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PTPN3 (protein tyrosine phosphatase non-receptor type 3)

Identity

Alias (NCBI)PTP-H1
PTPH1
HGNC (Hugo) PTPN3
HGNC Alias symbPTPH1
LocusID (NCBI) 5774
Atlas_Id 41918
Location 9q31.3  [Link to chromosome band 9q31]
Location_base_pair Starts at 109375700 and ends at 109498307 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALK (2p23.2) / PTPN3 (9q31.3)EPB41L4B (9q31.3) / PTPN3 (9q31.3)GRK5 (10q26.11) / PTPN3 (9q31.3)
PHEX (Xp22.11) / PTPN3 (9q31.3)PTPN3 (9q31.3) / SHOC2 (10q25.2)PTPN3 (9q31.3) / ZBTB38 (3q23)
RB1CC1 (8q11.23) / PTPN3 (9q31.3)EPB41L4B 9q31.3 / PTPN3 9q31.3RB1CC1 8q11.23 / PTPN3 9q31.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PTPN3   9655
Cards
Entrez_Gene (NCBI)PTPN3    protein tyrosine phosphatase non-receptor type 3
AliasesPTP-H1; PTPH1
GeneCards (Weizmann)PTPN3
Ensembl hg19 (Hinxton)ENSG00000070159 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000070159 [Gene_View]  ENSG00000070159 [Sequence]  chr9:109375700-109498307 [Contig_View]  PTPN3 [Vega]
ICGC DataPortalENSG00000070159
TCGA cBioPortalPTPN3
AceView (NCBI)PTPN3
Genatlas (Paris)PTPN3
SOURCE (Princeton)PTPN3
Genetics Home Reference (NIH)PTPN3
Genomic and cartography
GoldenPath hg38 (UCSC)PTPN3  -     chr9:109375700-109498307 -  9q31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTPN3  -     9q31.3   [Description]    (hg19-Feb_2009)
GoldenPathPTPN3 - 9q31.3 [CytoView hg19]  PTPN3 - 9q31.3 [CytoView hg38]
ImmunoBaseENSG00000070159
Genome Data Viewer NCBIPTPN3 [Mapview hg19]  
OMIM176877   
Gene and transcription
Genbank (Entrez)AK096975 AK295875 AK296265 AK296388 AK303608
RefSeq transcript (Entrez)NM_001145368 NM_001145369 NM_001145370 NM_001145371 NM_001145372 NM_002829
Consensus coding sequences : CCDS (NCBI)PTPN3
Gene ExpressionPTPN3 [ NCBI-GEO ]   PTPN3 [ EBI - ARRAY_EXPRESS ]   PTPN3 [ SEEK ]   PTPN3 [ MEM ]
Gene Expression Viewer (FireBrowse)PTPN3 [ Firebrowse - Broad ]
GenevisibleExpression of PTPN3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5774
GTEX Portal (Tissue expression)PTPN3
Human Protein AtlasENSG00000070159-PTPN3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP26045   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP26045  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP26045
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.483.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP26045
Domaine pattern : Prosite (Expaxy)FERM_1 (PS00660)    FERM_2 (PS00661)    FERM_3 (PS50057)    PDZ (PS50106)    TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)Band_41_domain    FERM/acyl-CoA-bd_prot_sf    FERM_2    FERM_central    FERM_CS    FERM_domain    FERM_N    FERM_PH-like_C    PDZ    PDZ_sf    PH-like_dom_sf    Prot-tyrosine_phosphatase-like    PTPase_domain    PTPN3/4_FERM_C    Tyr_Pase_AS    Tyr_Pase_cat    Tyr_Pase_non-rcpt_typ-3/4    TYR_PHOSPHATASE_dom    Ubiquitin-like_domsf   
Domain families : Pfam (Sanger)FERM_C (PF09380)    FERM_M (PF00373)    FERM_N (PF09379)    PDZ (PF00595)    Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam09380    pfam00373    pfam09379    pfam00595    pfam00102   
Domain families : Smart (EMBL)B41 (SM00295)  FERM_C (SM01196)  PDZ (SM00228)  PTPc (SM00194)  PTPc_motif (SM00404)  
Conserved Domain (NCBI)PTPN3
PDB (RSDB)2B49    4QUM    4QUN    4RH5    4RH9    4RHG    4RI4    4RI5    4S0G    6HKS   
PDB Europe2B49    4QUM    4QUN    4RH5    4RH9    4RHG    4RI4    4RI5    4S0G    6HKS   
PDB (PDBSum)2B49    4QUM    4QUN    4RH5    4RH9    4RHG    4RI4    4RI5    4S0G    6HKS   
PDB (IMB)2B49    4QUM    4QUN    4RH5    4RH9    4RHG    4RI4    4RI5    4S0G    6HKS   
Structural Biology KnowledgeBase2B49    4QUM    4QUN    4RH5    4RH9    4RHG    4RI4    4RI5    4S0G    6HKS   
SCOP (Structural Classification of Proteins)2B49    4QUM    4QUN    4RH5    4RH9    4RHG    4RI4    4RI5    4S0G    6HKS   
