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PTGR1 (prostaglandin reductase 1)

Identity

Alias_namesLTB4DH
leukotriene B4 12-hydroxydehydrogenase
Alias_symbol (synonym)ZADH3
Other aliasPGR1
HGNC (Hugo) PTGR1
LocusID (NCBI) 22949
Atlas_Id 51675
Location 9q31.3  [Link to chromosome band 9q31]
Location_base_pair Starts at 111562967 and ends at 111599855 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MBD2 (18q21.2) / PTGR1 (9q31.3)XRCC5 (2q35) / PTGR1 (9q31.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PTGR1   18429
Cards
Entrez_Gene (NCBI)PTGR1  22949  prostaglandin reductase 1
AliasesLTB4DH; PGR1; ZADH3
GeneCards (Weizmann)PTGR1
Ensembl hg19 (Hinxton)ENSG00000106853 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000106853 [Gene_View]  chr9:111562967-111599855 [Contig_View]  PTGR1 [Vega]
ICGC DataPortalENSG00000106853
TCGA cBioPortalPTGR1
AceView (NCBI)PTGR1
Genatlas (Paris)PTGR1
WikiGenes22949
SOURCE (Princeton)PTGR1
Genetics Home Reference (NIH)PTGR1
Genomic and cartography
GoldenPath hg38 (UCSC)PTGR1  -     chr9:111562967-111599855 -  9q31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTGR1  -     9q31.3   [Description]    (hg19-Feb_2009)
EnsemblPTGR1 - 9q31.3 [CytoView hg19]  PTGR1 - 9q31.3 [CytoView hg38]
Mapping of homologs : NCBIPTGR1 [Mapview hg19]  PTGR1 [Mapview hg38]
OMIM601274   
Gene and transcription
Genbank (Entrez)AA876375 AK091948 AK289597 AK298379 AK309450
RefSeq transcript (Entrez)NM_001146108 NM_001146109 NM_012212
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PTGR1
Cluster EST : UnigeneHs.584864 [ NCBI ]
CGAP (NCI)Hs.584864
Alternative Splicing GalleryENSG00000106853
Gene ExpressionPTGR1 [ NCBI-GEO ]   PTGR1 [ EBI - ARRAY_EXPRESS ]   PTGR1 [ SEEK ]   PTGR1 [ MEM ]
Gene Expression Viewer (FireBrowse)PTGR1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22949
GTEX Portal (Tissue expression)PTGR1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14914   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14914  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14914
Splice isoforms : SwissVarQ14914
Catalytic activity : Enzyme1.3.1.- [ Enzyme-Expasy ]   1.3.1.-1.3.1.- [ IntEnz-EBI ]   1.3.1.- [ BRENDA ]   1.3.1.- [ KEGG ]   
PhosPhoSitePlusQ14914
Domains : Interpro (EBI)ADH_C    B4_12hDH    GroES-like    NAD(P)-bd_dom    PKS_ER   
Domain families : Pfam (Sanger)ADH_zinc_N (PF00107)   
Domain families : Pfam (NCBI)pfam00107   
Domain families : Smart (EMBL)PKS_ER (SM00829)  
Conserved Domain (NCBI)PTGR1
DMDM Disease mutations22949
Blocks (Seattle)PTGR1
PDB (SRS)1ZSV    2Y05   
PDB (PDBSum)1ZSV    2Y05   
PDB (IMB)1ZSV    2Y05   
PDB (RSDB)1ZSV    2Y05   
Structural Biology KnowledgeBase1ZSV    2Y05   
SCOP (Structural Classification of Proteins)1ZSV    2Y05   
CATH (Classification of proteins structures)1ZSV    2Y05   
SuperfamilyQ14914
Human Protein AtlasENSG00000106853
Peptide AtlasQ14914
HPRD03173
IPIIPI00292657   IPI00642248   IPI00164901   IPI00643630   IPI01013515   
Protein Interaction databases
DIP (DOE-UCLA)Q14914
IntAct (EBI)Q14914
FunCoupENSG00000106853
BioGRIDPTGR1
STRING (EMBL)PTGR1
ZODIACPTGR1
Ontologies - Pathways
QuickGOQ14914
Ontology : AmiGOcytoplasm  leukotriene metabolic process  prostaglandin metabolic process  2-alkenal reductase [NAD(P)] activity  13-prostaglandin reductase activity  15-oxoprostaglandin 13-oxidase activity  oxidation-reduction process  extracellular exosome  response to antineoplastic agent  
Ontology : EGO-EBIcytoplasm  leukotriene metabolic process  prostaglandin metabolic process  2-alkenal reductase [NAD(P)] activity  13-prostaglandin reductase activity  15-oxoprostaglandin 13-oxidase activity  oxidation-reduction process  extracellular exosome  response to antineoplastic agent  
NDEx NetworkPTGR1
Atlas of Cancer Signalling NetworkPTGR1
Wikipedia pathwaysPTGR1
Orthology - Evolution
OrthoDB22949
GeneTree (enSembl)ENSG00000106853
Phylogenetic Trees/Animal Genes : TreeFamPTGR1
HOVERGENQ14914
HOGENOMQ14914
Homologs : HomoloGenePTGR1
Homology/Alignments : Family Browser (UCSC)PTGR1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTGR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTGR1
dbVarPTGR1
ClinVarPTGR1
1000_GenomesPTGR1 
Exome Variant ServerPTGR1
ExAC (Exome Aggregation Consortium)PTGR1 (select the gene name)
Genetic variants : HAPMAP22949
Genomic Variants (DGV)PTGR1 [DGVbeta]
DECIPHERPTGR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTGR1 
Mutations
ICGC Data PortalPTGR1 
TCGA Data PortalPTGR1 
Broad Tumor PortalPTGR1
OASIS PortalPTGR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTGR1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTGR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTGR1
DgiDB (Drug Gene Interaction Database)PTGR1
DoCM (Curated mutations)PTGR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTGR1 (select a term)
intoGenPTGR1
Cancer3DPTGR1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601274   
Orphanet
MedgenPTGR1
Genetic Testing Registry PTGR1
NextProtQ14914 [Medical]
TSGene22949
GENETestsPTGR1
Target ValidationPTGR1
Huge Navigator PTGR1 [HugePedia]
snp3D : Map Gene to Disease22949
BioCentury BCIQPTGR1
ClinGenPTGR1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD22949
Chemical/Pharm GKB GenePA162400322
Clinical trialPTGR1
Miscellaneous
canSAR (ICR)PTGR1 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTGR1
EVEXPTGR1
GoPubMedPTGR1
iHOPPTGR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:27:10 CEST 2017

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