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PTK7 (PTK7 protein tyrosine kinase 7)

Written2012-05Anne-Catherine Lhoumeau, Jean-Paul Borg
Inserm U1068, CNRS UMR7258, CRCM, Marseille, F-13009, France; Aix-Marseille Univ, F-13284, Marseille, France; Institut Paoli-Calmettes, Marseille, F-13009, France

(Note : for Links provided by Atlas : click)

Identity

Alias_namesPTK7 protein tyrosine kinase 7
protein tyrosine kinase 7
Alias_symbol (synonym)CCK4
Other alias
HGNC (Hugo) PTK7
LocusID (NCBI) 5754
Atlas_Id 41901
Location 6p21.1  [Link to chromosome band 6p21]
Location_base_pair Starts at 43076814 and ends at 43161720 bp from pter ( according to hg19-Feb_2009)  [Mapping PTK7.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
B4GALT5 (20q13.13) / PTK7 (6p21.1)DUSP22 (6p25.3) / PTK7 (6p21.1)MDGA1 (6p21.2) / PTK7 (6p21.1)
PTK7 (6p21.1) / DLK2 (6p21.1)PTK7 (6p21.1) / PTCRA (6p21.1)PTK7 (6p21.1) / PTK7 (6p21.1)
STEAP3 (2q14.2) / PTK7 (6p21.1)
Note PTK7 is an atypical tyrosine kinase receptor. It belongs to the group of pseudo-kinases as key residues required for catalytic activity are missing in its kinase domain (Mossie et al., 1995; Park et al.,1996; Banga et al., 1997). It represents the only member of its own family. This receptor is involved in many developmental processes as its loss gives rise to severe and lethal defects. PTK7 is implicated in planar cell polarity and in Wnt signaling pathways.

DNA/RNA

Note The gene of PTK7 spans approximately 85 kb in human and 65 kb in mouse. These two genes shared the same structure and are composed by 20 exons (Jung et al., 2002; Jung et al., 2004).
 
Description The PTK7 gene is organized in 20 exons in human and mouse (see figure below). In humans, exon 1 encodes the translation initiation codon and the signal peptide. Exons 2 to 13 encode the extracellular region. The 5'-half of exon 14 encodes the transmembrane region, and the rest of exon 14 and 5'-half of exon 15 encode the juxtamembrane region. The 3'-half of exon 15 and exons 16 to 20 encode the tyrosine kinase domain (Jung et al., 2002).
Transcription The 883-bp 5'-flanking sequence from the ATG start codon contains a functional promoter. Several canonical binding sites for transcription factors (NFAT, SP1, dEF1, LMO2COM, v-MYB, TCF11, NF1, IK-2, AP4) are present in this sequence and might be important for expression of PTK7 (Jung et al., 2002). Moreover, a report showed that expression of PTK7 is regulated by Cdx transcription factors. Indeed, several Cdx response elements in the 5'-flanking sequence of ptk7 have been identified by chromatin immunoprecipitation analysis and activity of these sites have been demonstrated in cultured cells (Savory et al., 2011).
mRNA: Alternative splicing give rise to five PTK7 isoforms in human, which have been described in testis. PTK7-1 is the full length form of PTK7 and the length of its mRNA is 3213 bp. Others isoforms have a loss of one or several exons coding for the extracellular part of the protein (i.e. immunoglobulin loops) and are summarized in the table above (Jung et al., 2002). Shorter PTK7 forms (i.e < 500 AA) have been reported in Ensembl but have not been validated by in vitro experiments.

Protein

Note PTK7 has a classical RTK structure with an extracellular region, a single transmembrane region and an intracellular tyrosine kinase domain.
 
