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PTPRB (protein tyrosine phosphatase, receptor type B)

Identity

Alias_namesPTPB
Other aliasHPTP-BETA
HPTPB
R-PTP-BETA
VEPTP
HGNC (Hugo) PTPRB
LocusID (NCBI) 5787
Atlas_Id 41924
Location 12q15  [Link to chromosome band 12q15]
Location_base_pair Starts at 70515871 and ends at 70637440 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CPSF6 (12q15) / PTPRB (12q15)PTGES3 (12q13.3) / PTPRB (12q15)ZZZ3 (1p31.1) / PTPRB (12q15)
CPSF6 12q15 / PTPRB 12q15

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Bone: Angiosarcoma
Bone: Vascular Tumors


External links

Nomenclature
HGNC (Hugo)PTPRB   9665
Cards
Entrez_Gene (NCBI)PTPRB  5787  protein tyrosine phosphatase, receptor type B
AliasesHPTP-BETA; HPTPB; PTPB; R-PTP-BETA; 
VEPTP
GeneCards (Weizmann)PTPRB
Ensembl hg19 (Hinxton)ENSG00000127329 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000127329 [Gene_View]  chr12:70515871-70637440 [Contig_View]  PTPRB [Vega]
ICGC DataPortalENSG00000127329
TCGA cBioPortalPTPRB
AceView (NCBI)PTPRB
Genatlas (Paris)PTPRB
WikiGenes5787
SOURCE (Princeton)PTPRB
Genetics Home Reference (NIH)PTPRB
Genomic and cartography
GoldenPath hg38 (UCSC)PTPRB  -     chr12:70515871-70637440 -  12q15   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTPRB  -     12q15   [Description]    (hg19-Feb_2009)
EnsemblPTPRB - 12q15 [CytoView hg19]  PTPRB - 12q15 [CytoView hg38]
Mapping of homologs : NCBIPTPRB [Mapview hg19]  PTPRB [Mapview hg38]
OMIM176882   
Gene and transcription
Genbank (Entrez)AI688145 AK023720 AK096717 AK097371 AK126121
RefSeq transcript (Entrez)NM_001109754 NM_001206971 NM_001206972 NM_001330204 NM_002837
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PTPRB
Cluster EST : UnigeneHs.434375 [ NCBI ]
CGAP (NCI)Hs.434375
Alternative Splicing GalleryENSG00000127329
Gene ExpressionPTPRB [ NCBI-GEO ]   PTPRB [ EBI - ARRAY_EXPRESS ]   PTPRB [ SEEK ]   PTPRB [ MEM ]
Gene Expression Viewer (FireBrowse)PTPRB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5787
GTEX Portal (Tissue expression)PTPRB
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23467   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP23467  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP23467
Splice isoforms : SwissVarP23467
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.483.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   
PhosPhoSitePlusP23467
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)FN3_dom    Ig-like_fold    Prot-tyrosine_phosphatase-like    PTPase_domain    Tyr_Pase_AS    Tyr_Pase_cat    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)fn3 (PF00041)    Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam00041    pfam00102   
Domain families : Smart (EMBL)FN3 (SM00060)  PTPc (SM00194)  PTPc_motif (SM00404)  
Conserved Domain (NCBI)PTPRB
DMDM Disease mutations5787
Blocks (Seattle)PTPRB
PDB (SRS)2AHS    2H02    2H03    2H04    2HC1    2HC2    2I3R    2I3U    2I4E    2I4G    2I4H    2I5X   
PDB (PDBSum)2AHS    2H02    2H03    2H04    2HC1    2HC2    2I3R    2I3U    2I4E    2I4G    2I4H    2I5X   
PDB (IMB)2AHS    2H02    2H03    2H04    2HC1    2HC2    2I3R    2I3U    2I4E    2I4G    2I4H    2I5X   
PDB (RSDB)2AHS    2H02    2H03    2H04    2HC1    2HC2    2I3R    2I3U    2I4E    2I4G    2I4H    2I5X   
Structural Biology KnowledgeBase2AHS    2H02    2H03    2H04    2HC1    2HC2    2I3R    2I3U    2I4E    2I4G    2I4H    2I5X   
