PTGR1 (prostaglandin reductase 1)

2010-09-01  

Identity

HGNC
LOCATION
9q31.3
LOCUSID
ALIAS
DIG-1,LTB4DH,PGR1,ZADH3
FUSION GENES

Other Information

Locus ID:

NCBI: 22949
MIM: 601274
HGNC: 18429
Ensembl: ENSG00000106853

Variants:

dbSNP: 22949
ClinVar: 22949
TCGA: ENSG00000106853
COSMIC: PTGR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106853ENST00000309195Q14914
ENSG00000106853ENST00000374324F6XGT7
ENSG00000106853ENST00000407693Q14914
ENSG00000106853ENST00000422125Q5JVP2
ENSG00000106853ENST00000466771F2Z3J9
ENSG00000106853ENST00000538962Q14914

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of Leukotrienes (LT) and Eoxins (EX)REACTOMER-HSA-2142691
Synthesis of Lipoxins (LX)REACTOMER-HSA-2142700

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
238781982013Modulation of nitro-fatty acid signaling: prostaglandin reductase-1 is a nitroalkene reductase.25
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
195954722010Restoration of leukotriene B(4)-12-hydroxydehydrogenase/15- oxo-prostaglandin 13-reductase (LTBDH/PGR) expression inhibits lung cancer growth in vitro and in vivo.7
208045022010A set of genes associated with the interferon-γ response of lung cancer patients undergoing α-galactosylceramide-pulsed dendritic cell therapy.5
251791602015Induction of complementary function reductase enzymes in colon cancer cells by dithiole-3-thione versus sodium selenite.4
280885502017Novel involvement of miR-522-3p in high-mobility group box 1-induced prostaglandin reductase 1 expression and reduction of phagocytosis.4
303369812018Role of leukotriene B4 12-hydroxydehydrogenase in α-galactosylceramide-pulsed dendritic cell therapy for non-small cell lung cancer.0

Citation

Dessen P

PTGR1 (prostaglandin reductase 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-09-01

Online version: http://atlasgeneticsoncology.org/gene/51675/ptgr1