  A. Structure and organization of PTK7 gene. Each box represents an exon. B. Structure and features of PTK7 protein. Structure and mapping of each immunoglobulin-like loop domains are indicated in the figure. The main features of the protein (i.e cleavage site and non-classical residues in the catalytic domain) are mentioned in the figure. Ig: immunoglobulin loops domain.TM: transmembrane domain. JM: juxtamembrane domain.
Description The human and mouse PTK7 proteins comprise 1070 and 1062 amino acids, respectively, and share 92.6% identity. The extracellular region is composed by seven immunoglobulin-like domains. Although the kinase domain is catalytically inactive, it is highly evolutionarily conserved during evolution. Three major non-classical sequences have been described: the GXGXXG ATP binding motif is changed in GXSXXG. The HDRL motif required for the catalytic proton transfer is changed in a HKDL motif, and the aspartate residue of the DFG motif usually coordinating Mg2+-ATP binding is changed to an uncharged alanine residue (ALG motif) (Jung et al., 2004; Boudeau et al., 2006). No convincing experimental data support yet a catalytic function of the PTK7 tyrosine kinase domain.
Expression PTK7 is ubiquitously expressed at low level in epithelial, endothelial and hematopoietic tissues. PTK7 is highly expressed in tumoral tissues: colon cancer (Mossie et al., 1995), melanoma (Easty et al., 1997), breast cancer (Speers et al., 2009), acute myeloid leukemia, acute lymphoid leukemia (Müller-Tidow et al., 2004; Prébet et al., 2010).
Localisation PTK7 is localized at the plasma membrane and has its extracellular domain exposed at the cell surface. It is described that PTK7 is processed by MT1-MPP, a metalloproteinase, that releases a soluble form of PTK7. From in vivo and in vitro studies, it appears that a fine-tuned balance between full length PTK7 and soluble PTK7 is required for normal embryonic development and directional cell migration (Golubkov et al., 2010; Golubkov et al., 2011).
Function The loss of PTK7 protein in mouse leads to a severe and lethal phenotype of neural tube defect closure (craniorachischisis) and abdomen defect closure. Also, PTK7 is implicated in planar cell polarity and in the convergent extension embryonic process (Lu et al., 2004; Yen et al., 2009).
Despite the lack of tyrosine kinase activity, PTK7 is involved in epithelial and hematopoietic cell migration. PTK7 is able to interact with VEGFR1 and is implicated into angiogenesis (Shin et al., 2008; Lee et al., 2011).
In term of signaling, PTK7 is able to bind to β-catenin and Dsh proteins (Shnitsar and Borchers, 2008). The formation of a tripartite complex Dsh-Rack1-Fz7 places PTK7 as an actor of non-canonical Wnt pathway (Wehner et al., 2011). Interaction with β-catenin suggests that PTK7 is also involved in canonical Wnt pathway (Puppo et al., 2011). However, the role of PTK7 as activator or inhibitor of Wnt canonical signaling is still controversial (Peradziryi et al., 2011). In Drosophila, PTK7 (also called OTK) forms a protein complex with members of the Plexin family proteins. Also, OTK is apparently also involved in the Plexin-Semaphorin pathway (Wagner et al., 2010).
Homology The extracellular part show similarities with adhesion molecules of the immunoglobulin superfamily due to the presence of immunoglobulin loops domains. Phylogenetic study showed that among the RTKs of the immunoglobulin superfamily, ptk7 and musk genes have derived very early during evolution and have created an independent branch probably endowed with particular functions. Indeed, Musk shows the highest identity sequence with PTK7 (42%) when the extracellular domains are compared (Grassot et al., 2006).

Mutations

Note Some mutations have been found in human ptk7, but to date none of them have been correlated to any diseases. However, frequent overexpression of the receptor is observed in solid and haematological cancers.

Implicated in

Note
  
Entity Development
Note PTK7 plays a major role in planar cell polarity and convergent extension processes.
Disease Gene-trapped PTK7 leads to neural tube and abdomen closure defects associated with several developmental abnormalities as polydactyly, smaller kidney and open eyes in the mouse (Lu et al., 2004).
Prognosis Embryonic lethal.
  
  
Entity Oncogenesis
Note PTK7 is highly expressed in tumoral tissues.
Disease Colon cancer, melanoma, breast cancer, acute myeloid leukemia, acute lymphoid leukemia.
Prognosis Controversial studies have been reported. In melanoma, loss of PTK7 expression was correlated with advanced stage of disease (Easty et al.,1997). In other cancer, expression of PTK7 is linked with adverse prognosis and increased resistance to chemotherapeutic drugs (AML) (Prébet et al., 2010), and breast cancer (Speers et al., 2009).
Hybrid/Mutated Gene Not described.
  
  
Entity Angiogenesis
Note PTK7 crosstalks with active receptor tyrosine kinase family members such as VEGFR1, and regulates migration of endothelial cells. In endothelial cells, VEGF-A triggers VEGFR1 phosphorylation and association with PTK7. This interaction is needed for optimal phosphorylation and activation of downstream components of VEGFR1 signaling, including AKT and FAK that are required for the angiogenic process (Lee et al., 2011). Accordingly, downregulation of PTK7 expression in vitro and in vivo leads to a decreased angiogenesis (Shin et al., 2008). An anti-angiogenic effect can be obtained using a soluble recombinant form of PTK7, suggesting a dominant-negative effect on the extracellular domain.
  
