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PTGR2 (prostaglandin reductase 2)

Identity

Alias_namesZADH1
zinc binding alcohol dehydrogenase domain containing 1
Alias_symbol (synonym)FLJ39091
Other aliasHEL-S-298
PGR2
HGNC (Hugo) PTGR2
LocusID (NCBI) 145482
Atlas_Id 53191
Location 14q24.3  [Link to chromosome band 14q24]
Location_base_pair Starts at 73851831 and ends at 73885466 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EPC1 (10p11.22) / PTGR2 (14q24.3)FAM208A (3p14.3) / PTGR2 (14q24.3)ZNF410 (14q24.3) / PTGR2 (14q24.3)
EPC1 10p11.22 / PTGR2 14q24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PTGR2   20149
Cards
Entrez_Gene (NCBI)PTGR2  145482  prostaglandin reductase 2
AliasesHEL-S-298; PGR2; ZADH1
GeneCards (Weizmann)PTGR2
Ensembl hg19 (Hinxton)ENSG00000140043 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140043 [Gene_View]  chr14:73851831-73885466 [Contig_View]  PTGR2 [Vega]
ICGC DataPortalENSG00000140043
TCGA cBioPortalPTGR2
AceView (NCBI)PTGR2
Genatlas (Paris)PTGR2
WikiGenes145482
SOURCE (Princeton)PTGR2
Genetics Home Reference (NIH)PTGR2
Genomic and cartography
GoldenPath hg38 (UCSC)PTGR2  -     chr14:73851831-73885466 +  14q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTGR2  -     14q24.3   [Description]    (hg19-Feb_2009)
EnsemblPTGR2 - 14q24.3 [CytoView hg19]  PTGR2 - 14q24.3 [CytoView hg38]
Mapping of homologs : NCBIPTGR2 [Mapview hg19]  PTGR2 [Mapview hg38]
OMIM608642   
Gene and transcription
Genbank (Entrez)AK096410 AK309188 AK311280 AY346133 AY424308
RefSeq transcript (Entrez)NM_001146154 NM_001146155 NM_152444
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PTGR2
Cluster EST : UnigeneHs.632344 [ NCBI ]
CGAP (NCI)Hs.632344
Alternative Splicing GalleryENSG00000140043
Gene ExpressionPTGR2 [ NCBI-GEO ]   PTGR2 [ EBI - ARRAY_EXPRESS ]   PTGR2 [ SEEK ]   PTGR2 [ MEM ]
Gene Expression Viewer (FireBrowse)PTGR2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)145482
GTEX Portal (Tissue expression)PTGR2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N8N7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N8N7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N8N7
Splice isoforms : SwissVarQ8N8N7
Catalytic activity : Enzyme1.3.1.48 [ Enzyme-Expasy ]   1.3.1.481.3.1.48 [ IntEnz-EBI ]   1.3.1.48 [ BRENDA ]   1.3.1.48 [ KEGG ]   
PhosPhoSitePlusQ8N8N7
Domains : Interpro (EBI)ADH_C    GroES-like    NAD(P)-bd_dom   
Domain families : Pfam (Sanger)ADH_zinc_N (PF00107)   
Domain families : Pfam (NCBI)pfam00107   
Conserved Domain (NCBI)PTGR2
DMDM Disease mutations145482
Blocks (Seattle)PTGR2
PDB (SRS)2VNA    2W4Q    2W98    2ZB4    2ZB7    2ZB8   
PDB (PDBSum)2VNA    2W4Q    2W98    2ZB4    2ZB7    2ZB8   
PDB (IMB)2VNA    2W4Q    2W98    2ZB4    2ZB7    2ZB8   
PDB (RSDB)2VNA    2W4Q    2W98    2ZB4    2ZB7    2ZB8   
Structural Biology KnowledgeBase2VNA    2W4Q    2W98    2ZB4    2ZB7    2ZB8   
SCOP (Structural Classification of Proteins)2VNA    2W4Q    2W98    2ZB4    2ZB7    2ZB8   
CATH (Classification of proteins structures)2VNA    2W4Q    2W98    2ZB4    2ZB7    2ZB8   
SuperfamilyQ8N8N7
Human Protein AtlasENSG00000140043
Peptide AtlasQ8N8N7
HPRD09782
IPIIPI00167515   IPI00869302   IPI01026155   IPI01026369   
Protein Interaction databases
DIP (DOE-UCLA)Q8N8N7
IntAct (EBI)Q8N8N7
FunCoupENSG00000140043
BioGRIDPTGR2
STRING (EMBL)PTGR2
ZODIACPTGR2
Ontologies - Pathways
QuickGOQ8N8N7
Ontology : AmiGOcytoplasm  prostaglandin metabolic process  zinc ion binding  13-prostaglandin reductase activity  15-oxoprostaglandin 13-oxidase activity  oxidation-reduction process  extracellular exosome  
Ontology : EGO-EBIcytoplasm  prostaglandin metabolic process  zinc ion binding  13-prostaglandin reductase activity  15-oxoprostaglandin 13-oxidase activity  oxidation-reduction process  extracellular exosome  
NDEx NetworkPTGR2
Atlas of Cancer Signalling NetworkPTGR2
Wikipedia pathwaysPTGR2
Orthology - Evolution
OrthoDB145482
GeneTree (enSembl)ENSG00000140043
Phylogenetic Trees/Animal Genes : TreeFamPTGR2
HOVERGENQ8N8N7
HOGENOMQ8N8N7
Homologs : HomoloGenePTGR2
Homology/Alignments : Family Browser (UCSC)PTGR2
Gene fusions - Rearrangements
Fusion : MitelmanEPC1/PTGR2 [10p11.22/14q24.3]  [t(10;14)(p11;q24)]  
Fusion : MitelmanZNF410/PTGR2 [14q24.3/14q24.3]  [t(14;14)(q24;q24)]  
Fusion: TCGAEPC1 10p11.22 PTGR2 14q24.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTGR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTGR2
dbVarPTGR2
ClinVarPTGR2
1000_GenomesPTGR2 
Exome Variant ServerPTGR2
ExAC (Exome Aggregation Consortium)PTGR2 (select the gene name)
Genetic variants : HAPMAP145482
Genomic Variants (DGV)PTGR2 [DGVbeta]
DECIPHERPTGR2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTGR2 
Mutations
ICGC Data PortalPTGR2 
TCGA Data PortalPTGR2 
Broad Tumor PortalPTGR2
OASIS PortalPTGR2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTGR2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTGR2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTGR2
DgiDB (Drug Gene Interaction Database)PTGR2
DoCM (Curated mutations)PTGR2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTGR2 (select a term)
intoGenPTGR2
Cancer3DPTGR2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608642   
Orphanet
MedgenPTGR2
Genetic Testing Registry PTGR2
NextProtQ8N8N7 [Medical]
TSGene145482
GENETestsPTGR2
Target ValidationPTGR2
Huge Navigator PTGR2 [HugePedia]
snp3D : Map Gene to Disease145482
BioCentury BCIQPTGR2
ClinGenPTGR2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD145482
Chemical/Pharm GKB GenePA162400323
Clinical trialPTGR2
Miscellaneous
canSAR (ICR)PTGR2 (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTGR2
EVEXPTGR2
GoPubMedPTGR2
iHOPPTGR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:04:47 CEST 2017

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