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PTPN22 (protein tyrosine phosphatase, non-receptor type 22)

Identity

Alias_namesPTPN8
protein tyrosine phosphatase, non-receptor type 8
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Alias_symbol (synonym)Lyp
Lyp1
Lyp2
HGNC (Hugo) PTPN22
LocusID (NCBI) 26191
Atlas_Id 52604
Location 1p13.2  [Link to chromosome band 1p13]
Location_base_pair Starts at 114356433 and ends at 114414381 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
SF3B2 (11q13.1) / PTPN22 (1p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PTPN22   9652
Cards
Entrez_Gene (NCBI)PTPN22  26191  protein tyrosine phosphatase, non-receptor type 22
AliasesLYP; LYP1; LYP2; PEP; 
PTPN8
GeneCards (Weizmann)PTPN22
Ensembl hg19 (Hinxton)ENSG00000134242 [Gene_View]  chr1:114356433-114414381 [Contig_View]  PTPN22 [Vega]
Ensembl hg38 (Hinxton)ENSG00000134242 [Gene_View]  chr1:114356433-114414381 [Contig_View]  PTPN22 [Vega]
ICGC DataPortalENSG00000134242
TCGA cBioPortalPTPN22
AceView (NCBI)PTPN22
Genatlas (Paris)PTPN22
WikiGenes26191
SOURCE (Princeton)PTPN22
Genetics Home Reference (NIH)PTPN22
Genomic and cartography
GoldenPath hg19 (UCSC)PTPN22  -     chr1:114356433-114414381 -  1p13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PTPN22  -     1p13.2   [Description]    (hg38-Dec_2013)
EnsemblPTPN22 - 1p13.2 [CytoView hg19]  PTPN22 - 1p13.2 [CytoView hg38]
Mapping of homologs : NCBIPTPN22 [Mapview hg19]  PTPN22 [Mapview hg38]
OMIM152700   180300   222100   600716   
Gene and transcription
Genbank (Entrez)AA836401 AF001846 AF077031 AF150732 AK303124
RefSeq transcript (Entrez)NM_001193431 NM_001308297 NM_012411 NM_015967
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_011432 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)PTPN22
Cluster EST : UnigeneHs.535276 [ NCBI ]
CGAP (NCI)Hs.535276
Alternative Splicing GalleryENSG00000134242
Gene ExpressionPTPN22 [ NCBI-GEO ]   PTPN22 [ EBI - ARRAY_EXPRESS ]   PTPN22 [ SEEK ]   PTPN22 [ MEM ]
Gene Expression Viewer (FireBrowse)PTPN22 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26191
GTEX Portal (Tissue expression)PTPN22
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y2R2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y2R2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y2R2
Splice isoforms : SwissVarQ9Y2R2
PhosPhoSitePlusQ9Y2R2
Domaine pattern : Prosite (Expaxy)TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)Prot-tyrosine_phosphatase-like    PTPase_domain    PTPN22    Tyr_Pase_AS    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam00102   
Domain families : Smart (EMBL)PTPc (SM00194)  
Conserved Domain (NCBI)PTPN22
DMDM Disease mutations26191
Blocks (Seattle)PTPN22
PDB (SRS)2P6X    2QCJ    2QCT    3BRH    3H2X    3OLR    3OMH    4J51   
PDB (PDBSum)2P6X    2QCJ    2QCT    3BRH    3H2X    3OLR    3OMH    4J51   
PDB (IMB)2P6X    2QCJ    2QCT    3BRH    3H2X    3OLR    3OMH    4J51   
PDB (RSDB)2P6X    2QCJ    2QCT    3BRH    3H2X    3OLR    3OMH    4J51   
Structural Biology KnowledgeBase2P6X    2QCJ    2QCT    3BRH    3H2X    3OLR    3OMH    4J51   
SCOP (Structural Classification of Proteins)2P6X    2QCJ    2QCT    3BRH    3H2X    3OLR    3OMH    4J51   
CATH (Classification of proteins structures)2P6X    2QCJ    2QCT    3BRH    3H2X    3OLR    3OMH    4J51   
SuperfamilyQ9Y2R2
Human Protein AtlasENSG00000134242
Peptide AtlasQ9Y2R2
HPRD06100
IPIIPI00970945   IPI00970947   IPI00103159   IPI01014122   IPI00748155   IPI00298016   IPI00983525   IPI00219138   IPI00985488   IPI00984213   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y2R2
IntAct (EBI)Q9Y2R2
FunCoupENSG00000134242
BioGRIDPTPN22
STRING (EMBL)PTPN22
ZODIACPTPN22
Ontologies - Pathways
QuickGOQ9Y2R2
Ontology : AmiGOprotein tyrosine phosphatase activity  protein binding  nucleus  cytoplasm  cytoplasm  protein dephosphorylation  protein dephosphorylation  autophagy  cytoplasmic side of plasma membrane  negative regulation of autophagy  positive regulation of gene expression  negative regulation of gene expression  phosphatase activity  SH3 domain binding  kinase binding  T cell differentiation  ubiquitin protein ligase binding  lipopolysaccharide-mediated signaling pathway  positive regulation of type I interferon production  response to lipopolysaccharide  negative regulation of tumor necrosis factor production  regulation of natural killer cell proliferation  positive regulation of toll-like receptor 3 signaling