  
Entity Wnt pathways
Note PTK7 is a key protein of Wnt pathway regulation. In one hand, PTK7 is involved in non-canonical PCP Wnt pathway, through a direct interaction with Dishevelled (Dsh) and Rack1. In this pathway, PTK7 probably induces a Rho/Rac/JNK signalling cascade that controls actin cytoskeleton remodelling (Montcouquiol et al., 2006). On the other hand, PTK7 interacts directly by its tyrosine kinase domain with β-catenin, which is a key protein of the canonical Wnt pathway. PTK7 deficient cells exhibit weakened β-catenin/T-cell factor transcriptional activity upon Wnt3a stimulation (Puppo et al., 2011). However, as Rack1 is known to antagonize canonical Wnt pathways, other authors suggest that the PTK7/Rack1 complex can potentially repress the canonical Wnt signaling (Peradziryi et al., 2012). Further studies will be necessary to highlight how PTK7 crosstalks between canonical and non-canonical Wnt pathways.
Disease Wnt pathway is a major signaling pathway during development and is involved in many cellular mechanisms including carcinogenesis.
  

To be noted

No ligand of PTK7 receptor has been yet identified. Despite the lack of tyrosine kinase activity, PTK7 appears to have a role in signal transduction and emerges as an important regulator of VEGFR1 and Wnt pathways (Lhoumeau et al., 2011).

Bibliography

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Banga SS, Ozer HL, Park SK, Lee ST.
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Loss of expression of receptor tyrosine kinase family genes PTK7 and SEK in metastatic melanoma.
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Potential relation of aberrant proteolysis of human protein tyrosine kinase 7 (PTK7) chuzhoi by membrane type 1 matrix metalloproteinase (MT1-MMP) to congenital defects.
Golubkov VS, Aleshin AE, Strongin AY.
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Origin and molecular evolution of receptor tyrosine kinases with immunoglobulin-like domains.
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Organization of the human PTK7 gene encoding a receptor protein tyrosine kinase-like molecule and alternative splicing of its mRNA.
Jung JW, Ji AR, Lee J, Kim UJ, Lee ST.
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Cloning and characterization of the full-length mouse Ptk7 cDNA encoding a defective receptor protein tyrosine kinase.
Jung JW, Shin WS, Song J, Lee ST.
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Flt-1 regulates vascular endothelial cell migration via a protein tyrosine kinase-7-dependent pathway.
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Blood. 2011 May 26;117(21):5762-71. Epub 2011 Apr 1.
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PTK7: a cell polarity receptor with multiple facets.
Lhoumeau AC, Puppo F, Prebet T, Kodjabachian L, Borg JP.
Cell Cycle. 2011 Apr 15;10(8):1233-6. Epub 2011 Apr 15.
PMID 21415598
 
PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates.
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Nature. 2004 Jul 1;430(6995):93-8.
PMID 15229603
 
Noncanonical Wnt signaling and neural polarity.
Montcouquiol M, Crenshaw EB 3rd, Kelley MW.
Annu Rev Neurosci. 2006;29:363-86. (REVIEW)
PMID 16776590
 
Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family.
Mossie K, Jallal B, Alves F, Sures I, Plowman GD, Ullrich A.
Oncogene. 1995 Nov 16;11(10):2179-84.
PMID 7478540
 
High-throughput analysis of genome-wide receptor tyrosine kinase expression in human cancers identifies potential novel drug targets.
Muller-Tidow C, Schwable J, Steffen B, Tidow N, Brandt B, Becker K, Schulze-Bahr E, Halfter H, Vogt U, Metzger R, Schneider PM, Buchner T, Brandts C, Berdel WE, Serve H.
Clin Cancer Res. 2004 Feb 15;10(4):1241-9.
PMID 14977821
 
Characterization of the human full-length PTK7 cDNA encoding a receptor protein tyrosine kinase-like molecule closely related to chick KLG.
Park SK, Lee HS, Lee ST.
J Biochem. 1996 Feb;119(2):235-9.
PMID 8882711
 
The many roles of PTK7: A versatile regulator of cell-cell communication.
Peradziryi H, Tolwinski NS, Borchers A.
Arch Biochem Biophys. 2012 Aug 1;524(1):71-6. Epub 2012 Jan 3.
PMID 22230326
 
The cell polarity PTK7 receptor acts as a modulator of the chemotherapeutic response in acute myeloid leukemia and impairs clinical outcome.
Prebet T, Lhoumeau AC, Arnoulet C, Aulas A, Marchetto S, Audebert S, Puppo F, Chabannon C, Sainty D, Santoni MJ, Sebbagh M, Summerour V, Huon Y, Shin WS, Lee ST, Esterni B, Vey N, Borg JP.
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PMID 20558616
 
