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PTPN4 (protein tyrosine phosphatase, non-receptor type 4)

Identity

Alias_namesprotein tyrosine phosphatase
Alias_symbol (synonym)PTPMEG
Other aliasMEG
PTPMEG1
HGNC (Hugo) PTPN4
LocusID (NCBI) 5775
Atlas_Id 41919
Location 2q14.2  [Link to chromosome band 2q14]
Location_base_pair Starts at 120517207 and ends at 120742474 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PTPN4 (2q14.2) / CD68 (17p13.1)PTPN4 (2q14.2) / PTPN4 (2q14.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PTPN4   9656
Cards
Entrez_Gene (NCBI)PTPN4  5775  protein tyrosine phosphatase, non-receptor type 4
AliasesMEG; PTPMEG; PTPMEG1
GeneCards (Weizmann)PTPN4
Ensembl hg19 (Hinxton)ENSG00000088179 [Gene_View]  chr2:120517207-120742474 [Contig_View]  PTPN4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000088179 [Gene_View]  chr2:120517207-120742474 [Contig_View]  PTPN4 [Vega]
ICGC DataPortalENSG00000088179
TCGA cBioPortalPTPN4
AceView (NCBI)PTPN4
Genatlas (Paris)PTPN4
WikiGenes5775
SOURCE (Princeton)PTPN4
Genetics Home Reference (NIH)PTPN4
Genomic and cartography
GoldenPath hg19 (UCSC)PTPN4  -     chr2:120517207-120742474 +  2q14.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PTPN4  -     2q14.2   [Description]    (hg38-Dec_2013)
EnsemblPTPN4 - 2q14.2 [CytoView hg19]  PTPN4 - 2q14.2 [CytoView hg38]
Mapping of homologs : NCBIPTPN4 [Mapview hg19]  PTPN4 [Mapview hg38]
OMIM176878   
Gene and transcription
Genbank (Entrez)AK025546 AK301218 AK314836 BC010674 BC037838
RefSeq transcript (Entrez)NM_002830
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_005403 NW_004929304
Consensus coding sequences : CCDS (NCBI)PTPN4
Cluster EST : UnigeneHs.469809 [ NCBI ]
CGAP (NCI)Hs.469809
Alternative Splicing GalleryENSG00000088179
Gene ExpressionPTPN4 [ NCBI-GEO ]   PTPN4 [ EBI - ARRAY_EXPRESS ]   PTPN4 [ SEEK ]   PTPN4 [ MEM ]
Gene Expression Viewer (FireBrowse)PTPN4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5775
GTEX Portal (Tissue expression)PTPN4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP29074   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP29074  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP29074
Splice isoforms : SwissVarP29074
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.483.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   
PhosPhoSitePlusP29074
Domaine pattern : Prosite (Expaxy)FERM_1 (PS00660)    FERM_2 (PS00661)    FERM_3 (PS50057)    PDZ (PS50106)    TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)Band_41_domain    FERM-adjacent    FERM/acyl-CoA-bd_prot_3-hlx    FERM_central    FERM_CS    FERM_domain    FERM_N    FERM_PH-like_C    PDZ    PH_dom-like    Prot-tyrosine_phosphatase-like    PTPase_domain    Tyr_Pase_AS    Tyr_Pase_non-rcpt_typ-3/4    TYR_PHOSPHATASE_dom    Ubiquitin-rel_dom   
Domain families : Pfam (Sanger)FA (PF08736)    FERM_C (PF09380)    FERM_M (PF00373)    FERM_N (PF09379)    PDZ (PF00595)    Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam08736    pfam09380    pfam00373    pfam09379    pfam00595    pfam00102   
Domain families : Smart (EMBL)B41 (SM00295)  PDZ (SM00228)  PTPc (SM00194)  
Conserved Domain (NCBI)PTPN4
DMDM Disease mutations5775
Blocks (Seattle)PTPN4
PDB (SRS)2CS5    2I75    2VPH    3NFK    3NFL   
PDB (PDBSum)2CS5    2I75    2VPH    3NFK    3NFL   
PDB (IMB)2CS5    2I75    2VPH    3NFK    3NFL   
PDB (RSDB)2CS5    2I75    2VPH    3NFK    3NFL   
Structural Biology KnowledgeBase2CS5    2I75    2VPH    3NFK    3NFL   
SCOP (Structural Classification of Proteins)2CS5    2I75    2VPH    3NFK    3NFL   
CATH (Classification of proteins structures)2CS5    2I75    2VPH    3NFK    3NFL   
SuperfamilyP29074
Human Protein AtlasENSG00000088179
Peptide AtlasP29074
HPRD01471
IPIIPI00019949   IPI00924773   IPI00927207   IPI00925002   IPI00927922   IPI00927494   IPI01015081   
Protein Interaction databases
DIP (DOE-UCLA)P29074
IntAct (EBI)P29074
FunCoupENSG00000088179
BioGRIDPTPN4
STRING (EMBL)PTPN4
ZODIACPTPN4
Ontologies - Pathways
QuickGOP29074
Ontology : AmiGOnon-membrane spanning protein tyrosine phosphatase activity  protein binding  cytoplasm  cytoskeleton  protein dephosphorylation  cytoskeletal protein binding  cytoplasmic side of plasma membrane  peptidyl-tyrosine dephosphorylation  
Ontology : EGO-EBInon-membrane spanning protein tyrosine phosphatase activity  protein binding  cytoplasm  cytoskeleton  protein dephosphorylation  cytoskeletal protein binding  cytoplasmic side of plasma membrane  peptidyl-tyrosine dephosphorylation  
NDEx NetworkPTPN4
Atlas of Cancer Signalling NetworkPTPN4
Wikipedia pathwaysPTPN4
Orthology - Evolution
OrthoDB5775
GeneTree (enSembl)ENSG00000088179
Phylogenetic Trees/Animal Genes : TreeFamPTPN4
HOVERGENP29074
HOGENOMP29074
Homologs : HomoloGenePTPN4
Homology/Alignments : Family Browser (UCSC)PTPN4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTPN4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTPN4
dbVarPTPN4
ClinVarPTPN4
1000_GenomesPTPN4 
Exome Variant ServerPTPN4
ExAC (Exome Aggregation Consortium)PTPN4 (select the gene name)
Genetic variants : HAPMAP5775
Genomic Variants (DGV)PTPN4 [DGVbeta]
DECIPHER (Syndromes)2:120517207-120742474  ENSG00000088179
CONAN: Copy Number AnalysisPTPN4 
Mutations
ICGC Data PortalPTPN4 
TCGA Data PortalPTPN4 
Broad Tumor PortalPTPN4
OASIS PortalPTPN4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTPN4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTPN4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTPN4
DgiDB (Drug Gene Interaction Database)PTPN4
DoCM (Curated mutations)PTPN4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTPN4 (select a term)
intoGenPTPN4
Cancer3DPTPN4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176878   
Orphanet
MedgenPTPN4
Genetic Testing Registry PTPN4
NextProtP29074 [Medical]
TSGene5775
GENETestsPTPN4
Huge Navigator PTPN4 [HugePedia]
snp3D : Map Gene to Disease5775
BioCentury BCIQPTPN4
ClinGenPTPN4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5775
Chemical/Pharm GKB GenePA34000
Clinical trialPTPN4
Miscellaneous
canSAR (ICR)PTPN4 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTPN4
EVEXPTPN4
GoPubMedPTPN4
iHOPPTPN4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:16:14 CEST 2017

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