Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PTGS1 (prostaglandin-endoperoxide synthase 1)

Identity

Alias_namesprostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Alias_symbol (synonym)COX1
PGHS-1
PTGHS
HGNC (Hugo) PTGS1
LocusID (NCBI) 5742
Atlas_Id 41896
Location 9q33.2  [Link to chromosome band 9q33]
Location_base_pair Starts at 125133284 and ends at 125157982 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PTGS1 (9q33.2) / GNAS (20q13.32)PTGS1 (9q33.2) / NDRG1 (8q24.22)PTGS1 (9q33.2) / SYNPO2 (4q26)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PTGS1   9604
Cards
Entrez_Gene (NCBI)PTGS1  5742  prostaglandin-endoperoxide synthase 1
AliasesCOX1; COX3; PCOX1; PES-1; 
PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS
GeneCards (Weizmann)PTGS1
Ensembl hg19 (Hinxton)ENSG00000095303 [Gene_View]  chr9:125133284-125157982 [Contig_View]  PTGS1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000095303 [Gene_View]  chr9:125133284-125157982 [Contig_View]  PTGS1 [Vega]
ICGC DataPortalENSG00000095303
TCGA cBioPortalPTGS1
AceView (NCBI)PTGS1
Genatlas (Paris)PTGS1
WikiGenes5742
SOURCE (Princeton)PTGS1
Genetics Home Reference (NIH)PTGS1
Genomic and cartography
GoldenPath hg19 (UCSC)PTGS1  -     chr9:125133284-125157982 +  9q33.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PTGS1  -     9q33.2   [Description]    (hg38-Dec_2013)
EnsemblPTGS1 - 9q33.2 [CytoView hg19]  PTGS1 - 9q33.2 [CytoView hg38]
Mapping of homologs : NCBIPTGS1 [Mapview hg19]  PTGS1 [Mapview hg38]
OMIM176805   
Gene and transcription
Genbank (Entrez)AF086438 AF129755 AI813317 AJ420464 AK290022
RefSeq transcript (Entrez)NM_000962 NM_001271164 NM_001271165 NM_001271166 NM_001271367 NM_001271368 NM_080591
RefSeq genomic (Entrez)NC_000009 NC_018920 NG_032900 NT_008470 NW_004929366
Consensus coding sequences : CCDS (NCBI)PTGS1
Cluster EST : UnigeneHs.201978 [ NCBI ]
CGAP (NCI)Hs.201978
Alternative Splicing GalleryENSG00000095303
Gene ExpressionPTGS1 [ NCBI-GEO ]   PTGS1 [ EBI - ARRAY_EXPRESS ]   PTGS1 [ SEEK ]   PTGS1 [ MEM ]
Gene Expression Viewer (FireBrowse)PTGS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5742
GTEX Portal (Tissue expression)PTGS1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23219   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP23219  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP23219
Splice isoforms : SwissVarP23219
Catalytic activity : Enzyme1.14.99.1 [ Enzyme-Expasy ]   1.14.99.11.14.99.1 [ IntEnz-EBI ]   1.14.99.1 [ BRENDA ]   1.14.99.1 [ KEGG ]   
PhosPhoSitePlusP23219
Domaine pattern : Prosite (Expaxy)EGF_3 (PS50026)    PEROXIDASE_3 (PS50292)   
Domains : Interpro (EBI)COX-1    EGF-like_dom    Haem_peroxidase    Haem_peroxidase_animal   
Domain families : Pfam (Sanger)An_peroxidase (PF03098)    EGF (PF00008)   
Domain families : Pfam (NCBI)pfam03098    pfam00008   
Domain families : Smart (EMBL)EGF (SM00181)  
Conserved Domain (NCBI)PTGS1
DMDM Disease mutations5742
Blocks (Seattle)PTGS1
SuperfamilyP23219
Human Protein AtlasENSG00000095303
Peptide AtlasP23219
HPRD07518
IPIIPI00298268   IPI01014071   IPI00298267   IPI00654627   IPI01011169   IPI00513747   
Protein Interaction databases
DIP (DOE-UCLA)P23219
IntAct (EBI)P23219
FunCoupENSG00000095303
BioGRIDPTGS1
STRING (EMBL)PTGS1
ZODIACPTGS1
Ontologies - Pathways
QuickGOP23219
