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PTPN13 (Protein tyrosine phosphatase, non-receptor type 13)

Written2008-09Alessandro Beghini
University of Milan, Medical Faculty, Department of Biology, Genetics for Medical Sciences, via Viotti 5, 20133-Milan, Italy

(Note : for Links provided by Atlas : click)


Alias (NCBI)DKFZp686J1497
HGNC (Hugo) PTPN13
HGNC Alias symbPTP1E
HGNC Alias nameAPO-1/CD95 (Fas)-associated phosphatase
HGNC Previous nameprotein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
LocusID (NCBI) 5783
Atlas_Id 41912
Location 4q21.3  [Link to chromosome band 4q21]
Location_base_pair Starts at 86594315 and ends at 86815175 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping PTPN13.png]
  Genomic view
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AFF1 (4q21.3)::PTPN13 (4q21.3)LRRC61 (7q36.1)::PTPN13 (4q21.3)MARCH1 (4q32.2)::PTPN13 (4q21.3)
PTPN13 (4q21.3)::PTPN13 (4q21.3)PTPN13 (4q21.3)::TUBA1A (12q13.12)TMEM63A (1q42.12)::PTPN13 (4q21.3)
TUBA1A (12q13.12)::PTPN13 (4q21.3)
Note Genomic context : PTPN13 lies in a head-to-head conformation with MAPK10/JNK3 and they share a 633bp bi-directional promoter which is a typical CpG island.


Description The gene covers 220.87 kb (from 87734485 to 87955350-NCBI) and contains 48 exons and 51 different introns (49 gt-ag, 2 gc-ag), initiates transcription within exon 2 and terminates in exon 48.
Transcription Transcription produces 13 different mRNAs, 9 alternatively spliced variants and 4 unspliced forms. RefSeq annotates 4 representative transcripts, but Homo sapiens cDNA sequences in GenBank support at least 9 spliced variants.


Description The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as IkappaBalpha through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway. Eight spliced and the unspliced mRNAs putatively encode good proteins.
  Schematic representation of PTPN13 structure and boxes represent functional domains. The KIND domain has been identified in silico by sequence homology.
Expression In all human normal tissues, including lymph node and peripheral blood mononuclear cells samples, PTPN13 is ubiquitously expressed.
Localisation The FERM domain binds to phosphatidylinositol 4,5-biphosphate leading to the enrichment of PTPN13 at a juxtamembrane localization. However, the PTPN13 protein is also detected throughout the cytoplasm. In HeLa cells, PTPN13 localizes to the centrosomes during metaphase.
Function Functionally, the gene has been tested for association to diseases (Bone Neoplasms; Carcinoma; Colorectal Neoplasms; Liver Neoplasms; lymphoma; Sarcoma, Ewing's ), proposed to participate in a pathway (FAS signaling pathway ( CD95 )) and a process (protein amino acid dephosphorylation). Proteins are expected to have molecular functions (non-membrane spanning protein tyrosine phosphatase activity, hydrolase activity, protein binding, structural molecule activity) and to localize in various compartments (nucleus, cytoplasm, cytoskeleton).


Note Different somatic mutations was identified in colorectal tumors (19% of the colorectal cancer samples analyzed), predicted to result in missense or non-sense mutations. Some of these mutant proteins led to reduce phosphatase activity.
  Distribution of mutations in PTPN13, black arrows indicate location of missense mutations, red arrows indicate location of nonsense mutations or frameshifts.

Implicated in

Entity Colorectal cancers
Disease A large-scale study that looked at the mutations in the tyrosine phosphatome from colorectal cancers identified PTPN13. The authors identified 19 mutations, non-sense and missense, seven of which were in the PTP domain.
Entity Lymphomas (Hodgkin and non-Hodgkin), gastric and hepatocellular tumors
Disease Hypermethylation of the PTPN13 promoter or allelic loss was observed leading to downregulation of PTPN13 mRNA.

To be noted

Several evidences suggest that PTPN13 may act differently as a tumor promoting gene depending upon the disease context. The modulation of Fas-mediated cell death by PTPN13 could enhance tumor growth by blocking death signaling.


