PTPN2 (protein tyrosine phosphatase non-receptor type 2)

2003-11-01  

Identity

HGNC
LOCATION
18p11.21
LOCUSID
ALIAS
PTN2,PTPT,TC-PTP,TCELLPTP,TCPTP
FUSION GENES

Other Information

Locus ID:

NCBI: 5771
MIM: 176887
HGNC: 9650
Ensembl: ENSG00000175354

Variants:

dbSNP: 5771
ClinVar: 5771
TCGA: ENSG00000175354
COSMIC: PTPN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175354ENST00000309660P17706
ENSG00000175354ENST00000327283P17706
ENSG00000175354ENST00000327283A8K3N4
ENSG00000175354ENST00000353319P17706
ENSG00000175354ENST00000585666K7EIE9
ENSG00000175354ENST00000587703K7ENP9
ENSG00000175354ENST00000589216K7ERU1
ENSG00000175354ENST00000591115P17706
ENSG00000175354ENST00000591305K7ERU1
ENSG00000175354ENST00000591497K7EQG9
ENSG00000175354ENST00000591901K7EIY0
ENSG00000175354ENST00000592059K7ELS9
ENSG00000175354ENST00000592776K7ER87
ENSG00000175354ENST00000645191D3DUJ3
ENSG00000175354ENST00000645816A0A2R8YD79
ENSG00000175354ENST00000646492D3DUJ3

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Jak-STAT signaling pathwayKEGGko04630
Jak-STAT signaling pathwayKEGGhsa04630
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300
Regulation of IFNG signalingREACTOMER-HSA-877312
Signal TransductionREACTOMER-HSA-162582
Signaling by METREACTOMER-HSA-6806834
Negative regulation of MET activityREACTOMER-HSA-6807004

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
192649852009Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes.405
175542612007Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.401
190739672008Shared and distinct genetic variants in type 1 diabetes and celiac disease.249
121381782002Identification of a nuclear Stat1 protein tyrosine phosphatase.156
198984812009Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.131
185198262008Molecular genetics of successful smoking cessation: convergent genome-wide association study results.130
184384052008Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis.128
184384052008Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis.128
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
123592252002The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation.69

Citation

Dessen P

PTPN2 (protein tyrosine phosphatase non-receptor type 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41915/ptpn2