PTPN2 (protein tyrosine phosphatase, non-receptor type 2)

Identity

Other names	PTPT
	TC-PTP
	TCELLPTP
	TCPTP
HGNC	PTPN2
Location	18p11.3-p11.2
Location_base_pair	Starts at 12783247 and ends at 12874334 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	PTPN2   9650
Entrez_Gene	PTPN2  5771  protein tyrosine phosphatase, non-receptor type 2
	Cards
GeneCards	PTPN2
Ensembl	ENSG00000175354 [Gene_View]  PTPN2 [Vega]
Genatlas	PTPN2
	Genomic and cartography
GoldenPath	PTPN2  -     chr18:12783247-12874334 -  18p11.21   [Description]    (hg18-March_2006)
Ensembl	PTPN2 - 18p11.21 [CytoView]
NCBI	Mapview
OMIM	176887 Disease map [OMIM]
HomoloGene	PTPN2
	Gene and transcription
Genbank	AB209569 [ ENTREZ ]
Genbank	AK225706 [ ENTREZ ]
Genbank	AK290649 [ ENTREZ ]
Genbank	AK292570 [ ENTREZ ]
Genbank	AW592324 [ ENTREZ ]
RefSeq	NM_002828 [ SRS ]    NM_002828 [ ENTREZ ]
RefSeq	NM_080422 [ SRS ]    NM_080422 [ ENTREZ ]
RefSeq	NM_080423 [ SRS ]    NM_080423 [ ENTREZ ]
RefSeq	AC_000061 [ SRS ]    AC_000061 [ ENTREZ ]
RefSeq	AC_000150 [ SRS ]    AC_000150 [ ENTREZ ]
RefSeq	NC_000018 [ SRS ]    NC_000018 [ ENTREZ ]
RefSeq	NT_010859 [ SRS ]    NT_010859 [ ENTREZ ]
RefSeq	NW_001838464 [ SRS ]    NW_001838464 [ ENTREZ ]
RefSeq	NW_926940 [ SRS ]    NW_926940 [ ENTREZ ]
CCDS	PTPN2 CCDS - NCBI
AceView	PTPN2 AceView - NCBI
Unigene	Hs.654527 [ SRS ]    Hs.654527 [ NCBI ]
Fast-db	1634 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P17706 [ SRS]    P17706 [ EXPASY ]     P17706 [ INTERPRO ]     P17706 [ UNIPROT ] P17706 [ VarSplice FASTA ]
Prosite	PS00383 TYR_PHOSPHATASE_1 [ SRS ]    PS00383 TYR_PHOSPHATASE_1 [ Expasy ]
Prosite	PS50056 TYR_PHOSPHATASE_2 [ SRS ]    PS50056 TYR_PHOSPHATASE_2 [ Expasy ]
Prosite	PS50055 TYR_PHOSPHATASE_PTP [ SRS ]    PS50055 TYR_PHOSPHATASE_PTP [ Expasy ]
Interpro	IPR000387 Tyr_Pase [ SRS ]    IPR000387 Tyr_Pase [ EBI ]
Interpro	IPR016130 Tyr_Pase_AS [ SRS ]    IPR016130 Tyr_Pase_AS [ EBI ]
Interpro	IPR012265 Tyr_Pase_non-rcpt_typ-1/2 [ SRS ]    IPR012265 Tyr_Pase_non-rcpt_typ-1/2 [ EBI ]
Interpro	IPR000242 Tyr_Pase_rcpt/non-rcpt [ SRS ]    IPR000242 Tyr_Pase_rcpt/non-rcpt [ EBI ]
CluSTr	P17706
Pfam	PF00102 Y_phosphatase [ SRS ]    PF00102 Y_phosphatase [ Sanger ]    pfam00102 [ NCBI-CDD ]
Smart	SM00194 PTPc [EMBL]
Blocks	P17706
PDB	1L8K [ SRS ]    1L8K [ PdbSum ],   1L8K [ IMB ]   1L8K [ RSDB ]
HPRD	06768
	Protein Interaction databases
DIP	P17706
IntAct	P17706
	Polymorphism : SNP, mutations, diseases
OMIM	176887    [ map ]
GENETests	176887
SNP	PTPN2 [dbSNP-NCBI]
SNP	NM_002828 [SNP-NCI]
SNP	NM_080422 [SNP-NCI]
SNP	NM_080423 [SNP-NCI]
SNP	PTPN2 [GeneSNPs - Utah]  PTPN2] [HGBASE - SRS]
HAPMAP	PTPN2 [HAPMAP]
COSMIC	PTPN2 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	PTPN2
Genetic Association	PTPN2
CDC HuGE	PTPN2
	General knowledge
Family Browser	PTPN2 [UCSC Family Browser]
SOURCE	NM_002828
SOURCE	NM_080422
SOURCE	NM_080423
SMD	Hs.654527
SAGE	Hs.654527
Enzyme	3.1.3.48 [ Enzyme-Expasy ]   3.1.3.48 [ Enzyme-SRS ]   3.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]
GO	protein tyrosine phosphatase activity [Amigo]  protein tyrosine phosphatase activity
GO	protein tyrosine phosphatase activity [Amigo]  protein tyrosine phosphatase activity
GO	receptor activity [Amigo]  receptor activity
GO	protein binding [Amigo]  protein binding
GO	cytoplasm [Amigo]  cytoplasm
GO	protein amino acid dephosphorylation [Amigo]  protein amino acid dephosphorylation
GO	protein amino acid dephosphorylation [Amigo]  protein amino acid dephosphorylation
GO	hydrolase activity [Amigo]  hydrolase activity
GO	phosphatase activity [Amigo]  phosphatase activity
PubGene	PTPN2
TreeFam	PTPN2
CTD	5771 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	PTPN2 Related clones (RZPD - Berlin)
	PubMed
PubMed	41 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Thu Nov 27 14:06:36 2008