Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PTPN5 (protein tyrosine phosphatase, non-receptor type 5)

Identity

Alias_namesprotein tyrosine phosphatase
Alias_symbol (synonym)STEP
PTPSTEP
STEP61
Other alias
HGNC (Hugo) PTPN5
LocusID (NCBI) 84867
Atlas_Id 49904
Location 11p15.1  [Link to chromosome band 11p15]
Location_base_pair Starts at 18727928 and ends at 18791842 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PTPN5   9657
Cards
Entrez_Gene (NCBI)PTPN5  84867  protein tyrosine phosphatase, non-receptor type 5
AliasesPTPSTEP; STEP; STEP61
GeneCards (Weizmann)PTPN5
Ensembl hg19 (Hinxton)ENSG00000110786 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110786 [Gene_View]  ENSG00000110786 [Sequence]  chr11:18727928-18791842 [Contig_View]  PTPN5 [Vega]
ICGC DataPortalENSG00000110786
TCGA cBioPortalPTPN5
AceView (NCBI)PTPN5
Genatlas (Paris)PTPN5
WikiGenes84867
SOURCE (Princeton)PTPN5
Genetics Home Reference (NIH)PTPN5
Genomic and cartography
GoldenPath hg38 (UCSC)PTPN5  -     chr11:18727928-18791842 -  11p15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTPN5  -     11p15.1   [Description]    (hg19-Feb_2009)
EnsemblPTPN5 - 11p15.1 [CytoView hg19]  PTPN5 - 11p15.1 [CytoView hg38]
Mapping of homologs : NCBIPTPN5 [Mapview hg19]  PTPN5 [Mapview hg38]
OMIM176879   
Gene and transcription
Genbank (Entrez)AK027333 AK055450 AK090923 AK127312 AK294374
RefSeq transcript (Entrez)NM_001039970 NM_001278236 NM_001278238 NM_001278239 NM_006906 NM_032781
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PTPN5
Cluster EST : UnigeneHs.79092 [ NCBI ]
CGAP (NCI)Hs.79092
Alternative Splicing GalleryENSG00000110786
Gene ExpressionPTPN5 [ NCBI-GEO ]   PTPN5 [ EBI - ARRAY_EXPRESS ]   PTPN5 [ SEEK ]   PTPN5 [ MEM ]
Gene Expression Viewer (FireBrowse)PTPN5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84867
GTEX Portal (Tissue expression)PTPN5
Human Protein AtlasENSG00000110786-PTPN5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP54829   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP54829  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP54829
Splice isoforms : SwissVarP54829
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.483.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   
PhosPhoSitePlusP54829
Domaine pattern : Prosite (Expaxy)TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)Prot-tyrosine_phosphatase-like    PTPase_domain    Tyr_Pase_AS    Tyr_Pase_cat    Tyr_Pase_KIM-con    Tyr_Pase_rcpt_R/non-rcpt_5    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam00102   
Domain families : Smart (EMBL)PTPc (SM00194)  PTPc_motif (SM00404)  
Conserved Domain (NCBI)PTPN5
DMDM Disease mutations84867
Blocks (Seattle)PTPN5
PDB (SRS)2BIJ    2BV5    2CJZ    5OVR    5OVX    5OW1   
PDB (PDBSum)2BIJ    2BV5    2CJZ    5OVR    5OVX    5OW1   
PDB (IMB)2BIJ    2BV5    2CJZ    5OVR    5OVX    5OW1   
PDB (RSDB)2BIJ    2BV5    2CJZ    5OVR    5OVX    5OW1   
Structural Biology KnowledgeBase2BIJ    2BV5    2CJZ    5OVR    5OVX    5OW1   
SCOP (Structural Classification of Proteins)2BIJ    2BV5    2CJZ    5OVR    5OVX    5OW1   
CATH (Classification of proteins structures)2BIJ    2BV5    2CJZ    5OVR    5OVX    5OW1   
SuperfamilyP54829
Human Protein Atlas [tissue]ENSG00000110786-PTPN5 [tissue]
Peptide AtlasP54829
HPRD01472
IPIIPI00008837   IPI00743309   IPI00792639   IPI00790935   IPI00980345   
Protein Interaction databases
DIP (DOE-UCLA)P54829
IntAct (EBI)P54829
FunCoupENSG00000110786
BioGRIDPTPN5
STRING (EMBL)PTPN5
ZODIACPTPN5
Ontologies - Pathways
QuickGOP54829
Ontology : AmiGOphosphotyrosine residue binding  protein tyrosine phosphatase activity  protein binding  nucleoplasm  endoplasmic reticulum membrane  protein dephosphorylation  integral component of membrane  peptidyl-tyrosine dephosphorylation  cellular response to cytokine stimulus  
Ontology : EGO-EBIphosphotyrosine residue binding  protein tyrosine phosphatase activity  protein binding  nucleoplasm  endoplasmic reticulum membrane  protein dephosphorylation  integral component of membrane  peptidyl-tyrosine dephosphorylation  cellular response to cytokine stimulus  
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkPTPN5
Atlas of Cancer Signalling NetworkPTPN5
Wikipedia pathwaysPTPN5
Orthology - Evolution
OrthoDB84867
GeneTree (enSembl)ENSG00000110786
Phylogenetic Trees/Animal Genes : TreeFamPTPN5
HOVERGENP54829
HOGENOMP54829
Homologs : HomoloGenePTPN5
Homology/Alignments : Family Browser (UCSC)PTPN5
Gene fusions - Rearrangements
Fusion : QuiverPTPN5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTPN5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTPN5
dbVarPTPN5
ClinVarPTPN5
1000_GenomesPTPN5 
Exome Variant ServerPTPN5
ExAC (Exome Aggregation Consortium)ENSG00000110786
GNOMAD BrowserENSG00000110786
Varsome BrowserPTPN5
Genetic variants : HAPMAP84867
Genomic Variants (DGV)PTPN5 [DGVbeta]
DECIPHERPTPN5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTPN5 
Mutations
ICGC Data PortalPTPN5 
TCGA Data PortalPTPN5 
Broad Tumor PortalPTPN5
OASIS PortalPTPN5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTPN5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTPN5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTPN5
DgiDB (Drug Gene Interaction Database)PTPN5
DoCM (Curated mutations)PTPN5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTPN5 (select a term)
intoGenPTPN5
Cancer3DPTPN5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176879   
Orphanet
DisGeNETPTPN5
MedgenPTPN5
Genetic Testing Registry PTPN5
NextProtP54829 [Medical]
TSGene84867
GENETestsPTPN5
Target ValidationPTPN5
Huge Navigator PTPN5 [HugePedia]
snp3D : Map Gene to Disease84867
BioCentury BCIQPTPN5
ClinGenPTPN5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84867
Chemical/Pharm GKB GenePA34001
Clinical trialPTPN5
Miscellaneous
canSAR (ICR)PTPN5 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTPN5
EVEXPTPN5
GoPubMedPTPN5
iHOPPTPN5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:47:13 CEST 2018
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