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PTPN2 (protein tyrosine phosphatase, non-receptor type 2)

Identity

Alias_namesPTPT
Alias_symbol (synonym)TCELLPTP
TC-PTP
TCPTP
Other aliasPTN2
HGNC (Hugo) PTPN2
LocusID (NCBI) 5771
Atlas_Id 41915
Location 18p11.21  [Link to chromosome band 18p11]
Location_base_pair Starts at 12785478 and ends at 12884335 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CNBD1 (8q21.3) / PTPN2 (18p11.21)PTPN2 (18p11.21) / BOLA2 (16p11.2)PTPN2 (18p11.21) / MYL12B (18p11.31)
PTPN2 (18p11.21) / PPARGC1B (5q32)PTPN2 (18p11.21) / UBLCP1 (5q33.3)CNBD1 8q21.3 / PTPN2 18p11.21
PTPN2 18p11.21 / MYL12B 18p11.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  del(18)(p11)
i(18)(q10)
t(5;18)(q33;p11) PTPN2/UBLCP1

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(8;18)(q21;p11) CNBD1/PTPN2
PTPN2/MYL12B (18p11)

External links

Nomenclature
HGNC (Hugo)PTPN2   9650
Cards
Entrez_Gene (NCBI)PTPN2  5771  protein tyrosine phosphatase, non-receptor type 2
AliasesPTN2; PTPT; TC-PTP; TCELLPTP; 
TCPTP
GeneCards (Weizmann)PTPN2
Ensembl hg19 (Hinxton)ENSG00000175354 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175354 [Gene_View]  ENSG00000175354 [Sequence]  chr18:12785478-12884335 [Contig_View]  PTPN2 [Vega]
ICGC DataPortalENSG00000175354
TCGA cBioPortalPTPN2
AceView (NCBI)PTPN2
Genatlas (Paris)PTPN2
WikiGenes5771
SOURCE (Princeton)PTPN2
Genetics Home Reference (NIH)PTPN2
Genomic and cartography
GoldenPath hg38 (UCSC)PTPN2  -     chr18:12785478-12884335 -  18p11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTPN2  -     18p11.21   [Description]    (hg19-Feb_2009)
EnsemblPTPN2 - 18p11.21 [CytoView hg19]  PTPN2 - 18p11.21 [CytoView hg38]
Mapping of homologs : NCBIPTPN2 [Mapview hg19]  PTPN2 [Mapview hg38]
OMIM176887   
Gene and transcription
Genbank (Entrez)AB209569 AK091525 AK225706 AK290649 AK292570
RefSeq transcript (Entrez)NM_001207013 NM_001308287 NM_002828 NM_080422 NM_080423
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PTPN2
Cluster EST : UnigeneHs.663373 [ NCBI ]
CGAP (NCI)Hs.663373
Alternative Splicing GalleryENSG00000175354
Gene ExpressionPTPN2 [ NCBI-GEO ]   PTPN2 [ EBI - ARRAY_EXPRESS ]   PTPN2 [ SEEK ]   PTPN2 [ MEM ]
Gene Expression Viewer (FireBrowse)PTPN2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5771
GTEX Portal (Tissue expression)PTPN2
Human Protein AtlasENSG00000175354-PTPN2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17706   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP17706  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP17706
Splice isoforms : SwissVarP17706
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.483.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   
PhosPhoSitePlusP17706
Domaine pattern : Prosite (Expaxy)TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)Prot-tyrosine_phosphatase-like    PTPase_domain    Ptpn1/Ptpn2    Tyr_Pase_AS    Tyr_Pase_cat    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam00102   
Domain families : Smart (EMBL)PTPc (SM00194)  PTPc_motif (SM00404)  
Conserved Domain (NCBI)PTPN2
DMDM Disease mutations5771
Blocks (Seattle)PTPN2
PDB (SRS)1L8K   
PDB (PDBSum)1L8K   
PDB (IMB)1L8K   
PDB (RSDB)1L8K   
Structural Biology KnowledgeBase1L8K   
SCOP (Structural Classification of Proteins)1L8K   
CATH (Classification of proteins structures)1L8K   
SuperfamilyP17706
Human Protein Atlas [tissue]ENSG00000175354-PTPN2 [tissue]
Peptide AtlasP17706
HPRD06768
IPIIPI00219695   IPI00218788   IPI00556472   IPI00106928   
Protein Interaction databases
DIP (DOE-UCLA)P17706
IntAct (EBI)P17706
FunCoupENSG00000175354
BioGRIDPTPN2
STRING (EMBL)PTPN2
ZODIACPTPN2
Ontologies - Pathways
QuickGOP17706
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  non-membrane spanning protein tyrosine phosphatase activity  integrin binding  protein binding  nucleoplasm  nucleoplasm  endoplasmic reticulum  endoplasmic reticulum-Golgi intermediate compartment  cytosol  cytosol  plasma membrane  negative regulation of cell proliferation  insulin receptor signaling pathway  negative regulation of tumor necrosis factor-mediated signaling pathway  negative regulation of lipid storage  protein kinase binding  syntaxin binding  B cell differentiation  T cell differentiation  erythrocyte differentiation  receptor tyrosine kinase binding  peptidyl-tyrosine dephosphorylation  negative regulation of epidermal growth factor receptor signaling pathway  negative regulation of tyrosine phosphorylation of STAT protein  glucose homeostasis  negative regulation of macrophage differentiation  positive regulation of gluconeogenesis  negative regulation of insulin receptor signaling pathway  negative regulation of inflammatory response  negative regulation of T cell receptor signaling pathway  negative regulation of chemotaxis  regulation of interferon-gamma-mediated signaling pathway  negative regulation of interferon-gamma-mediated signaling pathway  negative regulation of type I interferon-mediated signaling pathway  negative regulation of protein tyrosine kinase activity  negative