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PTPRE (protein tyrosine phosphatase, receptor type E)

Identity

Alias_symbol (synonym)PTPE
Other aliasHPTPE
R-PTP-EPSILON
HGNC (Hugo) PTPRE
LocusID (NCBI) 5791
Atlas_Id 41928
Location 10q26.2  [Link to chromosome band 10q26]
Location_base_pair Starts at 127907061 and ends at 128085855 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GRK5 (10q26.11) / PTPRE (10q26.2)NCOA2 (8q13.3) / PTPRE (10q26.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PTPRE   9669
Cards
Entrez_Gene (NCBI)PTPRE  5791  protein tyrosine phosphatase, receptor type E
AliasesHPTPE; PTPE; R-PTP-EPSILON
GeneCards (Weizmann)PTPRE
Ensembl hg19 (Hinxton)ENSG00000132334 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132334 [Gene_View]  chr10:127907061-128085855 [Contig_View]  PTPRE [Vega]
ICGC DataPortalENSG00000132334
TCGA cBioPortalPTPRE
AceView (NCBI)PTPRE
Genatlas (Paris)PTPRE
WikiGenes5791
SOURCE (Princeton)PTPRE
Genetics Home Reference (NIH)PTPRE
Genomic and cartography
GoldenPath hg38 (UCSC)PTPRE  -     chr10:127907061-128085855 +  10q26.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTPRE  -     10q26.2   [Description]    (hg19-Feb_2009)
EnsemblPTPRE - 10q26.2 [CytoView hg19]  PTPRE - 10q26.2 [CytoView hg38]
Mapping of homologs : NCBIPTPRE [Mapview hg19]  PTPRE [Mapview hg38]
OMIM600926   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_001316676 NM_001316677 NM_001323354 NM_001323355 NM_001323356 NM_001323357 NM_006504 NM_130435
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PTPRE
Cluster EST : UnigeneHs.127022 [ NCBI ]
CGAP (NCI)Hs.127022
Alternative Splicing GalleryENSG00000132334
Gene ExpressionPTPRE [ NCBI-GEO ]   PTPRE [ EBI - ARRAY_EXPRESS ]   PTPRE [ SEEK ]   PTPRE [ MEM ]
Gene Expression Viewer (FireBrowse)PTPRE [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5791
GTEX Portal (Tissue expression)PTPRE
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23469   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP23469  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP23469
Splice isoforms : SwissVarP23469
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.483.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   
PhosPhoSitePlusP23469
Domaine pattern : Prosite (Expaxy)TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)Prot-tyrosine_phosphatase-like    PTPase_domain    Tyr_Pase_AS    Tyr_Pase_cat    Tyr_Pase_rcpt_a/e-type    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam00102   
Domain families : Smart (EMBL)PTPc (SM00194)  PTPc_motif (SM00404)  
Conserved Domain (NCBI)PTPRE
DMDM Disease mutations5791
Blocks (Seattle)PTPRE
PDB (SRS)2JJD   
PDB (PDBSum)2JJD   
PDB (IMB)2JJD   
PDB (RSDB)2JJD   
Structural Biology KnowledgeBase2JJD   
SCOP (Structural Classification of Proteins)2JJD   
CATH (Classification of proteins structures)2JJD   
SuperfamilyP23469
Human Protein AtlasENSG00000132334
Peptide AtlasP23469
HPRD02956
IPIIPI00334825   IPI00954465   IPI00642849   IPI00909409   IPI00011644   IPI00646681   
Protein Interaction databases
DIP (DOE-UCLA)P23469
IntAct (EBI)P23469
FunCoupENSG00000132334
BioGRIDPTPRE
STRING (EMBL)PTPRE
ZODIACPTPRE
Ontologies - Pathways
QuickGOP23469
Ontology : AmiGOtransmembrane receptor protein tyrosine phosphatase activity  protein binding  nucleus  cytoplasm  plasma membrane  protein dephosphorylation  transmembrane receptor protein tyrosine phosphatase signaling pathway  integral component of membrane  regulation of mast cell activation  peptidyl-tyrosine dephosphorylation  protein homodimerization activity  negative regulation of insulin receptor signaling pathway  
Ontology : EGO-EBItransmembrane receptor protein tyrosine phosphatase activity  protein binding  nucleus  cytoplasm  plasma membrane  protein dephosphorylation  transmembrane receptor protein tyrosine phosphatase signaling pathway  integral component of membrane  regulation of mast cell activation  peptidyl-tyrosine dephosphorylation  protein homodimerization activity  negative regulation of insulin receptor signaling pathway  
NDEx NetworkPTPRE
Atlas of Cancer Signalling NetworkPTPRE
Wikipedia pathwaysPTPRE
Orthology - Evolution
OrthoDB5791
GeneTree (enSembl)ENSG00000132334
Phylogenetic Trees/Animal Genes : TreeFamPTPRE
HOVERGENP23469
HOGENOMP23469
Homologs : HomoloGenePTPRE
Homology/Alignments : Family Browser (UCSC)PTPRE
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTPRE [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTPRE
dbVarPTPRE
ClinVarPTPRE
1000_GenomesPTPRE 
Exome Variant ServerPTPRE
ExAC (Exome Aggregation Consortium)PTPRE (select the gene name)
Genetic variants : HAPMAP5791
Genomic Variants (DGV)PTPRE [DGVbeta]
DECIPHERPTPRE [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTPRE 
Mutations
ICGC Data PortalPTPRE 
TCGA Data PortalPTPRE 
Broad Tumor PortalPTPRE
OASIS PortalPTPRE [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTPRE  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTPRE
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTPRE
DgiDB (Drug Gene Interaction Database)PTPRE
DoCM (Curated mutations)PTPRE (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTPRE (select a term)
intoGenPTPRE
Cancer3DPTPRE(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600926   
Orphanet
MedgenPTPRE
Genetic Testing Registry PTPRE
NextProtP23469 [Medical]
TSGene5791
GENETestsPTPRE
Target ValidationPTPRE
Huge Navigator PTPRE [HugePedia]
snp3D : Map Gene to Disease5791
BioCentury BCIQPTPRE
ClinGenPTPRE
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5791
Chemical/Pharm GKB GenePA34014
Clinical trialPTPRE
Miscellaneous
canSAR (ICR)PTPRE (select the gene name)
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTPRE
EVEXPTPRE
GoPubMedPTPRE
iHOPPTPRE
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:51:49 CEST 2017

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