Identity
HGNC
LOCATION
9q33.2
LOCUSID
ALIAS
COX1,COX3,PCOX1,PES-1,PGG/HS,PGHS-1,PGHS1,PHS1,PTGHS
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5742
MIM: 176805
HGNC: 9604
Ensembl: ENSG00000095303
Variants:
dbSNP: 5742
ClinVar: 5742
TCGA: ENSG00000095303
COSMIC: PTGS1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10384 | antiinflammatory and antirheumatic products, non-steroids | Chemical | Pathway | associated | 22336956 | ||
| PA164712462 | Antiinflammatory agents, non-steroids | Chemical | ClinicalAnnotation | associated | PD | 20538124 | |
| PA164774763 | latanoprost | Chemical | ClinicalAnnotation | associated | PD | 25339146 | |
| PA165108401 | Acute coronary syndrome | Disease | ClinicalAnnotation | associated | PD | 20538124 | |
| PA166129560 | major adverse cardiac events (mace) | Disease | ClinicalAnnotation | associated | PD | ||
| PA443796 | Coronary Artery Disease | Disease | ClinicalAnnotation | associated | PD | 16493486, 22940005 | |
| PA444282 | Glaucoma, Open-Angle | Disease | ClinicalAnnotation | associated | PD | 25339146 | |
| PA445019 | Myocardial Infarction | Disease | ClinicalAnnotation | associated | PD | 16493486, 22940005 | |
| PA448497 | aspirin | Chemical | ClinicalAnnotation, Pathway | associated | PD | 16493486, 20938371, 22940005 | |
| PA449053 | clopidogrel | Chemical | ClinicalAnnotation | associated | PD | 22940005 | |
| PA449957 | ibuprofen | Chemical | Pathway | associated | 25502615 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36056535 | 2023 | The PTGS1 (rs1330344) CC Genotype Contributes to Susceptibility to Kawasaki Disease in Southern Chinese Children. | 2 |
| 36282419 | 2023 | EVI1 upregulates PTGS1 (COX1) and decreases the action of tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia cells. | 1 |
| 36056535 | 2023 | The PTGS1 (rs1330344) CC Genotype Contributes to Susceptibility to Kawasaki Disease in Southern Chinese Children. | 2 |
| 36282419 | 2023 | EVI1 upregulates PTGS1 (COX1) and decreases the action of tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia cells. | 1 |
| 35000048 | 2022 | COX-1, COX-2 and CYP2C19 variations may be related to cardiovascular events due to acetylsalicylic acid resistance. | 1 |
| 35631221 | 2022 | Association between Vitamin Intake and Chronic Kidney Disease According to a Variant Located Upstream of the PTGS1 Gene: A Cross-Sectional Analysis of Shika Study. | 1 |
| 35705023 | 2022 | Effect of CYP2C9, PTGS-1 and PTGS-2 gene polymorphisms on the efficiency and safety of postoperative analgesia with ketoprofen. | 0 |
| 36302763 | 2022 | Human mtRF1 terminates COX1 translation and its ablation induces mitochondrial ribosome-associated quality control. | 4 |
| 35000048 | 2022 | COX-1, COX-2 and CYP2C19 variations may be related to cardiovascular events due to acetylsalicylic acid resistance. | 1 |
| 35631221 | 2022 | Association between Vitamin Intake and Chronic Kidney Disease According to a Variant Located Upstream of the PTGS1 Gene: A Cross-Sectional Analysis of Shika Study. | 1 |
| 35705023 | 2022 | Effect of CYP2C9, PTGS-1 and PTGS-2 gene polymorphisms on the efficiency and safety of postoperative analgesia with ketoprofen. | 0 |
| 36302763 | 2022 | Human mtRF1 terminates COX1 translation and its ablation induces mitochondrial ribosome-associated quality control. | 4 |
| 32299908 | 2021 | Identification of a homozygous recessive variant in PTGS1 resulting in a congenital aspirin-like defect in platelet function. | 5 |
| 32584621 | 2021 | PTGS1 gene variations associated with bleeding and platelet dysfunction. | 5 |
| 33326144 | 2021 | A novel genetic variant in PTGS1 affects N-glycosylation of cyclooxygenase-1 causing a dominant-negative effect on platelet function and bleeding diathesis. | 2 |
Citation
Dessen P
PTGS1 (prostaglandin-endoperoxide synthase 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41896/ptgs1
