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PTPN14 (protein tyrosine phosphatase, non-receptor type 14)

Written2013-01Nicholas Hauschild, Leila Belle, Yeesim Khew-Goodall
Centre for Cancer Biology, SA Pathology, Adelaide, Australia

(Note : for Links provided by Atlas : click)


HGNC (Hugo) PTPN14
HGNC Alias symbPEZ
LocusID (NCBI) 5784
Atlas_Id 41913
Location 1q41  [Link to chromosome band 1q41]
Location_base_pair Starts at 214348702 and ends at 214551602 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping PTPN14.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MCCC1 (3q27.1)::PTPN14 (1q41)PCNX2 (1q42.2)::PTPN14 (1q32.3)PCNX2 (1q42.2)::PTPN14 (1q41)
PEX14 (1p36.22)::PTPN14 (1q41)PTPN14 (1q32.3)::ANKRD44 (2q33.1)PTPN14 (1q41)::ANKRD44 (2q33.1)
PTPN14 (1q41)::NLRP11 (19q13.42)PTPN14 (1q41)::PTPN14 (1q41)ZCCHC4 (4p15.2)::PTPN14 (1q41)


  Genomic and transcript structure of human PTPN14. A. The genomic arrangement of PTPN14 with vertical bars depicting the location and relative size of exons. Space between exons depicts relative sizes of introns/non-coding regions. B. The mature transcript arrangement of PTPN14. Exons are numbered and coding regions are depicted in light brown, with non-coding regions depicted in red. C. PTPN14 exon length and coding status.
Description The PTPN14 gene consists of 19 exons and 21 introns divided over 203 kb, including a coding region and 5' and 3' non-coding regions.
Transcription The PTPN14 transcript is processed into a mature mRNA in excess of 10 kb, estimated by Northern blot analysis (Smith et al., 1995). The mature transcript has a 3561 nucleotide open reading frame and ~9,2 kb 3' UTR followed by a polyadenylation site. No transcript variants have been identified.
Little investigation has been undertaken to elucidate the factors regulating PTPN14 transcription. However, real-time PCR and ChIP sequencing have shown that p63 induces PTPN14 expression by binding to a p63 consensus sequence within intron 3 of PTPN14 (Perez et al., 2007).


  Protein structure of PTPN14. A schematic of PTPN14 protein highlighting putative nuclear / mitochondrial localisation signals (red/grey box), the band 4.1 ezrin, radixin, meosin (FERM) homology domain (red), and the tyrosine-phosphatase (PTP) catalytic domain (blue). The linker region also contains an acidic region as well as two PPxY motifs.
Description PTPN14 is an 1187 amino acid non-receptor protein tyrosine phosphatase of approximately 135 kDa. It possesses an N-terminal FERM (band 4.1, ezrin, radixin, moesin homology) domain and C-terminal catalytic domain, as well as acidic and proline-rich regions in its central uncharacterised region (Smith et al., 1995).
FERM domain: the FERM domain has been shown in other proteins to be important for cytoskeletal association; however a role for the FERM domain in the PTPN14 protein has yet to be described.
Catalytic PTP domain: the crystal structure of the PTPN14 catalytic C-terminal PTP domain has been solved (Barr et al., 2006).
PPxY motifs: Pez contains two PPxY motifs in its central region. These motifs are known to facilitate binding to proteins containing WW domains. Indeed, both PPxY motifs in PTPN14 are critical for binding KIBRA and YAP, components of the Hippo signalling pathway that contain WW domains (Liu et al., 2013; Poernbacher et al., 2012).
Mitochondrial localisation signal: PTPN14 contains a putative mitochondrial localisation signal (MitoProt II), and may be localised to mitochondria in some cell types (Chao et al., 2011).
  Expression of PTPN14.
Localisation PTPN14 protein has been reported to localise to adherens junctions in confluent human umbilical vein endothelial cells (HUVEC) and translocate to the nucleus in sub-confluent, proliferating HUVEC (Wadham et al., 2000; Wadham et al., 2003). Localisation to the golgi apparatus in epithelial cell types (Wyatt and Khew-Goodall, 2008) and mitochondria in human sperm has also been reported (Chao et al., 2011).
Function PTPN14 intracellular signaling pathways/processes
Adherens junction integrity: PTPN14 protein has been reported to dephosphorylate the adherens junction protein beta-catenin. Over-expression of a dominant-negative form of PTPN14 caused an increase in phosphorylation at adherens junctions (Wadham et al., 2003), an event linked to adherence junction destabilisation.
TGF-β: PTPN14 promotes epithelial-mesenchymal transition (EMT) via increased TGF-beta production in MDCK epithelial cells (Wyatt et al., 2007)
Lymphangiogenesis: PTPN14 forms a complex with VEGFR3 and is required for normal lymphangiogenesis in human and mouse models (Au et al., 2010).
Hippo signalling: PTPN14 has been shown to interact with Kibra/WWC1 (Poernbacher et al., 2012; Wang et al., 2012) and YAP (Liu et al., 2013; Huang et al., 2012; Wang et al., 2012), two members of the Hippo signalling pathway. In Drosophila, PTPN14 interacts with Kibra via a PPxY:WW domain interaction, to negatively regulate the transcriptional activity of the downstream effector Yorkie, resulting in a decrease in intestinal stem cell proliferation (Poernbacher et al., 2012). Pez interacts with YAP (the mammalian homolog of Drosophila Yorkie), also via a PPxY:WW domain interaction, and regulates its activity by controlling YAP cytoplasmic retention (resulting in a loss of transcription of YAP target genes) (Liu et al., 2013, Huang et al., 2012, Wang et al., 2012).
Mast cell degranulation: PTPN14 siRNA mediated knock-down in mast cells caused a decrease in IgE dependent mast cell degranulation (Zhang et al., 2010).
Homology PTPN14 belongs to a FERM domain-containing family of non-receptor protein tyrosine phosphatases including PTPN3 (PTPH1), PTPN4 (PTP-MEG1), PTPN13 (PTP-BAS / FAP-1) and PTPN21 (PTPD2). PTPN14 displays a higher degree of homology to PTPN21 than other members of this sub-family (Smith et al., 1995; Alonso et al., 2004).