PTPL1: a large phosphatase with a split personality.
Abaan OD, Toretsky JA.
Cancer Metastasis Rev. 2008 Jun; 27(2): 205-214. (Review)
PMID 18265946
A novel protein-tyrosine phosphatase with homology to both the cytoskeletal proteins of the band 4.1 family and junction-associated guanylate kinases.
Banville D, Ahmad S, Stocco R, Shen SH.
J. Biol. Chem. 1994; 269: 22320-22327.
PMID 8071359
PTPN13, a Fas-associated protein tyrosine phosphatase, is located on the long arm of chromosome 4 at band q21.3.
Inazawa J, Ariyama T, Abe T, Druck T, Ohta M, Huebner K, Yanagisawa J, Reed JC, Sato T.
Genomics 1996; 31: 240-242.
PMID 8824809
Molecular cloning of a novel protein-tyrosine phosphatase containing a membrane-binding domain and GLGF repeats.
Maekawa K, Imagawa N, Nagamatsu M, Harada S.
FEBS Lett. 1994; 337: 200-206.
PMID 8287977
Cloning and characterization of PTPL1, a protein tyrosine phosphatase with similarities to cytoskeletal-associated proteins.
Saras J, Claesson-Welsh L, Heldin CH, Gonez LJ.
J. Biol. Chem. 1994; 269: 24082-24089.
PMID 7929060
Mutational analysis of the tyrosine phosphatome in colorectal cancers.
Wang Z, Shen D, Parsons DW, Bardelli A, Sager J, Szabo S, Ptak J, Silliman N, Peters BA, van der Heijden MS, Parmigiani G, Yan H, Wang TL, Riggins G, Powell SM, Willson JKV, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE.
Science 2004; 304: 1164-1166.
PMID 15155950
Genetic characterization of fas-associated phosphatase-1 as a putative tumor suppressor gene on chromosome 4q21.3 in hepatocellular carcinoma.
Yeh SH, Wu DC, Tsai CY, Kuo TJ, Yu WC, Chang YS, Chen CL, Chang CF, Chen DS, Chen PJ.
Clin Cancer Res. 2006 Feb 15; 12(4): 1097-1108.
PMID 16489062
Epigenetic disruption of two proapoptotic genes MAPK10/JNK3 and PTPN13/FAP-1 in multiple lymphomas and carcinomas through hypermethylation of a common bidirectional promoter.
Ying J, Li H, Cui Y, Wong AH, Langford C, Tao Q.
Leukemia. 2006 Jun; 20(6): 1173-1175.
PMID 16572203
Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1) and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and seven polymorphisms of the FAP-1 gene.
Yoshida S, Harada H, Nagai H, Fukino K, Teramoto A, Emi M.
J. Hum. Genet. 2002; 47: 614-619.
PMID 12436199
The gene (PTPN13) encoding the protein tyrosine phosphatase PTP-BL/PTP-BAS is located in mouse chromosome region 5E/F and human chromosome region 4q21.
van den Maagdenberg AM, Olde Weghuis D, Rijss J, Merkx GF, Wieringa B, Geurts van Kessel A, Hendriks WJ.
Cytogenet. Cell Genet. 1996; 74: 153-155.
PMID 8893825


This paper should be referenced as such :
Beghini, A
PTPN13 (Protein tyrosine phosphatase, non-receptor type 13)
Atlas Genet Cytogenet Oncol Haematol. 2009;13(8):573-575.
Free journal version : [ pdf ]   [ DOI ]

External links

HGNC (Hugo)PTPN13   9646
Entrez_Gene (NCBI)PTPN13    protein tyrosine phosphatase non-receptor type 13
AliasesFAP-1; PNP1; PTP-BAS; PTP-BL; 
GeneCards (Weizmann)PTPN13
Ensembl hg19 (Hinxton)ENSG00000163629 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163629 [Gene_View]  ENSG00000163629 [Sequence]  chr4:86594315-86815175 [Contig_View]  PTPN13 [Vega]
ICGC DataPortalENSG00000163629
TCGA cBioPortalPTPN13
AceView (NCBI)PTPN13
Genatlas (Paris)PTPN13
SOURCE (Princeton)PTPN13
Genetics Home Reference (NIH)PTPN13
Genomic and cartography
GoldenPath hg38 (UCSC)PTPN13  -     chr4:86594315-86815175 +  4q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTPN13  -     4q21.3   [Description]    (hg19-Feb_2009)
GoldenPathPTPN13 - 4q21.3 [CytoView hg19]  PTPN13 - 4q21.3 [CytoView hg38]
Genome Data Viewer NCBIPTPN13 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AB208904 AF233323 AK056151 BC039610 BC139915
RefSeq transcript (Entrez)NM_006264 NM_080683 NM_080684 NM_080685
Consensus coding sequences : CCDS (NCBI)PTPN13
Gene ExpressionPTPN13 [ NCBI-GEO ]   PTPN13 [ EBI - ARRAY_EXPRESS ]   PTPN13 [ SEEK ]   PTPN13 [ MEM ]
Gene Expression Viewer (FireBrowse)PTPN13 [ Firebrowse - Broad ]
GenevisibleExpression of PTPN13 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5783
GTEX Portal (Tissue expression)PTPN13
Human Protein AtlasENSG00000163629-PTPN13 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)PTPN13
Human Protein Atlas [tissue]ENSG00000163629-PTPN13 [tissue]
Protein Interaction databases
Ontologies - Pathways
PubMed137 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Oct 8 21:26:09 CEST 2021

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