Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PTK2B (protein tyrosine kinase 2 beta)

Identity

Alias_namesFAK2
FAK2
Alias_symbol (synonym)CAKB
PYK2
RAFTK
PTK
CADTK
Other aliasFADK2
PKB
HGNC (Hugo) PTK2B
LocusID (NCBI) 2185
Atlas_Id 41899
Location 8p21.2  [Link to chromosome band 8p21]
Location_base_pair Starts at 27325479 and ends at 27459391 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDCA4 (14q32.33) / PTK2B (8p21.2)DLGAP3 (1p34.3) / PTK2B (8p21.2)EPHX2 (8p21.2) / PTK2B (8p21.2)
EPHX2 8p21.2 / PTK2B 8p21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(8;9)(p21;q21) TMEM2/PTK2B

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  EPHX2/PTK2B (8p21)

External links

Nomenclature
HGNC (Hugo)PTK2B   9612
Cards
Entrez_Gene (NCBI)PTK2B  2185  protein tyrosine kinase 2 beta
AliasesCADTK; CAKB; FADK2; FAK2; 
PKB; PTK; PYK2; RAFTK
GeneCards (Weizmann)PTK2B
Ensembl hg19 (Hinxton)ENSG00000120899 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120899 [Gene_View]  ENSG00000120899 [Sequence]  chr8:27325479-27459391 [Contig_View]  PTK2B [Vega]
ICGC DataPortalENSG00000120899
TCGA cBioPortalPTK2B
AceView (NCBI)PTK2B
Genatlas (Paris)PTK2B
WikiGenes2185
SOURCE (Princeton)PTK2B
Genetics Home Reference (NIH)PTK2B
Genomic and cartography
GoldenPath hg38 (UCSC)PTK2B  -     chr8:27325479-27459391 +  8p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTK2B  -     8p21.2   [Description]    (hg19-Feb_2009)
GoldenPathPTK2B - 8p21.2 [CytoView hg19]  PTK2B - 8p21.2 [CytoView hg38]
ImmunoBaseENSG00000120899
Mapping of homologs : NCBIPTK2B [Mapview hg19]  PTK2B [Mapview hg38]
OMIM601212   
Gene and transcription
Genbank (Entrez)AB209085 AK128371 AL120380 AW130888 AY429564
RefSeq transcript (Entrez)NM_004103 NM_173174 NM_173175 NM_173176
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PTK2B
Cluster EST : UnigeneHs.735450 [ NCBI ]
CGAP (NCI)Hs.735450
Alternative Splicing GalleryENSG00000120899
Gene ExpressionPTK2B [ NCBI-GEO ]   PTK2B [ EBI - ARRAY_EXPRESS ]   PTK2B [ SEEK ]   PTK2B [ MEM ]
Gene Expression Viewer (FireBrowse)PTK2B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2185
GTEX Portal (Tissue expression)PTK2B
Human Protein AtlasENSG00000120899-PTK2B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14289   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14289  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14289
Splice isoforms : SwissVarQ14289
PhosPhoSitePlusQ14289
Domaine pattern : Prosite (Expaxy)FERM_3 (PS50057)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)   
Domains : Interpro (EBI)Band_41_domain    FERM/acyl-CoA-bd_prot_sf    FERM_2    FERM_central    FERM_domain    Focal_adhe_kin_target_dom_sf    Focal_adhesion_kin_target_dom    Kinase-like_dom_sf    PH-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    PTK2B    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS    Tyr_kinase_cat_dom    Ubiquitin-like_domsf   
Domain families : Pfam (Sanger)FERM_M (PF00373)    Focal_AT (PF03623)    Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam00373    pfam03623    pfam07714   
Domain families : Smart (EMBL)B41 (SM00295)  TyrKc (SM00219)  
Domain structure : Prodom (Prabi Lyon)Focal_adhesion_target_reg (PD006413)   
Conserved Domain (NCBI)PTK2B
DMDM Disease mutations2185
Blocks (Seattle)PTK2B
PDB (RSDB)2FO6    2LK4    3CC6    3ET7    3FZO    3FZP    3FZR    3FZS    3FZT    3GM1    3GM2    3GM3    3H3C    3U3F    4EKU    4H1J    4H1M    4R32    4XEF    4XEK    4XEV    5TO8    5TOB   
PDB Europe2FO6    2LK4    3CC6    3ET7    3FZO    3FZP    3FZR    3FZS    3FZT    3GM1    3GM2    3GM3    3H3C    3U3F    4EKU    4H1J    4H1M    4R32    4XEF    4XEK    4XEV    5TO8    5TOB   
PDB (PDBSum)2FO6    2LK4    3CC6    3ET7    3FZO    3FZP    3FZR    3FZS    3FZT    3GM1    3GM2    3GM3    3H3C    3U3F    4EKU    4H1J    4H1M    4R32    4XEF    4XEK    4XEV    5TO8    5TOB   
PDB (IMB)2FO6    2LK4    3CC6    3ET7    3FZO    3FZP    3FZR    3FZS    3FZT    3GM1    3GM2    3GM3    3H3C    3U3F    4EKU    4H1J    4H1M    4R32    4XEF    4XEK    4XEV    5TO8    5TOB   