Germinal A deletion in PTPN14 has been described in a kindred with inherited lymphedema-choanal atresia syndrome, characterised by defects in lymphatic vasculature (Au et al., 2010).
Somatic Missense mutations in PTPN14 have been reported in sporadic human colorectal cancers (Wang et al., 2004), breast cancers (Sjöblom et al., 2006), and HCV-associated hepatocellular carcinoma (Li et al., 2011).

Implicated in

Entity Various cancers
Note Several studies have identified mutations associated with PTPN14 in colorectal (Wang et al., 2004), breast (Sjöblom et al., 2006) and liver cancers (Li et al., 2011), although the functional consequences of these mutations are yet to be determined.
Entity Colorectal cancer
Note PTPN14 has been shown to interact with and de-phosphorylate residue Y128 of p130 Crk-associated substrate (p130Cas) in colorectal cancer cells (CRC) (Zhang et al., 2012). CRC homozygous for a non-phosphorylatable Y128F mutant form of p130Cas display a reduction in migration,anchorage-independent growth and xenograft tumor growth in nude mice, suggesting that Pez, via p130Cas Y128 dephosphorylation, may function as a tumour suppressor in colorectal cancer.
Entity Pancreatic cancer
Note PTPN14 expression was found to be lower in liver metastases compared to primary tumours in an orthotopic transplantation model of pancreatic adenocarcinoma (Niedergethmann et al., 2007), implicating PTPN14 as a suppressor of metastasis in this model.
Entity Epithelial-mesenchymal transition
Note Over-expression of PTPN14 in epithelial cells (MDCK) resulted in increased TGF-beta secretion and subsequent induction of epithelial-mesenchymal transition (EMT) (Wyatt et al., 2007).
Entity Sperm motility
Note PTPN14 expression in human sperm was correlated with motility, where moderate-motility sperm had less PTPN14 expression than highly-motile sperm (Chao et al., 2011).
Entity Lymphedema-choanal atresia syndrome
Note Analyses of a kindred with autosomal-recessive lyphedema-choanal atresia syndrome showed a loss of function mutation in PTPN14. PTPN14-/- mice developed lymphatic hyperplasia with lymphedema. PTPN14 was also shown to interact with VEGFR3, a signalling receptor essential to lymphangiogenesis (Au et al., 2010).
Entity Hereditary haemorrhagic telangiectasia
Note PTPN14 maps to a chromosomal region that modifies the penetrance of a vascular dysgenesis phenotype in Tgfb1-/- mice, and can modulate angiogenesis in 3D primary endothelial cell culture (Benzinou et al., 2012), suggesting that Pez contributes to angiogenesis, possibly an interaction with the TGF-beta signalling pathway.


