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PTPN12 (protein tyrosine phosphatase, non-receptor type 12)

Identity

Other namesPTP-PEST
PTPG1
HGNC (Hugo) PTPN12
LocusID (NCBI) 5782
Location 7q11.23
Location_base_pair Starts at 77167352 and ends at 77269388 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PTPN12   9645
Entrez_Gene (NCBI)PTPN12  5782  protein tyrosine phosphatase, non-receptor type 12
Cards
GeneCards (Weizmann)PTPN12
Ensembl (Hinxton)ENSG00000127947 [Gene_View]  chr7:77167352-77269388 [Contig_View]  PTPN12 [Vega]
AceView (NCBI)PTPN12
Genatlas (Paris)PTPN12
SOURCE (Stanford)NM_001131008 NM_001131009 NM_002835
Genomic and cartography
GoldenPath (UCSC)PTPN12  -  7q11.23   chr7:77167352-77269388 +  7q11.23   [Description]    (hg19-Feb_2009)
EnsemblPTPN12 - 7q11.23 [CytoView]
Mapping of homologs : NCBIPTPN12 [Mapview]
OMIM600079   
Gene and transcription
Genbank (Entrez)AB209524 AK289573 AK296764 AK303602 AK314236
RefSeq transcript (SRS)NM_001131008 NM_001131009 NM_002835
RefSeq transcript (Entrez)NM_001131008 NM_001131009 NM_002835
RefSeq genomic (SRS)AC_000068 AC_000139 NC_000007 NC_018918 NG_008394 NT_007933 NT_079595 NW_001839063 NW_004078032
RefSeq genomic (Entrez)AC_000068 AC_000139 NC_000007 NC_018918 NG_008394 NT_007933 NT_079595 NW_001839063 NW_004078032
Consensus coding sequences : CCDS (NCBI)PTPN12
Cluster EST : UnigeneHs.61812 [ SRS ] Hs.61812 [ NCBI ]
CGAP (NCI)Hs.61812
Alternative Splicing : Fast-db (Paris)GSHG0027476
Alternative Splicing GalleryENSG00000127947
Gene ExpressionPTPN12 [ NCBI-GEO ]   PTPN12 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ05209 (SRS) Q05209 (Uniprot)
NextProtQ05209
With graphics : InterProQ05209
Splice isoforms : SwissVarQ05209(Swissvar)
Domaine pattern : Prosite (SRS)TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domaine pattern : Prosite (Expaxy)TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (SRS)Ptpn_12    Tyr/Dual-sp_Pase    Tyr_Pase_AS    Tyr_Pase_rcpt/non-rcpt   
Domains : Interpro (EBI)Ptpn_12    Tyr/Dual-sp_Pase    Tyr_Pase_AS    Tyr_Pase_rcpt/non-rcpt   
Related proteins : CluSTrQ05209
Domain families : Pfam (SRS)Y_phosphatase (PF00102)   
Domain families : Pfam (Sanger)Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam00102   
Domain families : Smart (EMBL)PTPc (SM00194)  
DMDM5782
Blocks (Seattle)Q05209
Human Protein AtlasENSG00000127947
HPRD02513
IPIIPI00289082   IPI00925973   IPI00816374   IPI00816298   IPI00973179   IPI00908446   IPI00926813   IPI00926563   IPI00926188   IPI00985478   IPI00981014   IPI00911100   
Protein Interaction databases
DIP (DOE-UCLA)Q05209
IntAct (EBI)Q05209
FunCoupENSG00000127947
REACTOMEPTPN12
Protein Interaction Database5782
BioGRIDPTPN12
InParanoidQ05209
Interologous Interaction database Q05209
IntegromeDBPTPN12
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PTPN12
SNP (GeneSNP Utah)PTPN12
SNP : HGBasePTPN12
Genetic variants : HAPMAPPTPN12
Somatic Mutations in Cancer : COSMICPTPN12 
CONAN: Copy Number AnalysisPTPN12 
Mutations and Diseases : HGMDPTPN12
OMIM600079   
GENETests600079   
Disease Genetic AssociationPTPN12
Huge Navigator PTPN12 [HugePedia]  PTPN12 [HugeCancerGEM]
Genomic VariantsPTPN12  PTPN12 [DGVbeta]
ClinVarPTPN12
snp3D : Map Gene to Disease5782
General knowledge
Homologs : HomoloGenePTPN12
Homology/Alignments : Family Browser (UCSC)PTPN12
Phylogenetic Trees/Animal Genes : TreeFamPTPN12
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.48 [ Enzyme-SRS ]   3.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   
Chemical/Protein Interactions : CTD5782
Chemical/Pharm GKB GenePA33987
Clinical trialPTPN12
Cancer Resource (Charite)ENSG00000127947
Ontology : AmiGOpodosome  non-membrane spanning protein tyrosine phosphatase activity  protein binding  cytoplasm  cytosol  plasma membrane  protein dephosphorylation  SH3 domain binding  cell junction  cell projection  
Ontology : EGO-EBIpodosome  non-membrane spanning protein tyrosine phosphatase activity  protein binding  cytoplasm  cytosol  plasma membrane  protein dephosphorylation  SH3 domain binding  cell junction  cell projection  
Other databases
Probes
Litterature
PubMed72 Pubmed reference(s) in Entrez
PubGenePTPN12
iHOPPTPN12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 14 17:55:39 CEST 2013
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