Protein tyrosine kinase 7 has a conserved role in Wnt/?-catenin canonical signalling.
Puppo F, Thome V, Lhoumeau AC, Cibois M, Gangar A, Lembo F, Belotti E, Marchetto S, Lecine P, Prebet T, Sebbagh M, Shin WS, Lee ST, Kodjabachian L, Borg JP.
EMBO Rep. 2011 Jan;12(1):43-9. Epub 2010 Dec 3.
PMID 21132015
 
Cdx mediates neural tube closure through transcriptional regulation of the planar cell polarity gene Ptk7.
Savory JG, Mansfield M, Rijli FM, Lohnes D.
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PMID 21350009
 
Soluble PTK7 inhibits tube formation, migration, and invasion of endothelial cells and angiogenesis.
Shin WS, Maeng YS, Jung JW, Min JK, Kwon YG, Lee ST.
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PMID 18471990
 
PTK7 recruits dsh to regulate neural crest migration.
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PMID 19004858
 
Identification of novel kinase targets for the treatment of estrogen receptor-negative breast cancer.
Speers C, Tsimelzon A, Sexton K, Herrick AM, Gutierrez C, Culhane A, Quackenbush J, Hilsenbeck S, Chang J, Brown P.
Clin Cancer Res. 2009 Oct 15;15(20):6327-40. Epub 2009 Oct 6.
PMID 19808870
 
PlexinA1 interacts with PTK7 and is required for neural crest migration.
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PMID 20946874
 
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PMID 21350015
 
PTK7 is essential for polarized cell motility and convergent extension during mouse gastrulation.
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PMID 19439496
 

Citation

This paper should be referenced as such :
Lhoumeau, AC ; Borg, JP
PTK7 (PTK7 protein tyrosine kinase 7)
Atlas Genet Cytogenet Oncol Haematol. 2012;16(11):817-820.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/PTK7ID41901ch6p21.html