Protein tyrosine phosphatases in the human genome.
Alonso A, Sasin J, Bottini N, Friedberg I, Friedberg I, Osterman A, Godzik A, Hunter T, Dixon J, Mustelin T.
Cell. 2004 Jun 11;117(6):699-711.
PMID 15186772
Protein tyrosine phosphatase PTPN14 is a regulator of lymphatic function and choanal development in humans.
Au AC, Hernandez PA, Lieber E, Nadroo AM, Shen YM, Kelley KA, Gelb BD, Diaz GA.
Am J Hum Genet. 2010 Sep 10;87(3):436-44. doi: 10.1016/j.ajhg.2010.08.008.
PMID 20826270
Crystal structure of human protein tyrosine phosphatase 14 (PTPN14) at 1.65-A resolution.
Barr AJ, Debreczeni JE, Eswaran J, Knapp S.
Proteins. 2006 Jun 1;63(4):1132-6.
PMID 16534812
Mouse and human strategies identify PTPN14 as a modifier of angiogenesis and hereditary haemorrhagic telangiectasia.
Benzinou M, Clermont FF, Letteboer TG, Kim JH, Espejel S, Harradine KA, Arbelaez J, Luu MT, Roy R, Quigley D, Higgins MN, Zaid M, Aouizerat BE, van Amstel JK, Giraud S, Dupuis-Girod S, Lesca G, Plauchu H, Hughes CC, Westermann CJ, Akhurst RJ.
Nat Commun. 2012 Jan 10;3:616. doi: 10.1038/ncomms1633.
PMID 22233626
Protein tyrosine phosphatase non-receptor type 14 is a novel sperm-motility biomarker.
Chao HC, Chung CL, Pan HA, Liao PC, Kuo PL, Hsu CC.
J Assist Reprod Genet. 2011 Sep;28(9):851-61. doi: 10.1007/s10815-011-9602-0. Epub 2011 Jun 24.
PMID 21701840
Computational method to predict mitochondrially imported proteins and their targeting sequences.
Claros MG, Vincens P.
Eur J Biochem. 1996 Nov 1;241(3):779-86.
PMID 8944766
YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the non-receptor type protein tyrosine phosphatase 14.
Huang JM, Nagatomo I, Suzuki E, Mizuno T, Kumagai T, Berezov A, Zhang H, Karlan B, Greene MI, Wang Q.
Oncogene. 2012 Jun 11. doi: 10.1038/onc.2012.231. [Epub ahead of print]
PMID 22689061
Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma.
Li M, Zhao H, Zhang X, Wood LD, Anders RA, Choti MA, Pawlik TM, Daniel HD, Kannangai R, Offerhaus GJ, Velculescu VE, Wang L, Zhou S, Vogelstein B, Hruban RH, Papadopoulos N, Cai J, Torbenson MS, Kinzler KW.
Nat Genet. 2011 Aug 7;43(9):828-9. doi: 10.1038/ng.903.
PMID 21822264
PTPN14 interacts with and negatively regulates the oncogenic function of YAP.
Liu X, Yang N, Figel SA, Wilson KE, Morrison CD, Gelman IH, Zhang J.
Oncogene. 2013 Mar 7;32(10):1266-73. doi: 10.1038/onc.2012.147. Epub 2012 Apr 23.
PMID 22525271
Gene expression profiling of liver metastases and tumour invasion in pancreatic cancer using an orthotopic SCID mouse model.
Niedergethmann M, Alves F, Neff JK, Heidrich B, Aramin N, Li L, Pilarsky C, Grutzmann R, Allgayer H, Post S, Gretz N.