Structural Biology KnowledgeBase2FO6    2LK4    3CC6    3ET7    3FZO    3FZP    3FZR    3FZS    3FZT    3GM1    3GM2    3GM3    3H3C    3U3F    4EKU    4H1J    4H1M    4R32    4XEF    4XEK    4XEV    5TO8    5TOB   
SCOP (Structural Classification of Proteins)2FO6    2LK4    3CC6    3ET7    3FZO    3FZP    3FZR    3FZS    3FZT    3GM1    3GM2    3GM3    3H3C    3U3F    4EKU    4H1J    4H1M    4R32    4XEF    4XEK    4XEV    5TO8    5TOB   
CATH (Classification of proteins structures)2FO6    2LK4    3CC6    3ET7    3FZO    3FZP    3FZR    3FZS    3FZT    3GM1    3GM2    3GM3    3H3C    3U3F    4EKU    4H1J    4H1M    4R32    4XEF    4XEK    4XEV    5TO8    5TOB   
SuperfamilyQ14289
Human Protein Atlas [tissue]ENSG00000120899-PTK2B [tissue]
Peptide AtlasQ14289
HPRD03131
IPIIPI00029702   IPI00216435   IPI00443767   IPI00793811   IPI01010221   IPI00976504   IPI01009861   IPI00985238   
Protein Interaction databases
DIP (DOE-UCLA)Q14289
IntAct (EBI)Q14289
FunCoupENSG00000120899
BioGRIDPTK2B
STRING (EMBL)PTK2B
ZODIACPTK2B
Ontologies - Pathways
QuickGOQ14289
Ontology : AmiGOMAPK cascade  angiogenesis  oocyte maturation  response to hypoxia  positive regulation of cell-matrix adhesion  sprouting angiogenesis  adaptive immune response  marginal zone B cell differentiation  calmodulin-dependent protein kinase activity  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  NMDA glutamate receptor activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  cytoskeleton  focal adhesion  focal adhesion  cell cortex  protein phosphorylation  apoptotic process  cellular defense response  response to osmotic stress  signal transduction  cell surface receptor signaling pathway  signal complex assembly  epidermal growth factor receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  integrin-mediated signaling pathway  protein C-terminus binding  positive regulation of cell proliferation  negative regulation of cell proliferation  regulation of cell shape  response to mechanical stimulus  response to hormone  response to glucose  response to lithium ion  positive regulation of endothelial cell migration  negative regulation of muscle cell apoptotic process  regulation of cGMP-mediated signaling  regulation of macrophage chemotaxis  positive regulation of neuron projection development  glial cell proliferation  postsynaptic density  postsynaptic density  NMDA selective glutamate receptor complex  peptidyl-tyrosine phosphorylation  lamellipodium  cell differentiation  regulation of cell adhesion  regulation of cell adhesion  positive regulation of cell growth  positive regulation of cell migration  dendrite  growth cone  negative regulation of bone mineralization  positive regulation of actin filament polymerization  neuron projection development  extrinsic component of cytoplasmic side of plasma membrane  ubiquitin protein ligase binding  regulation of inositol trisphosphate biosynthetic process  tumor necrosis factor-mediated signaling pathway  ionotropic glutamate receptor signaling pathway  response to immobilization stress  peptidyl-tyrosine autophosphorylation  peptidyl-tyrosine autophosphorylation  peptidyl-tyrosine autophosphorylation  interleukin-2-mediated signaling pathway  regulation of cell proliferation  response to cocaine  response to hydrogen peroxide  activation of Janus kinase activity  neuronal cell body  negative regulation of apoptotic process  stress fiber assembly  dendritic spine  negative regulation of potassium ion transport  3-phosphoinositide-dependent protein kinase binding  positive regulation of JUN kinase activity  negative regulation of neuron apoptotic process  blood vessel endothelial cell migration  positive regulation of phosphatidylinositol 3-kinase activity  cell body  protein-containing complex binding  membrane raft  positive regulation of nitric oxide biosynthetic process  bone resorption  response to ethanol  negative regulation of myeloid cell differentiation  