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PTPN3 (protein tyrosine phosphatase, non-receptor type 3)

Identity

Alias_symbol (synonym)PTPH1
Other aliasPTP-H1
HGNC (Hugo) PTPN3
LocusID (NCBI) 5774
Atlas_Id 41918
Location 9q31.3  [Link to chromosome band 9q31]
Location_base_pair Starts at 112137974 and ends at 112260593 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ALK (2p23.2) / PTPN3 (9q31.3)EPB41L4B (9q31.3) / PTPN3 (9q31.3)GRK5 (10q26.11) / PTPN3 (9q31.3)
PHEX (Xp22.11) / PTPN3 (9q31.3)PTPN3 (9q31.3) / SHOC2 (10q25.2)PTPN3 (9q31.3) / ZBTB38 (3q23)
RB1CC1 (8q11.23) / PTPN3 (9q31.3)EPB41L4B 9q31.3 / PTPN3 9q31.3RB1CC1 8q11.23 / PTPN3 9q31.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)PTPN3   9655
Cards
Entrez_Gene (NCBI)PTPN3  5774  protein tyrosine phosphatase, non-receptor type 3
AliasesPTP-H1; PTPH1
GeneCards (Weizmann)PTPN3
Ensembl hg19 (Hinxton)ENSG00000070159 [Gene_View]  chr9:112137974-112260593 [Contig_View]  PTPN3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000070159 [Gene_View]  chr9:112137974-112260593 [Contig_View]  PTPN3 [Vega]
ICGC DataPortalENSG00000070159
TCGA cBioPortalPTPN3
AceView (NCBI)PTPN3
Genatlas (Paris)PTPN3
WikiGenes5774
SOURCE (Princeton)PTPN3
Genetics Home Reference (NIH)PTPN3
Genomic and cartography
GoldenPath hg19 (UCSC)PTPN3  -     chr9:112137974-112260593 -  9q31.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PTPN3  -     9q31.3   [Description]    (hg38-Dec_2013)
EnsemblPTPN3 - 9q31.3 [CytoView hg19]  PTPN3 - 9q31.3 [CytoView hg38]
Mapping of homologs : NCBIPTPN3 [Mapview hg19]  PTPN3 [Mapview hg38]
OMIM176877   
Gene and transcription
Genbank (Entrez)AK096975 AK295875 AK296265 AK296388 AK303608
RefSeq transcript (Entrez)NM_001145368 NM_001145369 NM_001145370 NM_001145371 NM_001145372 NM_002829
RefSeq genomic (Entrez)NC_000009 NC_018920 NT_008470 NW_004929366
Consensus coding sequences : CCDS (NCBI)PTPN3
Cluster EST : UnigeneHs.436429 [ NCBI ]
CGAP (NCI)Hs.436429
Alternative Splicing GalleryENSG00000070159
Gene ExpressionPTPN3 [ NCBI-GEO ]   PTPN3 [ EBI - ARRAY_EXPRESS ]   PTPN3 [ SEEK ]   PTPN3 [ MEM ]
Gene Expression Viewer (FireBrowse)PTPN3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5774
GTEX Portal (Tissue expression)PTPN3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP26045   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP26045  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP26045
Splice isoforms : SwissVarP26045
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.483.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   
PhosPhoSitePlusP26045
Domaine pattern : Prosite (Expaxy)FERM_1 (PS00660)    FERM_2 (PS00661)    FERM_3 (PS50057)    PDZ (PS50106)    TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)Band_41_domain    FERM/acyl-CoA-bd_prot_3-hlx    FERM_central    FERM_CS    FERM_domain    FERM_N    FERM_PH-like_C    PDZ    PH_dom-like    Prot-tyrosine_phosphatase-like    PTPase_domain    Tyr_Pase_AS    Tyr_Pase_non-rcpt_typ-3/4    TYR_PHOSPHATASE_dom    Ubiquitin-rel_dom   
Domain families : Pfam (Sanger)FERM_C (PF09380)    FERM_M (PF00373)    FERM_N (PF09379)    PDZ (PF00595)    Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam09380    pfam00373    pfam09379    pfam00595    pfam00102   
Domain families : Smart (EMBL)B41 (SM00295)  PDZ (SM00228)  PTPc (SM00194)  
Conserved Domain (NCBI)PTPN3
DMDM Disease mutations5774
Blocks (Seattle)PTPN3
PDB (SRS)2B49    4QUM    4QUN    4RH5    4RH9    4RHG    4RI4    4RI5    4S0G   
PDB (PDBSum)2B49    4QUM    4QUN    4RH5    4RH9    4RHG    4RI4    4RI5    4S0G   
PDB (IMB)2B49    4QUM    4QUN    4RH5    4RH9    4RHG    4RI4    4RI5    4S0G   
PDB (RSDB)2B49    4QUM    4QUN    4RH5    4RH9    4RHG    4RI4    4RI5    4S0G   
Structural Biology KnowledgeBase2B49    4QUM    4QUN    4RH5    4RH9    4RHG    4RI4    4RI5    4S0G   
