PTGR2 (prostaglandin reductase 2)

2013-02-01  

Identity

HGNC
LOCATION
14q24.3
LOCUSID
ALIAS
HEL-S-298,PGR2,ZADH1
FUSION GENES

Other Information

Locus ID:

NCBI: 145482
MIM: 608642
HGNC: 20149
Ensembl: ENSG00000258653

Variants:

dbSNP: 145482
ClinVar: 145482
TCGA: ENSG00000258653
COSMIC: PTGR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000258653ENST00000556551G3V3Y1

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)REACTOMER-HSA-2162123

References

Pubmed IDYearTitleCitations
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
190008232008Structural basis for catalytic and inhibitory mechanisms of human prostaglandin reductase PTGR2.10
268207382016Inhibition of Prostaglandin Reductase 2, a Putative Oncogene Overexpressed in Human Pancreatic Adenocarcinoma, Induces Oxidative Stress-Mediated Cell Death Involving xCT and CTH Gene Expressions through 15-Keto-PGE2.7
229987752012Prostaglandin reductase 2 modulates ROS-mediated cell death and tumor transformation of gastric cancer cells and is associated with higher mortality in gastric cancer patients.4
150044682003Cloning and characterization of a novel splicing variant of the ZADH1 gene.1

Citation

Dessen P

PTGR2 (prostaglandin reductase 2)

Atlas Genet Cytogenet Oncol Haematol. 2013-02-01

Online version: http://atlasgeneticsoncology.org/gene/53191/ptgr2