Br J Cancer. 2007 Nov 19;97(10):1432-40. Epub 2007 Oct 16.
PMID 17940512
p63 consensus DNA-binding site: identification, analysis and application into a p63MH algorithm.
Perez CA, Ott J, Mays DJ, Pietenpol JA.
Oncogene. 2007 Nov 15;26(52):7363-70. Epub 2007 Jun 11.
PMID 17563751
Drosophila Pez acts in Hippo signaling to restrict intestinal stem cell proliferation.
Poernbacher I, Baumgartner R, Marada SK, Edwards K, Stocker H.
Curr Biol. 2012 Mar 6;22(5):389-96. doi: 10.1016/j.cub.2012.01.019. Epub 2012 Feb 2.
PMID 22305752
The consensus coding sequences of human breast and colorectal cancers.
Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE.
Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7.
PMID 16959974
Pez: a novel human cDNA encoding protein tyrosine phosphatase- and ezrin-like domains.
Smith AL, Mitchell PJ, Shipley J, Gusterson BA, Rogers MV, Crompton MR.
Biochem Biophys Res Commun. 1995 Apr 26;209(3):959-65.
PMID 7733990
The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin.
Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y.
Mol Biol Cell. 2003 Jun;14(6):2520-9. Epub 2003 Feb 6.
PMID 12808048
PTPN14 is required for the density-dependent control of YAP1.
Wang W, Huang J, Wang X, Yuan J, Li X, Feng L, Park JI, Chen J.
Genes Dev. 2012 Sep 1;26(17):1959-71. doi: 10.1101/gad.192955.112.
PMID 22948661
Mutational analysis of the tyrosine phosphatome in colorectal cancers.
Wang Z, Shen D, Parsons DW, Bardelli A, Sager J, Szabo S, Ptak J, Silliman N, Peters BA, van der Heijden MS, Parmigiani G, Yan H, Wang TL, Riggins G, Powell SM, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE.
Science. 2004 May 21;304(5674):1164-6.
PMID 15155950
PTP-Pez: a novel regulator of TGFbeta signaling.
Wyatt L, Khew-Goodall Y.
Cell Cycle. 2008 Aug;7(15):2290-5. Epub 2008 Jun 17.
PMID 18677119
The protein tyrosine phosphatase Pez regulates TGFbeta, epithelial-mesenchymal transition, and organ development.
Wyatt L, Wadham C, Crocker LA, Lardelli M, Khew-Goodall Y.
J Cell Biol. 2007 Sep 24;178(7):1223-35.
PMID 17893246
Small interfering RNA screen for phosphatases involved in IgE-mediated mast cell degranulation.
Zhang J, Mendoza M, Guiraldelli MF, Barbu EA, Siraganian RP.
J Immunol. 2010 Jun 15;184(12):7178-85. doi: 10.4049/jimmunol.0904169. Epub 2010 May 7.
PMID 20483767
Identification and functional characterization of p130Cas as a substrate of protein tyrosine phosphatase nonreceptor 14.
Zhang P, Guo A, Possemato A, Wang C, Beard L, Carlin C, Markowitz SD, Polakiewicz RD, Wang Z.
Oncogene. 2012 Jun 18. doi: 10.1038/onc.2012.220. [Epub ahead of print]
PMID 22710723