pathway  positive regulation of toll-like receptor 4 signaling pathway  peptidyl-tyrosine dephosphorylation  peptidyl-tyrosine dephosphorylation  phosphoanandamide dephosphorylation  negative regulation of JUN kinase activity  regulation of innate immune response  perinuclear region of cytoplasm  regulation of B cell receptor signaling pathway  negative regulation of T cell receptor signaling pathway  negative regulation of T cell activation  positive regulation of ERK1 and ERK2 cascade  negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  cellular response to muramyl dipeptide  negative regulation of interleukin-6 secretion  regulation of NIK/NF-kappaB signaling  positive regulation of protein K63-linked ubiquitination  positive regulation of interferon-gamma secretion  negative regulation of p38MAPK cascade  negative regulation of interleukin-8 secretion  
Ontology : EGO-EBIprotein tyrosine phosphatase activity  protein binding  nucleus  cytoplasm  cytoplasm  protein dephosphorylation  protein dephosphorylation  autophagy  cytoplasmic side of plasma membrane  negative regulation of autophagy  positive regulation of gene expression  negative regulation of gene expression  phosphatase activity  SH3 domain binding  kinase binding  T cell differentiation  ubiquitin protein ligase binding  lipopolysaccharide-mediated signaling pathway  positive regulation of type I interferon production  response to lipopolysaccharide  negative regulation of tumor necrosis factor production  regulation of natural killer cell proliferation  positive regulation of toll-like receptor 3 signaling pathway  positive regulation of toll-like receptor 4 signaling pathway  peptidyl-tyrosine dephosphorylation  peptidyl-tyrosine dephosphorylation  phosphoanandamide dephosphorylation  negative regulation of JUN kinase activity  regulation of innate immune response  perinuclear region of cytoplasm  regulation of B cell receptor signaling pathway  negative regulation of T cell receptor signaling pathway  negative regulation of T cell activation  positive regulation of ERK1 and ERK2 cascade  negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  cellular response to muramyl dipeptide  negative regulation of interleukin-6 secretion  regulation of NIK/NF-kappaB signaling  positive regulation of protein K63-linked ubiquitination  positive regulation of interferon-gamma secretion  negative regulation of p38MAPK cascade  negative regulation of interleukin-8 secretion  
NDEx NetworkPTPN22
Atlas of Cancer Signalling NetworkPTPN22
Wikipedia pathwaysPTPN22
Orthology - Evolution
OrthoDB26191
GeneTree (enSembl)ENSG00000134242
Phylogenetic Trees/Animal Genes : TreeFamPTPN22
HOVERGENQ9Y2R2
HOGENOMQ9Y2R2
Homologs : HomoloGenePTPN22
Homology/Alignments : Family Browser (UCSC)PTPN22
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTPN22 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTPN22
dbVarPTPN22
ClinVarPTPN22
1000_GenomesPTPN22 
Exome Variant ServerPTPN22
ExAC (Exome Aggregation Consortium)PTPN22 (select the gene name)
Genetic variants : HAPMAP26191
Genomic Variants (DGV)PTPN22 [DGVbeta]
DECIPHER (Syndromes)1:114356433-114414381  ENSG00000134242
CONAN: Copy Number AnalysisPTPN22 
Mutations
ICGC Data PortalPTPN22 
TCGA Data PortalPTPN22 
Broad Tumor PortalPTPN22
OASIS PortalPTPN22 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTPN22  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTPN22
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
BioMutasearch PTPN22
DgiDB (Drug Gene Interaction Database)PTPN22
DoCM (Curated mutations)PTPN22 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTPN22 (select a term)
intoGenPTPN22
Cancer3DPTPN22(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM152700    180300    222100    600716   
Orphanet759    876    7028    11710    11709    12394   
MedgenPTPN22
Genetic Testing Registry PTPN22
NextProtQ9Y2R2 [Medical]
TSGene26191
GENETestsPTPN22
Huge Navigator PTPN22 [HugePedia]
snp3D : Map Gene to Disease26191
BioCentury BCIQPTPN22
ClinGenPTPN22
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26191
Chemical/Pharm GKB GenePA33995
Clinical trialPTPN22
Miscellaneous
canSAR (ICR)PTPN22 (select the gene name)
Probes
Litterature
PubMed438 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTPN22
EVEXPTPN22
GoPubMedPTPN22
iHOPPTPN22
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Nov 18 19:48:58 CET 2016

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