SCOP (Structural Classification of Proteins)2AHS    2H02    2H03    2H04    2HC1    2HC2    2I3R    2I3U    2I4E    2I4G    2I4H    2I5X   
CATH (Classification of proteins structures)2AHS    2H02    2H03    2H04    2HC1    2HC2    2I3R    2I3U    2I4E    2I4G    2I4H    2I5X   
SuperfamilyP23467
Human Protein AtlasENSG00000127329
Peptide AtlasP23467
HPRD01474
IPIIPI00943305   IPI00954453   IPI00745991   IPI01011659   IPI00922867   IPI01021475   IPI01022284   IPI01021030   IPI01021143   IPI01022941   
Protein Interaction databases
DIP (DOE-UCLA)P23467
IntAct (EBI)P23467
FunCoupENSG00000127329
BioGRIDPTPRB
STRING (EMBL)PTPRB
ZODIACPTPRB
Ontologies - Pathways
QuickGOP23467
Ontology : AmiGOangiogenesis  transmembrane receptor protein tyrosine phosphatase activity  protein binding  plasma membrane  integral component of plasma membrane  protein dephosphorylation  phosphate-containing compound metabolic process  dephosphorylation  peptidyl-tyrosine dephosphorylation  specific granule membrane  receptor complex  neutrophil degranulation  tertiary granule membrane  
Ontology : EGO-EBIangiogenesis  transmembrane receptor protein tyrosine phosphatase activity  protein binding  plasma membrane  integral component of plasma membrane  protein dephosphorylation  phosphate-containing compound metabolic process  dephosphorylation  peptidyl-tyrosine dephosphorylation  specific granule membrane  receptor complex  neutrophil degranulation  tertiary granule membrane  
Pathways : BIOCARTASprouty regulation of tyrosine kinase signals [Genes]   
Pathways : KEGGAdherens junction   
NDEx NetworkPTPRB
Atlas of Cancer Signalling NetworkPTPRB
Wikipedia pathwaysPTPRB
Orthology - Evolution
OrthoDB5787
GeneTree (enSembl)ENSG00000127329
Phylogenetic Trees/Animal Genes : TreeFamPTPRB
HOVERGENP23467
HOGENOMP23467
Homologs : HomoloGenePTPRB
Homology/Alignments : Family Browser (UCSC)PTPRB
Gene fusions - Rearrangements
Fusion : MitelmanPTGES3/PTPRB [12q13.3/12q15]  [t(12;12)(q13;q15)]  
Fusion: TCGACPSF6 12q15 PTPRB 12q15 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTPRB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTPRB
dbVarPTPRB
ClinVarPTPRB
1000_GenomesPTPRB 
Exome Variant ServerPTPRB
ExAC (Exome Aggregation Consortium)PTPRB (select the gene name)
Genetic variants : HAPMAP5787
Genomic Variants (DGV)PTPRB [DGVbeta]
DECIPHERPTPRB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTPRB 
Mutations
ICGC Data PortalPTPRB 
TCGA Data PortalPTPRB 
Broad Tumor PortalPTPRB
OASIS PortalPTPRB [ Somatic mutations - Copy number]
Cancer Gene: CensusPTPRB 
Somatic Mutations in Cancer : COSMICPTPRB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTPRB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTPRB
DgiDB (Drug Gene Interaction Database)PTPRB
DoCM (Curated mutations)PTPRB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTPRB (select a term)
intoGenPTPRB
Cancer3DPTPRB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176882   
Orphanet
MedgenPTPRB
Genetic Testing Registry PTPRB
NextProtP23467 [Medical]
TSGene5787
GENETestsPTPRB
Target ValidationPTPRB
Huge Navigator PTPRB [HugePedia]
snp3D : Map Gene to Disease5787
BioCentury BCIQPTPRB
ClinGenPTPRB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5787
Chemical/Pharm GKB GenePA34010
Clinical trialPTPRB
Miscellaneous
canSAR (ICR)PTPRB (select the gene name)
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTPRB
EVEXPTPRB
GoPubMedPTPRB
iHOPPTPRB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:51:48 CEST 2017

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