PTOV1 (PTOV1 extended AT-hook containing adaptor protein)

2003-02-01  

Identity

HGNC
PTOV1
LOCATION
19q13.33
LOCUSID
53635
ALIAS
ACID2,PTOV-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 53635
MIM: 610195
HGNC: 9632
Ensembl: ENSG00000104960

Variants:

dbSNP: 53635
ClinVar: 53635
TCGA: ENSG00000104960
COSMIC: PTOV1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104960ENST00000391842Q86YD1
ENSG00000104960ENST00000594151M0QYH7
ENSG00000104960ENST00000597730M0QX53
ENSG00000104960ENST00000599732Q86YD1
ENSG00000104960ENST00000600603A0A0C4DGR2
ENSG00000104960ENST00000600793M0QZB9
ENSG00000104960ENST00000601093M0QYH6
ENSG00000104960ENST00000601612M0QYQ4
ENSG00000104960ENST00000601638M0QY25
ENSG00000104960ENST00000601675Q86YD1

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
157136442005PTOV1 enables the nuclear translocation and mitogenic activity of flotillin-1, a major protein of lipid rafts.32
125983232003PTOV-1, a novel protein overexpressed in prostate cancer, shuttles between the cytoplasm and the nucleus and promotes entry into the S phase of the cell division cycle.18
184512242008PTOV1 expression predicts prostate cancer in men with isolated high-grade prostatic intraepithelial neoplasia in needle biopsy.14
246847542014Prostate tumor OVerexpressed-1 (PTOV1) down-regulates HES1 and HEY1 notch targets genes and promotes prostate cancer progression.12
211109512011PTOV1 antagonizes MED25 in RAR transcriptional activation.10
211814142011PTOV1 is overexpressed in human high-grade malignant tumors.10
233214992013Zyxin cooperates with PTOV1 to confer retinoic acid resistance by repressing RAR activity.7
249471662014Overexpression of prostate tumor overexpressed 1 correlates with tumor progression and predicts poor prognosis in breast cancer.5
269922422016Prostate tumor overexpressed-1, in conjunction with human papillomavirus status, predicts outcome in early-stage human laryngeal squamous cell carcinoma.5
225073192012Is there a role for prostate tumour overexpressed-1 in the diagnosis of HGPIN and of prostatic adenocarcinoma? A comparison with alpha-methylacyl CoA racemase.4

Citation

Dessen P

PTOV1 (PTOV1 extended AT-hook containing adaptor protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41905/ptov1