positive regulation of translation  positive regulation of angiogenesis  positive regulation of protein kinase activity  positive regulation of JNK cascade  protein autophosphorylation  vascular endothelial growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  focal adhesion assembly  regulation of synaptic plasticity  perinuclear region of cytoplasm  positive regulation of peptidyl-tyrosine phosphorylation  regulation of calcium-mediated signaling  positive regulation of nitric-oxide synthase activity  regulation of release of sequestered calcium ion into cytosol  response to cAMP  response to calcium ion  positive regulation of synaptic transmission, glutamatergic  long-term synaptic potentiation  long-term synaptic depression  protein-containing complex assembly  chemokine-mediated signaling pathway  positive regulation of ERK1 and ERK2 cascade  cellular response to retinoic acid  cellular response to fluid shear stress  activation of GTPase activity  apical dendrite  glutamatergic synapse  regulation of ubiquitin-dependent protein catabolic process  positive regulation of ubiquitin-dependent protein catabolic process  regulation of establishment of cell polarity  regulation of actin cytoskeleton reorganization  regulation of NMDA receptor activity  positive regulation of excitatory postsynaptic potential  positive regulation of B cell chemotaxis  positive regulation of DNA biosynthetic process  
Ontology : EGO-EBIMAPK cascade  angiogenesis  oocyte maturation  response to hypoxia  positive regulation of cell-matrix adhesion  sprouting angiogenesis  adaptive immune response  marginal zone B cell differentiation  calmodulin-dependent protein kinase activity  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  NMDA glutamate receptor activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  cytoskeleton  focal adhesion  focal adhesion  cell cortex  protein phosphorylation  apoptotic process  cellular defense response  response to osmotic stress  signal transduction  cell surface receptor signaling pathway  signal complex assembly  epidermal growth factor receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  integrin-mediated signaling pathway  protein C-terminus binding  positive regulation of cell proliferation  negative regulation of cell proliferation  regulation of cell shape  response to mechanical stimulus  response to hormone  response to glucose  response to lithium ion  positive regulation of endothelial cell migration  negative regulation of muscle cell apoptotic process  regulation of cGMP-mediated signaling  regulation of macrophage chemotaxis  positive regulation of neuron projection development  glial cell proliferation  postsynaptic density  postsynaptic density  NMDA selective glutamate receptor complex  peptidyl-tyrosine phosphorylation  lamellipodium  cell differentiation  regulation of cell adhesion  regulation of cell adhesion  positive regulation of cell growth  positive regulation of cell migration  dendrite  growth cone  negative regulation of bone mineralization  positive regulation of actin filament polymerization  neuron projection development  extrinsic component of cytoplasmic side of plasma membrane  ubiquitin protein ligase binding  regulation of inositol trisphosphate biosynthetic process  tumor necrosis factor-mediated signaling pathway  ionotropic glutamate receptor signaling pathway  response to immobilization stress  peptidyl-tyrosine autophosphorylation  peptidyl-tyrosine autophosphorylation  peptidyl-tyrosine autophosphorylation  interleukin-2-mediated signaling pathway  regulation of cell proliferation  response to cocaine  response to hydrogen peroxide  activation of Janus kinase activity  neuronal cell body  negative regulation of apoptotic process  stress fiber assembly  dendritic spine  negative regulation of potassium ion transport  3-phosphoinositide-dependent protein kinase binding  positive regulation of JUN kinase activity  negative regulation of neuron apoptotic process  blood