CATH (Classification of proteins structures)2B49    4QUM    4QUN    4RH5    4RH9    4RHG    4RI4    4RI5    4S0G    6HKS   
SuperfamilyP26045
AlphaFold pdb e-kbP26045   
Human Protein Atlas [tissue]ENSG00000070159-PTPN3 [tissue]
HPRD06767
Protein Interaction databases
DIP (DOE-UCLA)P26045
IntAct (EBI)P26045
BioGRIDPTPN3
STRING (EMBL)PTPN3
ZODIACPTPN3
Ontologies - Pathways
QuickGOP26045
Ontology : AmiGOMAPK cascade  phosphotyrosine residue binding  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  protein binding  cytoplasm  cytoplasm  cytosol  cytoskeleton  plasma membrane  protein dephosphorylation  cytoskeletal protein binding  cytoplasmic side of plasma membrane  cytoplasmic side of plasma membrane  sodium channel regulator activity  peptidyl-tyrosine dephosphorylation  negative regulation of epidermal growth factor receptor signaling pathway  negative regulation of mitotic cell cycle  negative regulation of membrane protein ectodomain proteolysis  ATPase binding  liver regeneration  regulation of membrane depolarization during action potential  regulation of sodium ion transmembrane transporter activity  
Ontology : EGO-EBIMAPK cascade  phosphotyrosine residue binding  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  protein binding  cytoplasm  cytoplasm  cytosol  cytoskeleton  plasma membrane  protein dephosphorylation  cytoskeletal protein binding  cytoplasmic side of plasma membrane  cytoplasmic side of plasma membrane  sodium channel regulator activity  peptidyl-tyrosine dephosphorylation  negative regulation of epidermal growth factor receptor signaling pathway  negative regulation of mitotic cell cycle  negative regulation of membrane protein ectodomain proteolysis  ATPase binding  liver regeneration  regulation of membrane depolarization during action potential  regulation of sodium ion transmembrane transporter activity  
NDEx NetworkPTPN3
Atlas of Cancer Signalling NetworkPTPN3
Wikipedia pathwaysPTPN3
Orthology - Evolution
OrthoDB5774
GeneTree (enSembl)ENSG00000070159
Phylogenetic Trees/Animal Genes : TreeFamPTPN3
Homologs : HomoloGenePTPN3
Homology/Alignments : Family Browser (UCSC)PTPN3
Gene fusions - Rearrangements
Fusion : MitelmanALK/PTPN3 [2p23.2/9q31.3]  
Fusion : MitelmanEPB41L4B/PTPN3 [9q31.3/9q31.3]  
Fusion : MitelmanRB1CC1/PTPN3 [8q11.23/9q31.3]  
Fusion : QuiverPTPN3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTPN3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTPN3
dbVarPTPN3
ClinVarPTPN3
MonarchPTPN3
1000_GenomesPTPN3 
Exome Variant ServerPTPN3
GNOMAD BrowserENSG00000070159
Varsome BrowserPTPN3
ACMGPTPN3 variants
VarityP26045
Genomic Variants (DGV)PTPN3 [DGVbeta]
DECIPHERPTPN3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTPN3 
Mutations
ICGC Data PortalPTPN3 
TCGA Data PortalPTPN3 
Broad Tumor PortalPTPN3
OASIS PortalPTPN3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTPN3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPTPN3
Mutations and Diseases : HGMDPTPN3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPTPN3
DgiDB (Drug Gene Interaction Database)PTPN3
DoCM (Curated mutations)PTPN3
CIViC (Clinical Interpretations of Variants in Cancer)PTPN3
Cancer3DPTPN3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176877   
Orphanet10951   
DisGeNETPTPN3
MedgenPTPN3
Genetic Testing Registry PTPN3
NextProtP26045 [Medical]
GENETestsPTPN3
Target ValidationPTPN3
Huge Navigator PTPN3 [HugePedia]
ClinGenPTPN3
Clinical trials, drugs, therapy
MyCancerGenomePTPN3
Protein Interactions : CTDPTPN3
Pharm GKB GenePA33999
PharosP26045
Clinical trialPTPN3
Miscellaneous
canSAR (ICR)PTPN3
HarmonizomePTPN3
DataMed IndexPTPN3
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPTPN3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:27:30 CEST 2021

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