PTP4A3 (protein tyrosine phosphatase 4A3)

2003-02-01  

Identity

HGNC
PTP4A3
LOCATION
8q24.3
LOCUSID
11156
ALIAS
PRL-3,PRL-R,PRL3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11156
MIM: 606449
HGNC: 9636
Ensembl: ENSG00000184489

Variants:

dbSNP: 11156
ClinVar: 11156
TCGA: ENSG00000184489
COSMIC: PTP4A3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184489ENST00000329397O75365
ENSG00000184489ENST00000349124O75365
ENSG00000184489ENST00000520105O75365
ENSG00000184489ENST00000521578O75365
ENSG00000184489ENST00000523147E5RGR3
ENSG00000184489ENST00000524028E5RFQ4

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
115982672001A phosphatase associated with metastasis of colorectal cancer.176
206093522010PCBP1 suppresses the translation of metastasis-associated PRL-3 phosphatase.69
146545422003PRL-3 expression in metastatic cancers.58
155341082004High expression of PRL-3 promotes cancer cell motility and liver metastasis in human colorectal cancer: a predictive molecular marker of metachronous liver and lung metastases.50
224697862012miR-495 and miR-551a inhibit the migration and invasion of human gastric cancer cells by directly interacting with PRL-3.48
224139912013Molecular mechanisms of the PRL phosphatases.47
162037712005PRL-3 phosphatase is implicated in ovarian cancer growth.46
151616392004Phosphatase of regenerating liver-3 promotes motility and metastasis of mouse melanoma cells.45
168324102006Expression and prognostic impact of the protein tyrosine phosphatases PRL-1, PRL-2, and PRL-3 in breast cancer.37
179340702008Overexpression and involvement in migration by the metastasis-associated phosphatase PRL-3 in human myeloma cells.36

Citation

Dessen P

PTP4A3 (protein tyrosine phosphatase 4A3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41908/ptp4a3