vessel endothelial cell migration  positive regulation of phosphatidylinositol 3-kinase activity  cell body  protein-containing complex binding  membrane raft  positive regulation of nitric oxide biosynthetic process  bone resorption  response to ethanol  negative regulation of myeloid cell differentiation  positive regulation of translation  positive regulation of angiogenesis  positive regulation of protein kinase activity  positive regulation of JNK cascade  protein autophosphorylation  vascular endothelial growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  focal adhesion assembly  regulation of synaptic plasticity  perinuclear region of cytoplasm  positive regulation of peptidyl-tyrosine phosphorylation  regulation of calcium-mediated signaling  positive regulation of nitric-oxide synthase activity  regulation of release of sequestered calcium ion into cytosol  response to cAMP  response to calcium ion  positive regulation of synaptic transmission, glutamatergic  long-term synaptic potentiation  long-term synaptic depression  protein-containing complex assembly  chemokine-mediated signaling pathway  positive regulation of ERK1 and ERK2 cascade  cellular response to retinoic acid  cellular response to fluid shear stress  activation of GTPase activity  apical dendrite  glutamatergic synapse  regulation of ubiquitin-dependent protein catabolic process  positive regulation of ubiquitin-dependent protein catabolic process  regulation of establishment of cell polarity  regulation of actin cytoskeleton reorganization  regulation of NMDA receptor activity  positive regulation of excitatory postsynaptic potential  positive regulation of B cell chemotaxis  positive regulation of DNA biosynthetic process  
Pathways : KEGGCalcium signaling pathway    Chemokine signaling pathway    Natural killer cell mediated cytotoxicity    Leukocyte transendothelial migration    GnRH signaling pathway    Hepatitis B   
NDEx NetworkPTK2B
Atlas of Cancer Signalling NetworkPTK2B
Wikipedia pathwaysPTK2B
Orthology - Evolution
OrthoDB2185
GeneTree (enSembl)ENSG00000120899
Phylogenetic Trees/Animal Genes : TreeFamPTK2B
HOGENOMQ14289
Homologs : HomoloGenePTK2B
Homology/Alignments : Family Browser (UCSC)PTK2B
Gene fusions - Rearrangements
Fusion : MitelmanEPHX2/PTK2B [8p21.2/8p21.2]  [t(8;8)(p21;p21)]  
Fusion PortalEPHX2 8p21.2 PTK2B 8p21.2 BLCA
Fusion : QuiverPTK2B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTK2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTK2B
dbVarPTK2B
ClinVarPTK2B
1000_GenomesPTK2B 
Exome Variant ServerPTK2B
ExAC (Exome Aggregation Consortium)ENSG00000120899
GNOMAD BrowserENSG00000120899
Varsome BrowserPTK2B
Genetic variants : HAPMAP2185
Genomic Variants (DGV)PTK2B [DGVbeta]
DECIPHERPTK2B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTK2B 
Mutations
ICGC Data PortalPTK2B 
TCGA Data PortalPTK2B 
Broad Tumor PortalPTK2B
OASIS PortalPTK2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTK2B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPTK2B
Mutations and Diseases : HGMDPTK2B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTK2B
DgiDB (Drug Gene Interaction Database)PTK2B
DoCM (Curated mutations)PTK2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTK2B (select a term)
intoGenPTK2B
Cancer3DPTK2B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601212   
Orphanet
DisGeNETPTK2B
MedgenPTK2B
Genetic Testing Registry PTK2B
NextProtQ14289 [Medical]
TSGene2185
GENETestsPTK2B
Target ValidationPTK2B
Huge Navigator PTK2B [HugePedia]
snp3D : Map Gene to Disease2185
BioCentury BCIQPTK2B
ClinGenPTK2B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2185
Chemical/Pharm GKB GenePA33956
Clinical trialPTK2B
Miscellaneous
canSAR (ICR)PTK2B (select the gene name)
DataMed IndexPTK2B
Probes
Litterature
PubMed298 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTK2B
EVEXPTK2B
GoPubMedPTK2B
iHOPPTK2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 18:03:17 CET 2019
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