External links

Nomenclature
HGNC (Hugo)PTK7   9618
Cards
AtlasPTK7ID41901ch6p21
Entrez_Gene (NCBI)PTK7  5754  protein tyrosine kinase 7 (inactive)
AliasesCCK-4; CCK4
GeneCards (Weizmann)PTK7
Ensembl hg19 (Hinxton)ENSG00000112655 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112655 [Gene_View]  chr6:43076814-43161720 [Contig_View]  PTK7 [Vega]
ICGC DataPortalENSG00000112655
TCGA cBioPortalPTK7
AceView (NCBI)PTK7
Genatlas (Paris)PTK7
WikiGenes5754
SOURCE (Princeton)PTK7
Genetics Home Reference (NIH)PTK7
Genomic and cartography
GoldenPath hg38 (UCSC)PTK7  -     chr6:43076814-43161720 +  6p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTK7  -     6p21.1   [Description]    (hg19-Feb_2009)
EnsemblPTK7 - 6p21.1 [CytoView hg19]  PTK7 - 6p21.1 [CytoView hg38]
Mapping of homologs : NCBIPTK7 [Mapview hg19]  PTK7 [Mapview hg38]
OMIM601890   
Gene and transcription
Genbank (Entrez)AB209350 AF531868 AF531869 AF531870 AF531871
RefSeq transcript (Entrez)NM_001270398 NM_002821 NM_152880 NM_152881 NM_152882 NM_152883
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PTK7
Cluster EST : UnigeneHs.90572 [ NCBI ]
CGAP (NCI)Hs.90572
Alternative Splicing GalleryENSG00000112655
Gene ExpressionPTK7 [ NCBI-GEO ]   PTK7 [ EBI - ARRAY_EXPRESS ]   PTK7 [ SEEK ]   PTK7 [ MEM ]
Gene Expression Viewer (FireBrowse)PTK7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5754
GTEX Portal (Tissue expression)PTK7
Human Protein AtlasENSG00000112655-PTK7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13308   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13308  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13308
Splice isoforms : SwissVarQ13308
PhosPhoSitePlusQ13308
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub    Ig_sub2    Kinase-like_dom    Prot_kinase_dom    PTK7    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS   
Domain families : Pfam (Sanger)I-set (PF07679)    Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam07679    pfam07714   
Domain families : Smart (EMBL)IG (SM00409)  IGc2 (SM00408)  
Conserved Domain (NCBI)PTK7
DMDM Disease mutations5754
Blocks (Seattle)PTK7
SuperfamilyQ13308
Human Protein Atlas [tissue]ENSG00000112655-PTK7 [tissue]
Peptide AtlasQ13308
HPRD03534
IPIIPI00298292   IPI00170814   IPI00168813   IPI00478565   IPI00174794   IPI00903118   IPI00922030   IPI00186793   IPI00555762   IPI00946135   IPI00743413   IPI00946792   IPI00947545   IPI00946306   IPI00947089   IPI00946128   IPI00947239   
Protein Interaction databases
DIP (DOE-UCLA)Q13308
IntAct (EBI)Q13308
FunCoupENSG00000112655
BioGRIDPTK7
STRING (EMBL)PTK7
ZODIACPTK7
Ontologies - Pathways
QuickGOQ13308
Ontology : AmiGOestablishment of planar polarity  ventricular septum development  axis elongation  protein kinase activity  protein binding  ATP binding  integral component of plasma membrane  cell-cell junction  focal adhesion  protein phosphorylation  cell adhesion  signal transduction  positive regulation of neuron projection development  cell migration  actin cytoskeleton reorganization  wound healing  establishment of epithelial cell apical/basal polarity  convergent extension  canonical Wnt signaling pathway  lung-associated mesenchyme development  coronary vasculature development  cellular response to retinoic acid  cochlea morphogenesis  planar cell polarity pathway involved in neural tube closure  coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway  
Ontology : EGO-EBIestablishment of planar polarity  ventricular septum development  axis elongation  protein kinase activity  protein binding  ATP binding  integral component of plasma membrane  cell-cell junction  focal adhesion  protein phosphorylation  cell adhesion  signal transduction  positive regulation of neuron projection development  cell migration  actin cytoskeleton reorganization  wound healing  establishment of epithelial cell apical/basal polarity  convergent extension  canonical Wnt signaling pathway  lung-associated mesenchyme development  coronary vasculature development  cellular response to retinoic acid  cochlea morphogenesis  planar cell polarity pathway involved in neural tube closure  coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway  
NDEx NetworkPTK7
Atlas of Cancer Signalling NetworkPTK7
Wikipedia pathwaysPTK7
Orthology - Evolution
OrthoDB5754
GeneTree (enSembl)ENSG00000112655
Phylogenetic Trees/Animal Genes : TreeFamPTK7
HOVERGENQ13308
HOGENOMQ13308
Homologs : HomoloGenePTK7
Homology/Alignments : Family Browser (UCSC)PTK7
Gene fusions - Rearrangements
Fusion : MitelmanDUSP22/PTK7 [6p25.3/6p21.1]  [t(6;6)(p21;p25)]  
Fusion : MitelmanMDGA1/PTK7 [6p21.2/6p21.1]  [t(6;6)(p21;p21)]  
Fusion : MitelmanPTK7/DLK2 [6p21.1/6p21.1]  [t(6;6)(p21;p21)]  
Fusion : MitelmanPTK7/PTCRA [6p21.1/6p21.1]  [t(6;6)(p21;p21)]  
Fusion: TCGA_MDACCDUSP22 6p25.3 PTK7 6p21.1 PRAD
Fusion: TCGA_MDACCMDGA1 6p21.2 PTK7 6p21.1 GBM
Fusion: TCGA_MDACCPTK7 6p21.1 DLK2 6p21.1 LUAD
Fusion: TCGA_MDACCPTK7 6p21.1 PTCRA 6p21.1 BRCA
Tumor Fusion PortalPTK7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTK7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTK7
dbVarPTK7
ClinVarPTK7
1000_GenomesPTK7 
Exome Variant ServerPTK7
ExAC (Exome Aggregation Consortium)ENSG00000112655
GNOMAD BrowserENSG00000112655
Genetic variants : HAPMAP5754
Genomic Variants (DGV)PTK7 [DGVbeta]
DECIPHERPTK7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTK7 
Mutations
ICGC Data PortalPTK7 
TCGA Data PortalPTK7 
Broad Tumor PortalPTK7
OASIS PortalPTK7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTK7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTK7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTK7
DgiDB (Drug Gene Interaction Database)PTK7
DoCM (Curated mutations)PTK7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTK7 (select a term)
intoGenPTK7
NCG5 (London)PTK7
Cancer3DPTK7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601890   
Orphanet
DisGeNETPTK7
MedgenPTK7
Genetic Testing Registry PTK7
NextProtQ13308 [Medical]
TSGene5754
GENETestsPTK7
Target ValidationPTK7
Huge Navigator PTK7 [HugePedia]
snp3D : Map Gene to Disease5754
BioCentury BCIQPTK7
ClinGenPTK7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5754
Chemical/Pharm GKB GenePA33961
Clinical trialPTK7
Miscellaneous
canSAR (ICR)PTK7 (select the gene name)
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTK7
EVEXPTK7
GoPubMedPTK7
iHOPPTK7
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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