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PTPRF (protein tyrosine phosphatase, receptor type, F)

Identity

Other namesLAR
HGNC (Hugo) PTPRF
LocusID (NCBI) 5792
Location 1p34.2
Location_base_pair Starts at 43996547 and ends at 44089343 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PTPRF   9670
Entrez_Gene (NCBI)PTPRF  5792  protein tyrosine phosphatase, receptor type, F
Cards
GeneCards (Weizmann)PTPRF
Ensembl (Hinxton)ENSG00000142949 [Gene_View]  chr1:43996547-44089343 [Contig_View]  PTPRF [Vega]
AceView (NCBI)PTPRF
Genatlas (Paris)PTPRF
SOURCE (Stanford)NM_002840 NM_130440
Genomic and cartography
GoldenPath (UCSC)PTPRF  -  1p34.2   chr1:43996547-44089343 +  1p34.2   [Description]    (hg19-Feb_2009)
EnsemblPTPRF - 1p34.2 [CytoView]
Mapping of homologs : NCBIPTPRF [Mapview]
OMIM179590   
Gene and transcription
Genbank (Entrez)AB177856 AB177857 AB209478 AB621807 AK023775
RefSeq transcript (SRS)NM_002840 NM_130440
RefSeq transcript (Entrez)NM_002840 NM_130440
RefSeq genomic (SRS)AC_000133 NC_000001 NC_018912 NT_032977 NW_001838578 NW_004077990
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NT_032977 NW_001838578 NW_004077990
Consensus coding sequences : CCDS (NCBI)PTPRF
Cluster EST : UnigeneHs.272062 [ SRS ] Hs.272062 [ NCBI ]
CGAP (NCI)Hs.272062
Alternative Splicing : Fast-db (Paris)GSHG0000449
Alternative Splicing GalleryENSG00000142949
Gene ExpressionPTPRF [ NCBI-GEO ]   PTPRF [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10586 (SRS) P10586 (Uniprot)
NextProtP10586
With graphics : InterProP10586
Splice isoforms : SwissVarP10586(Swissvar)
Domaine pattern : Prosite (SRS)FN3 (PS50853)    IG_LIKE (PS50835)    TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    IG_LIKE (PS50835)    TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (SRS)Fibronectin_type3    Ig-like    Ig-like_fold    Ig_I-set    Ig_sub2    Tyr/Dual-specificity_Pase    Tyr_Pase_AS    Tyr_Pase_rcpt/non-rcpt   
Domains : Interpro (EBI)Fibronectin_type3    Ig-like    Ig-like_fold    Ig_I-set    Ig_sub2    Tyr/Dual-specificity_Pase    Tyr_Pase_AS    Tyr_Pase_rcpt/non-rcpt   
Related proteins : CluSTrP10586
Domain families : Pfam (SRS)fn3 (PF00041)    I-set (PF07679)    Y_phosphatase (PF00102)   
Domain families : Pfam (Sanger)fn3 (PF00041)    I-set (PF07679)    Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam00041    pfam07679    pfam00102   
Domain families : Smart (EMBL)FN3 (SM00060)  IGc2 (SM00408)  PTPc (SM00194)  
DMDM5792
Blocks (Seattle)P10586
PDB (SRS)1LAR    2DJU    2DN7    2EDX    2EDY    2YD5    2YD8   
PDB (PDBSum)1LAR    2DJU    2DN7    2EDX    2EDY    2YD5    2YD8   
PDB (IMB)1LAR    2DJU    2DN7    2EDX    2EDY    2YD5    2YD8   
PDB (RSDB)1LAR    2DJU    2DN7    2EDX    2EDY    2YD5    2YD8   
Human Protein AtlasENSG00000142949
HPRD01552
IPIIPI00107831   IPI00465186   IPI00853550   IPI00853169   IPI00384626   IPI00655814   IPI00480183   IPI01019036   
Protein Interaction databases
DIP (DOE-UCLA)P10586
IntAct (EBI)P10586
FunCoupENSG00000142949
REACTOMEPTPRF
Protein Interaction Database5792
BioGRIDPTPRF
InParanoidP10586
Interologous Interaction database P10586
IntegromeDBPTPRF
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PTPRF
SNP (GeneSNP Utah)PTPRF
SNP : HGBasePTPRF
Genetic variants : HAPMAPPTPRF
Somatic Mutations in Cancer : COSMICPTPRF 
CONAN: Copy Number AnalysisPTPRF 
Mutations and Diseases : HGMDPTPRF
OMIM179590   
GENETests179590   
Disease Genetic AssociationPTPRF
Huge Navigator PTPRF [HugePedia]  PTPRF [HugeCancerGEM]
Genomic VariantsPTPRF  PTPRF [DGVbeta]
snp3D : Map Gene to Disease5792
General knowledge
Homologs : HomoloGenePTPRF
Homology/Alignments : Family Browser (UCSC)PTPRF
Phylogenetic Trees/Animal Genes : TreeFamPTPRF
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.48 [ Enzyme-SRS ]   3.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   
Chemical/Protein Interactions : CTD5792
Chemical/Pharm GKB GenePA34015
Clinical trialPTPRF
Cancer Resource (Charite)ENSG00000142949
Ontology : AmiGOnegative regulation of cytokine-mediated signaling pathway  protein tyrosine phosphatase activity  transmembrane receptor protein tyrosine phosphatase activity  insulin receptor binding  endosome  integral to plasma membrane  cell adhesion  homophilic cell adhesion  transmembrane receptor protein tyrosine phosphatase signaling pathway  heparin binding  negative regulation of cell proliferation  growth cone  receptor tyrosine kinase binding  negative regulation of cell projection organization  negative regulation of epidermal growth factor receptor signaling pathway  phosphate ion binding  neuronal cell body  positive regulation of neuron apoptotic process  negative regulation of insulin receptor signaling pathway  positive regulation of dendrite morphogenesis  regulation of synapse structure and activity  negative regulation of nerve growth factor receptor signaling pathway  excitatory synapse  
Ontology : EGO-EBInegative regulation of cytokine-mediated signaling pathway  protein tyrosine phosphatase activity  transmembrane receptor protein tyrosine phosphatase activity  insulin receptor binding  endosome  integral to plasma membrane  cell adhesion  homophilic cell adhesion  transmembrane receptor protein tyrosine phosphatase signaling pathway  heparin binding  negative regulation of cell proliferation  growth cone  receptor tyrosine kinase binding  negative regulation of cell projection organization  negative regulation of epidermal growth factor receptor signaling pathway  phosphate ion binding  neuronal cell body  positive regulation of neuron apoptotic process  negative regulation of insulin receptor signaling pathway  positive regulation of dendrite morphogenesis  regulation of synapse structure and activity  negative regulation of nerve growth factor receptor signaling pathway  excitatory synapse  
Pathways : KEGGCell adhesion molecules (CAMs)Insulin signaling pathwayAdherens junction
Other databases
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
PubGenePTPRF
iHOPPTPRF
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:23:44 CEST 2013
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