Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PTGS1 (prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase))

Identity

Other namesCOX1
COX3
PCOX1
PES-1
PGG/HS
PGHS-1
PGHS1
PHS1
PTGHS
HGNC (Hugo) PTGS1
LocusID (NCBI) 5742
Location 9q33.2
Location_base_pair Starts at 125133284 and ends at 125157982 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PTGS1   9604
Cards
Entrez_Gene (NCBI)PTGS1  5742  prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
GeneCards (Weizmann)PTGS1
Ensembl (Hinxton)ENSG00000095303 [Gene_View]  chr9:125133284-125157982 [Contig_View]  PTGS1 [Vega]
ICGC DataPortalENSG00000095303
cBioPortalPTGS1
AceView (NCBI)PTGS1
Genatlas (Paris)PTGS1
WikiGenes5742
SOURCE (Princeton)NM_000962 NM_001271164 NM_001271165 NM_001271166 NM_001271367 NM_001271368 NM_080591
Genomic and cartography
GoldenPath (UCSC)PTGS1  -  9q33.2   chr9:125133284-125157982 +  9q33.2   [Description]    (hg19-Feb_2009)
EnsemblPTGS1 - 9q33.2 [CytoView]
Mapping of homologs : NCBIPTGS1 [Mapview]
OMIM176805   
Gene and transcription
Genbank (Entrez)AF086438 AF129755 AI813317 AJ420464 AK290022
RefSeq transcript (Entrez)NM_000962 NM_001271164 NM_001271165 NM_001271166 NM_001271367 NM_001271368 NM_080591
RefSeq genomic (Entrez)AC_000141 NC_000009 NC_018920 NG_032900 NT_008470 NW_001839239 NW_004929366
Consensus coding sequences : CCDS (NCBI)PTGS1
Cluster EST : UnigeneHs.201978 [ NCBI ]
CGAP (NCI)Hs.201978
Alternative Splicing : Fast-db (Paris)GSHG0030423
Alternative Splicing GalleryENSG00000095303
Gene ExpressionPTGS1 [ NCBI-GEO ]     PTGS1 [ SEEK ]   PTGS1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23219 (Uniprot)
NextProtP23219  [Medical]
With graphics : InterProP23219
Splice isoforms : SwissVarP23219 (Swissvar)
Catalytic activity : Enzyme1.14.99.1 [ Enzyme-Expasy ]   1.14.99.11.14.99.1 [ IntEnz-EBI ]   1.14.99.1 [ BRENDA ]   1.14.99.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)EGF_3 (PS50026)    PEROXIDASE_3 (PS50292)   
Domains : Interpro (EBI)EG-like_dom [organisation]   Haem_peroxidase [organisation]   Haem_peroxidase_animal [organisation]   Haem_peroxidase_animal_subgr [organisation]  
Related proteins : CluSTrP23219
Domain families : Pfam (Sanger)An_peroxidase (PF03098)   
Domain families : Pfam (NCBI)pfam03098   
Domain families : Smart (EMBL)EGF (SM00181)  
DMDM Disease mutations5742
Blocks (Seattle)P23219
Human Protein AtlasENSG00000095303 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP23219
HPRD07518
IPIIPI00298268   IPI01014071   IPI00298267   IPI00654627   IPI01011169   IPI00513747   
Protein Interaction databases
DIP (DOE-UCLA)P23219
IntAct (EBI)P23219
FunCoupENSG00000095303
BioGRIDPTGS1
InParanoidP23219
Interologous Interaction database P23219
IntegromeDBPTGS1
STRING (EMBL)PTGS1
Ontologies - Pathways
Ontology : AmiGOprostaglandin biosynthetic process  photoreceptor outer segment  peroxidase activity  prostaglandin-endoperoxide synthase activity  prostaglandin-endoperoxide synthase activity  nucleus  cytoplasm  cytoplasm  endoplasmic reticulum membrane  lipid metabolic process  xenobiotic metabolic process  response to oxidative stress  regulation of blood pressure  arachidonic acid metabolic process  cyclooxygenase pathway  cyclooxygenase pathway  heme binding  regulation of cell proliferation  intracellular membrane-bounded organelle  small molecule metabolic process  metal ion binding  dioxygenase activity  oxidation-reduction process  
Ontology : EGO-EBIprostaglandin biosynthetic process  photoreceptor outer segment  peroxidase activity  prostaglandin-endoperoxide synthase activity  prostaglandin-endoperoxide synthase activity  nucleus  cytoplasm  cytoplasm  endoplasmic reticulum membrane  lipid metabolic process  xenobiotic metabolic process  response to oxidative stress  regulation of blood pressure  arachidonic acid metabolic process  cyclooxygenase pathway  cyclooxygenase pathway  heme binding  regulation of cell proliferation  intracellular membrane-bounded organelle  small molecule metabolic process  metal ion binding  dioxygenase activity  oxidation-reduction process  
Pathways : BIOCARTAAspirin Blocks Signaling Pathway Involved in Platelet Activation [Genes]    Mechanism of Acetaminophen Activity and Toxicity [Genes]    Eicosanoid Metabolism [Genes]   
Pathways : KEGGArachidonic acid metabolism    Serotonergic synapse   
Protein Interaction DatabasePTGS1
Wikipedia pathwaysPTGS1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PTGS1
snp3D : Map Gene to Disease5742
SNP (GeneSNP Utah)PTGS1
SNP : HGBasePTGS1
Genetic variants : HAPMAPPTGS1
Exome VariantPTGS1
1000_GenomesPTGS1 
ICGC programENSG00000095303 
Somatic Mutations in Cancer : COSMICPTGS1 
CONAN: Copy Number AnalysisPTGS1 
Mutations and Diseases : HGMDPTGS1
Genomic VariantsPTGS1  PTGS1 [DGVbeta]
dbVarPTGS1
ClinVarPTGS1
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM176805   
MedgenPTGS1
GENETestsPTGS1
Disease Genetic AssociationPTGS1
Huge Navigator PTGS1 [HugePedia]  PTGS1 [HugeCancerGEM]
General knowledge
Homologs : HomoloGenePTGS1
Homology/Alignments : Family Browser (UCSC)PTGS1
Phylogenetic Trees/Animal Genes : TreeFamPTGS1
Chemical/Protein Interactions : CTD5742
Chemical/Pharm GKB GenePA24346
Clinical trialPTGS1
Cancer Resource (Charite)ENSG00000095303
Other databases
Probes
Litterature
PubMed221 Pubmed reference(s) in Entrez
CoreMinePTGS1
iHOPPTGS1
OncoSearchPTGS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 14:11:40 CEST 2014

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