Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PTGS1 (prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase))

Identity

Other namesCOX1
COX3
PCOX1
PES-1
PGG/HS
PGHS-1
PGHS1
PHS1
PTGHS
HGNC (Hugo) PTGS1
LocusID (NCBI) 5742
Location 9q33.2
Location_base_pair Starts at 125133284 and ends at 125157982 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PTGS1   9604
Entrez_Gene (NCBI)PTGS1  5742  prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Cards
GeneCards (Weizmann)PTGS1
Ensembl (Hinxton)ENSG00000095303 [Gene_View]  chr9:125133284-125157982 [Contig_View]  PTGS1 [Vega]
AceView (NCBI)PTGS1
Genatlas (Paris)PTGS1
SOURCE (Stanford)NM_000962 NM_001271164 NM_001271165 NM_001271166 NM_001271367 NM_001271368 NM_080591
Genomic and cartography
GoldenPath (UCSC)PTGS1  -  9q33.2   chr9:125133284-125157982 +  9q33.2   [Description]    (hg19-Feb_2009)
EnsemblPTGS1 - 9q33.2 [CytoView]
Mapping of homologs : NCBIPTGS1 [Mapview]
OMIM176805   
Gene and transcription
Genbank (Entrez)AF086438 AF129755 AI813317 AJ420464 AK290022
RefSeq transcript (SRS)NM_000962 NM_001271164 NM_001271165 NM_001271166 NM_001271367 NM_001271368 NM_080591
RefSeq transcript (Entrez)NM_000962 NM_001271164 NM_001271165 NM_001271166 NM_001271367 NM_001271368 NM_080591
RefSeq genomic (SRS)AC_000141 NC_000009 NC_018920 NG_032900 NT_008470 NW_001839239 NW_004078058
RefSeq genomic (Entrez)AC_000141 NC_000009 NC_018920 NG_032900 NT_008470 NW_001839239 NW_004078058
Consensus coding sequences : CCDS (NCBI)PTGS1
Cluster EST : UnigeneHs.201978 [ SRS ] Hs.201978 [ NCBI ]
CGAP (NCI)Hs.201978
Alternative Splicing : Fast-db (Paris)GSHG0030423
Alternative Splicing GalleryENSG00000095303
Gene ExpressionPTGS1 [ NCBI-GEO ]   PTGS1 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23219 (SRS) P23219 (Uniprot)
NextProtP23219
With graphics : InterProP23219
Splice isoforms : SwissVarP23219(Swissvar)
Domaine pattern : Prosite (SRS)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    PEROXIDASE_3 (PS50292)   
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    PEROXIDASE_3 (PS50292)   
Domains : Interpro (SRS)EG-like_dom    Haem_peroxidase    Haem_peroxidase_animal    Haem_peroxidase_animal_subgr   
Domains : Interpro (EBI)EG-like_dom    Haem_peroxidase    Haem_peroxidase_animal    Haem_peroxidase_animal_subgr   
Related proteins : CluSTrP23219
Domain families : Pfam (SRS)An_peroxidase (PF03098)   
Domain families : Pfam (Sanger)An_peroxidase (PF03098)   
Domain families : Pfam (NCBI)pfam03098   
Domain families : Smart (EMBL)EGF (SM00181)  
DMDM5742
Blocks (Seattle)P23219
Human Protein AtlasENSG00000095303
HPRD07518
IPIIPI00298268   IPI01014071   IPI00298267   IPI00654627   IPI01011169   IPI00513747   
Protein Interaction databases
DIP (DOE-UCLA)P23219
IntAct (EBI)P23219
FunCoupENSG00000095303
REACTOMEPTGS1
Protein Interaction Database5742
BioGRIDPTGS1
InParanoidP23219
Interologous Interaction database P23219
IntegromeDBPTGS1
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PTGS1
SNP (GeneSNP Utah)PTGS1
SNP : HGBasePTGS1
Genetic variants : HAPMAPPTGS1
Somatic Mutations in Cancer : COSMICPTGS1 
CONAN: Copy Number AnalysisPTGS1 
Mutations and Diseases : HGMDPTGS1
OMIM176805   
GENETests176805   
Disease Genetic AssociationPTGS1
Huge Navigator PTGS1 [HugePedia]  PTGS1 [HugeCancerGEM]
Genomic VariantsPTGS1  PTGS1 [DGVbeta]
snp3D : Map Gene to Disease5742
General knowledge
Homologs : HomoloGenePTGS1
Homology/Alignments : Family Browser (UCSC)PTGS1
Phylogenetic Trees/Animal Genes : TreeFamPTGS1
Catalytic activity : Enzyme1.14.99.1 [ Enzyme-Expasy ]   1.14.99.1 [ Enzyme-SRS ]   1.14.99.1 [ IntEnz-EBI ]   1.14.99.1 [ BRENDA ]   1.14.99.1 [ KEGG ]   
Chemical/Protein Interactions : CTD5742
Chemical/Pharm GKB GenePA24346
Clinical trialPTGS1
Cancer Resource (Charite)ENSG00000095303
Ontology : AmiGOprostaglandin biosynthetic process  photoreceptor outer segment  peroxidase activity  prostaglandin-endoperoxide synthase activity  nucleus  nuclear envelope  cytoplasm  endoplasmic reticulum membrane  lipid metabolic process  xenobiotic metabolic process  response to oxidative stress  aging  regulation of blood pressure  lipid binding  response to organic nitrogen  negative regulation of norepinephrine secretion  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen  cyclooxygenase pathway  heme binding  negative regulation of epinephrine secretion  regulation of cell proliferation  intracellular membrane-bounded organelle  small molecule metabolic process  cytoplasmic part  positive regulation of vasoconstriction  positive regulation of smooth muscle contraction  metal ion binding  response to corticosterone stimulus  
Ontology : EGO-EBIprostaglandin biosynthetic process  photoreceptor outer segment  peroxidase activity  prostaglandin-endoperoxide synthase activity  nucleus  nuclear envelope  cytoplasm  endoplasmic reticulum membrane  lipid metabolic process  xenobiotic metabolic process  response to oxidative stress  aging  regulation of blood pressure  lipid binding  response to organic nitrogen  negative regulation of norepinephrine secretion  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen  cyclooxygenase pathway  heme binding  negative regulation of epinephrine secretion  regulation of cell proliferation  intracellular membrane-bounded organelle  small molecule metabolic process  cytoplasmic part  positive regulation of vasoconstriction  positive regulation of smooth muscle contraction  metal ion binding  response to corticosterone stimulus  
Pathways : BIOCARTAAspirin Blocks Signaling Pathway Involved in Platelet Activation [Genes]    Mechanism of Acetaminophen Activity and Toxicity [Genes]    Eicosanoid Metabolism [Genes]   
Pathways : KEGGArachidonic acid metabolism
Other databases
Probes
Litterature
PubMed200 Pubmed reference(s) in Entrez
PubGenePTGS1
iHOPPTGS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:45:59 CEST 2013
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