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PTPN23 (protein tyrosine phosphatase, non-receptor type 23)

Identity

Alias_symbol (synonym)DKFZP564F0923
KIAA1471
HD-PTP
Other aliasHDPTP
PTP-TD14
HGNC (Hugo) PTPN23
LocusID (NCBI) 25930
Atlas_Id 41917
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 47380982 and ends at 47413441 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ECE1 (1p36.12) / PTPN23 (3p21.31)EFHC1 (6p12.2) / PTPN23 (3p21.31)MED13L (12q24.21) / PTPN23 (3p21.31)
PTPN23 (3p21.31) / ELP6 (3p21.31)PTPN23 (3p21.31) / FLT4 (5q35.3)PTPN23 (3p21.31) / ICA1L (2q33.2)
STT3A (11q24.2) / PTPN23 (3p21.31)PTPN23 3p21.31 / ICA1L 2q33.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PTPN23   14406
Cards
Entrez_Gene (NCBI)PTPN23  25930  protein tyrosine phosphatase, non-receptor type 23
AliasesHD-PTP; HDPTP; PTP-TD14
GeneCards (Weizmann)PTPN23
Ensembl hg19 (Hinxton)ENSG00000076201 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000076201 [Gene_View]  chr3:47380982-47413441 [Contig_View]  PTPN23 [Vega]
ICGC DataPortalENSG00000076201
TCGA cBioPortalPTPN23
AceView (NCBI)PTPN23
Genatlas (Paris)PTPN23
WikiGenes25930
SOURCE (Princeton)PTPN23
Genetics Home Reference (NIH)PTPN23
Genomic and cartography
GoldenPath hg38 (UCSC)PTPN23  -     chr3:47380982-47413441 +  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTPN23  -     3p21.31   [Description]    (hg19-Feb_2009)
EnsemblPTPN23 - 3p21.31 [CytoView hg19]  PTPN23 - 3p21.31 [CytoView hg38]
Mapping of homologs : NCBIPTPN23 [Mapview hg19]  PTPN23 [Mapview hg38]
OMIM606584   
Gene and transcription
Genbank (Entrez)AB025194 AB040904 AF169350 AF290614 AK055157
RefSeq transcript (Entrez)NM_001304482 NM_015466
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PTPN23
Cluster EST : UnigeneHs.25524 [ NCBI ]
CGAP (NCI)Hs.25524
Alternative Splicing GalleryENSG00000076201
Gene ExpressionPTPN23 [ NCBI-GEO ]   PTPN23 [ EBI - ARRAY_EXPRESS ]   PTPN23 [ SEEK ]   PTPN23 [ MEM ]
Gene Expression Viewer (FireBrowse)PTPN23 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)25930
GTEX Portal (Tissue expression)PTPN23
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H3S7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H3S7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H3S7
Splice isoforms : SwissVarQ9H3S7
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.483.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   
PhosPhoSitePlusQ9H3S7
Domaine pattern : Prosite (Expaxy)BRO1 (PS51180)    TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)ALIX_V_dom    BRO1_dom    Prot-tyrosine_phosphatase-like    PTPase_domain    PTPN23    Tyr_Pase_AS    Tyr_Pase_cat    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)ALIX_LYPXL_bnd (PF13949)    BRO1 (PF03097)    Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam13949    pfam03097    pfam00102   
Domain families : Smart (EMBL)BRO1 (SM01041)  PTPc (SM00194)  PTPc_motif (SM00404)  
Conserved Domain (NCBI)PTPN23
DMDM Disease mutations25930
Blocks (Seattle)PTPN23
PDB (SRS)3RAU    5CRU    5CRV    5LM1    5LM2   
PDB (PDBSum)3RAU    5CRU    5CRV    5LM1    5LM2   
PDB (IMB)3RAU    5CRU    5CRV    5LM1    5LM2   
PDB (RSDB)3RAU    5CRU    5CRV    5LM1    5LM2   
Structural Biology KnowledgeBase3RAU    5CRU    5CRV    5LM1    5LM2   
SCOP (Structural Classification of Proteins)3RAU    5CRU    5CRV    5LM1    5LM2   
