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PTPMT1 (protein tyrosine phosphatase, mitochondrial 1)

Identity

Alias_symbol (synonym)PLIP
DUSP23
MOSP
Other aliasPNAS-129
HGNC (Hugo) PTPMT1
LocusID (NCBI) 114971
Atlas_Id 53737
Location 11p11.2  [Link to chromosome band 11p11]
Location_base_pair Starts at 47586982 and ends at 47595013 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
KDM5C (Xp11.22) / PTPMT1 (11p11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PTPMT1   26965
Cards
Entrez_Gene (NCBI)PTPMT1  114971  protein tyrosine phosphatase, mitochondrial 1
AliasesDUSP23; MOSP; PLIP; PNAS-129
GeneCards (Weizmann)PTPMT1
Ensembl hg19 (Hinxton)ENSG00000110536 [Gene_View]  chr11:47586982-47595013 [Contig_View]  PTPMT1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000110536 [Gene_View]  chr11:47586982-47595013 [Contig_View]  PTPMT1 [Vega]
ICGC DataPortalENSG00000110536
TCGA cBioPortalPTPMT1
AceView (NCBI)PTPMT1
Genatlas (Paris)PTPMT1
WikiGenes114971
SOURCE (Princeton)PTPMT1
Genetics Home Reference (NIH)PTPMT1
Genomic and cartography
GoldenPath hg19 (UCSC)PTPMT1  -     chr11:47586982-47595013 +  11p11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PTPMT1  -     11p11.2   [Description]    (hg38-Dec_2013)
EnsemblPTPMT1 - 11p11.2 [CytoView hg19]  PTPMT1 - 11p11.2 [CytoView hg38]
Mapping of homologs : NCBIPTPMT1 [Mapview hg19]  PTPMT1 [Mapview hg38]
OMIM609538   
Gene and transcription
Genbank (Entrez)AF277187 AK294640 AY333987 BC014048 BC018974
RefSeq transcript (Entrez)NM_001143984 NM_175732
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_009237 NW_004929378
Consensus coding sequences : CCDS (NCBI)PTPMT1
Cluster EST : UnigeneHs.742231 [ NCBI ]
CGAP (NCI)Hs.742231
Alternative Splicing GalleryENSG00000110536
Gene ExpressionPTPMT1 [ NCBI-GEO ]   PTPMT1 [ EBI - ARRAY_EXPRESS ]   PTPMT1 [ SEEK ]   PTPMT1 [ MEM ]
Gene Expression Viewer (FireBrowse)PTPMT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)114971
GTEX Portal (Tissue expression)PTPMT1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WUK0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WUK0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WUK0
Splice isoforms : SwissVarQ8WUK0
Catalytic activity : Enzyme3.1.3.27 [ Enzyme-Expasy ]   3.1.3.273.1.3.27 [ IntEnz-EBI ]   3.1.3.27 [ BRENDA ]   3.1.3.27 [ KEGG ]   
PhosPhoSitePlusQ8WUK0
Domaine pattern : Prosite (Expaxy)TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)   
Domains : Interpro (EBI)Dual-sp_phosphatase_cat-dom    DUSP    Prot-tyrosine_phosphatase-like    Tyr_Pase_AS    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)DSPc (PF00782)   
Domain families : Pfam (NCBI)pfam00782   
Conserved Domain (NCBI)PTPMT1
DMDM Disease mutations114971
Blocks (Seattle)PTPMT1
SuperfamilyQ8WUK0
Human Protein AtlasENSG00000110536
Peptide AtlasQ8WUK0
IPIIPI00174190   IPI00647467   IPI00983086   IPI00921066   
Protein Interaction databases
DIP (DOE-UCLA)Q8WUK0
IntAct (EBI)Q8WUK0
FunCoupENSG00000110536
BioGRIDPTPMT1
STRING (EMBL)PTPMT1
ZODIACPTPMT1
Ontologies - Pathways
QuickGOQ8WUK0
Ontology : AmiGOphosphatidylinositol-4,5-bisphosphate 5-phosphatase activity  protein tyrosine phosphatase activity  protein binding  nucleus  mitochondrion  protein tyrosine/serine/threonine phosphatase activity  phosphatidylglycerophosphatase activity  integral component of mitochondrial inner membrane  cardiolipin biosynthetic process  peptidyl-tyrosine dephosphorylation  
Ontology : EGO-EBIphosphatidylinositol-4,5-bisphosphate 5-phosphatase activity  protein tyrosine phosphatase activity  protein binding  nucleus  mitochondrion  protein tyrosine/serine/threonine phosphatase activity  phosphatidylglycerophosphatase activity  integral component of mitochondrial inner membrane  cardiolipin biosynthetic process  peptidyl-tyrosine dephosphorylation  
NDEx NetworkPTPMT1
Atlas of Cancer Signalling NetworkPTPMT1
Wikipedia pathwaysPTPMT1
Orthology - Evolution
OrthoDB114971
GeneTree (enSembl)ENSG00000110536
Phylogenetic Trees/Animal Genes : TreeFamPTPMT1
HOVERGENQ8WUK0
HOGENOMQ8WUK0
Homologs : HomoloGenePTPMT1
Homology/Alignments : Family Browser (UCSC)PTPMT1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTPMT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTPMT1
dbVarPTPMT1
ClinVarPTPMT1
1000_GenomesPTPMT1 
Exome Variant ServerPTPMT1
ExAC (Exome Aggregation Consortium)PTPMT1 (select the gene name)
Genetic variants : HAPMAP114971
Genomic Variants (DGV)PTPMT1 [DGVbeta]
DECIPHER (Syndromes)11:47586982-47595013  ENSG00000110536
CONAN: Copy Number AnalysisPTPMT1 
Mutations
ICGC Data PortalPTPMT1 
TCGA Data PortalPTPMT1 
Broad Tumor PortalPTPMT1
OASIS PortalPTPMT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTPMT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTPMT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch PTPMT1
DgiDB (Drug Gene Interaction Database)PTPMT1
DoCM (Curated mutations)PTPMT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTPMT1 (select a term)
intoGenPTPMT1
Cancer3DPTPMT1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609538   
Orphanet
MedgenPTPMT1
Genetic Testing Registry PTPMT1
NextProtQ8WUK0 [Medical]
TSGene114971
GENETestsPTPMT1
Huge Navigator PTPMT1 [HugePedia]
snp3D : Map Gene to Disease114971
BioCentury BCIQPTPMT1
ClinGenPTPMT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD114971
Chemical/Pharm GKB GenePA142671115
Clinical trialPTPMT1
Miscellaneous
canSAR (ICR)PTPMT1 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTPMT1
EVEXPTPMT1
GoPubMedPTPMT1
iHOPPTPMT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:16:12 CEST 2017

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