PTPN3 (protein tyrosine phosphatase non-receptor type 3)

2003-11-01  

Identity

HGNC
LOCATION
9q31.3
LOCUSID
ALIAS
PTP-H1,PTPH1
FUSION GENES

Other Information

Locus ID:

NCBI: 5774
MIM: 176877
HGNC: 9655
Ensembl: ENSG00000070159

Variants:

dbSNP: 5774
ClinVar: 5774
TCGA: ENSG00000070159
COSMIC: PTPN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000070159ENST00000262539J3KN34
ENSG00000070159ENST00000374541P26045
ENSG00000070159ENST00000412145P26045
ENSG00000070159ENST00000446349P26045

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
EGFR downregulationREACTOMER-HSA-182971

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
245031272014Activating mutations in PTPN3 promote cholangiocarcinoma cell proliferation and migration and are associated with tumor recurrence in patients.42
122070262002Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1.35
171669062007Degradation of tyrosine phosphatase PTPN3 (PTPH1) by association with oncogenic human papillomavirus E6 proteins.34
223344422012Discovery of ALK-PTPN3 gene fusion from human non-small cell lung carcinoma cell line using next generation RNA sequencing.34
203322382010PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction.27
146729522004PTPH1 is a predominant protein-tyrosine phosphatase capable of interacting with and dephosphorylating the T cell receptor zeta subunit.22
189786782008Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts.21
179211432007Protein-tyrosine phosphatase H1 controls growth hormone receptor signaling and systemic growth.18
179475172007Protein tyrosine phosphatase H1 is a target of the E6 oncoprotein of high-risk genital human papillomaviruses.15
211195992011PTPH1 cooperates with vitamin D receptor to stimulate breast cancer growth through their mutual stabilization.15

Citation

Dessen P

PTPN3 (protein tyrosine phosphatase non-receptor type 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41918/ptpn3