CATH (Classification of proteins structures)3RAU    5CRU    5CRV    5LM1    5LM2   
SuperfamilyQ9H3S7
Human Protein AtlasENSG00000076201
Peptide AtlasQ9H3S7
HPRD05959
IPIIPI00034006   IPI00909596   IPI00924503   
Protein Interaction databases
DIP (DOE-UCLA)Q9H3S7
IntAct (EBI)Q9H3S7
FunCoupENSG00000076201
BioGRIDPTPN23
STRING (EMBL)PTPN23
ZODIACPTPN23
Ontologies - Pathways
QuickGOQ9H3S7
Ontology : AmiGOprotein tyrosine phosphatase activity  protein binding  nucleus  nucleoplasm  cytoplasm  endosome  early endosome  negative regulation of epithelial cell migration  protein transport  nuclear body  protein kinase binding  peptidyl-tyrosine dephosphorylation  ciliary basal body  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  cilium assembly  extracellular exosome  positive regulation of homophilic cell adhesion  positive regulation of adherens junction organization  positive regulation of early endosome to late endosome transport  
Ontology : EGO-EBIprotein tyrosine phosphatase activity  protein binding  nucleus  nucleoplasm  cytoplasm  endosome  early endosome  negative regulation of epithelial cell migration  protein transport  nuclear body  protein kinase binding  peptidyl-tyrosine dephosphorylation  ciliary basal body  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  cilium assembly  extracellular exosome  positive regulation of homophilic cell adhesion  positive regulation of adherens junction organization  positive regulation of early endosome to late endosome transport  
NDEx NetworkPTPN23
Atlas of Cancer Signalling NetworkPTPN23
Wikipedia pathwaysPTPN23
Orthology - Evolution
OrthoDB25930
GeneTree (enSembl)ENSG00000076201
Phylogenetic Trees/Animal Genes : TreeFamPTPN23
HOVERGENQ9H3S7
HOGENOMQ9H3S7
Homologs : HomoloGenePTPN23
Homology/Alignments : Family Browser (UCSC)PTPN23
Gene fusions - Rearrangements
Fusion : MitelmanPTPN23/ICA1L [3p21.31/2q33.2]  
Fusion: TCGAPTPN23 3p21.31 ICA1L 2q33.2 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTPN23 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTPN23
dbVarPTPN23
ClinVarPTPN23
1000_GenomesPTPN23 
Exome Variant ServerPTPN23
ExAC (Exome Aggregation Consortium)PTPN23 (select the gene name)
Genetic variants : HAPMAP25930
Genomic Variants (DGV)PTPN23 [DGVbeta]
DECIPHERPTPN23 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTPN23 
Mutations
ICGC Data PortalPTPN23 
TCGA Data PortalPTPN23 
Broad Tumor PortalPTPN23
OASIS PortalPTPN23 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTPN23  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTPN23
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTPN23
DgiDB (Drug Gene Interaction Database)PTPN23
DoCM (Curated mutations)PTPN23 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTPN23 (select a term)
intoGenPTPN23
Cancer3DPTPN23(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606584   
Orphanet
MedgenPTPN23
Genetic Testing Registry PTPN23
NextProtQ9H3S7 [Medical]
TSGene25930
GENETestsPTPN23
Huge Navigator PTPN23 [HugePedia]
snp3D : Map Gene to Disease25930
BioCentury BCIQPTPN23
ClinGenPTPN23
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD25930
Chemical/Pharm GKB GenePA33996
Clinical trialPTPN23
Miscellaneous
canSAR (ICR)PTPN23 (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTPN23
EVEXPTPN23
GoPubMedPTPN23
iHOPPTPN23
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:33:29 CEST 2017

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