Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PTPN5 (protein tyrosine phosphatase non-receptor type 5)

Identity

Alias (NCBI)PTPSTEP
STEP
STEP61
HGNC (Hugo) PTPN5
HGNC Alias symbSTEP
PTPSTEP
STEP61
HGNC Alias namestriatal-enriched protein tyrosine phosphatase
HGNC Previous nameprotein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
LocusID (NCBI) 84867
Atlas_Id 49904
Location 11p15.1  [Link to chromosome band 11p15]
Location_base_pair Starts at 18727928 and ends at 18791798 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)PTPN5   9657
Cards
Entrez_Gene (NCBI)PTPN5    protein tyrosine phosphatase non-receptor type 5
AliasesPTPSTEP; STEP; STEP61
GeneCards (Weizmann)PTPN5
Ensembl hg19 (Hinxton)ENSG00000110786 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110786 [Gene_View]  ENSG00000110786 [Sequence]  chr11:18727928-18791798 [Contig_View]  PTPN5 [Vega]
ICGC DataPortalENSG00000110786
TCGA cBioPortalPTPN5
AceView (NCBI)PTPN5
Genatlas (Paris)PTPN5
SOURCE (Princeton)PTPN5
Genetics Home Reference (NIH)PTPN5
Genomic and cartography
GoldenPath hg38 (UCSC)PTPN5  -     chr11:18727928-18791798 -  11p15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTPN5  -     11p15.1   [Description]    (hg19-Feb_2009)
GoldenPathPTPN5 - 11p15.1 [CytoView hg19]  PTPN5 - 11p15.1 [CytoView hg38]
ImmunoBaseENSG00000110786
Genome Data Viewer NCBIPTPN5 [Mapview hg19]  
OMIM176879   
Gene and transcription
Genbank (Entrez)AK027333 AK055450 AK090923 AK127312 AK294374
RefSeq transcript (Entrez)NM_001039970 NM_001278236 NM_001278238 NM_001278239 NM_006906 NM_032781
Consensus coding sequences : CCDS (NCBI)PTPN5
Gene ExpressionPTPN5 [ NCBI-GEO ]   PTPN5 [ EBI - ARRAY_EXPRESS ]   PTPN5 [ SEEK ]   PTPN5 [ MEM ]
Gene Expression Viewer (FireBrowse)PTPN5 [ Firebrowse - Broad ]
GenevisibleExpression of PTPN5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84867
GTEX Portal (Tissue expression)PTPN5
Human Protein AtlasENSG00000110786-PTPN5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP54829   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP54829  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP54829
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.483.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP54829
Domaine pattern : Prosite (Expaxy)TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)Prot-tyrosine_phosphatase-like    PTPase_domain    Tyr_Pase_AS    Tyr_Pase_cat    Tyr_Pase_KIM-con    Tyr_Pase_rcpt_R/non-rcpt_5    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam00102   
Domain families : Smart (EMBL)PTPc (SM00194)  PTPc_motif (SM00404)  
Conserved Domain (NCBI)PTPN5
PDB (RSDB)2BIJ    2BV5    2CJZ    5OVR    5OVX    5OW1    6H8R   
PDB Europe2BIJ    2BV5    2CJZ    5OVR    5OVX    5OW1    6H8R   
PDB (PDBSum)2BIJ    2BV5    2CJZ    5OVR    5OVX    5OW1    6H8R   
PDB (IMB)2BIJ    2BV5    2CJZ    5OVR    5OVX    5OW1    6H8R   
Structural Biology KnowledgeBase2BIJ    2BV5    2CJZ    5OVR    5OVX    5OW1    6H8R   
SCOP (Structural Classification of Proteins)2BIJ    2BV5    2CJZ    5OVR    5OVX    5OW1    6H8R   
CATH (Classification of proteins structures)2BIJ    2BV5    2CJZ    5OVR    5OVX    5OW1    6H8R   
SuperfamilyP54829
AlphaFold pdb e-kbP54829   
Human Protein Atlas [tissue]ENSG00000110786-PTPN5 [tissue]
HPRD01472
Protein Interaction databases
DIP (DOE-UCLA)P54829
IntAct (EBI)P54829
BioGRIDPTPN5
STRING (EMBL)PTPN5
ZODIACPTPN5
Ontologies - Pathways
QuickGOP54829
Ontology : AmiGOphosphotyrosine residue binding  protein tyrosine phosphatase activity  protein binding  nucleoplasm  endoplasmic reticulum membrane  protein dephosphorylation  integral component of membrane  peptidyl-tyrosine dephosphorylation  cellular response to cytokine stimulus  
Ontology : EGO-EBIphosphotyrosine residue binding  protein tyrosine phosphatase activity  protein binding  nucleoplasm  endoplasmic reticulum membrane  protein dephosphorylation  integral component of membrane  peptidyl-tyrosine dephosphorylation  cellular response to cytokine stimulus  
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkPTPN5
Atlas of Cancer Signalling NetworkPTPN5
Wikipedia pathwaysPTPN5
Orthology - Evolution
OrthoDB84867
GeneTree (enSembl)ENSG00000110786
Phylogenetic Trees/Animal Genes : TreeFamPTPN5
Homologs : HomoloGenePTPN5
Homology/Alignments : Family Browser (UCSC)PTPN5
Gene fusions - Rearrangements
Fusion : QuiverPTPN5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTPN5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTPN5
dbVarPTPN5
ClinVarPTPN5
MonarchPTPN5
1000_GenomesPTPN5 
Exome Variant ServerPTPN5
GNOMAD BrowserENSG00000110786
Varsome BrowserPTPN5
ACMGPTPN5 variants
VarityP54829
Genomic Variants (DGV)PTPN5 [DGVbeta]
DECIPHERPTPN5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTPN5 
Mutations
ICGC Data PortalPTPN5 
TCGA Data PortalPTPN5 
Broad Tumor PortalPTPN5
OASIS PortalPTPN5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTPN5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPTPN5
Mutations and Diseases : HGMDPTPN5
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPTPN5
DgiDB (Drug Gene Interaction Database)PTPN5
DoCM (Curated mutations)PTPN5
CIViC (Clinical Interpretations of Variants in Cancer)PTPN5
Cancer3DPTPN5
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176879   
Orphanet
DisGeNETPTPN5
MedgenPTPN5
Genetic Testing Registry PTPN5
NextProtP54829 [Medical]
GENETestsPTPN5
Target ValidationPTPN5
Huge Navigator PTPN5 [HugePedia]
ClinGenPTPN5
Clinical trials, drugs, therapy
MyCancerGenomePTPN5
Protein Interactions : CTDPTPN5
Pharm GKB GenePA34001
PharosP54829
Clinical trialPTPN5
Miscellaneous
canSAR (ICR)PTPN5
HarmonizomePTPN5
DataMed IndexPTPN5
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPTPN5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:27:30 CEST 2021
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