Ontology : AmiGOprostaglandin biosynthetic process  photoreceptor outer segment  peroxidase activity  prostaglandin-endoperoxide synthase activity  prostaglandin-endoperoxide synthase activity  nucleus  nuclear envelope  cytoplasm  cytoplasm  endoplasmic reticulum membrane  Golgi apparatus  lipid metabolic process  xenobiotic metabolic process  inflammatory response  response to oxidative stress  aging  learning  memory  regulation of blood pressure  lipid binding  response to organonitrogen compound  negative regulation of norepinephrine secretion  sensory perception of pain  cyclooxygenase pathway  cyclooxygenase pathway  heme binding  negative regulation of epinephrine secretion  maintenance of blood-brain barrier  regulation of cell proliferation  intracellular membrane-bounded organelle  intracellular membrane-bounded organelle  positive regulation of vasoconstriction  positive regulation of smooth muscle contraction  metal ion binding  dioxygenase activity  response to corticosterone  oxidation-reduction process  extracellular exosome  response to fatty acid  cellular oxidant detoxification  cellular oxidant detoxification  
Ontology : EGO-EBIprostaglandin biosynthetic process  photoreceptor outer segment  peroxidase activity  prostaglandin-endoperoxide synthase activity  prostaglandin-endoperoxide synthase activity  nucleus  nuclear envelope  cytoplasm  cytoplasm  endoplasmic reticulum membrane  Golgi apparatus  lipid metabolic process  xenobiotic metabolic process  inflammatory response  response to oxidative stress  aging  learning  memory  regulation of blood pressure  lipid binding  response to organonitrogen compound  negative regulation of norepinephrine secretion  sensory perception of pain  cyclooxygenase pathway  cyclooxygenase pathway  heme binding  negative regulation of epinephrine secretion  maintenance of blood-brain barrier  regulation of cell proliferation  intracellular membrane-bounded organelle  intracellular membrane-bounded organelle  positive regulation of vasoconstriction  positive regulation of smooth muscle contraction  metal ion binding  dioxygenase activity  response to corticosterone  oxidation-reduction process  extracellular exosome  response to fatty acid  cellular oxidant detoxification  cellular oxidant detoxification  
Pathways : BIOCARTAAspirin Blocks Signaling Pathway Involved in Platelet Activation [Genes]    Mechanism of Acetaminophen Activity and Toxicity [Genes]    Eicosanoid Metabolism [Genes]   
Pathways : KEGGArachidonic acid metabolism    Serotonergic synapse   
NDEx NetworkPTGS1
Atlas of Cancer Signalling NetworkPTGS1
Wikipedia pathwaysPTGS1
Orthology - Evolution
OrthoDB5742
GeneTree (enSembl)ENSG00000095303
Phylogenetic Trees/Animal Genes : TreeFamPTGS1
HOVERGENP23219
HOGENOMP23219
Homologs : HomoloGenePTGS1
Homology/Alignments : Family Browser (UCSC)PTGS1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTGS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTGS1
dbVarPTGS1
ClinVarPTGS1
1000_GenomesPTGS1 
Exome Variant ServerPTGS1
ExAC (Exome Aggregation Consortium)PTGS1 (select the gene name)
Genetic variants : HAPMAP5742
Genomic Variants (DGV)PTGS1 [DGVbeta]
DECIPHER (Syndromes)9:125133284-125157982  ENSG00000095303
CONAN: Copy Number AnalysisPTGS1 
Mutations
ICGC Data PortalPTGS1 
TCGA Data PortalPTGS1 
Broad Tumor PortalPTGS1
OASIS PortalPTGS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTGS1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTGS1
intOGen PortalPTGS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTGS1
DgiDB (Drug Gene Interaction Database)PTGS1
DoCM (Curated mutations)PTGS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTGS1 (select a term)
intoGenPTGS1
Cancer3DPTGS1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176805   
Orphanet
MedgenPTGS1
Genetic Testing Registry PTGS1
NextProtP23219 [Medical]
TSGene5742
GENETestsPTGS1
Huge Navigator PTGS1 [HugePedia]
snp3D : Map Gene to Disease5742
BioCentury BCIQPTGS1
ClinGenPTGS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5742
Chemical/Pharm GKB GenePA24346
Clinical trialPTGS1
Miscellaneous
canSAR (ICR)PTGS1 (select the gene name)
Probes
Litterature
PubMed234 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTGS1
EVEXPTGS1
GoPubMedPTGS1
iHOPPTGS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:48:57 CET 2016

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