PTPRB (protein tyrosine phosphatase receptor type B)

2003-11-01  

Identity

HGNC
LOCATION
12q15
LOCUSID
ALIAS
HPTP-BETA,HPTPB,PTPB,R-PTP-BETA,VEPTP
FUSION GENES

Other Information

Locus ID:

NCBI: 5787
MIM: 176882
HGNC: 9665
Ensembl: ENSG00000127329

Variants:

dbSNP: 5787
ClinVar: 5787
TCGA: ENSG00000127329
COSMIC: PTPRB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127329ENST00000261266P23467
ENSG00000127329ENST00000334414P23467
ENSG00000127329ENST00000538708P23467
ENSG00000127329ENST00000547715H0YHE8
ENSG00000127329ENST00000548122Q6ZR19
ENSG00000127329ENST00000550358F8VU56
ENSG00000127329ENST00000550857P23467
ENSG00000127329ENST00000551525F8VSD5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Adherens junctionKEGGko04520
Adherens junctionKEGGhsa04520
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
246331572014Recurrent PTPRB and PLCG1 mutations in angiosarcoma.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
251806012014Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature.55
191366122009Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis.51
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.45
222753602012Picomolar concentrations of free zinc(II) ions regulate receptor protein-tyrosine phosphatase β activity.41
203011962010Promotion of cell spreading and migration by vascular endothelial-protein tyrosine phosphatase (VE-PTP) in cooperation with integrins.13
191167662009Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells.11
156387282005Protein tyrosine phosphatases and their inhibitors.7
273145622016Protein tyrosine phosphatase PTPRB regulates Src phosphorylation and tumour progression in NSCLC.7

Citation

Dessen P

PTPRB (protein tyrosine phosphatase receptor type B)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41924/ptprb