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PTP4A2 (protein tyrosine phosphatase type IVA, member 2)

Identity

Alias_namesPTP4A
Alias_symbol (synonym)HU-PP-1
PTPCAAX2
OV-1
ptp-IV1a
PRL-2
Other aliasHH13
HH7-2
PRL2
ptp-IV1b
HGNC (Hugo) PTP4A2
LocusID (NCBI) 8073
Atlas_Id 41907
Location 1p35.2  [Link to chromosome band 1p35]
Location_base_pair Starts at 31906421 and ends at 31919658 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BRK1 (3p25.3) / PTP4A2 (1p35.2)PTP4A2 (1p35.2) / CLDN16 (3q28)PTP4A2 (1p35.2) / MALAT1 (11q13.1)
cytochrome_b () / PTP4A2 (1p35.2)BRK1 3p25.3 / PTP4A2 1p35.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PTP4A2   9635
Cards
Entrez_Gene (NCBI)PTP4A2  8073  protein tyrosine phosphatase type IVA, member 2
AliasesHH13; HH7-2; HU-PP-1; OV-1; 
PRL-2; PRL2; PTP4A; PTPCAAX2; ptp-IV1a; ptp-IV1b
GeneCards (Weizmann)PTP4A2
Ensembl hg19 (Hinxton)ENSG00000184007 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184007 [Gene_View]  chr1:31906421-31919658 [Contig_View]  PTP4A2 [Vega]
ICGC DataPortalENSG00000184007
TCGA cBioPortalPTP4A2
AceView (NCBI)PTP4A2
Genatlas (Paris)PTP4A2
WikiGenes8073
SOURCE (Princeton)PTP4A2
Genetics Home Reference (NIH)PTP4A2
Genomic and cartography
GoldenPath hg38 (UCSC)PTP4A2  -     chr1:31906421-31919658 -  1p35.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTP4A2  -     1p35.2   [Description]    (hg19-Feb_2009)
EnsemblPTP4A2 - 1p35.2 [CytoView hg19]  PTP4A2 - 1p35.2 [CytoView hg38]
Mapping of homologs : NCBIPTP4A2 [Mapview hg19]  PTP4A2 [Mapview hg38]
OMIM601584   
Gene and transcription
Genbank (Entrez)AF208850 AK129578 AK292703 AK297280 AM392609
RefSeq transcript (Entrez)NM_001195100 NM_001195101 NM_003479 NM_080391 NM_080392
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PTP4A2
Cluster EST : UnigeneHs.713025 [ NCBI ]
CGAP (NCI)Hs.713025
Alternative Splicing GalleryENSG00000184007
Gene ExpressionPTP4A2 [ NCBI-GEO ]   PTP4A2 [ EBI - ARRAY_EXPRESS ]   PTP4A2 [ SEEK ]   PTP4A2 [ MEM ]
Gene Expression Viewer (FireBrowse)PTP4A2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8073
GTEX Portal (Tissue expression)PTP4A2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ12974   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ12974  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ12974
Splice isoforms : SwissVarQ12974
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.483.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   
PhosPhoSitePlusQ12974
Domaine pattern : Prosite (Expaxy)TYR_PHOSPHATASE_2 (PS50056)   
Domains : Interpro (EBI)Prot-tyrosine_phosphatase-like    PTPase_domain    Tyr_Pase_cat    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam00102   
Domain families : Smart (EMBL)PTPc_motif (SM00404)  
Conserved Domain (NCBI)PTP4A2
DMDM Disease mutations8073
Blocks (Seattle)PTP4A2
PDB (SRS)5K22    5K23    5K25   
PDB (PDBSum)5K22    5K23    5K25   
PDB (IMB)5K22    5K23    5K25   
PDB (RSDB)5K22    5K23    5K25   
Structural Biology KnowledgeBase5K22    5K23    5K25   
SCOP (Structural Classification of Proteins)5K22    5K23    5K25   
CATH (Classification of proteins structures)5K22    5K23    5K25   
SuperfamilyQ12974
Human Protein AtlasENSG00000184007
Peptide AtlasQ12974
HPRD03348
IPIIPI00020191   IPI00040537   IPI00909081   IPI00985126   IPI00975554   IPI00984481   
Protein Interaction databases
DIP (DOE-UCLA)Q12974
IntAct (EBI)Q12974
FunCoupENSG00000184007
BioGRIDPTP4A2
STRING (EMBL)PTP4A2
ZODIACPTP4A2
Ontologies - Pathways
QuickGOQ12974
Ontology : AmiGOprenylated protein tyrosine phosphatase activity  nucleus  cytoplasm  early endosome  cytosol  plasma membrane  peptidyl-tyrosine dephosphorylation  extracellular exosome  
Ontology : EGO-EBIprenylated protein tyrosine phosphatase activity  nucleus  cytoplasm  early endosome  cytosol  plasma membrane  peptidyl-tyrosine dephosphorylation  extracellular exosome  
NDEx NetworkPTP4A2
Atlas of Cancer Signalling NetworkPTP4A2
Wikipedia pathwaysPTP4A2
Orthology - Evolution
OrthoDB8073
GeneTree (enSembl)ENSG00000184007
Phylogenetic Trees/Animal Genes : TreeFamPTP4A2
HOVERGENQ12974
HOGENOMQ12974
Homologs : HomoloGenePTP4A2
Homology/Alignments : Family Browser (UCSC)PTP4A2
Gene fusions - Rearrangements
Fusion : MitelmanBRK1/PTP4A2 [3p25.3/1p35.2]  [t(1;3)(p35;p25)]  
Fusion : MitelmanPTP4A2/MALAT1 [1p35.2/11q13.1]  [t(1;11)(p35;q13)]  
Fusion: TCGABRK1 3p25.3 PTP4A2 1p35.2 PRAD
Fusion Cancer (Beijing)cytochrome_b [PTP4A2]  -  1p35.2 [FUSC002838]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTP4A2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTP4A2
dbVarPTP4A2
ClinVarPTP4A2
1000_GenomesPTP4A2 
Exome Variant ServerPTP4A2
ExAC (Exome Aggregation Consortium)PTP4A2 (select the gene name)
Genetic variants : HAPMAP8073
Genomic Variants (DGV)PTP4A2 [DGVbeta]
DECIPHERPTP4A2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTP4A2 
Mutations
ICGC Data PortalPTP4A2 
TCGA Data PortalPTP4A2 
Broad Tumor PortalPTP4A2
OASIS PortalPTP4A2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTP4A2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTP4A2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTP4A2
DgiDB (Drug Gene Interaction Database)PTP4A2
DoCM (Curated mutations)PTP4A2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTP4A2 (select a term)
intoGenPTP4A2
Cancer3DPTP4A2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601584   
Orphanet
MedgenPTP4A2
Genetic Testing Registry PTP4A2
NextProtQ12974 [Medical]
TSGene8073
GENETestsPTP4A2
Huge Navigator PTP4A2 [HugePedia]
snp3D : Map Gene to Disease8073
BioCentury BCIQPTP4A2
ClinGenPTP4A2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8073
Chemical/Pharm GKB GenePA33978
Clinical trialPTP4A2
Miscellaneous
canSAR (ICR)PTP4A2 (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTP4A2
EVEXPTP4A2
GoPubMedPTP4A2
iHOPPTP4A2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:33:28 CEST 2017

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