SCOP (Structural Classification of Proteins)2B49    4QUM    4QUN    4RH5    4RH9    4RHG    4RI4    4RI5    4S0G   
CATH (Classification of proteins structures)2B49    4QUM    4QUN    4RH5    4RH9    4RHG    4RI4    4RI5    4S0G   
SuperfamilyP26045
Human Protein AtlasENSG00000070159
Peptide AtlasP26045
HPRD06767
IPIIPI00289649   IPI00647108   IPI00921957   IPI00922112   IPI00480052   IPI00922282   IPI00922196   
Protein Interaction databases
DIP (DOE-UCLA)P26045
IntAct (EBI)P26045
FunCoupENSG00000070159
BioGRIDPTPN3
STRING (EMBL)PTPN3
ZODIACPTPN3
Ontologies - Pathways
QuickGOP26045
Ontology : AmiGOphosphotyrosine binding  protein tyrosine phosphatase activity  protein binding  cytoplasm  cytoskeleton  protein dephosphorylation  cytoskeletal protein binding  cytoplasmic side of plasma membrane  sodium channel regulator activity  peptidyl-tyrosine dephosphorylation  peptidyl-tyrosine dephosphorylation  peptidyl-tyrosine dephosphorylation  negative regulation of mitotic cell cycle  negative regulation of membrane protein ectodomain proteolysis  ATPase binding  liver regeneration  regulation of membrane depolarization during action potential  regulation of sodium ion transmembrane transporter activity  
Ontology : EGO-EBIphosphotyrosine binding  protein tyrosine phosphatase activity  protein binding  cytoplasm  cytoskeleton  protein dephosphorylation  cytoskeletal protein binding  cytoplasmic side of plasma membrane  sodium channel regulator activity  peptidyl-tyrosine dephosphorylation  peptidyl-tyrosine dephosphorylation  peptidyl-tyrosine dephosphorylation  negative regulation of mitotic cell cycle  negative regulation of membrane protein ectodomain proteolysis  ATPase binding  liver regeneration  regulation of membrane depolarization during action potential  regulation of sodium ion transmembrane transporter activity  
NDEx NetworkPTPN3
Atlas of Cancer Signalling NetworkPTPN3
Wikipedia pathwaysPTPN3
Orthology - Evolution
OrthoDB5774
GeneTree (enSembl)ENSG00000070159
Phylogenetic Trees/Animal Genes : TreeFamPTPN3
HOVERGENP26045
HOGENOMP26045
Homologs : HomoloGenePTPN3
Homology/Alignments : Family Browser (UCSC)PTPN3
Gene fusions - Rearrangements
Fusion : MitelmanALK/PTPN3 [2p23.2/9q31.3]  [t(2;9)(p23;q31)]  
Fusion : MitelmanEPB41L4B/PTPN3 [9q31.3/9q31.3]  [t(9;9)(q31;q31)]  
Fusion : MitelmanRB1CC1/PTPN3 [8q11.23/9q31.3]  [t(8;9)(q11;q31)]  
Fusion: TCGAEPB41L4B 9q31.3 PTPN3 9q31.3 BRCA
Fusion: TCGARB1CC1 8q11.23 PTPN3 9q31.3 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTPN3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTPN3
dbVarPTPN3
ClinVarPTPN3
1000_GenomesPTPN3 
Exome Variant ServerPTPN3
ExAC (Exome Aggregation Consortium)PTPN3 (select the gene name)
Genetic variants : HAPMAP5774
Genomic Variants (DGV)PTPN3 [DGVbeta]
DECIPHER (Syndromes)9:112137974-112260593  ENSG00000070159
CONAN: Copy Number AnalysisPTPN3 
Mutations
ICGC Data PortalPTPN3 
TCGA Data PortalPTPN3 
Broad Tumor PortalPTPN3
OASIS PortalPTPN3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTPN3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTPN3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTPN3
DgiDB (Drug Gene Interaction Database)PTPN3
DoCM (Curated mutations)PTPN3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTPN3 (select a term)
intoGenPTPN3
Cancer3DPTPN3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176877   
Orphanet10951   
MedgenPTPN3
Genetic Testing Registry PTPN3
NextProtP26045 [Medical]
TSGene5774
GENETestsPTPN3
Huge Navigator PTPN3 [HugePedia]
snp3D : Map Gene to Disease5774
BioCentury BCIQPTPN3
ClinGenPTPN3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5774
Chemical/Pharm GKB GenePA33999
Clinical trialPTPN3
Miscellaneous
canSAR (ICR)PTPN3 (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTPN3
EVEXPTPN3
GoPubMedPTPN3
iHOPPTPN3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:16:13 CEST 2017

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