This paper should be referenced as such :
Hauschild, N ; Belle, L ; Khew-Goodall, Y
PTPN14 (protein tyrosine phosphatase, non-receptor type 14)
Atlas Genet Cytogenet Oncol Haematol. 2013;17(7):462-466.
Free journal version : [ pdf ]   [ DOI ]

External links


HGNC (Hugo)PTPN14   9647
Entrez_Gene (NCBI)PTPN14    protein tyrosine phosphatase non-receptor type 14
GeneCards (Weizmann)PTPN14
Ensembl hg19 (Hinxton)ENSG00000152104 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000152104 [Gene_View]  ENSG00000152104 [Sequence]  chr1:214348702-214551602 [Contig_View]  PTPN14 [Vega]
ICGC DataPortalENSG00000152104
TCGA cBioPortalPTPN14
AceView (NCBI)PTPN14
Genatlas (Paris)PTPN14
SOURCE (Princeton)PTPN14
Genetics Home Reference (NIH)PTPN14
Genomic and cartography
GoldenPath hg38 (UCSC)PTPN14  -     chr1:214348702-214551602 -  1q32.3-q41   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTPN14  -     1q32.3-q41   [Description]    (hg19-Feb_2009)
GoldenPathPTPN14 - 1q32.3-q41 [CytoView hg19]  PTPN14 - 1q32.3-q41 [CytoView hg38]
Genome Data Viewer NCBIPTPN14 [Mapview hg19]  
OMIM603155   613611   
Gene and transcription
Genbank (Entrez)AF086517 AK056963 AK090596 AK291641 AK298120
RefSeq transcript (Entrez)NM_005401
Consensus coding sequences : CCDS (NCBI)PTPN14
Gene ExpressionPTPN14 [ NCBI-GEO ]   PTPN14 [ EBI - ARRAY_EXPRESS ]   PTPN14 [ SEEK ]   PTPN14 [ MEM ]
Gene Expression Viewer (FireBrowse)PTPN14 [ Firebrowse - Broad ]
GenevisibleExpression of PTPN14 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5784
GTEX Portal (Tissue expression)PTPN14
Human Protein AtlasENSG00000152104-PTPN14 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15678   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15678  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15678
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ] [ IntEnz-EBI ] [ BRENDA ] [ KEGG ]   [ MEROPS ]
Domaine pattern : Prosite (Expaxy)FERM_1 (PS00660)    FERM_2 (PS00661)    FERM_3 (PS50057)    TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)Band_41_domain    FERM/acyl-CoA-bd_prot_sf    FERM_2    FERM_central    FERM_CS    FERM_domain    FERM_N    FERM_PH-like_C    PH-like_dom_sf    Prot-tyrosine_phosphatase-like    PTP_non-rcpt_14/21    PTPase_domain    PTPN14/21_FERM_C    Tyr_Pase_AS    Tyr_Pase_cat    TYR_PHOSPHATASE_dom    Ubiquitin-like_domsf   
Domain families : Pfam (Sanger)FERM_C (PF09380)    FERM_M (PF00373)    FERM_N (PF09379)    Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam09380    pfam00373    pfam09379    pfam00102   
Domain families : Smart (EMBL)B41 (SM00295)  FERM_C (SM01196)  PTPc (SM00194)  PTPc_motif (SM00404)  
Conserved Domain (NCBI)PTPN14
PDB (RSDB)2BZL    6IWD    6JJW   
PDB Europe2BZL    6IWD    6JJW   
PDB (PDBSum)2BZL    6IWD    6JJW   
PDB (IMB)2BZL    6IWD    6JJW   
Structural Biology KnowledgeBase2BZL    6IWD    6JJW   
SCOP (Structural Classification of Proteins)2BZL    6IWD    6JJW   
CATH (Classification of proteins structures)2BZL    6IWD    6JJW   
AlphaFold pdb e-kbQ15678   
Human Protein Atlas [tissue]ENSG00000152104-PTPN14 [tissue]
Protein Interaction databases
IntAct (EBI)Q15678
Ontologies - Pathways
Ontology : AmiGOlymphangiogenesis  lymphangiogenesis  transcription coregulator activity  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytoplasm  cytoskeleton  regulation of transcription, DNA-templated  protein dephosphorylation  negative regulation of cell population proliferation  receptor tyrosine kinase binding  peptidyl-tyrosine dephosphorylation  regulation of protein export from nucleus  cellular response to cytokine stimulus  
Ontology : EGO-EBIlymphangiogenesis  lymphangiogenesis  transcription coregulator activity  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytoplasm  cytoskeleton  regulation of transcription, DNA-templated  protein dephosphorylation  negative regulation of cell population proliferation  receptor tyrosine kinase binding  peptidyl-tyrosine dephosphorylation  regulation of protein export from nucleus  cellular response to cytokine stimulus  
REACTOMEQ15678 [protein]
REACTOME PathwaysR-HSA-9008059 [pathway]   
NDEx NetworkPTPN14
Atlas of Cancer Signalling NetworkPTPN14
Wikipedia pathwaysPTPN14
Orthology - Evolution
GeneTree (enSembl)ENSG00000152104
Phylogenetic Trees/Animal Genes : TreeFamPTPN14
Homologs : HomoloGenePTPN14
Homology/Alignments : Family Browser (UCSC)PTPN14
Gene fusions - Rearrangements
Fusion : MitelmanPCNXL2::PTPN14 [1q42.2/1q41]  
Fusion : MitelmanPTPN14::ANKRD44 [1q41/2q33.1]  
Fusion : QuiverPTPN14
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTPN14 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTPN14
Exome Variant ServerPTPN14
GNOMAD BrowserENSG00000152104
Varsome BrowserPTPN14
ACMGPTPN14 variants
Genomic Variants (DGV)PTPN14 [DGVbeta]
DECIPHERPTPN14 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTPN14 
ICGC Data PortalPTPN14 
TCGA Data PortalPTPN14 
Broad Tumor PortalPTPN14
OASIS PortalPTPN14 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTPN14  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPTPN14
Mutations and Diseases : HGMDPTPN14
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
DgiDB (Drug Gene Interaction Database)PTPN14
DoCM (Curated mutations)PTPN14
CIViC (Clinical Interpretations of Variants in Cancer)PTPN14
NCG (London)PTPN14
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
OMIM603155    613611   
Genetic Testing Registry PTPN14
NextProtQ15678 [Medical]
Target ValidationPTPN14
Huge Navigator PTPN14 [HugePedia]
Clinical trials, drugs, therapy
Protein Interactions : CTDPTPN14
Pharm GKB GenePA33989
Clinical trialPTPN14
DataMed IndexPTPN14
PubMed81 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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