]  PTGES2 [Mapview hg38]
OMIM608152   
Gene and transcription
Genbank (Entrez)AK024100 AK057049 AK223520 AK301618 AL525982
RefSeq transcript (Entrez)NM_001256335 NM_025072 NM_198938 NM_198939 NM_198940
RefSeq genomic (Entrez)NC_000009 NC_018920 NG_012488 NT_008470 NW_004929366
Consensus coding sequences : CCDS (NCBI)PTGES2
Cluster EST : UnigeneHs.495219 [ NCBI ]
CGAP (NCI)Hs.495219
Alternative Splicing GalleryENSG00000148334
Gene ExpressionPTGES2 [ NCBI-GEO ]   PTGES2 [ EBI - ARRAY_EXPRESS ]   PTGES2 [ SEEK ]   PTGES2 [ MEM ]
Gene Expression Viewer (FireBrowse)PTGES2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80142
GTEX Portal (Tissue expression)PTGES2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H7Z7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H7Z7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H7Z7
Splice isoforms : SwissVarQ9H7Z7
PhosPhoSitePlusQ9H7Z7
Domaine pattern : Prosite (Expaxy)GLUTAREDOXIN_1 (PS00195)    GLUTAREDOXIN_2 (PS51354)    GST_CTER (PS50405)   
Domains : Interpro (EBI)Glutaredoxin    Glutathione-S-Trfase_C-like    Glutathione_S-Trfase_N    GST_C    Thioredoxin-like_fold   
Domain families : Pfam (Sanger)GST_C_3 (PF14497)    GST_N_3 (PF13417)   
Domain families : Pfam (NCBI)pfam14497    pfam13417   
Conserved Domain (NCBI)PTGES2
DMDM Disease mutations80142
Blocks (Seattle)PTGES2
SuperfamilyQ9H7Z7
Human Protein AtlasENSG00000148334
Peptide AtlasQ9H7Z7
HPRD07458
IPIIPI00303568   IPI00395565   IPI00514138   IPI00947368   
Protein Interaction databases
DIP (DOE-UCLA)Q9H7Z7
IntAct (EBI)Q9H7Z7
FunCoupENSG00000148334
BioGRIDPTGES2
STRING (EMBL)PTGES2
ZODIACPTGES2
Ontologies - Pathways
QuickGOQ9H7Z7
Ontology : AmiGOGolgi membrane  prostaglandin biosynthetic process  DNA binding  protein binding  nucleus  mitochondrion  cytosol  electron carrier activity  protein disulfide oxidoreductase activity  integral component of membrane  lyase activity  heme binding  glutathione binding  cell redox homeostasis  positive regulation of transcription, DNA-templated  secretion  perinuclear region of cytoplasm  prostaglandin-E synthase activity  oxidation-reduction process  
Ontology : EGO-EBIGolgi membrane  prostaglandin biosynthetic process  DNA binding  protein binding  nucleus  mitochondrion  cytosol  electron carrier activity  protein disulfide oxidoreductase activity  integral component of membrane  lyase activity  heme binding  glutathione binding  cell redox homeostasis  positive regulation of transcription, DNA-templated  secretion  perinuclear region of cytoplasm  prostaglandin-E synthase activity  oxidation-reduction process  
Pathways : KEGGArachidonic acid metabolism   
NDEx NetworkPTGES2
Atlas of Cancer Signalling NetworkPTGES2
Wikipedia pathwaysPTGES2
Orthology - Evolution
OrthoDB80142
GeneTree (enSembl)ENSG00000148334
Phylogenetic Trees/Animal Genes : TreeFamPTGES2
HOVERGENQ9H7Z7
HOGENOMQ9H7Z7
Homologs : HomoloGenePTGES2
Homology/Alignments : Family Browser (UCSC)PTGES2
Gene fusions - Rearrangements
Fusion : MitelmanCOL5A1/PTGES2 [9q34.3/9q34.11]  [t(9;9)(q34;q34)]  
Fusion : MitelmanFAM102A/PTGES2 [9q34.11/9q34.11]  [t(9;9)(q34;q34)]  
Fusion : MitelmanPTGES2/DENND1A [9q34.11/9q33.3]  [t(9;9)(q33;q34)]  
Fusion : MitelmanPTGES2/MLXIP [9q34.11/12q24.31]  [t(9;12)(q34;q24)]  
Fusion: TCGACOL5A1 9q34.3 PTGES2 9q34.11 BLCA
Fusion: TCGAFAM102A 9q34.11 PTGES2 9q34.11 LUAD
Fusion: TCGAPTGES2 9q34.11 DENND1A 9q33.3 BRCA
Fusion: TCGAPTGES2 9q34.11 MLXIP 12q24.31 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTGES2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTGES2
dbVarPTGES2
ClinVarPTGES2
1000_GenomesPTGES2 
Exome Variant ServerPTGES2
ExAC (Exome Aggregation Consortium)PTGES2 (select the gene name)
Genetic variants : HAPMAP80142
Genomic Variants (DGV)PTGES2 [DGVbeta]
DECIPHER (Syndromes)9:130882972-130890467  ENSG00000148334
CONAN: Copy Number AnalysisPTGES2 
Mutations
ICGC Data PortalPTGES2 
TCGA Data PortalPTGES2 
Broad Tumor PortalPTGES2
OASIS PortalPTGES2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTGES2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTGES2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch PTGES2
DgiDB (Drug Gene Interaction Database)PTGES2
DoCM (Curated mutations)PTGES2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTGES2 (select a term)
intoGenPTGES2
Cancer3DPTGES2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608152   
Orphanet
MedgenPTGES2
Genetic Testing Registry PTGES2
NextProtQ9H7Z7 [Medical]
TSGene80142
GENETestsPTGES2
Huge Navigator PTGES2 [HugePedia]
snp3D : Map Gene to Disease80142
BioCentury BCIQPTGES2
ClinGenPTGES2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD80142
Chemical/Pharm GKB GenePA33949
Clinical trialPTGES2
Miscellaneous
canSAR (ICR)PTGES2 (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTGES2
EVEXPTGES2
GoPubMedPTGES2
iHOPPTGES2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:16:10 CEST 2017

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