PTH1R (parathyroid hormone 1 receptor)

2008-12-01  

Identity

HGNC
LOCATION
3p21.31
LOCUSID
ALIAS
EKNS,PFE,PTHR,PTHR1

Other Information

Locus ID:

NCBI: 5745
MIM: 168468
HGNC: 9608
Ensembl: ENSG00000160801

Variants:

dbSNP: 5745
ClinVar: 5745
TCGA: ENSG00000160801
COSMIC: PTH1R

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160801ENST00000313049Q03431
ENSG00000160801ENST00000313049A0A024R2Z8
ENSG00000160801ENST00000418619Q03431
ENSG00000160801ENST00000418619A0A024R2Z8
ENSG00000160801ENST00000422115H7C0Q3
ENSG00000160801ENST00000427125E7EWE7
ENSG00000160801ENST00000428220F2Z314
ENSG00000160801ENST00000430002Q03431
ENSG00000160801ENST00000430002A0A024R2Z8
ENSG00000160801ENST00000449590Q03431
ENSG00000160801ENST00000449590A0A024R2Z8

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Endocrine and other factor-regulated calcium reabsorptionKEGGko04961
Endocrine and other factor-regulated calcium reabsorptionKEGGhsa04961
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
164926672006Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.161
186983602008Control of bone mass and remodeling by PTH receptor signaling in osteocytes.138
183757602008Molecular recognition of parathyroid hormone by its G protein-coupled receptor.107
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
120753542002Na(+)/H(+ ) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling.82
214450582011Retromer terminates the generation of cAMP by internalized PTH receptors.82
162367272005Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism.61
197306832009The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.59
178723772008Altered selectivity of parathyroid hormone (PTH) and PTH-related protein (PTHrP) for distinct conformations of the PTH/PTHrP receptor.55
178848162007NHERF1 regulates parathyroid hormone receptor membrane retention without affecting recycling.53

Citation

Dessen P

PTH1R (parathyroid hormone 1 receptor)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50463/pth1r