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PTPN9 (protein tyrosine phosphatase, non-receptor type 9)

Identity

Other namesMEG2
PTPMEG2
HGNC (Hugo) PTPN9
LocusID (NCBI) 5780
Atlas_Id 41922
Location 15q24.2
Location_base_pair Starts at 75759462 and ends at 75871632 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PTPN9 (15q24.2) / AGBL1 (15q25.3)PTPN9 (15q24.2) / BUB3 (10q26.13)PTPN9 (15q24.2) / TOR1AIP2 (1q25.2)
SIN3A (15q24.2) / PTPN9 (15q24.2)PTPN9 15q24.2 / AGBL1 15q25.3SIN3A 15q24.2 / PTPN9 15q24.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PTPN9   9661
Cards
Entrez_Gene (NCBI)PTPN9  5780  protein tyrosine phosphatase, non-receptor type 9
AliasesMEG2; PTPMEG2
GeneCards (Weizmann)PTPN9
Ensembl hg19 (Hinxton)ENSG00000169410 [Gene_View]  chr15:75759462-75871632 [Contig_View]  PTPN9 [Vega]
Ensembl hg38 (Hinxton)ENSG00000169410 [Gene_View]  chr15:75759462-75871632 [Contig_View]  PTPN9 [Vega]
ICGC DataPortalENSG00000169410
TCGA cBioPortalPTPN9
AceView (NCBI)PTPN9
Genatlas (Paris)PTPN9
WikiGenes5780
SOURCE (Princeton)PTPN9
Genomic and cartography
GoldenPath hg19 (UCSC)PTPN9  -     chr15:75759462-75871632 -  15q24.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PTPN9  -     15q24.2   [Description]    (hg38-Dec_2013)
EnsemblPTPN9 - 15q24.2 [CytoView hg19]  PTPN9 - 15q24.2 [CytoView hg38]
Mapping of homologs : NCBIPTPN9 [Mapview hg19]  PTPN9 [Mapview hg38]
OMIM600768   
Gene and transcription
Genbank (Entrez)BC010863 BC071574 BT007405 DQ890986 M83738
RefSeq transcript (Entrez)NM_002833
RefSeq genomic (Entrez)NC_000015 NC_018926 NT_010194 NW_004929398
Consensus coding sequences : CCDS (NCBI)PTPN9
Cluster EST : UnigeneHs.445775 [ NCBI ]
CGAP (NCI)Hs.445775
Alternative Splicing GalleryENSG00000169410
Gene ExpressionPTPN9 [ NCBI-GEO ]   PTPN9 [ EBI - ARRAY_EXPRESS ]   PTPN9 [ SEEK ]   PTPN9 [ MEM ]
Gene Expression Viewer (FireBrowse)PTPN9 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5780
GTEX Portal (Tissue expression)PTPN9
Protein : pattern, domain, 3D structure
UniProt/SwissProtP43378 (Uniprot)
NextProtP43378  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP43378
Splice isoforms : SwissVarP43378 (Swissvar)
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.483.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   
PhosPhoSitePlusP43378
Domaine pattern : Prosite (Expaxy)CRAL_TRIO (PS50191)    TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)CRAL-TRIO_dom    CRAL/TRIO_N_dom    Prot-tyrosine_phosphatase-like    PTPase_domain    Tyr_Pase_AS    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)CRAL_TRIO (PF00650)    Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam00650    pfam00102   
Domain families : Smart (EMBL)CRAL_TRIO_N (SM01100)  PTPc (SM00194)  SEC14 (SM00516)  
DMDM Disease mutations5780
Blocks (Seattle)PTPN9
PDB (SRS)2PA5    4GE2    4GE5    4GE6    4ICZ   
PDB (PDBSum)2PA5    4GE2    4GE5    4GE6    4ICZ   
PDB (IMB)2PA5    4GE2    4GE5    4GE6    4ICZ   
PDB (RSDB)2PA5    4GE2    4GE5    4GE6    4ICZ   
Structural Biology KnowledgeBase2PA5    4GE2    4GE5    4GE6    4ICZ   
SCOP (Structural Classification of Proteins)2PA5    4GE2    4GE5    4GE6    4ICZ   
CATH (Classification of proteins structures)2PA5    4GE2    4GE5    4GE6    4ICZ   
SuperfamilyP43378
Human Protein AtlasENSG00000169410
Peptide AtlasP43378
HPRD02864
IPIIPI00852804   IPI01010466   
Protein Interaction databases
DIP (DOE-UCLA)P43378
IntAct (EBI)P43378
FunCoupENSG00000169410
BioGRIDPTPN9
STRING (EMBL)PTPN9
ZODIACPTPN9
Ontologies - Pathways
QuickGOP43378
Ontology : AmiGOprotein tyrosine phosphatase activity  non-membrane spanning protein tyrosine phosphatase activity  protein binding  cytoplasm  protein dephosphorylation  peptidyl-tyrosine dephosphorylation  
Ontology : EGO-EBIprotein tyrosine phosphatase activity  non-membrane spanning protein tyrosine phosphatase activity  protein binding  cytoplasm  protein dephosphorylation  peptidyl-tyrosine dephosphorylation  
NDEx Network
Atlas of Cancer Signalling NetworkPTPN9
Wikipedia pathwaysPTPN9
Orthology - Evolution
OrthoDB5780
GeneTree (enSembl)ENSG00000169410
Phylogenetic Trees/Animal Genes : TreeFamPTPN9
Homologs : HomoloGenePTPN9
Homology/Alignments : Family Browser (UCSC)PTPN9
Gene fusions - Rearrangements
Fusion: TCGAPTPN9 15q24.2 AGBL1 15q25.3 BRCA
Fusion: TCGASIN3A 15q24.2 PTPN9 15q24.2 LGG
Polymorphisms : SNP, variants
NCBI Variation ViewerPTPN9 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTPN9
dbVarPTPN9
ClinVarPTPN9
1000_GenomesPTPN9 
Exome Variant ServerPTPN9
ExAC (Exome Aggregation Consortium)PTPN9 (select the gene name)
Genetic variants : HAPMAP5780
Genomic Variants (DGV)PTPN9 [DGVbeta]
Mutations
ICGC Data PortalPTPN9 
TCGA Data PortalPTPN9 
Broad Tumor PortalPTPN9
OASIS PortalPTPN9 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTPN9 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTPN9
DgiDB (Drug Gene Interaction Database)PTPN9
DoCM (Curated mutations)PTPN9 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTPN9 (select a term)
intoGenPTPN9
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)15:75759462-75871632  ENSG00000169410
CONAN: Copy Number AnalysisPTPN9 
Mutations and Diseases : HGMDPTPN9
OMIM600768   
MedgenPTPN9
Genetic Testing Registry PTPN9
NextProtP43378 [Medical]
TSGene5780
GENETestsPTPN9
Huge Navigator PTPN9 [HugePedia]
snp3D : Map Gene to Disease5780
BioCentury BCIQPTPN9
ClinGenPTPN9
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5780
Chemical/Pharm GKB GenePA34005
Clinical trialPTPN9
Miscellaneous
canSAR (ICR)PTPN9 (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTPN9
EVEXPTPN9
GoPubMedPTPN9
iHOPPTPN9
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat May 28 11:17:41 CEST 2016

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