Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PTPN22 (protein tyrosine phosphatase, non-receptor type 22 (lymphoid))

Identity

Other namesLYP
LYP1
LYP2
PEP
PTPN8
HGNC (Hugo) PTPN22
LocusID (NCBI) 26191
Location 1p13.2
Location_base_pair Starts at 114356433 and ends at 114414375 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)PTPN22   9652
Cards
Entrez_Gene (NCBI)PTPN22  26191  protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
GeneCards (Weizmann)PTPN22
Ensembl (Hinxton)ENSG00000134242 [Gene_View]  chr1:114356433-114414375 [Contig_View]  PTPN22 [Vega]
ICGC DataPortalENSG00000134242
cBioPortalPTPN22
AceView (NCBI)PTPN22
Genatlas (Paris)PTPN22
WikiGenes26191
SOURCE (Princeton)NM_001193431 NM_012411 NM_015967
Genomic and cartography
GoldenPath (UCSC)PTPN22  -  1p13.2   chr1:114356433-114414375 -  1p13.2   [Description]    (hg19-Feb_2009)
EnsemblPTPN22 - 1p13.2 [CytoView]
Mapping of homologs : NCBIPTPN22 [Mapview]
OMIM152700   180300   222100   600716   
Gene and transcription
Genbank (Entrez)AA836401 AF001846 AF077031 AF150732 AK303124
RefSeq transcript (Entrez)NM_001193431 NM_012411 NM_015967
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_011432 NT_032977 NW_001838594 NW_004929290
Consensus coding sequences : CCDS (NCBI)PTPN22
Cluster EST : UnigeneHs.535276 [ NCBI ]
CGAP (NCI)Hs.535276
Alternative Splicing : Fast-db (Paris)GSHG0002374
Alternative Splicing GalleryENSG00000134242
Gene ExpressionPTPN22 [ NCBI-GEO ]     PTPN22 [ SEEK ]   PTPN22 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y2R2 (Uniprot)
NextProtQ9Y2R2  [Medical]
With graphics : InterProQ9Y2R2
Splice isoforms : SwissVarQ9Y2R2 (Swissvar)
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.483.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)Non-rcpt_Tyr_Pase_8/22 [organisation]   Prot-tyrosine_phosphatase-like [organisation]   Tyr/Dual-sp_Pase [organisation]   Tyr_Pase_AS [organisation]   Tyr_Pase_rcpt/non-rcpt [organisation]  
Related proteins : CluSTrQ9Y2R2
Domain families : Pfam (Sanger)Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam00102   
Domain families : Smart (EMBL)PTPc (SM00194)  
DMDM Disease mutations26191
Blocks (Seattle)Q9Y2R2
PDB (SRS)2P6X    2QCJ    2QCT    3BRH    3H2X    3OLR    3OMH    4J51   
PDB (PDBSum)2P6X    2QCJ    2QCT    3BRH    3H2X    3OLR    3OMH    4J51   
PDB (IMB)2P6X    2QCJ    2QCT    3BRH    3H2X    3OLR    3OMH    4J51   
PDB (RSDB)2P6X    2QCJ    2QCT    3BRH    3H2X    3OLR    3OMH    4J51   
Human Protein AtlasENSG00000134242 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ9Y2R2
HPRD06100
IPIIPI00970945   IPI00970947   IPI00103159   IPI01014122   IPI00748155   IPI00298016   IPI00983525   IPI00219138   IPI00985488   IPI00984213   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y2R2
IntAct (EBI)Q9Y2R2
FunCoupENSG00000134242
BioGRIDPTPN22
InParanoidQ9Y2R2
Interologous Interaction database Q9Y2R2
IntegromeDBPTPN22
STRING (EMBL)PTPN22
Ontologies - Pathways
Ontology : AmiGOprotein tyrosine phosphatase activity  protein binding  nucleus  cytoplasm  cytoplasm  protein dephosphorylation  protein dephosphorylation  cytoplasmic side of plasma membrane  SH3 domain binding  kinase binding  T cell differentiation  regulation of natural killer cell proliferation  peptidyl-tyrosine dephosphorylation  peptidyl-tyrosine dephosphorylation  phosphoanandamide dephosphorylation  regulation of innate immune response  perinuclear region of cytoplasm  regulation of B cell receptor signaling pathway  negative regulation of T cell receptor signaling pathway  negative regulation of T cell activation  
Ontology : EGO-EBIprotein tyrosine phosphatase activity  protein binding  nucleus  cytoplasm  cytoplasm  protein dephosphorylation  protein dephosphorylation  cytoplasmic side of plasma membrane  SH3 domain binding  kinase binding  T cell differentiation  regulation of natural killer cell proliferation  peptidyl-tyrosine dephosphorylation  peptidyl-tyrosine dephosphorylation  phosphoanandamide dephosphorylation  regulation of innate immune response  perinuclear region of cytoplasm  regulation of B cell receptor signaling pathway  negative regulation of T cell receptor signaling pathway  negative regulation of T cell activation  
Protein Interaction DatabasePTPN22
Wikipedia pathwaysPTPN22
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PTPN22
snp3D : Map Gene to Disease26191
SNP (GeneSNP Utah)PTPN22
SNP : HGBasePTPN22
Genetic variants : HAPMAPPTPN22
Exome VariantPTPN22
1000_GenomesPTPN22 
ICGC programENSG00000134242 
Somatic Mutations in Cancer : COSMICPTPN22 
CONAN: Copy Number AnalysisPTPN22 
Mutations and Diseases : HGMDPTPN22
Genomic VariantsPTPN22  PTPN22 [DGVbeta]
dbVarPTPN22
ClinVarPTPN22
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM152700    180300    222100    600716   
MedgenPTPN22
GENETestsPTPN22
Disease Genetic AssociationPTPN22
Huge Navigator PTPN22 [HugePedia]  PTPN22 [HugeCancerGEM]
General knowledge
Homologs : HomoloGenePTPN22
Homology/Alignments : Family Browser (UCSC)PTPN22
Phylogenetic Trees/Animal Genes : TreeFamPTPN22
Chemical/Protein Interactions : CTD26191
Chemical/Pharm GKB GenePA33995
Clinical trialPTPN22
Cancer Resource (Charite)ENSG00000134242
Other databases
Probes
Litterature
PubMed393 Pubmed reference(s) in Entrez
CoreMinePTPN22
iHOPPTPN22
OncoSearchPTPN22
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jul 26 14:44:49 CEST 2014

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.