regulation of interleukin-6-mediated signaling pathway  negative regulation of ERK1 and ERK2 cascade  cellular response to cytokine stimulus  STAT family protein binding  regulation of hepatocyte growth factor receptor signaling pathway  negative regulation of interleukin-2-mediated signaling pathway  negative regulation of interleukin-4-mediated signaling pathway  negative regulation of macrophage colony-stimulating factor signaling pathway  negative regulation of positive thymic T cell selection  positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  positive regulation of PERK-mediated unfolded protein response  negative regulation of platelet-derived growth factor receptor-beta signaling pathway  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  non-membrane spanning protein tyrosine phosphatase activity  integrin binding  protein binding  nucleoplasm  nucleoplasm  endoplasmic reticulum  endoplasmic reticulum-Golgi intermediate compartment  cytosol  cytosol  plasma membrane  negative regulation of cell proliferation  insulin receptor signaling pathway  negative regulation of tumor necrosis factor-mediated signaling pathway  negative regulation of lipid storage  protein kinase binding  syntaxin binding  B cell differentiation  T cell differentiation  erythrocyte differentiation  receptor tyrosine kinase binding  peptidyl-tyrosine dephosphorylation  negative regulation of epidermal growth factor receptor signaling pathway  negative regulation of tyrosine phosphorylation of STAT protein  glucose homeostasis  negative regulation of macrophage differentiation  positive regulation of gluconeogenesis  negative regulation of insulin receptor signaling pathway  negative regulation of inflammatory response  negative regulation of T cell receptor signaling pathway  negative regulation of chemotaxis  regulation of interferon-gamma-mediated signaling pathway  negative regulation of interferon-gamma-mediated signaling pathway  negative regulation of type I interferon-mediated signaling pathway  negative regulation of protein tyrosine kinase activity  negative regulation of interleukin-6-mediated signaling pathway  negative regulation of ERK1 and ERK2 cascade  cellular response to cytokine stimulus  STAT family protein binding  regulation of hepatocyte growth factor receptor signaling pathway  negative regulation of interleukin-2-mediated signaling pathway  negative regulation of interleukin-4-mediated signaling pathway  negative regulation of macrophage colony-stimulating factor signaling pathway  negative regulation of positive thymic T cell selection  positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  positive regulation of PERK-mediated unfolded protein response  negative regulation of platelet-derived growth factor receptor-beta signaling pathway  
NDEx NetworkPTPN2
Atlas of Cancer Signalling NetworkPTPN2
Wikipedia pathwaysPTPN2
Orthology - Evolution
OrthoDB5771
GeneTree (enSembl)ENSG00000175354
Phylogenetic Trees/Animal Genes : TreeFamPTPN2
HOVERGENP17706
HOGENOMP17706
Homologs : HomoloGenePTPN2
Homology/Alignments : Family Browser (UCSC)PTPN2
Gene fusions - Rearrangements
Fusion : MitelmanCNBD1/PTPN2 [8q21.3/18p11.21]  [t(8;18)(q21;p11)]  
Fusion : MitelmanPTPN2/MYL12B [18p11.21/18p11.31]  [t(18;18)(p11;p11)]  
Fusion : MitelmanPTPN2/UBLCP1 [18p11.21/5q33.3]  [t(5;18)(q33;p11)]  
Fusion PortalCNBD1 8q21.3 PTPN2 18p11.21 BLCA
Fusion PortalPTPN2 18p11.21 MYL12B 18p11.31 LUAD
Fusion : QuiverPTPN2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTPN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTPN2
dbVarPTPN2
ClinVarPTPN2
1000_GenomesPTPN2 
Exome Variant ServerPTPN2
ExAC (Exome Aggregation Consortium)ENSG00000175354
GNOMAD BrowserENSG00000175354
Varsome BrowserPTPN2
Genetic variants : HAPMAP5771
Genomic Variants (DGV)PTPN2 [DGVbeta]
DECIPHERPTPN2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTPN2 
Mutations
ICGC Data PortalPTPN2 
TCGA Data PortalPTPN2 
Broad Tumor PortalPTPN2
OASIS PortalPTPN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTPN2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTPN2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTPN2
DgiDB (Drug Gene Interaction Database)PTPN2
DoCM (Curated mutations)PTPN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTPN2 (select a term)
intoGenPTPN2
Cancer3DPTPN2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176887   
Orphanet11710    11709   
DisGeNETPTPN2
MedgenPTPN2
Genetic Testing Registry PTPN2
NextProtP17706 [Medical]
TSGene5771
GENETestsPTPN2
Target ValidationPTPN2
Huge Navigator PTPN2 [HugePedia]
snp3D : Map Gene to Disease5771
BioCentury BCIQPTPN2
ClinGenPTPN2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5771
Chemical/Pharm GKB GenePA33993
Clinical trialPTPN2
Miscellaneous
canSAR (ICR)PTPN2 (select the gene name)
Probes
Litterature
PubMed155 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTPN2
EVEXPTPN2
GoPubMedPTPN2
iHOPPTPN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 27 11:47:12 CEST 2018
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